• Hepatocyte growth factor (HGF) or scatter factor (SF) is a paracrine cellular growth, motility and morphogenic factor. (wikipedia.org)
  • Hepatocyte growth factor regulates cell growth, cell motility, and morphogenesis by activating a tyrosine kinase signaling cascade after binding to the proto-oncogenic c-Met receptor. (wikipedia.org)
  • Hepatocyte growth factor is secreted by platelets, and mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. (wikipedia.org)
  • Hepatocyte growth factor has been shown to interact with the protein product of the c-Met oncogene, identified as the HGF receptor (HGFR). (wikipedia.org)
  • Both overexpression of the Met/HGFR receptor protein and autocrine activation of Met/HGFR by simultaneous expression of the hepatocyte growth factor ligand have been implicated in oncogenesis. (wikipedia.org)
  • Hepatocyte growth factor interacts with the sulfated glycosaminoglycans heparan sulfate and dermatan sulfate. (wikipedia.org)
  • The interaction with heparan sulfate allows hepatocyte growth factor to form a complex with c-Met that is able to transduce intracellular signals leading to cell division and cell migration. (wikipedia.org)
  • In characterizing the molecular differentiation of developing peripheral auditory structures, we discovered that hepatocyte growth factor ( Hgf ) is expressed in the future stria vascularis of the cochlear epithelium. (jneurosci.org)
  • SIGNIFICANCE STATEMENT We found the roles of hepatocyte growth factor (HGF) signaling in stria vascularis development for the first time and that lack of HGF signaling in the inner ear leads to profound hearing loss in the mouse. (jneurosci.org)
  • Hepatocyte growth factor (HGF) is produced by stromal and mesenchymal cells, and it stimulates epithelial cell proliferation, motility, morphogenesis and angiogenesis in various organs via tyrosine phosphorylation of its cognate receptor, Met. (spandidos-publications.com)
  • HGF was cloned as a growth factor for hepatocytes ( 1 , 2 ), is identical to scatter factor (SF) and was originally discovered as a fibroblast-derived cell motility factor for epithelial cells ( 3 ). (spandidos-publications.com)
  • Various growth factors, cytokines, and prostaglandins upregulate HGF gene expression, including basic fibroblast growth factor, oncostatin M, hypoxia-inducible factor 1α and nuclear factor-κB (NF-κB) ( 9 ). (spandidos-publications.com)
  • By contrast, transforming growth factor (TGF)-β1 was demonstrated to markedly downregulate HGF gene expression ( 10 , 11 ). (spandidos-publications.com)
  • G (p.F841V) in MET (mesenchymal epithelial transition factor), which encodes the receptor for hepatocyte growth factor. (bmj.com)
  • Conclusions We identified a missense mutation of MET , encoding the hepatocyte growth factor receptor, as a likely cause of hearing loss in humans. (bmj.com)
  • Lung cancer with epidermal growth factor receptor (EGFR)-activating mutations responds favorably to the EGFR tyrosine kinase inhibitors gefitinib and erlotinib. (aacrjournals.org)
  • Here, we showed that hepatocyte growth factor (HGF), a ligand of MET oncoprotein, induces gefitinib resistance of lung adenocarcinoma cells with EGFR -activating mutations by restoring the phosphatidylinositol 3-kinase/Akt signaling pathway via phosphorylation of MET, but not EGFR or ErbB3. (aacrjournals.org)
  • The process involves several factors, such as hepatocyte growth factor (HGF), which restrains hepatic injury and facilitates reversibility of fibrotic reaction in response to an acute insult. (uni-regensburg.de)
  • Description: A sandwich quantitative ELISA assay kit for detection of Rabbit Hepatocyte Growth Factor (HGF) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. (bioemm.com)
  • Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Rabbit Hepatocyte Growth Factor (HGF) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids. (bioemm.com)
  • Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Rabbit Hepatocyte Growth Factor (HGF) in samples from Serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids with no significant corss-reactivity with analogues from other species. (bioemm.com)
  • Most of the anti-angiogenic agents approved for cancer treatment rely on targeting vascular endothelial growth factor (VEGF) actions, as VEGF signaling is considered the main angiogenesis promotor. (mdpi.com)
  • One such approach involves the use of growth factors ( 3-6 ). (spandidos-publications.com)
  • Alterations in liver growth factors were postulated to contribute to the carcinogenic effect of peroxisome proliferators. (psu.edu)
  • Administration of these compounds to rodents results in down-regulation of hepatocyte growth factor (HGF) and supplementing culture medium with HGF is reported to suppress cell proliferation of preneoplastic and neoplastic cells from WY-14,643-treated livers. (psu.edu)
  • Any process that modulates the frequency, rate or extent of hepatocyte growth factor receptor signaling pathway. (cyverse.org)
  • Link to all annotated objects annotated to regulation of hepatocyte growth factor receptor signaling pathway. (cyverse.org)
  • Background The Hepatocyte Growth Factor (HGF) is a pleiotropic cytokine involved in many physiological processes including skeletal muscle placenta and liver development. (technologybooksindustrialprojectreports.com)
  • The Hepatocyte Growth Factor (HGF) is a mesenchyme-derived multifunctional molecule that elicits mitogenic and morphogenic activities in SCH900776 development as well as in many patho-physiological processes [8]. (technologybooksindustrialprojectreports.com)
  • Hepatocyte Growth Factor-Loaded Biomaterials for Mesenchymal S. (rwth-aachen.de)
  • Insulin-like growth factors (IGFs) and their binding proteins (IGFBPs) are key elements in fetal growth. (ox.ac.uk)
  • Hepatocyte growth factor (HGF) signaling through its receptor Met has been implicated in hepatocellular carcinoma tumorigenesis and progression. (ebi.ac.uk)
  • Hepatocyte growth factor plasma levels in patients with acute LF and liver function tests in acute LF cases, Sierra Leone, 2015-2018. (cdc.gov)
  • Plasma hepatocyte growth factor as a noninvasive biomarker in small cell lung cancer. (bvsalud.org)
  • Hepatocyte growth factor (HGF) is a peptide -containing multifunctional cytokine , which is overexpressed and/or activated in multiple malignancies and is reported to be associated with tumor development and inferior survival . (bvsalud.org)
  • Hepatocyte growth factor can substitute for M-CSF to support osteoclastogenesis. (ox.ac.uk)
  • Hepatocyte growth factor (HGF) and M-CSF signal through tyrosine kinase receptors and phosphorylate common transducers and effectors such as Src, Grb2, and PI3-Kinase. (ox.ac.uk)
  • Bedaiwy MA, Burlingame JM, Hussein M, Flyckt R, Assad R, Falcone T. Assessment of vascular endothelial growth factor, basic fibroblast growth factor and transforming growth factor levels in amniotic fluid. (medscape.com)
  • Effect of insulin-like growth factors on lung development in a nitrofen-induced CDH rat model. (medscape.com)
  • Kutasy B, Friemacher F, Duess JW, Puri P. Prenatal administration of retinoic acid increases the trophoblastic insulin-like-growth factor 2 protein expression in the nitrofen model of congenital diaphragmatic hernia. (medscape.com)
  • MET was discovered as an oncogene that is activated by its ligand, hepatocyte growth factor. (rcsb.org)
  • We investigate the association of serum hepatocyte growth factor (HGF) and serum vascular endothelial growth factor (VEGF) levels with clinicopathologic parameters in untreated clear cell RCC patients. (tokushima-u.ac.jp)
  • This study evaluates the impact of a dual therapeutic intervention utilizing hepatocyte growth factor (HGF) and hiPSC-NS/PC transplantation on motor function restoration following spinal cord injury (SCI). (biomedcentral.com)
  • Hepatocyte growth factor (HGF) is a highly promising clinically relevant candidate for enhancing the efficacy of NS/PC transplantation. (biomedcentral.com)
  • many growth factors and their functions have been elucidated. (medscape.com)
  • As greater understanding of the growth factors involved in wound healing emerges, future patient care may include scarless wound healing and transplant of tissues engineered from stem cell progenitors. (medscape.com)
  • Platelets release platelet-derived growth factor (PDGF) and transforming growth factor beta (TGF-b) from their alpha granules to attract neutrophils and macrophages. (medscape.com)
  • Macrophages continue to emit growth factors to attract fibroblasts and usher in the next phase of wound healing (see Table below). (medscape.com)
  • Multifunctional growth factor which regulates both cell growth and cell motility. (bvsalud.org)
  • As a result, reactive oxygen species and inflammatory mediators (eg, platelet-derived growth factor, transforming growth factors, connective tissue growth factor) are released. (msdmanuals.com)
  • Finally, we demonstrate its usefulness by conjugation to the Alexa Fluor 647 and TAMRA fluorophores and coupling to a surface plasmon resonance chip for interaction studies with the hepatocyte growth factor known to interact with the GAG heparan sulfate. (lu.se)
  • Investigators have demonstrated other substrates for factor XIIIa, including proteins such as osteopontin, factor V, thrombospondin, vinculin, and endothelial cell receptors α v β 3 integrin and VEGFR-2. (medscape.com)
  • HGF was able to support monocyte-osteoclast differentiation in the presence of receptor activator for nuclear factor kappaB ligand as evidenced by the formation of numerous multinucleated tartrate-resistant acid phosphatase and vitronectin receptor positive cells which formed F-actin rings and were capable of lacunar resorption. (ox.ac.uk)
  • Mesencephalic astrocyte-derived neurotrophic factor (MANF) is an evolutionarily conserved protein related to the unfolded protein response. (chinaphar.com)
  • The HNF1B gene provides instructions for making a protein called hepatocyte nuclear factor-1 beta (HNF-1β). (medlineplus.gov)
  • Based on this role, the protein is called a transcription factor. (medlineplus.gov)
  • The HNF-1β protein is one of a large group of transcription factors called homeodomain proteins. (medlineplus.gov)
  • In this study, we developed a protocol to establish highly pure primary cultures of human fetal hepatocytes in vitro and investigated their expression of IGFBP-1 messenger RNA (mRNA) and protein and the effects of hypoxia on their expression of IGFBP-1 mRNA and protein. (ox.ac.uk)
  • This study demonstrates that human fetal hepatocytes can be cultured in defined medium, as primary cultures with high purity, and that they express IGFBP-1 mRNA and secrete IGFBP-1 protein in vitro. (ox.ac.uk)
  • In addition, the data demonstrate that hypoxia up-regulates fetal hepatocyte IGFBP-1 mRNA steady-state levels and protein, with this being the major IGFBP derived from the fetal hepatocyte. (ox.ac.uk)
  • Silencing of TFEB decreases the level of autophagy-related protein LC3BII/I and increases p62 expression level in hepatocytes after exposure to Hcy. (lu.se)
  • Factor VIIIa is inactivated by thrombin or activated protein C (APC). (medscape.com)
  • To circumvent the hepatic functional redundancy of the Foxa proteins, we used the T-77 transgenic (TG) mouse line in which the -3-kb transthyretin (TTR) promoter functioned to increase hepatocyte expression of the Foxa2 cDNA. (duke.edu)
  • By cross-linking bacterial surface proteins to fibrinogen, factor XIIIa causes bacteria to be immobilized and killed. (medscape.com)
  • The role of the glutathione peroxidase/reductase (GSH-Px/GSSG-Rd) enzyme system in protection from paracetamol toxicity was investigated in isolated mouse hepatocytes in primary culture. (nih.gov)
  • We have developed a robust and efficient method to differentiate mesenchymal stem cells into induced functional hepatocytes, which exhibits characteristics of mouse hepatocytes. (niscair.res.in)
  • Objective: To investigate the mutation pattern in the different transcription factor genes with special reference to HNF1-alpha which are highly penetrant with 63% mutation carriers manifesting clinical diabetes by the age of 25 years. (scirp.org)
  • Together, these results provide evidence for a major regulatory function of this liver-enriched transcription factor in UGT1A1 activity in both rodents and human. (aspetjournals.org)
  • A forkhead transcription factor that regulates expression of metabolic GENES and is involved in EMBRYONIC DEVELOPMENT. (reference.md)
  • Scholars@Duke publication: Elevated hepatocyte levels of the Forkhead box A2 (HNF-3beta) transcription factor cause postnatal steatosis and mitochondrial damage. (duke.edu)
  • The Forkhead box (Fox) transcription factor Foxa2 (HNF-3beta) and related family members Foxa1 (HNF-3alpha) and Foxa3 (HNF-3gamma) act in concert with other hepatocyte nuclear factors (HNF) to coordinately regulate liver-specific gene expression. (duke.edu)
  • A shortage of this transcription factor disrupts the activity of genes that direct the development and function of certain tissues and organs. (medlineplus.gov)
  • Abnormal nephron development associated with a frameshift mutation in the transcription factor hepatocyte nuclear factor-1 beta. (uchicago.edu)
  • Here, we investigate the relationship between Hcy-induced autophagy level and the expression of nuclear transcription factor EB (TFEB). (lu.se)
  • Fibrous tracts join branches of afferent portal veins and efferent hepatic veins, bypassing the hepatocytes and limiting their blood supply. (msdmanuals.com)
  • In conclusion, our model proposes that in response to reduction in hepatocyte glycogen storage, the TTR-Foxa2 TG mice survive by maintaining sufficient serum levels of glucose through gluconeogenesis using deaminated amino acids with dicarboxylate products of peroxisomal lipid beta-oxidation shuttled through the tricarboxylic acid cycle. (duke.edu)
  • MODY can result from mutations in any one of the six different genes, one of which encodes the glycolytic enzyme Glucokinase, associated with MO-DY2 and the other five encode transcription factors HNF4-alpha associated with MODY 1, HNF1-alpha associated with MODY 3, IPF with MODY 4, HNF1-Beta with MODY 5 and NeuroD1 with MO-DY6. (scirp.org)
  • Studies related to mutations in the MODY genes have led to a better understanding of the genetic causes of the Beta cell dysfunction as genetic factors plays a great role in this disorder. (scirp.org)
  • Our study confirmed that induction of functional hepatocyte shows typical epithelial morphology, express hepatic genes and acquire hepatocyte functions. (niscair.res.in)
  • Protocols for hepatocyte differentiation from iPS cells have been studied. (spandidos-publications.com)
  • After two days of culture in HSM, the expression levels of α-fetoprotein (AFP) and albumin, which are hepatocyte markers, were upregulated, suggesting that hepatocyte differentiation was initiated ( 19 ). (spandidos-publications.com)
  • It was hypothesized that the addition of glucose and galactose promoted hepatocyte differentiation of iPS cell. (spandidos-publications.com)
  • The HSM was modified into a hepatocyte differentiation inducer (HDI). (spandidos-publications.com)
  • Overexpression of hepatocyte nuclear factor (Foxa-2), a master regulator significantly enhances the hepatic differentiation by triggering targeted liver-specific gene expression for liver development. (niscair.res.in)
  • The postnatal TG mice displayed significant reduction in serum glucose levels and in hepatocyte glycogen storage without increased serum levels of ketone bodies and free fatty acid suggesting that they are not undergoing a starvation response. (duke.edu)
  • Hepatocytes from two-week-old mice were less susceptible to both t-BOOH and paracetamol toxicity than were those from adult mice. (nih.gov)
  • However, after inhibition of GSSG-Rd with BCNU, hepatocytes from these postnatal mice were more susceptible to paracetamol toxicity. (nih.gov)
  • This suggests that the higher activity of GSH-Px/GSSG-Rd in hepatocytes from two-week-old mice is responsible for their reduced susceptibility to paracetamol toxicity. (nih.gov)
  • Moreover, after chronic-plus-binge ethanol feeding, hepatocyte-specific MANF knockout (HKO) mice displayed more severe hepatic steatosis and liver injury than wild-type (WT) control mice. (chinaphar.com)
  • Osteopetrotic mice lacking functional macrophage-colony stimulating factor (M-CSF) recover with ageing, suggesting that alternative osteoclastogenesis pathways exist. (ox.ac.uk)
  • Furthermore, these cells exhibited hepatic functions in vitro , including glycogen storage, albumin production, urea secretion and functional assessment of hepatocytes. (niscair.res.in)
  • Hepatocytes derived from iPS cells are suitable for transplantation into patients with liver insufficiency and for use in toxicity tests ( 2 ). (spandidos-publications.com)
  • Although liver failure can be treated via hepatocyte transplantation, it also faces multiple problems comprising the shortage of high-quality hepatocytes sources, rejection of allogeneic transplants, difficulty to expand, and losing hepatic characteristics in vitro [ 7 , 8 ]. (springer.com)
  • Therefore, MSCs may help resolve issues restricting the application of hepatocyte transplantation. (springer.com)
  • [ 8 ] In a mouse model, isolated hepatocytes transplantation did not correct hemophilia A, but transplantation of a cellular fraction enriched in liver endothelial cells did. (medscape.com)
  • Under these conditions, iPS cells begin to differentiate into a hepatocyte lineage. (spandidos-publications.com)
  • MSCs have the capacity of multiple differentiations and self-renewal and have been proven to be able to differentiate into a series of cell lineages, such as adipocytes, osteoblasts, chondroblasts, and hepatocyte-like cells (HLCs). (springer.com)
  • Human liver organoids are formed from the assembly of hepatocyte-like cells differentiated from iPS cells, human umbilical vascular endothelial cells and mesenchymal stem cells ( 9 ). (spandidos-publications.com)
  • ABSTRACT Hepatitis B and C virus (HBV and HCV) infections remain major public health problems in Egypt and data are needed on risk factors for infection. (who.int)
  • 1998).Linkage and molecular scaning analysis of MODY 3/hepatocyte nuclear factor 1-alpha gene in typical familial type 2 diabetes: Evidence for novel mutation in exon 8 and 10. (scirp.org)
  • Diabetes in subjects with hepatocyte nuclear factor (HNF)-1α gene mutations (maturity-onset diabetes of the young [MODY]-3) is characterized by impaired insulin secretion. (diabetesjournals.org)
  • Mutations in the hepatocyte nuclear factor (HNF)-1α gene cause the most common form of maturity-onset diabetes of the young (MODY), type 3 ( 1 ). (diabetesjournals.org)
  • The factor VIII gene is located on the X chromosome. (medscape.com)
  • Description: Quantitativesandwich ELISA kit for measuring Rat Hepatocyte nuclear factor 1-alpha (HNF1A) in samples from serum, plasma, cell culture supernates, tissue homogenates. (wildpalm.net)
  • Identification of a novel hepatocyte nuclear factor-1 alpha (HNF1A) variant in maturity onset diabetes of the young type 3 (HNF1A-MODY). (cdc.gov)
  • Glibenclamide uptake into hepatocytes was dramatically decreased in vivo and in vitro. (diabetesjournals.org)
  • Hepatocyte-specific MANF knockout led to decreased ASS1 activity, whereas overexpression of MANF contributed to enhanced ASS1 activity in vitro. (chinaphar.com)
  • These observations have suggested physiologic and pathologic roles for factor XIII in angiogenesis, atherosclerosis, and inflammation. (medscape.com)
  • Tissue factor/coagulation factor VII (fVII) complex formation on the surface of cancer cells plays important roles in cancer biology, such as cell migration and invasion, angiogenesis, and antiapoptotic effects. (figshare.com)
  • The functional hepatocyte was determined by observing morphological changes, expression of liver specific markers through immunocytochemical analysis, qRT-PCR, Western Blot and specific liver function assays. (niscair.res.in)
  • Hepatocytes were cultured in defined medium, and Northern analysis revealed expression of a 1.5-kb IGFBP-1 mRNA transcript in hepatocytes cultured under normoxic conditions, for 24 h, that did not increase in steady-state levels after 48 h in culture. (ox.ac.uk)
  • Unlike hepatic expression, hepatocyte nuclear factor-4 binding to the promoter is not required for ectopic FVII expression, although Sp1 binding is essential. (figshare.com)
  • Apparently, induction of functional hepatocytes will pave a better cellular therapy or effective cell source within a short timeline to facilitate the development of hepatocytes for future clinical applications of regenerative medicine. (niscair.res.in)
  • Lobules are the functional units of the liver and consist of millions of cells called hepatocytes. (medicalnewstoday.com)
  • In occurs through the inhibition of DNA binding of cognate cis- hematopoiesis there exist several lineage branch points with regulatory motif while in the other case DNA binding is unaffected identified key transcription factors and external signals [3-5]. (lu.se)
  • Hepatocyte cultures were characterized by immunocytochemistry and were compared with hepatocytes in situ in human fetal liver tissue, by immunohistochemistry, using specific antibodies and indirect immunofluorescence. (ox.ac.uk)
  • Understanding how the body repairs damaged tissue and what factors influence the wound healing process helps the surgeon ensure an acceptable outcome from surgery. (medscape.com)
  • Commonly, fibrosis progresses, disrupting hepatic architecture and eventually function, as regenerating hepatocytes attempt to replace and repair damaged tissue. (msdmanuals.com)
  • Autophagy plays a critical role in the physiology and pathophysiology of hepatocytes. (lu.se)
  • HGF is a well-established survival factor and viability assays and live/dead staining showed that it promoted the survival and proliferation of monocytes and osteoclasts in a manner similar to M-CSF. (ox.ac.uk)
  • High level of homocysteine (Hcy) promotes autophagy in hepatocytes, but the underlying mechanism is still unknown. (lu.se)
  • Factor VIII assays are used to help replacement therapy in patients with hemophilia. (medscape.com)
  • Hepatocyte Nuclear Factors" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (umassmed.edu)
  • Wound healing is promoted by factor XIIIa via cross-linking of the provisional matrix, a process that influences the extracellular matrix-leukocyte interaction. (medscape.com)
  • To investigate the underlying molecular principles of metabolic and morphogenic zonation of the human liver lobule, we generated an integrated epigenetic map across three zones (pericentral, intermediate and periportal) by methylation and transcriptomic analysis of hepatocytes captured by laser micro-dissection. (lisym.org)
  • Hepatocytes were isolated from second-trimester human fetal livers (n = 7) and purified by Percoll gradient centrifugation. (ox.ac.uk)
  • [ 5 ] Several commercial lyophilized factor VIII concentrates that use cryoprecipitate of pooled normal human plasmas are available. (medscape.com)
  • Factor XIII is a plasma transglutaminase that catalyzes the final step in the coagulation cascade, cross-linking the loose fibrin polymer into a highly organized structure. (medscape.com)
  • Fresh frozen plasma (FFP), cryoprecipitate, and factor XIII (FXIII) concentrates have been used for replacement of factor XIII and the treatment of acute bleeding. (medscape.com)
  • For years, the treatment of choice has been plasma-derived factor XIII concentrate that is pasteurized to provide virologic safety and is less likely than plasma to cause systemic reactions. (medscape.com)
  • The factor XIII zymogen circulates in plasma as a tetramer composed of 2 catalytic A subunits and 2 carrier B subunits (A 2 B 2 ). (medscape.com)
  • Multivariate analysis revealed plasma HGF was an independent predictor for LM and prognostic factor of OS. (bvsalud.org)
  • Both of cryoprecipitate and fresh-frozen plasma (FFP) contain factor VIII and were the only products available for treatment in the past. (medscape.com)
  • A large volume of plasma must be infused to achieve and maintain even lowest factor VIII levels. (medscape.com)
  • The highest factor VIII level achieved with plasma is about 20% of normal, which may not be adequate for hemostasis. (medscape.com)