• disease
  • To determine how strain influences the transcriptional response to pressure overload-induced heart failure (HF) and which of these changes accurately reflect the human disease, we analyzed the myocardial transcriptional profile of mouse strains with high (C57BL/6J) and low (129S1/SvImJ) susceptibility for HF development, which we compared to that of human failing hearts. (readbyqxmd.com)
  • vascular
  • 15,16 Thus, vascular calcification introduces compliance mismatch that can promote mechanical failure due to stress concentration at the interfaces of calcium deposits with softer plaque components. (ahajournals.org)
  • heart
  • In human heart failure, there are characteristic alterations in the cardiac β-adrenoceptor system: selective downregulation of β 1 -adrenoceptors with little or no change in β 2 -adrenoceptors, reduced adenylyl cyclase activity, increased G protein-coupled receptor kinases (GRKs) activity, and reduced neuronal noradrenaline transporter. (ahajournals.org)
  • 1-6 ⇓ ⇓ ⇓ ⇓ ⇓ We and others have recently shown that the monocrotaline rat model of right heart failure exhibits alterations in myocardial β-adrenoceptors that resemble those in human heart failure: a decrease in β-adrenoceptors, a reduction in adenylyl cyclase, an increase in GRK, and a reduction in neuronal noradrenaline transporter. (ahajournals.org)
  • Specific cardiomyopathies describe heart muscle diseases that have been further defined based in part on their etiologies and their association with specific systemic or cardiac disorders. (asmscience.org)
  • 2003. Metalloproteinases 2 and 9 are increased in plasma of patients with heart failure. (asmscience.org)
  • 2003. Dendritic cell-induced autoimmune heart failure requires cooperation between adaptive and innate immunity. (asmscience.org)
  • 2000. G proteins and heart failure: is Gaq a novel target for heart failure? (asmscience.org)
  • Adipose tissue lipolysis occurs during the development of heart failure as a consequence of chronic adrenergic stimulation. (readbyqxmd.com)
  • To investigate the role of adipose tissue lipolysis during heart failure, we generated mice with tissue-specific deletion of ATGL (atATGL-KO). (readbyqxmd.com)
  • effects
  • Most cardiovascular studies have implicated the central transcription factor nuclear factor kappa B (NF-κB) as contributing to the detrimental effects of cardiac injury. (pubmedcentralcanada.ca)
  • mass
  • SHR have higher cardiac mass and fibrosis, more VPB, and a decreased HR. Cluster analysis demonstrated that trandolapril was only effective in SHR. (ahajournals.org)
  • 2003. Plasma 99th percentile reference limits for cardiac troponin and creatine kinase MB mass for use with European Society of Cardiology/American College of Cardiology consensus recommendations. (asmscience.org)
  • changes
  • This is associated with characteristic changes in right ventricular β-adrenoceptors (β-AR), neuronal noradrenaline transporter (NAT) density and activity (uptake 1 ), and G protein-coupled receptor kinase (GRK) activity. (ahajournals.org)