• He also hypothesized that contrasts in sexual selection acting along with natural selection were significant factors in the geographical differentiation in human appearance of some isolated groups, as he did not believe that natural selection alone provided a satisfactory answer. (wikipedia.org)
  • Mechanisms of sex differentiation in animals and man / edited by C. R. Austin and R. G. Edwards. (who.int)
  • Recent research has highlighted a strong correlation between tissue-specific cancer risk and the lifetime number of tissue-specific stem-cell divisions. (nature.com)
  • First, we demonstrate that the correlation between stem-cell division and cancer risk does not distinguish between the effects of intrinsic and extrinsic factors. (nature.com)
  • Figure 2: Correlation analysis of stem-cell division and cancer risk does not distinguish contribution of extrinsic versus intrinsic factors to cancer risk. (nature.com)
  • He reasoned that since the bodies of females are more nearly hairless, the loss of fur was due to sexual selection of females at a remote prehistoric time when males had overwhelming selective power, and that it nonetheless affected males due to genetic correlation between the sexes. (wikipedia.org)
  • Below are some of the important functions and biological roles transcription factors are involved in: In eukaryotes, an important class of transcription factors called general transcription factors (GTFs) are necessary for transcription to occur. (wikipedia.org)
  • Future research in this area should focus on increased risks based on biological sex, physical limitations, race and income level. (hopkinsmedicine.org)
  • Sexual selection is a biological way one sex chooses a mate for the best reproductive success. (wikipedia.org)
  • The purpose of our study is to determine the possible factors affecting the prevalence of thyroid diseases and the epidemiological characteristics of thyroid diseases in Hainan. (hindawi.com)
  • The study therefore aimed at determining the prevalence of syphilis in HIV positive antiretroviral therapy naive patients in Cape Coast and the associated risk factors involved in infection. (scirp.org)
  • Although thousands of prognostic factor studies are published each year, often they are of variable quality and the findings are inconsistent. (bmj.com)
  • According to Silke Appel-Cresswell, MD , Marg Meikle Professor for Parkinson's Research at the University of British Columbia, Vancouver, the findings align with previous prospective cohort studies demonstrating an increased risk of Parkinson's disease with greater consumption of dairy. (medscape.com)
  • Findings are consistent with a vicious cycle of family, work related and financial stress factors, and mental and physical burden, particularly in men. (biomedcentral.com)
  • Like in some of the previous studies, the authors find sex differences with an increased risk for men but not women. (medscape.com)
  • This research is urgently needed and analyses will need to take sex differences and a large range of potential other factors into account. (medscape.com)
  • We hypothesize that a neutrophil-mediated endogenous analgesic mechanism is responsible for sex differences in nociception secondary to oral squamous cell carcinoma (SCC). (frontiersin.org)
  • Transcription factors use a variety of mechanisms for the regulation of gene expression. (wikipedia.org)
  • whilst in the other, the struggle is likewise between the individuals of the same sex, in order to excite or charm those of the opposite sex, generally the females, which no longer remain passive, but select the more agreeable partners. (wikipedia.org)
  • Systematic reviews and meta-analyses are therefore needed that summarise the evidence about the prognostic value of particular factors. (bmj.com)
  • In factor analyses, variables measuring pregnancy intendedness were represented by a single latent factor, pregnancy desirability. (guttmacher.org)
  • Asare-Bediako, P. , Dankwa, K. , Azumah, D. and Nuvor, S. (2018) Seroprevalence and Risk Factors of Syphilis Infection among Antiretroviral Therapy Naive HIV Patients at the Cape Coast Teaching Hospital, Ghana. (scirp.org)
  • Recently, there was a cohort study analysing the risk factors of incident syphilis infection among HIV-positive MSM in Japan, 17 but behavioural factors were not assessed. (who.int)
  • HIV infection, previously reported to be a risk factor for meningococcal disease ( 8 ), was controlled for in the analysis. (cdc.gov)
  • Dairy a Risk Factor for Parkinson's? (medscape.com)
  • Previous studies highlighted dairy intake as a risk factor of Parkinson's disease," the investigators wrote in Movement Disorders . (medscape.com)
  • Alcohol use has also been implicated as a risk factor for the development of oral SCC and premalignant lesions. (medscape.com)
  • In two studies using nationally representative data from the National Health and Aging Trends Study gathered on thousands of Americans, researchers from the Johns Hopkins University School of Medicine and Bloomberg School of Public Health have significantly added to evidence that social isolation is a substantial risk factor for dementia in community-dwelling (noninstitutionalized) older adults, and identified technology as an effective way to intervene. (hopkinsmedicine.org)
  • Positive thyroid autoantibody was a risk factor for abnormal thyroid function, which has almost become a recognized fact in the academic circles [ 2 - 4 , 6 , 12 , 13 ]. (hindawi.com)
  • 7 ] confirmed MB as an independent risk factor for gambling problems while controlling for other demographic risk factors and gambling preference. (biomedcentral.com)
  • Age is a risk factor for Parkinson's disease. (michaeljfox.org)
  • 10-13 Using mobile phone applications and the Internet to seek partners has also been reported as a potential risk factor for STIs, including syphilis, among MSM. (who.int)
  • Is insomnia a risk factor for new-onset asthma? (bmj.com)
  • Objectives To determine whether insomnia at baseline is a risk factor for new-onset asthma. (bmj.com)
  • Conclusions This large population-based study suggests that insomnia at baseline is a risk factor for developing asthma. (bmj.com)
  • Outbreak investigations should consider routinely capturing information regarding drug use and sex-related risk factors. (cdc.gov)
  • The number of transcription factors found within an organism increases with genome size, and larger genomes tend to have more transcription factors per gene. (wikipedia.org)
  • There are approximately 2800 proteins in the human genome that contain DNA-binding domains, and 1600 of these are presumed to function as transcription factors, though other studies indicate it to be a smaller number. (wikipedia.org)
  • Therefore, approximately 10% of genes in the genome code for transcription factors, which makes this family the single largest family of human proteins. (wikipedia.org)
  • Hence, the combinatorial use of a subset of the approximately 2000 human transcription factors easily accounts for the unique regulation of each gene in the human genome during development. (wikipedia.org)
  • Most compete with others of the same sex for the best mate to contribute their genome for future generations. (wikipedia.org)
  • Our aim was to identify latent factors underlying multiple observed risk factors for older adult falls and to examine their effects on falls by age and sex. (cdc.gov)
  • Although there is some research on the biologic factors that affect diabetes in general - they affect the neurologic, vascular, and hormonal systems - and the potential role that these impairments may play on the sexual function of diabetic women, the strongest evidence for lifestyle intervention has to do with improving the psychosocial factors that I mentioned. (medscape.com)
  • In molecular biology, a transcription factor (TF) (or sequence-specific DNA-binding factor) is a protein that controls the rate of transcription of genetic information from DNA to messenger RNA, by binding to a specific DNA sequence. (wikipedia.org)
  • Figure 1: Schematic showing how intrinsic processes and extrinsic factors relate to cancer risks through stem-cell division. (nature.com)
  • This study shows that access and use of simple technologies are important factors that protect older adults against social isolation, which is associated with significant health risks. (hopkinsmedicine.org)
  • Probably the most important psychological or psychiatric factor is depression and its association with the disease state and its complications. (medscape.com)
  • This database, created in 2000, is updated every three months with newly published scientific articles, books, and other publications related to improving or safeguarding the welfare of animals used in research. (awionline.org)
  • Global estimates and projections of population by sex and age : the 1984 assessment. (who.int)
  • Other scientists who contributed to this research are Laura Prichett, Cynthia Boyd, David Roth, Tom Cidav, Shang-En Chung, Halima Amjad, and Roland Thorpe of the Johns Hopkins University School of Medicine and Bloomberg School of Public Health. (hopkinsmedicine.org)
  • Since then, the study has changed how research is done and what scientists know about the brain. (michaeljfox.org)
  • Data collected between March 2002 and February 2003 from 701 women in a public family planning clinic and 671 women in a public prenatal clinic in New Orleans were analyzed to examine factors underlying intendedness (including attitudes toward pregnancy and motivations to achieve or avoid pregnancy). (guttmacher.org)
  • RESEARCH DESIGN AND METHODS -The present article reports on a nested case-control study from the EURODIAB Prospective Complications Study of Europeans with type 1 diabetes. (diabetesjournals.org)
  • ABSTRACT Factors affecting parents' decision to involve their children in clinical research have not been studied in all cultural backgrounds. (who.int)
  • This trend is thought to be a reflection of the general acceptance of social habits such as smoking and drinking by both sexes. (medscape.com)
  • NHIRD does not include some important confounding factors, such as exposure to house dust mites, smoking habits, body mass index, family history or medical compliance. (bmj.com)
  • How cocaine affects a person depends on many factors, such as the form and amount used and whether it's smoked, snorted, injected, or taken orally. (healthline.com)
  • The transcription factor can either do this directly or recruit other proteins with this catalytic activity. (wikipedia.org)
  • Olsson I, Gatanaga T, Gullberg U, Lantz M, Granger GA. Tumour necrosis factor (TNF) binding proteins (soluble TNF receptor forms) with possible roles in inflammation and malignancy. (aaem.pl)
  • Oral cancer cells secrete granulocyte colony stimulating factor (G-CSF), a growth factor that recruits neutrophils from bone marrow to the cancer microenvironment. (frontiersin.org)
  • Socially isolated older adults have smaller social networks, live alone and have limited participation in social activities," says Alison Huang, Ph.D., M.P.H. , senior research associate at the Johns Hopkins Bloomberg School of Public Health. (hopkinsmedicine.org)
  • Over the four-year research period for this second study, older adults who had access to such technology consistently showed a 31% lower risk for social isolation than the rest of the cohort. (hopkinsmedicine.org)
  • 2021. Patterns of wounding in mixed-sex social groups of western lowland gorillas (Gorilla gorilla gorilla). (awionline.org)
  • Although there are biologic factors, probably the most important factors affecting the sexuality of women with diabetes has to do with their social and relational context, as well as their disease adaptation and their self-image and feelings about themselves related to diabetes. (medscape.com)
  • The paper determines risk factors, mental and physical health burden of probable GD for both men and women in the general population. (biomedcentral.com)
  • These problems occur in an age-related manner and sometimes in the context of biopsychosocial factors or physical changes associated with diabetes and diabetic conditions. (medscape.com)
  • We can counsel patients to improve cardiovascular risk factors and neurologic function, exercise, diet, particularly the Mediterranean diet, weight loss, improving physical and sexual self-esteem by being stronger, with muscular development, and improving bone health. (medscape.com)
  • However, case-control studies to evaluate unique risk factors among this population are lacking. (cdc.gov)
  • 6 7 In this article, we focus on prognostic factors. (bmj.com)
  • A Feature Paper should be a substantial original Article that involves several techniques or approaches, provides an outlook for future research directions and describes possible research applications. (mdpi.com)
  • All of these things can have a feedforward effect on overall body image, self-image, enthusiasm, and energy for sex and sexual function, specifically. (medscape.com)
  • Here we provide evidence that intrinsic risk factors contribute only modestly (less than ~10-30% of lifetime risk) to cancer development. (nature.com)
  • Collectively, we conclude that cancer risk is heavily influenced by extrinsic factors. (nature.com)
  • Song, M. & Giovannucci, E. L. Cancer risk: many factors contribute. (nature.com)
  • Endometrial cancer invasion depends on cancer-derived tumor necrosis factor-alpha and stromal derived hepatocyte growth factor. (aaem.pl)
  • Onsrud M, Shabana A, Austgulen R, Nustad K. Comparison between soluble tumor necrosis factor receptors and CA125 in peritoneal fluids as a marker for epithelial ovarian cancer. (aaem.pl)
  • Opala T, Rzymski P, Wilczak M, Woźniak J. Evaluation of soluble tumour necrosis factor alpha receptors p55 and p75 in ovarian cancer patients. (aaem.pl)
  • In people with germline mutations, changes in other genes, together with environmental and lifestyle factors, also influence whether a person will develop breast cancer. (medlineplus.gov)
  • Risk factors for illness during a serogroup C meningococcal disease outbreak among men who have sex with men in New York City, New York, USA, in 2012-2013 included methamphetamine and cocaine use and sexually transmitted infections. (cdc.gov)
  • To more fully understand risk factors associated with the outbreak, the NYC Department of Health and Mental Hygiene (DOHMH) conducted a case-control study. (cdc.gov)
  • To better understand the syphilis outbreak among MSM in Tokyo, we conducted a clinic-based case-control study based on a self-administered questionnaire to assess the potential risk factors, including modifiable behavioural factors, for incident syphilis. (who.int)
  • The U.S. Centers for Disease Control and Prevention (CDC) would like to thank the following persons who worked diligently over a number of years to research, write, and compile the information presented in this document. (cdc.gov)
  • Recent studies among MSM have reported that factors associated with syphilis were low educational attainment, sex with casual partners without a condom and coinfection with other sexually transmitted infections (STIs). (who.int)
  • 4 Qualitative studies, too, have demonstrated that pregnancy intendedness is not a simple construct, and that multiple factors affect a woman's prior or current intentions and attitudes. (guttmacher.org)
  • We aimed to explore the attitudes and beliefs influencing parents' decision to involve their children in clinical research in Mansoura, Egypt. (who.int)
  • Only 98 (27.5%) parents consented to involve their child in clinical research. (who.int)
  • Prognostic factors are associated with the risk of future health outcomes in individuals with a particular health condition or some clinical start point (eg, a particular diagnosis). (bmj.com)
  • Furthermore, genes are often flanked by several binding sites for distinct transcription factors, and efficient expression of each of these genes requires the cooperative action of several different transcription factors (see, for example, hepatocyte nuclear factors). (wikipedia.org)
  • Distinct roles of the two tumor necrosis factor (TNF) receptors in modulating TNF and lymphotoxin alpha effects. (aaem.pl)
  • Haider S, Knofler M. Human tumour necrosis factor: physiological and pathological roles in placenta and endometrium. (aaem.pl)
  • Research finds that alcohol can increase cravings for cocaine. (healthline.com)
  • For women with diabetes, there's no specific research on these medications, but they can potentially be helpful in the right populations. (medscape.com)
  • 40 years old), from 3% in 1973 to approximately 6% in 1993, and many of the affected individuals are without traditional risk factors. (medscape.com)
  • Men who have sex with men (MSM) in Tokyo have contributed substantially to the increase in syphilis notifications. (who.int)
  • 5-7 In Japan, while more recent increases in syphilis have been among heterosexual men and women, 8 during 2013-2014, this increase was predominantly associated with men who have sex with men (MSM). (who.int)
  • In poikilothermic animals, temperature is a major abiotic factor influencing. (awionline.org)
  • However, they are also important for summarising other evidence, such as the accuracy of screening and diagnostic tests, 1 the causal association of risk factors for disease onset, and the prognostic ability of bespoke factors and biomarkers. (bmj.com)
  • For example, in many cancers, tumour grade at the time of histological examination is a prognostic factor because it is associated with time to disease recurrence or death. (bmj.com)
  • A cross-sectional study was carried out using initial HIV rapid and confirmation tests, and then Venereal Disease Research Laboratory test with the Ultra Rapid Test Kits for syphilis. (scirp.org)
  • Transcription factors bind to either enhancer or promoter regions of DNA adjacent to the genes that they regulate. (wikipedia.org)
  • Other transcription factors differentially regulate the expression of various genes by binding to enhancer regions of DNA adjacent to regulated genes. (wikipedia.org)
  • OBJECTIVE -Transforming growth factor (TGF)-β1 is overexpressed in diabetes as a consequence of hyperglycemia and the creation of early glycated end products and may be responsible for the characteristic structural renal changes associated with diabetes. (diabetesjournals.org)
  • For example, being anxious or worried about diabetes management, getting anxious or becoming hypoglycemic during the sexual event, worrying about how the apparatus might impact the way they look toward their partner, or their comfort during sexual activity could all be factors. (medscape.com)
  • There's no specific research on women with diabetes, but also no clear reason why it would be contraindicated with careful monitoring and dose adjustment, as would be done in any postmenopausal woman. (medscape.com)
  • Feature papers represent the most advanced research with significant potential for high impact in the field. (mdpi.com)
  • Despite no significant difference in wounding between bachelor and mixed-sex groups of western lowland gorillas (Gorilla gorilla gorilla) in zoological settings, anecdotal concerns around the frequency and severity of wounding in bachelor groups have perpetuated. (awionline.org)