• It is considered an extracellular matrix receptor that may serve as a co-receptor for fibroblast growth factor and related molecules. (bdbiosciences.com)
  • Chemokine (C-X-C motif) ligand 1 (CXCL1), also known as growth-regulated oncogene-alpha or melanoma growth stimulatory activity, alpha, is a secreted growth factor that interacts with the G-protein coupled receptor CXCR2, also known as interleukin-8 receptor type beta (IL8RB) [ 7 , 8 ], that plays a key role in inflammation and as a chemoattractant for neutrophils [ 9 , 10 ]. (thno.org)
  • Transient receptor potential channel TRPV4 mediates TGF-β1-induced differentiation of human ventricular fibroblasts. (fgf-erk.com)
  • Light molecular weighted FGF (fibroblast growth factor) receptor agonistic tripeptide peptide for wound healing. (myshopify.com)
  • Among these, fibroblast growth factor receptor 3 ( FGFR3 )-related skeletal dysplasia is a relatively common subgroup of skeletal dysplasia. (e-apem.org)
  • FGFR3 is a receptor tyrosine kinase that comprises an extracellular ligand-binding domain, a transmembrane domain, and 2 intracellular tyrosine kinase domains [ 8 ]. (e-apem.org)
  • Among one of the actionable targets is the fibroblast growth factor receptor (FGFR) pathway, triggered by specific ligands. (123dok.org)
  • Among such actionable targets in BC is the fibroblast growth factor receptor (FGFR). (123dok.org)
  • FGFRs are a class of receptor tyrosine kinase (RTK) and are single-pass membrane proteins made of N-terminal extracellular (EC) domains with three immunoglobulin-like subdomains (D1, D2 and D3), a transmembrane (TM) domain with a single α-helix, and an intracellular (IC) region which includes tyrosine kinase motifs, a juxta-membrane domain and a carboxyl-terminal tail [12-14]. (123dok.org)
  • This gene provides instructions for making a protein called fibroblast growth factor receptor 2 (FGFR2). (medlineplus.gov)
  • Kim and Morshead, 2003), and the fibroblast that SSEA4 associated with CD133 can be used for growth factor (FGF) receptor 4 (Cai et al. (lu.se)
  • Not long after FGF1 and FGF2 were isolated, another group of investigators isolated a pair of heparin-binding growth factors that they named HBGF-1 and HBGF-2, while a third group isolated a pair of growth factors that caused proliferation of cells in a bioassay containing blood vessel endothelium cells, which they called ECGF1 and ECGF2. (wikipedia.org)
  • Platelets, megakaryocytes, and monocytes are thought to secrete several cytokines, such as transforming growth factor beta (TGF-β), platelet-derived growth factor (PDGF), interleukin 1 (IL-1), epidermal growth factor (EGF), and basic fibroblast growth factor (bFGF), which may result in fibroblast formation and extracellular matrix proliferation. (medscape.com)
  • Sustained hypoxia or lack of nutrients leads to fibroblast dysfunction, decreased keratinocyte migration and proliferation, and tissue loss [ 6 ]. (hindawi.com)
  • WAT is characterised by its capacity to adapt and expand in response to surplus energy through processes of adipocyte hypertrophy and/or recruitment and proliferation of precursor cells in combination with vascular and extracellular matrix remodelling. (springer.com)
  • Systemic administration of HL2401 in mice bearing bladder and prostate xenograft tumors retarded tumor growth through the inhibition of cellular proliferation and angiogenesis along with an induction of apoptosis. (thno.org)
  • Activities such as impaired angiogenic response and microvascular complications, macrophage and neutrophil function, keratinocyte and fibroblast migration and proliferation, sustained production of pro-inflammatory cytokines and reduced growth factor production has been reported in diabetic animal models 3 , 9 . (scialert.net)
  • Tissue remodeling due to extracellular matrix production and fibroblasts proliferation is directly modulated by growth factors classified according to their biological properties into pro-fibrotic and non-fibrotic growth factors ( 6 ). (atsjournals.org)
  • Profibrotic growth factors and cytokines contribute directly to fibroblast proliferation and collagen production. (cdc.gov)
  • [2] These pathologies lead to a disequilibrium between proangiogenic and antiangiogenic factors that can result in the proliferation and migration of vascular endothelial cells into the corneal stroma. (aao.org)
  • Accordingly, the activation of fibroblasts/myofibroblasts, which is characteristic for the asthmatic process, may facilitate lung cancer progression. (spandidos-publications.com)
  • Asthma is a chronic inflammatory disease associated with remodeling of the airways ( 1 ) as shown by subepithelial fibrosis ( 2 ) and by the activation of fibroblasts and myofibroblasts ( 3 ). (atsjournals.org)
  • Still, activation of SF by LN1 may serve as a model for activation of fibroblasts by extracellular matrix compounds in the presence of growth factors or cytokines, and both pathways contribute to the aggressive invasive growth of SF in the course of RA. (biomedcentral.com)
  • A majority of the nonanticoagulant actions of heparin on the endothelium appear to be related to heparin interactions with the fibroblast growth factors (FGFs). (nih.gov)
  • Members FGF11, FGF12, FGF13, and FGF14, also known as FGF homologous factors 1-4 (FHF1-FHF4), have been shown to have distinct functions compared to the FGFs. (wikipedia.org)
  • Although these factors possess remarkably similar sequence homology, they do not bind FGFRs and are involved in intracellular processes unrelated to the FGFs. (wikipedia.org)
  • These studies are currently focusing on elucidating the mechanisms by which agrin modulates the function of heparin-binding growth factors and morphogens, such as fibroblast growth factors (Fgfs) and sonic hedgehog (Shh), during zebrafish nervous system development. (nccu.edu)
  • Fibroblast growth factors (FGFs) and FGF receptors (FGFRs) play essential roles in human axial and craniofacial skeletal development. (e-apem.org)
  • The Fibroblast Growth Factor Receptors/Fibroblast Growth Factors (FGFRs/FGFs) axis offers interesting molecular targets to be pursued in clinical development. (123dok.org)
  • The FGFR family is characterized by four receptors, binding to 18 ligands called fibroblast growth factors (FGFs), employing heparin as a co-factor [2-4]. (123dok.org)
  • Increased expression of inflammatory cytokines, lysyl oxidase, transforming growth factor-β, impaired megakaryocyte function, and aberrant JAK-STAT signaling have all been implicated in the pathogenesis of bone marrow fibrosis. (haematologica.org)
  • In addition, cells were activated with cytokines and growth factors such as transforming growth factor beta (TGF-β). (biomedcentral.com)
  • The in-growth of new blood vessels is mediated by the upregulation of angiogenic cytokines. (aao.org)
  • This conference is a continuation of the Fibroblast Growth Factors in Development and Repair series with an expanded scope that includes other growth factors and cytokines that are involved in tissue repair and regeneration/regenerative medicine. (fusion-conferences.com)
  • MATERIALS AND METHODS: A systemic search of gene expression profiles of multiple tissues in NSCLC was carried out to determine the expression intensities of traditional fibroblast biomarkers and CAF-secreted protumorigenic cytokines. (cdc.gov)
  • CNT-induced fibrosis involves a multitude of cell types and is characterized by the early onset of inflammation, oxidative stress and accumulation of extracellular matrix. (cdc.gov)
  • In particular, cancer-associated fibroblasts (CAFs) participate in cancer progression and metastasis ( 10 , 11 ). (spandidos-publications.com)
  • Cancer-associated fibroblasts (CAFs) play a vital role in cancer chemoresistance, but detailed understanding of the process particularly in chemoresistant lung cancer is lacking. (cdc.gov)
  • Members of this family of potent endothelial mitogens and angiogenic factors have been shown to bind with high affinity to immobilized heparin. (nih.gov)
  • First, we cocultured dermal fibroblasts with dermal microvascular endothelial cells at a ratio of 2 : 1. (hindawi.com)
  • A fibrous sheet was formed by the interactions between the fibroblasts and the endothelial cells, and capillary-like structures were observed after 20 days of coculture. (hindawi.com)
  • ELISA demonstrated that vascularization was promoted by significant upregulation of vascularization associated growth factors due to interactions among the 3 types of cells in the bilayer, as compared to cocultures of fibroblast and endothelial cells and monocultures. (hindawi.com)
  • We explored whether LPL affects (a) lipoprotein transport across bovine aortic endothelial cells or (b) lipoprotein binding to subendothelial cell matrix (retention). (jci.org)
  • VEGF paves the way for new blood vessel formation by upregulating matrix metalloproteinases production by endothelial cells in the limbal vascular plexus. (aao.org)
  • A mitogenic growth factor activity was found in pituitary extracts by Armelin in 1973 and further work by Gospodarowicz as reported in 1974 described a more defined isolation of proteins from cow brain extract which, when tested in a bioassay that caused fibroblasts to proliferate, led these investigators to apply the name "fibroblast growth factor. (wikipedia.org)
  • These independently discovered proteins were eventually demonstrated to be the same sets of molecules, namely FGF1, HBGF-1 and ECGF-1 were all the same acidic fibroblast growth factor described by Gospodarowicz, et al. (wikipedia.org)
  • Fibulin-4 is a member of the fibulin family, a group of extracellular matrix proteins prominently expressed in medial layers of large veins and arteries. (uzh.ch)
  • Adipocyte-derived factors involved in tumor progression include proteins such as adiponectin, leptin, TNF-α, monocyte chemotactic protein-1 (MCP-1), IL-6, and ECM components that control tumor cell behavior within the tumor microenvironment. (jci.org)
  • These growth factors typically act as systemic or locally circulating molecules of extracellular origin that activate cell surface receptors. (wikipedia.org)
  • In humans, 23 members of the FGF family have been identified, all of which are structurally related signaling molecules: Members FGF1 through FGF10 all bind fibroblast growth factor receptors (FGFRs). (wikipedia.org)
  • Heparin, which binds ligands including PDGF and SCF, and imatininib which blocks downstream tyrosine kinase receptors, both inhibited lung fibroblast migration individually but showed synergy in SSc cells. (ucl.ac.uk)
  • In contrast, FGF7 (keratinocyte growth factor, KGF) binds only to FGFR2b (KGFR). (wikipedia.org)
  • Local inflammation induces the differentiation of bronchial fibroblasts into α-smooth muscle actin (α-SMA) positive myofibroblasts and increases their longevity ( 5 ) through paracrine (for example TGFβ-dependent) and cell adhesion-dependent mechanisms ( 3 , 6 , 7 ). (spandidos-publications.com)
  • A high extracellular matrix-producing activity and contractility of myofibroblasts ( 8 ) participates in bronchial fibrosis, fibrotic remodeling of airways and lung parenchymal compartments, and a pulmonary dysfunction. (spandidos-publications.com)
  • An artificially bioengineered ECM provides an excellent model for studying the molecular mechanisms underlying self-renewal and differentiation of PSCs, without multiple unknown and variable factors associated with natural substrates. (bvsalud.org)
  • Degradation of matrix extracellular phosphoglycoprotein (MEPE) and DMP-1 and release of acidic serine-rich and aspartate-rich MEPE-associated motif (ASARM) peptides are chiefly responsible for the hypophosphatemic rickets mineralization defect and changes in osteoblast-osteoclast differentiation. (medscape.com)
  • The practice of dentistry is likely to be revolutionized by biological therapies based on growth and differentiation factors that accelerate and/or induce a natural biological regeneration. (bvsalud.org)
  • FGF1 is also known as acidic fibroblast growth factor, and FGF2 is also known as basic fibroblast growth factor. (wikipedia.org)
  • In 1975, they further fractionated the extract using acidic and basic pH and isolated two slightly different forms that were named "acidic fibroblast growth factor" (FGF1) and "basic fibroblast growth factor" (FGF2). (wikipedia.org)
  • An addition of soluble factors produced by adenocarcinoma altered the inflammatory response of the pleural mesothelial cells after stimulation with sclerosing agents. (medscimonit.com)
  • Chronic bronchitis is another chronic obstructive disease of the airways in which inflammation is a continuous process probably commencing with an increase in inflammatory cells ( 4 ) and followed by airway remodeling with extracellular matrix deposition on the airways wall ( 5 ). (atsjournals.org)
  • Many cells and soluble factors are involved in the wound healing process, which can be divided into inflammatory, proliferative and remodeling phases. (fgf-erk.com)
  • Increased reactive oxygen species activate various cytokine/growth factor signaling cascades resulting in increased expression of inflammatory and fibrotic genes. (cdc.gov)
  • For example, seeding fibroblasts or keratinocytes results in faster vascularization due to growth factor secretion. (hindawi.com)
  • The exposure of lung fibroblasts to supernatant from mesothelial cell (with or without adenocarcinoma) did not affect collagen secretion. (medscimonit.com)
  • Mechanistically, an upregulation of PDL-1 in chemotherapy-treated CAFs led to an increase in hepatocyte growth factor (HGF) secretion, which stimulates cancer progression, cell invasion, and stemness of lung cancer cells, while inhibiting apoptosis. (cdc.gov)
  • One classical approach to promoting vascularization is to decorate or supplement the scaffolds with proangiogenic factors such as VEGF, bFGF, and PDGF [ 8 ]. (hindawi.com)
  • Different types of scaffolds containing these factors have been combined to enhance capillary formation in dermal wound healing models [ 9 , 10 ]. (hindawi.com)
  • Extracellular matrix scaffolds derived from porcine small intestinal submucosa (SIS-ECM) have been shown to promote the formation of site-specific tissue in a number of preclinical animal studies. (researchgate.net)
  • Literature review: This review summarizes current knowledge, barriers, and challenges in the clinical use of adult stem cells, scaffolds, and growth factors for the development and evaluation of regenerative endodontic therapies. (bvsalud.org)
  • Objective To evaluate the role of Fibroblast growth factor 23 (FGF-23), matrix extracellular phosphoglycoprotein (MEPE) and secreted Frizzled related protein 4 (sFRP4) in pathogenesis of Tumor induced osteomalacia (TIO). (magtechjournal.com)
  • 6 ) emphasized that the inclusion of serum tumor markers is an important factor in the postoperative monitoring of breast cancer patients ( 7 , 8 ). (iiarjournals.org)
  • Normal lung but not skin fibroblasts consistently elongated and aligned with underlying collagen and migrated dependent on PDGF or serum. (ucl.ac.uk)
  • Plasma 1,25-dihydroxyvitamin D (1,25(OH) 2 D) is tightly controlled by plasma parathyroid hormone (PTH), serum calcium, serum phosphate, and fibroblast-like growth factor 23 (FGF-23). (medscape.com)
  • Furthermore, chemokines have been known to regulate multiple processes during tumor progression including primary tumor growth, tumor angiogenesis and development of metastatic disease [ 4 , 5 ]. (thno.org)
  • Chemokines have also been known to enhance epithelial-stromal interactions facilitating tumor growth and invasion [ 6 ]. (thno.org)
  • Thus, some are sequestered in the extracellular matrix of tissues that contains heparan sulfate proteoglycans and are released locally upon injury or tissue remodeling. (wikipedia.org)
  • Angiogenesis is an important factor for tissue-engineered skin constructs. (hindawi.com)
  • Fibroblasts are the most common cells of connective tissue in animals, and they synthesize the extracellular matrix, the complex scaffolding between cells. (livescience.com)
  • Transcriptional profiling and functional validation studies demonstrate that these include effects dependent on increased expression of tissue inhibitor of metalloproteinase-sensitive proteases, enzymes more commonly associated with extracellular matrix remodelling. (gla.ac.uk)
  • 0.1% PE-Cf reduced wound area (2-7th day), hyper-nociception (5-10th day), crust detachment (5-7th day), scar tissue formation (10th day), leukocyte infiltration (5-7th day) and increased fibroblast/myofibroblast (5th and 7th day). (scialert.net)
  • pSmad2 and CTGF immunostaining of aortic and lung tissue revealed an increase in transforming growth factor (TGF)beta signaling. (uzh.ch)
  • Muscle does not exist in a vacuum, but rather it exists with a substantial connective tissue membrane surrounding it, which may be one of the major determinants of growth for that muscle. (jaquishbiomedical.com)
  • As referenced above, through natural growth, this connective tissue membrane stretches in humans, and muscle growth shortly follows. (jaquishbiomedical.com)
  • Collagen VI (COL6) is highly expressed in adipose tissue, upregulated in the obese state, and enriched in breast cancer lesions and is a stimulator of mammary tumor growth. (jci.org)
  • The Growth Factors in Regeneration and Regenerative Medicine Fusion Conference aims to bring together researchers and clinicians from different disciplines with an interest in the function of growth factors in tissue regeneration and their use for regenerative medicine. (fusion-conferences.com)
  • The key elements of tissue engineering are stem cells, morphogen, and a scaffold of extracellular matrix. (bvsalud.org)
  • A significant correlation was found between the number of epithelial or submucosal cells expressing TGF- β in both asthma and chronic bronchitis and basement membrane thickness and fibroblast number. (atsjournals.org)
  • cardiac fibroblasts (CF) is the principal extracellular matrix-producing cells. (fgf-erk.com)
  • Furthermore, inhibition of paracrine factor hepatocyte growth factor (HGF) signaling in vivo suppressed the BMPC-mediated inhibition of miR-155 expression and the associated protective effect on cardiac fibrosis and function. (indexindex.com)
  • In vitro studies confirmed that the conditioned media of BMPC inhibited miR-155 expression and profibrotic signaling in mouse cardiac fibroblasts under diabetic conditions. (indexindex.com)
  • Furthermore, miR-155 over-expression in mouse cardiac fibroblasts inhibited antifibrotic Sloan-Kettering Institute proto-oncogene (Ski) and Ski-related novel gene, non-Alu-containing (SnoN) signaling and abrogated antifibrogenic response of HGF. (indexindex.com)
  • its expression was compared with that of epidermal growth factor (EGF) and granulocyte macrophage colony-stimulating factor (GM-CSF) in bronchial mucosal biopsies from 13 normal subjects, 24 asthmatics, and 19 patients with chronic bronchitis. (atsjournals.org)
  • Epidermal growth factor (EGF) is another growth factor that participates in repair processes targeted at the resurfacing of a wound with new epithelium ( 12 ). (atsjournals.org)
  • During the asthmatic process, epithelial damage is followed by the thickening of asthmatic bronchial walls, which is mechanistically linked to the local inflammation and the activation of bronchial fibroblasts ( 2 - 4 ). (spandidos-publications.com)
  • Camptodactyly, tall stature, scoliosis, and hearing loss (CATSHL) syndrome has been reported in 2 families, showing excessive skeletal growth due to loss-of-function of FGFR3 [ 3 , 4 ]. (e-apem.org)
  • Cadaver-collected fibroblasts can be reprogrammed into induced pluripotent stem cells using chemicals known as growth factors that are linked with stem cell activity. (livescience.com)
  • Reverse transcription quantitative polymerase chain reaction and Western blot analyses further confirmed that the expression of osteogenic-specific genes and major matrix components were up-regulated. (researchgate.net)
  • Recent advances have been made in the of host factors, polymorphisms, and candidate genes associated characterization of the immune response to low-molecular- with occupational asthma may improve our understanding of weight agents. (cdc.gov)
  • Transforming growth factor-β (TGF-β) is an important pro-fibrotic growth factor implicated in airway remodeling and pulmonary fibrosis ( 6-9 ). (atsjournals.org)
  • We also discuss the physicochemical properties of CNTs and their effects on pulmonary toxicities as well as various biological factors contributing to the development of fibrosis. (cdc.gov)
  • They have been alternately referred to as "pluripotent" growth factors and as "promiscuous" growth factors due to their multiple actions on multiple cell types. (wikipedia.org)
  • Researchers produced pluripotent stem cells from the fibroblast cells in the brain lining of human corpses. (livescience.com)
  • Now scientists have taken fibroblasts from the scalps and the brain linings of 146 human brain donors and grown induced pluripotent stem cells from them as well. (livescience.com)
  • There is growing interest in the functional roles of the extracellular matrix (ECM) in regulating the fate of pluripotent stem cells (PSCs). (bvsalud.org)
  • This process depends on adequate levels of ionized calcium and phosphate in the extracellular fluid. (medscape.com)
  • X-linked hypophosphatemic rickets and autosomal recessive hypophosphatemic rickets are the result of mutations in PHEX (a phosphate-regulating gene with homologies to endopeptidases on the X chromosome) and dentin matrix protein 1 ( DMP1 ), respectively. (medscape.com)
  • To estimate the effect of the asthmatic microenvironment on the invasiveness of lung cancer cells, the present study compared the behavior of human non‑small cell lung cancer A549 cells exposed to the signals from human bronchial fibroblasts (HBFs) derived from non‑asthmatic donors (NA HBFs) and from asthmatic patients (AS HBFs). (spandidos-publications.com)
  • These data indicated that the interactions between lung cancer cells and HBFs in asthmatic bronchi may facilitate the colonization of lung tumors by fibroblasts. (spandidos-publications.com)
  • However, the contribution of asthmatic bronchial fibroblasts in systemic dissemination of lung cancer cells remains unaddressed. (spandidos-publications.com)
  • Further, lung fibroblasts were cultured with and without cell supernatants from previously established cell cultures for 24 h. (medscimonit.com)
  • Novel patterned collagen substrates were used to investigate alignment and migration of skin and lung fibroblasts from SSc patients and healthy controls. (ucl.ac.uk)
  • SSc lung fibroblasts remained growth factor dependent, did not migrate more rapidly and were less restricted to alignment of the collagen. (ucl.ac.uk)
  • Pathologic lung fibroblasts from SSc patients modify ECM during migration but remain growth factor dependent and sensitive to inhibitors. (ucl.ac.uk)
  • Multiple collagen proline and lysine-modifying enzymes were identified in SSc but not control fibroblast extracellular matrix preparations, indicating differential levels of ECM modification by the diseased cells. (ucl.ac.uk)
  • However, both in vitro and in vivo studies have revealed that a significant proportion of the cell-synthesized FGF is found outside the cells, localized in the extracellular matrix bound to heparin-like glycosaminoglycans. (nih.gov)
  • These findings have led to the suggestion that matrix-associated FGF represents an extracellular reservoir that may be released by the action of heparan sulfate degrading enzymes introduced during inflammation or tumor metastasis or by heparin that is released from mast cells. (nih.gov)
  • In contrast to NA HBFs, which formed A549‑impenetrable lateral barriers, α‑SMA+ AS HBFs actively infiltrated A549 monolayers and secreted chemotactic factors that arrested A549 cells within AS HBF/A549 contact zone. (spandidos-publications.com)
  • Skin substitutes seeded with cells producing growth factor on a continuous basis provide an attractive alternative [ 12 ]. (hindawi.com)
  • This inhibitory activity is not due to a direct effect of FGF9 on cells of the oligodendrocyte lineage but is mediated by factors secreted by astrocytes. (gla.ac.uk)
  • We aimed to model pathogenic fibroblast migration in SSc in order to identify enhancing factors, measure the effect of migrating cells on underlying extracellular matrix (ECM) and test possible therapeutic inhibitors. (ucl.ac.uk)
  • Fibroblasts were seeded onto LN1-coated vessels (BD BioCoat ® ) for 24-72 hours and cells attached to cell culture vessels served as controls in all experiments. (biomedcentral.com)
  • Our results highlight the crucial role of ETP as an obesity-associated factor that promotes tumor growth in the context of adipocyte interactions with tumor and stromal cells. (jci.org)
  • The major areas of research that might have application in the development of regenerative endodontic techniques are (a) postnatal stem cells, (b) scaffold materials, (c) morphogen/growth factors, (d) implantation. (bvsalud.org)
  • Granulocyte macrophage-colony stimulating factor (GM-CSF) is a hematopoietic growth factor over-expressed in the bronchial mucosa of asthmatics, which is involved in eosinophil and macrophage accumulation in tissues ( 14 , 15 ). (atsjournals.org)
  • Although there is some evidence showing that GM-CSF may have some fibrogenic properties, it is considered as a hematopoietic growth factor rather than a fibrogenic growth factor ( 6 ). (atsjournals.org)
  • To evaluate the role of growth factors in the pathogenesis of airway remodeling, a study was undertaken to study the expression of a known fibrogenic growth factor (TGF-β), of a putative fibrogenic growth factor (EGF) and of a hematopoietic growth factor (GM-CSF) in the central airways of asthmatic and chronic bronchitis patients using immunohistochemistry. (atsjournals.org)
  • while FGF2, HBGF-2, and ECGF-2 were all the same basic fibroblast growth factor. (wikipedia.org)
  • The same treatment had been shown to increase mast cell expression of basic fibroblast growth factor and fibroblast number (1), potentially responsible for increased production of extracellular matrix. (fupress.net)
  • Taken together, our results argue that CXCL1 plays an important role in sustaining the growth of bladder and prostate tumors via up-regulation of IL6 and down-regulation of TIMP4. (thno.org)
  • This was confirmed by pSmad2 immunoblotting of fibroblast cultures. (uzh.ch)
  • Expression of IL-1α, IL-1β, IL-6, IL-8, IL-16, IL-18 as well as matrix metalloproteinase (MMP)-1 and MMP-3 were investigated in RA SF ( n = 6) or osteoarthritis SF ( n = 7) in primary or early passage cultures. (biomedcentral.com)
  • The FGFRs consist of three extracellular immunoglobulin-type domains (D1-D3), a single-span trans-membrane domain and an intracellular split tyrosine kinase domain. (wikipedia.org)
  • Our interest in mechanisms of neural injury and repair prompted us to investigate the role of trophic factor interactions in a well characterized model of collateral sprouting in the adult rat hippocampus. (jneurosci.org)
  • We now report actively demyelinating lesions in patients with multiple sclerosis are associated with increased glial expression of fibroblast growth factor 9 (FGF9), which we demonstrate inhibits myelination and remyelination in vitro. (gla.ac.uk)
  • The mechanisms through which aberrant cellular CXCL1 levels promote specific steps in tumor growth and progression are unknown. (thno.org)
  • Adipocytes represent a major cell type in the mammary tumor microenvironment and are important for tumor growth. (jci.org)
  • Moreover, ETP expression was associated with aggressive mammary tumor growth and high metastatic growth. (jci.org)
  • Hence, the adipocyte, as a major constituent of the mammary tumor stroma ( 3 ), is a likely contributor to tumor growth. (jci.org)
  • Despite the proposed role for nerve growth factor (NGF) in this sprouting, we observed no change in NGF mRNA or protein at several postlesion time points. (jneurosci.org)
  • Although much evidence supports the role of endogenous NGF in promoting neuronal survival in vivo ( Barde, 1989 ), less is known about its ability to influence axonal growth. (jneurosci.org)
  • His longstanding research interest has been the role of the extracellular matrix in nervous system development, especially the function of the heparan sulfate proteoglycan agrin. (nccu.edu)
  • To investigate the molecular mechanisms of cholinergic sprouting in the hippocampus after removal of entorhinal cortical inputs, we evaluated trophic factor gene expression in the denervated hippocampus. (jneurosci.org)
  • Environmental factors that can detect specific IgE antibodies against most low-molecular- affect the initiation of occupational asthma include the intrinsic weight agents has resulted in a search for alternative or characteristics of causative agents as well as the influence of the complementary physiopathologic mechanisms leading to airway level and route of exposure at the workplace. (cdc.gov)