• diabetes
  • For example, in cases where people have not had a heart attack but may be at risk of having one due to high or elevated cholesterol we look at the risk factors such as diabetes, smoking, weight, blood pressure, family history. (hospitalnews.com)
  • Are you a member of a high-risk race or ethnic group for diabetes (African American, Latin American, Native American, Asian American, or Pacific Islander)? (acog.org)
  • Primary hyperlipidemia is usually due to genetic causes (such as a mutation in a receptor protein), while secondary hyperlipidemia arises due to other underlying causes such as diabetes. (wikipedia.org)
  • Myocardial infarction and stroke prophylaxis in patients with type II diabetes There have been recent studies suggesting that high-dose statin therapy plays a plaque-stabilizing role in people suffering from acute coronary syndrome and thrombotic stroke. (wikipedia.org)
  • premature
  • To explore the hypothesis that tHcy level and the C677T mutation of methylenetetrahydrofolate reductase are associated with familial risk of premature CVD in FH, we examined these factors among children, in whom tHcy levels are less likely to be affected by established cardiovascular risk factors and by clinical or subclinical vascular lesions. (ahajournals.org)
  • treatment
  • It is currently unknown what would be the best treatment option for patients with mixed hyperlipidemia who fail to meet their lipid targets with statin monotherapy at conventional does, i.e. high dose rosuvastatin or conventional statin dose plus micronized fenofibrate or conventional statin dose plus niacin/laropiprant. (clinicaltrials.gov)
  • Nevertheless, treatment (including higher statin doses) is usually effective. (wikipedia.org)
  • liver
  • You can also get cholesterol through animal food sources, though these are usually high in saturated and trans fats, which force your liver to make even more cholesterol than it would on its own. (bidmc.org)
  • SCD-1 expression is significantly increased in liver tissue and heart in response to a high-carbohydrate diet, whereas SCD-2 expression is observed in brain tissue and induced during the neonatal myelination. (wikipedia.org)
  • Mice that were fed a high-carbohydrate diet had an induced expression of the liver SCD-1 gene and other lipogenic genes through an insulin-mediated SREBP-1c-dependent mechanism. (wikipedia.org)
  • diet
  • You can get these good fats in your diet or you can get high doses in a fish oil supplement or by prescription. (verywell.com)
  • This often includes eating a diet that is high in fat . (medlineplus.gov)
  • High cholesterol can usually be successfully improved and managed through healthy diet and lifestyle changes. (bidmc.org)
  • I'm sure that diet will help, but genetics almost always plays a large role in numbers that high - I hope they are monitoring you closely. (sparkpeople.com)
  • A diet that is low in cholesterol and saturated fat may help to control LDL levels in people at high risk. (baptistjax.com)
  • Diets high in high-saturated as well as monounsaturated-fat can also increase SCD-1 expression, although not to the extent of the lipogenic effect of a high-carb diet. (wikipedia.org)
  • Statin
  • Since individuals with FH underlying body biochemistry is slightly different, their high cholesterol levels are less responsive to the kinds of cholesterol control methods which are usually more effective in people without FH (such as dietary modification and statin tablets). (wikipedia.org)
  • PCSK9
  • PCSK9 inhibitors, such as alirocumab (Praluent) and evolocumab (Repatha) These represent a newer class of drugs to treat high cholesterol. (baptistjax.com)
  • Interestingly, the plasma PCSK9 concentration is higher in women compared to men, and the PCSK9 concentrations decrease with age in men but increasein women, suggesting that estrogen level most likely plays a role. (wikipedia.org)
  • Prognosis
  • It has been recognized for over one-half century that significant LMCA disease is associated with a poor prognosis, with 3-year mortality rates in the pre-revascularization era as high as 63% in high-risk subgroups (1) . (onlinejacc.org)
  • conditions
  • When levels are somewhere between borderline high and the low end of high (150 to 200 mg/dL), and are not joined by other serious conditions, it's possible to decrease triglycerides without drugs. (verywell.com)
  • When the body produces insulin under conditions of insulin resistance, the cells are resistant to the insulin and are unable to use it as effectively, leading to high blood sugar. (wikipedia.org)
  • history
  • Do you have a history of breast biopsy results that are associated with a high risk of breast cancer? (acog.org)
  • increase
  • Very high levels that would increase the risk of pancreatitis is treated with a drug from the fibrate class. (wikipedia.org)
  • Beta cells in the pancreas subsequently increase their production of insulin, further contributing to a high blood insulin level. (wikipedia.org)
  • insulin
  • These lipases are activated by high epinephrine and glucagon levels in the blood (or norepinephrine secreted by sympathetic nerves in adipose tissue), caused by declining blood glucose levels after meals, which simultaneously lowers the insulin level in the blood. (wikipedia.org)
  • patients
  • Some doctors tell their patients that they don't have to fast to have a lipid panel drawn, but triglycerides tend to be high in the non-fasting state, so I tell my patients to fast for six hours (water is OK). (postindependent.com)
  • Geriatric: Plasma concentrations of atorvastatin in healthy elderly subjects are higher than those in young adults, and clinical data suggests a greater degree of LDL-lowering at any dose for patients in the population as compared to young adults. (wikipedia.org)
  • Arterial baroreceptors are reset to a higher pressure in hypertensive patients, and this peripheral resetting reverts to normal when arterial pressure is normalized. (wikipedia.org)