Heterozygous familialHeFHStatinsActive ingredient simvastatinHoFHHyperlipidemiaForm of familial hypercholesterolemiaCoronaryAtorvastatin or simvastatinZOCORAtherosclerosisTabletsChildren and adolescentsStatin therapy2023DosagePatientsCardiovascularEzetimibe and simvastatinTherapyVytorinMyopathyPeople simvastatinDiagnosisPitavastatinClinicallyReduceDecreasesEndothelial dysfunctionGeneticsCaused by mutationsHypersensitivityInadequateGeneticCholesterol in yourDoseTriglyceridesTreatmentHigh cholesterol
Heterozygous familial11
- Metacarpophalangeal joint tendon xanthomas in a 45-year-old man with heterozygous familial hypercholesterolemia. (medscape.com)
- In adults and pediatric patients aged 10 years and older with heterozygous familial hypercholesterolemia (HeFH). (nih.gov)
- Primary Hypercholesterolaemia EZETIMIBE/SIMVASTATIN-MEDIS is indicated as adjunctive therapy to diet in patients with primary (heterozygous familial and non-familial) hypercholesterolaemia or mixed hyperlipidaemia where use of a combination product is appropriate: Patients not appropriately controlled with a statin or ezetimibe alone. (healthdirect.gov.au)
- Children and Adolescents 10-17 years (pubertal status: boys Tanner Stage II and above and girls who are at least one year post- menarche),Heterozygous Familial Hypercholesterolaemia (HeFH) EZETIMIBE/SIMVASTATIN-MEDIS is indicated as adjunctive therapy to diet in adolescent patients (10-17 years old) with heterozygous familial hypercholesterolaemia where use of a combination product is appropriate: Patients not appropriately controlled with a statin or ezetimibe alone. (healthdirect.gov.au)
- Reduce elevated total cholesterol (total-C), low-density lipoprotein cholesterol (LDL-C), apolipoprotein B (Apo B), and triglycerides (TG), and to increase high-density lipoprotein cholesterol (HDL-C) in patients with primary hyperlipidemia (Fredrickson type IIa, heterozygous familial and nonfamilial) or mixed dyslipidemia (Fredrickson type IIb). (globalrph.com)
- Heterozygous familial hypercholesterolemia individuals inherit one mutated copy of the LDL receptor gene from one parent and one normal copy from the other parent. (delveinsight.com)
- A major difference between homozygous and heterozygous familial hypercholesterolemia is the presence of cholesterol levels. (delveinsight.com)
- The ENHANCE ( Effect of Combination Ezetimibe and High-Dose Simvastatin vs. Simvastatin Alone on the Atherosclerotic Process in Patients with Heterozygous Familial Hypercholesterolemia) trial results were released by Merck and Schering-Plough Pharmaceuticals on January 14, 2008. (acc.org)
- Ezetimibe and simvastatin tablets are indicated for the reduction of elevated total cholesterol (total-C), low-density lipoprotein cholesterol (LDL-C), apolipoprotein B (Apo B), triglycerides (TG), and non-high-density lipoprotein cholesterol (non-HDL-C), and to increase high-density lipoprotein cholesterol (HDL-C) in patients with primary (heterozygous familial and non-familial) hyperlipidemia or mixed hyperlipidemia. (tevapharm.com)
- It is most commonly used to treat high cholesterol ( hyperlipidemia) and a condition called heterozygous familial hypercholesterolemia. (chenandchencpa.com)
- Zocor is also used to treat heterozygous familial hypercholesterolemia (HeFH) in adolescents (males and females that are one-year post menarche , 10 to 17 years old). (rxlist.com)
HeFH1
- While most people suffer from HeFH, in rare cases, the mutations in both copies of genes related to cholesterol metabolism give rise to the lethal form of familial hypercholesterolemia, i.e. (delveinsight.com)
Statins7
- Like other members of its class (the "statins"), simvastatin lowers total serum cholesterol and particularly low density lipoprotein (LDL) cholesterol concentrations, thereby reducing the risk of atherosclerosis and its complications - myocardial infarction and stroke. (nih.gov)
- What is the effectiveness of different statins for children with familial hypercholesterolemia? (paho.org)
- Simvastatin (Flolipid or Zocor) belongs to a class of drugs called statins and is currently the 10th most prescribed drug in America. (medika.life)
- Simvastatin is in a class of medications called HMG-CoA reductase inhibitors (statins). (pharmacious.com)
- The active ingredient simvastatin, from the class of "statins", inhibits the body's own production of cholesterol in the liver. (gl-pharma.com)
- Familial hypercholesterolemia and statins in the COVID-19 era: Mitigating the risk of ischemic stroke. (cdc.gov)
- May statins and PCSK9 inhibitors be protective from COVID-19 in familial hypercholesterolemia subjects? (cdc.gov)
Active ingredient simvastatin1
- Zocor tablets contain the active ingredient simvastatin, which is a type of medicine called a statin. (dokteronline.com)
HoFH7
- As an adjunct to other LDL-C-lowering therapies to reduce LDL-C in adults with homozygous familial hypercholesterolemia (HoFH). (nih.gov)
- Homozygous Familial Hypercholesterolaemia (HoFH) EZETIMIBE/SIMVASTATIN-MEDIS is indicated in patients with HoFH. (healthdirect.gov.au)
- Homozygous Familial Hypercholesterolaemia (HoFH) EZETIMIBE/SIMVASTATIN-MEDIS is indicated in adolescent patients (10-17 years old) with HoFH. (healthdirect.gov.au)
- Reduce total-C and LDL-C in patients with homozygous familial hypercholesterolemia (HoFH) as an adjunct to other lipid-lowering treatments (e.g. (globalrph.com)
- Homozygous familial hypercholesterolemia (HoFH) is a rare form of familial hypercholesterolemia, an autosomal-dominant genetic disorder of lipid metabolism characterized by strikingly elevated levels of low-density lipoprotein cholesterol (LDL-C). (delveinsight.com)
- What is Homozygous Familial Hypercholesterolemia (HoFH)? (delveinsight.com)
- This is because patients with homozygous familial hypercholesterolemia (HoFH) lack functional LDL receptor activity and most of the current drugs work mainly through upregulation of LDL receptor in the liver. (ijpsr.com)
Hyperlipidemia11
- Hyperlipidemia vs. Hypercholesterolemia: What's the Difference? (healthline.com)
- What's the Difference Between Hyperlipidemia and Hypercholesterolemia? (healthline.com)
- You may have also heard of hyperlipidemia and hypercholesterolemia and wondered if these conditions are the same and how they relate to your cholesterol or triglyceride levels. (healthline.com)
- Hypercholesterolemia is a specific type of hyperlipidemia. (healthline.com)
- This type of hyperlipidemia is called primary hyperlipidemia, or familial hyperlipidemia . (healthline.com)
- The risk factors, potential causes, and possible health impacts are the same for hypercholesterolemia as they are for hyperlipidemia. (healthline.com)
- What are the key differences between hypercholesterolemia and hyperlipidemia? (healthline.com)
- Hypercholesterolemia is a type of hyperlipidemia. (healthline.com)
- Neither hyperlipidemia nor hypercholesterolemia cause symptoms in most people. (healthline.com)
- Simvastatin is not indicated where hypertriglyceridemia is the main abnormality (i.e., hyperlipidemia types I, IV and V). (bernofarm.com)
- The tablet, which is available as a once-daily tablet containing 10 mg of ezetimibe combined with 10, 20, 40, or 80 mg of atorvastatin, can be used to treat elevated LDL-cholesterol levels in patients with primary or mixed hyperlipidemia as an adjunct to dietary changes, as well as for reducing cholesterol levels in patients with homozygous familial hypercholesterolemia (FH). (acc.org)
Form of familial hypercholesterolemia1
- Simvastatin is not effective in patients with homozygous form of familial hypercholesterolemia. (bernofarm.com)
Coronary8
- However, one parent will have severe hypercholesterolemia and will also probably have either a personal or family history for premature coronary artery disease (CAD). (medscape.com)
- Familial hypercholesterolaemia is underdiagnosed and undertreated in the general population: guidance for clinicians to prevent coronary heart disease: Consensus Statement of the European Atherosclerosis Society. (medscape.com)
- Simvastatin and niacin, antioxidant vitamins, or the combination for the prevention of coronary disease. (medscape.com)
- Familial hypercholesterolemia and coronary heart disease: a HuGE association review. (medscape.com)
- Current indications for simvastatin are hypercholesterolemia and reduction in risk for death from coronary, cerebrovascular and peripheral artery disease in patients with these diseases. (nih.gov)
- Adults (=18 years),Prevention of Cardiovascular Disease EZETIMIBE/SIMVASTATIN-MEDIS is indicated in patients with coronary heart disease (CHD) and a history of acute coronary syndrome (ACS) taking their maximum tolerated dose of simvastatin and in need of additional lowering of LDL-C in the expectation of a modest further reduction in the risk of cardiovascular events following at least one year of therapy (see Clinical Trials). (healthdirect.gov.au)
- Simvastatin can also be used to reduce the risk of coronary heart disease in people who have already had a heart attack, or who suffer from angina or diabetes. (dokteronline.com)
- Development of coronary heart disease in familial hypercholesterolemia. (jamanetwork.com)
Atorvastatin or simvastatin2
- This proposal would mean patients who meet the Special Authority criteria (or equivalent Hospital Restrictions) who have high cholesterol and who have not responded to atorvastatin or simvastatin (with or without ezetimibe), would have access to another funded option. (pharmac.govt.nz)
- Prescribers would have the option to prescribe rosuvastatin for patients with high cardiovascular risk and high cholesterol who have not responded adequately to atorvastatin or simvastatin (with or without ezetimibe). (pharmac.govt.nz)
ZOCOR9
- Simvastatin is available generic forms and under the commercial name of Zocor in tablets of 5, 10, 20, 40 and 80 mg. the recommended dose is 5 to 80 mg daily based upon tolerability and lipid levels. (nih.gov)
- ZOCOR (simvastatin) is a lipid-lowering agent that is derived synthetically from a fermentation product of Aspergillus terreus. (globalrph.com)
- Purchase Simvastatin without a prescription or Generic Zocor from 500mg.org and get exceptional drug on reduced international prices. (llclinic.com)
- Buy generic Zocor online at the finest affordable cost from 500mg.org and get your Simvastatin pills sent at your doorstep in time. (llclinic.com)
- familial hypercholesterolemia), sources of cholesterol in the upper the Academy of lowering of LDL, out that Combien Online Zocor Houston draw Combien Online Zocor Houston mass strategy in the can clear out the cholesterol deposits, soy milk, soy one preliminary cause. (jmcompanionservices.com)
- Simvastatin is available under the following different brand names: Flolipid, Zocor. (medika.life)
- Additionally, 2 mg of Livalo lowers cholesterol to an extent similar to 20 mg of Zocor (simvastatin) LIVALO (pitavastatin) is indicated as an adjunctive therapy to diet to reduce elevated total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), apolipoprotein B (Apo B), triglycerides. (chenandchencpa.com)
- Mevacor ( lovastatin ) and Zocor ( simvastatin ) are both used to reduce cholesterol levels. (rxlist.com)
- Zocor (simvastatin) is a statin that lowers lipids and cholesterol levels used in conjunction with lifestyle changes such as a low-fat, low cholesterol diet, and exercise to reduce the chances of cardiovascular disease and ischemic strokes in patients with elevated lipids and cholesterol. (rxlist.com)
Atherosclerosis3
- Treatment with lipid-altering agents can be considered for use in patients which have increased atherosclerosis vascular risk due to hypercholesterolemia. (bernofarm.com)
- Familial Hypercholesterolemia (FH) is an autosomal dominant disorder caused by mutation in the LDL receptor gene and characterized by raised LDL-C, tendon xanthomata and premature atherosclerosis. (ijpsr.com)
- Familial hypercholesterolemia (FH) is an autosomal-dominant condition that is characterized by elevated levels of plasma LDL cholesterol and apo-lipoprotein B resulting in an increased risk for atherosclerosis 1 . (ijpsr.com)
Tablets9
- These highlights do not include all the information needed to use SIMVASTATIN TABLETS safely and effectively. (nih.gov)
- See full prescribing information for SIMVASTATIN TABLETS. (nih.gov)
- SIMVASTATIN tablets, for oral use. (nih.gov)
- Teva Pharmaceutical Industries Ltd., (NYSE and TASE:TEVA) today announced the launch of generic Vytorin ®1 (ezetimibe and simvastatin) tablets in the U.S. (tevapharm.com)
- Ezetimibe and simvastatin tablets further enhance Teva's statin portfolio. (tevapharm.com)
- Ezetimibe and simvastatin tablets are indicated for the reduction of elevated total-C and LDL-C in patients with homozygous familial hypercholesterolemia, as an adjunct to other lipid-lowering treatments (e.g. (tevapharm.com)
- Limitations of Use: No incremental benefit of ezetimibe and simvastatin tablets on cardiovascular morbidity and mortality over and above that demonstrated for simvastatin has been established. (tevapharm.com)
- Ezetimibe and simvastatin tablets have not been studied in Fredrickson type I, III, IV, and V dyslipidemias. (tevapharm.com)
- Livalo has less drug-drug interaction than atorvastatin and simvastatin, as Livalo is minimally metabolized by cytochrome P450 (CYP) enzyme Important Safety Informationfor LIVALO ® (pitavastatin) tablets. (chenandchencpa.com)
Children and adolescents2
- Familial hypercholesterolaemia in children and adolescents: gaining decades of life by optimizing detection and treatment. (medscape.com)
- Attainment of LDL Cholesterol Treatment Goals in Children and Adolescents With Familial Hypercholesterolemia. (revespcardiol.org)
Statin therapy1
- The Knowns and Unknowns of Contemporary Statin Therapy for Familial Hypercholesterolemia. (cdc.gov)
20231
- HDL in Familial Hypercholesterolemia" Encyclopedia , https://encyclopedia.pub/entry/12508 (accessed December 02, 2023). (encyclopedia.pub)
Dosage7
- Maximum recommended dosage is simvastatin 40 mg once daily. (nih.gov)
- Simvastatin 80 mg daily dosage is restricted to patients who have been taking simvastatin 80 mg daily chronically (e.g., for 12 months or more) without evidence of muscle toxicity. (nih.gov)
- See full prescribing information for simvastatin dosage modifications due to drug interactions. (nih.gov)
- Myopathy and Rhabdomyolysis: Risk factors include age 65 years or greater, uncontrolled hypothyroidism, renal impairment, concomitant use with certain other drugs, and higher simvastatin dosage. (nih.gov)
- Inform patients of the risk of myopathy and rhabdomyolysis when starting or increasing simvastatin dosage. (nih.gov)
- 500mg.org offers you the possibility to purchase inexpensive Simvastatin 5, 10, 20, 40 mg online and also find out more about Simvastatin side effects, dosage information and drug interactions. (llclinic.com)
- Patients in renal insufficiency : Dosage adjustment is not necessary, because Simvastatin does not undergo significant renal excretion. (bernofarm.com)
Patients23
- For patients that require a high-intensity statin or are unable to achieve their LDL-C goal receiving simvastatin 40 mg daily, prescribe alternative LDL-C lowering treatment. (nih.gov)
- Use another simvastatin product to initiate dosing in such patients. (nih.gov)
- Temporarily discontinue simvastatin in patients experiencing an acute or serious condition at high risk of developing renal failure secondary to rhabdomyolysis. (nih.gov)
- Up to 5% of patients taking simvastatin chronically may experience minor elevations in serum ALT levels during therapy, but confirmed elevations to above three times the upper limit of normal (ULN) occur in only 1% to 2% of patients. (nih.gov)
- ALT elevations are clearly more frequent in patients taking higher doses of simvastatin (40 and 80 mg daily). (nih.gov)
- In several studies, ALT elevations were no more frequent in patients taking 10 and 20 mg of simvastatin daily than in placebo recipients. (nih.gov)
- This includes patients with homozygous familial hypercholesterolemia and those who have previously had a heart attack or stroke. (medlineplus.gov)
- Ezetimibe and simvastatin should be administered to women of childbearing age only when such patients are highly unlikely to conceive. (tevapharm.com)
- Little is known about the characteristics of persons with familial hypercholesterolemia (FH) younger than 18 years, the lipid-lowering therapy used in these patients, and the lipid goals reached in real life. (revespcardiol.org)
- This dose is only recommended in patients with severe hypercholesterolaemia and high risk for cardiovascular complication who have not achieved their treatment goals on lower doses and when benefits are expected to outweigh the potential risks. (medscape.co.uk)
- A dose of 5mg daily in combination with non-pharmacological measures (e.g. exercise, diet and weight reduction) may be suitable for patients with less severe hypercholesterolaemia. (medscape.co.uk)
- Reduction of elevated total and LDL-cholesterol levels in patients with primary hypercholesterolemia (Types IIa and IIb). (bernofarm.com)
- In several hypercholesterolemia patients, although LDL-cholesterol is low or normal, total cholesterol can be high. (bernofarm.com)
- The patients should be placed on a standard cholesterol-lowering diet before receiving and should continue on this diet during treatment with Simvastatin. (bernofarm.com)
- Patients taking immunosuppressive drugs concomitantly with HMG-CoA reductase inhibitor, should be given the recommended lowest dose of Simvastatin. (bernofarm.com)
- However, caution should be exercised when Simvastatin is administered to patient with severe renal insufficiency, such patients should be started at 5 mg/day and be closely monitored. (bernofarm.com)
- Therapy with Simvastatin should be stopped temporarily or discontinued in patients with an acute and severe myopathy or having a risk secondary renal failure due to rhabdomyolysis or elevation of creatinine phosphokinase (CPK). (bernofarm.com)
- Of critically ill patients, quicker access, ultrasound provisional diagnosis, of deep vein thrombosis and pulmonary embolism should include a clinical probability sinvastamed simvastatin pharmacy South Africa of pulmonary embolism a negative quantitative dimer. (hybridnutrition.co.za)
- For a specific period, than necessary sionals, but patients may, what is Sinvastamed made of generic simvastatin manifest itself as a cost to the economy or taxation system. (hybridnutrition.co.za)
- As adjunctive therapy to diet for reduction or elevated sitosterol and campesterol in patients with homozygous familial sitosterolemia. (exploremyplan.com)
- Simvastatin Therapy Increased miR-150-5p Expression in the Patients with Type 2 Diabetes and COVID-19. (cdc.gov)
- Brief recommendations on the management of adult patients with familial hypercholesterolemia during the COVID-19 pandemic. (cdc.gov)
- Further, not all patients with hypercholesterolemia will need a statin. (medscape.com)
Cardiovascular3
- Familial hypercholesterolemia (FH) is a genetic disorder characterized by high cholesterol levels, specifically very high levels of low-density lipoprotein cholesterol (LDL cholesterol), in the blood and early cardiovascular diseases. (wikipedia.org)
- The treatment of Familial Hypercholesteraemia is recommended to reduce the risk of future cardiovascular events. (breastfeedingnetwork.org.uk)
- Family history of cardiovascular events and endothelial dysfunction in children with familial hypercholesterolemia. (jamanetwork.com)
Ezetimibe and simvastatin1
- Ezesim ® contains the active substances ezetimibe and simvastatin. (gl-pharma.com)
Therapy8
- Familial hypercholesterolemia: a challenge of diagnosis and therapy. (medscape.com)
- Simvastatin is a commonly used cholesterol lowering agent (statin) that is associated with mild, asymptomatic and self-limited serum aminotransferase elevations during therapy, and rarely with clinically apparent acute liver injury. (nih.gov)
- Isolated cases of an autoimmune hepatitis-like syndrome associated with simvastatin therapy have been reported, some of which did not reverse completely with discontinuation, resulting in a chronic hepatitis requiring long term immunosuppressive therapy. (nih.gov)
- Therapy with lipid-altering agents should be only one component of multiple risk factor intervention in individuals at significantly increased risk for atherosclerotic vascular disease due to hypercholesterolemia. (globalrph.com)
- Prior to initiating therapy with Simvastatin, secondary causes for hypercholesterolemia (e.g., poorly controlled diabetes mellitus, hypothyroidism, nephrotic syndrome, dysproteinemias, obstructive liver disease, other drug therapy, alcoholism) should be exclude and a lipid profile performed to measure Total cholesterol, HDL cholesterol and triglycerides (TG). (bernofarm.com)
- Concomitant therapy with other drug : Simvastatin is effective alone or in combination with bile acid sequestrants. (bernofarm.com)
- Cholesterol examination should be done periodically during therapy with Simvastatin. (bernofarm.com)
- Although ezetimibe is approved as monotherapy for the treatment of primary hypercholesterolemia, concomitant therapy with a statin has demonstrated effectiveness in improving serum lipid profiles beyond either treatment alone, and in clinical trials, greater effectiveness has been seen from a statin plus ezetimibe than from increased doses of statin monotherapy. (exploremyplan.com)
Vytorin6
- Simvastatin is also available as a fixed combination with ezetimibe under the brand name Vytorin. (nih.gov)
- Media reports indicate that the results of the trial show no benefit from the combination of ezetimibe (Zetia) and simvastatin (sold together as Vytorin) over simvastatin alone in terms of changes in carotid artery thickness. (acc.org)
- The study was designed to prove that Vytorin could slow the growth of plaque in carotid arteries supplying the brain more than simvastatin alone. (acc.org)
- The difference in the changes in carotid artery thickening was 0.006 in the simvastatin group and 0.011 mm in the Vytorin group. (acc.org)
- Three large trials comparing Vytorin to Simvastatin will be published within the next 3 years. (acc.org)
- A combination tablet (Vytorin) that includes simvastatin and ezetimibe is already available in the US. (acc.org)
Myopathy4
- Discontinue simvastatin if markedly elevated CK levels occur or myopathy is diagnosed or suspected. (nih.gov)
- Simvastatin occasionally causes myopathy manifested as muscle pain, tenderness or weakness with creatine kinase above ten times the upper limit of normal (ULN). (tevapharm.com)
- The SEARCH genome-wide association study, which has been independently replicated, found a significant association between the rs4149056 (c.521T>C) single-nucleotide polymorphism (SNP) in the SLCO1B1 gene, and myopathy in individuals taking 80 mg simvastatin per day, with an odds ratio of 4.5 per rs4149056 C allele. (plos.org)
- Using data from the SEARCH study, calculated values for the clinical sensitivity, specificity, positive- and negative-predictive values of a test for the C allele to predict definite or incipient myopathy during 5 years of 80 mg/day simvastatin use were 70.4%, 73.7%, 4.1% and 99.4% respectively. (plos.org)
People simvastatin1
- In these people simvastatin slows down hardening of the arteries, regardless of your cholesterol level. (dokteronline.com)
Diagnosis3
- The diagnosis of both homozygous and heterozygous FH is based primarily on the finding of severe LDLc elevations in the absence of secondary causes of hypercholesterolemia. (medscape.com)
- A review on the diagnosis, natural history, and treatment of familial hypercholesterolaemia. (medscape.com)
- Neonatal diagnosis of familial type-II hyperlipoproteinemia. (jamanetwork.com)
Pitavastatin1
- Pitavastatin was approved for use in hypercholesterolemia and for the prevention of CVDs outside South and Southeast Asia. (chenandchencpa.com)
Clinically3
- Clinically apparent liver injury due to simvastatin is rare. (nih.gov)
- But in view of the wide use of simvastatin, clinically apparent liver injury is exceeding rare and is estimated to occur in 1 per 100,000 patient years of exposure. (nih.gov)
- Additionally, the clinically relevant genetics tests of Warfarin, Clopidogrel and Simvastatin pharmacogenetics are included. (heartgenetics.com)
Reduce2
- If LDL-cholesterol concentration decreases under 75 mg/dl (1.94 mmol/l) or plasma cholesterol total concentration decreases under 140 mg/dl (3.6 mmol/l), it should be considered to reduce Simvastatin dose. (bernofarm.com)
- Simvastatin is used together with diet, weight-loss, and exercise to reduce the risk of heart attack and stroke and to decrease the chance that heart surgery will be needed in people who have heart disease or who are at risk of developing heart disease. (pharmacious.com)
Decreases1
- Simvastatin decreases the production of LDL cholesterol by blocking the action of the enzyme in the liver (called HMG-CoA reductase) that is responsible for its production. (dokteronline.com)
Endothelial dysfunction1
- Familial hypercholesterolaemia and COVID-19: A two-hit scenario for endothelial dysfunction amenable to treatment. (cdc.gov)
Genetics1
- Simvastatin is used to lower cholesterol in people who have high levels either due to genetics (familial hypercholesterolaemia) or as a result of diet and lifestyle. (dokteronline.com)
Caused by mutations1
- Autosomal recessive hypercholesterolemia caused by mutations in a putative LDL receptor adaptor protein. (medscape.com)
Hypersensitivity1
- Hypersensitivity to Simvastatin and any component of the drug. (bernofarm.com)
Inadequate1
- Adjunctive treatment of primary hypercholesterolaemia or mixed dyslipidaemia with dietary measures when response to diet and other non-pharmacological treatments (e.g. exercise and weight reduction) is inadequate. (medscape.co.uk)
Genetic3
- There are five types of familial dyslipidemia (not including subtypes), and each are classified from both the altered lipid profile and by the genetic abnormality. (wikipedia.org)
- HeartGenetics, a spin-off from Tecnico Lisboa, has developed new certified CE-IVD medical devices, which include genetic tests and AI software tools for data interpretation, to assess the individual risk for conditions such as Hereditary Thrombophilia (TRB), Arterial Hypertension (AHTN), Hypertrophic Cardiomyopathy (HCM), and Familial Hypercholesterolemia (FH). (heartgenetics.com)
- Familial hypercholesterolemia (one form of familial type II hyperlipoproteinemia): a study of its biochemical, genetic, and clinical presentation in childhood. (jamanetwork.com)
Cholesterol in your2
- With hypercholesterolemia, you either have too much LDL cholesterol or too little high-density lipoprotein (HDL) cholesterol in your blood. (healthline.com)
- Hypercholesterolemia is above normal levels of LDL or total cholesterol in your blood. (healthline.com)
Dose3
- Use of simvastatin is contraindicated in medications that are strong inhibitors of cytochrome P450 activity (such as cyclosporine, ketoconazole, diltiazem, ciprofloxacin or amiodarone), and dose adjustments are appropriate for its use with other agents that inhibit CYP 3A4. (nih.gov)
- Patient with mild to moderate hypercholesterolemia can be started with a starting dose of 5 mg/day. (bernofarm.com)
- Your doctor may start you on a low dose of simvastatin and gradually increase your dose, not more than once every 4 weeks. (pharmacious.com)
Triglycerides3
- Simvastatin also causes a small decrease in the production of other 'bad fats' in the blood called triglycerides, and a small increase in the level of HDL cholesterol. (dokteronline.com)
- USES: Simvastatin is used along with a proper diet to help lower "bad" cholesterol and fats (such as LDL, triglycerides) and raise "good" cholesterol (HDL) in the blood. (bidrx.com)
- Simvastatin is also used to decrease the amount of fatty substances such as low-density lipoprotein (LDL) cholesterol (''bad cholesterol'') and triglycerides in the blood and to increase the amount of high-density lipoprotein (HDL) cholesterol (''good cholesterol'') in the blood. (pharmacious.com)
Treatment2
- Dietary treatment of familial hypercholesterolemia. (medscape.com)
- Adjunctive treatment of homozygous familial hypercholesterolaemia with diet and other lipid lowering treatments (e.g. (medscape.co.uk)
High cholesterol1
- Familial hypercholesterolaemia is inherited high cholesterol. (patient.info)