• Sex cord-stromal tumors account for approximately 8% of all ovarian tumors. (medscape.com)
  • The International Federation of Gynecology and Obstetrics (FIGO) staging of ovarian tumors is outline below. (medscape.com)
  • [5] Ovarian teratomas represent about a quarter of ovarian tumors and are typically noticed during middle age. (mdwiki.org)
  • CD56 is a sensitive marker of ovarian sex cord-stromal tumors and may also be useful in the diagnosis of this group of neoplasms, especially in cases that are inhibin or calretinin negative, and the differential diagnosis includes neoplasms that are CD56 negative. (medscape.com)
  • Teratomas occur in the coccyx in about one in 30,000 newborns, making them one of the most common tumors in this age group. (mdwiki.org)
  • A worldwide database analysis revealed that younger age, smaller tumor size, early stage, and granulosa cell tumor histologic type appear to be independent prognostic factors for improved survival in patients with malignant sex cord-stromal tumors who undergo lymph node dissection. (medscape.com)
  • They are a type of germ cell tumor (a tumor that begins in the cells that give rise to sperm or eggs ). (mdwiki.org)
  • Immature teratoma has one of the lowest rates of somatic mutation of any tumor type and results from one of five mechanisms of meiotic failure. (mdwiki.org)
  • 70%) comprising the largest group of tumors. (medscape.com)
  • The pattern-based (Silva) classification of invasive HPV-associated endocervical adenocarcinomas (HPVA) is an established and reproducible method to predict outcomes for this otherwise stage-dependent group of tumors. (stanford.edu)
  • Germ cell tumors occur less frequently (20%), while sex cord-stromal tumors make up the smallest proportion, accounting for approximately 8% of all ovarian neoplasms. (medscape.com)
  • 13. Malignant testicular unclassified sex cord stromal tumor: a case report. (nih.gov)
  • The rare malignant thecoma likely represents a tumor with a small admixture of granulosa cells. (medscape.com)
  • 1. Incorporating gonadal health counseling into pediatric care of sickle cell patients. (nih.gov)
  • 11. Genotype of congenital adrenal hyperplasia patients with testicular adrenal rest tumor. (nih.gov)
  • Dr. Howitt is a gynecologic and sarcoma pathologist, with academic interests in gynecologic mesenchymal tumors and morphologic and clinical correlates of molecular alterations in gynecologic neoplasia. (stanford.edu)
  • Microfollicular pattern of an adult granulosa cell tumor at 100X magnification. (medscape.com)
  • Pathogenic alterations, molecular signatures, tumor mutational burden (TMB), and copy number alterations (CNA) were correlated with pattern of invasion.45 HPVA (11 pattern A, 17 pattern B and 17 pattern C tumors) were included. (stanford.edu)
  • APOBEC mutational signature was detected only in Silva pattern C tumors (5/17), and pathogenic PIK3CA changes were detected only in destructively invasive HPVA (patterns B and C). When cases were grouped as low-risk (pattern A and pattern B without LVI) and high-risk (pattern B with LVI and pattern C), high-risk tumors were enriched in mutations in PIK3CA, ATRX, and ERBB2. (stanford.edu)
  • There was a statistically significant difference in TMB between low-risk and high-risk pattern tumors (p=0.006), as well as between Pattern C tumors with and without an APOBEC signature (p=0.002). (stanford.edu)
  • CNA burden increased from pattern A to C.Our findings further indicate that key molecular events in HPVA correlate with the morphologic invasive properties of the tumor and their aggressiveness. (stanford.edu)
  • Pattern B tumors with LVI clustered with pattern C tumors, whereas pattern B tumors without LVI approached pattern A genotypically. (stanford.edu)