• The protein encoded by this gene is a decoy receptor for certain cytokines that belongs to the interleukin-1 receptor family. (wikipedia.org)
  • Gp130 serves as the signal transducing receptor subunit for the IL-6-type cytokines consisting of interleukin (IL)-6, IL-11, leukemia inhibitory factor (LIF), oncostatin M (OSM), ciliary neurotrophic factor (CNTF), new neurotrophin factor-1 (NNT-1), IL-27, cardiotrophin-1 (CT-1), and cardiotrophin like cytokine (CLC) (2 - 5). (rndsystems.com)
  • These cytokines are involved in a variety of functions including the modulation of inflammatory and immune responses, heart development, fertility, and many other activities (2). (rndsystems.com)
  • When cytokines bind to their cognate receptor, JAKs phosphorylate the cytokine receptor and subsequently the STATs, which then dissociate from the JAK-receptor complex. (medscape.com)
  • Inflammasomes are intracellular multiprotein complexes that regulate the activity of caspase-1 and can be activated by various cellular dangers that trigger the processing and release of pro-inflammatory cytokines to engage innate immunity ( 3 ). (spandidos-publications.com)
  • The NLRP3 inflammasome is a multiprotein complex that activates cysteine protease caspase-1, which leads to the maturation and secretion of pro-inflammatory cytokines, such as interleukin-1β (IL)-1β and IL-18 ( 7 ). (spandidos-publications.com)
  • There are several cytokines in the IL-1 family, including IL-1α, IL-1β, IL-18 and IL-33. (spandidos-publications.com)
  • We also explore the potential aetiologies of the lymphopenia associated with severe COVID-19: the virus' expanded tropism, elevated serum cytokines (particularly interleukin-6 and tumour necrosis factor-α), and excessive lymphocyte recruitment to the lungs. (ersjournals.com)
  • Furthermore, IL-21 promotes differential expression of many cytokines including interleukins and chemokines. (intechopen.com)
  • by normal individuals cause broncho-constriction in Cytokines often have overlapping biological activities, patients with asthma. (cdc.gov)
  • LIF R alpha binds the pleiotropic cytokine LIF with low affinity, and the soluble isoform retains LIF-binding activity (5). (rndsystems.com)
  • Recombinant IL-10 soluble receptor, consisting of the extracellular domain of IL-10 R, binds IL-10 with high affinity in solution and is a potent IL-10 antagonist. (bio-techne.com)
  • Soluble biglycan then binds to TLR2 and TLR4 and activates the mitogen-activated protein PAC-1 kinase p38 extracellular signal-regulated kinase (Erk) and nuclear factor kappa-light-chain enhancer of activated B cells (NF-κB) pathways leading to the secretion of tumor necrosis factor (TNF)-α in a myeloid differentiation primary response 88 (MyD88) dependent fashion [60]. (researchdataservice.com)
  • alpha of the intestinal rRNA, soluble to the density-fluctuation of bacterium requirements, domains in vasodilator of microenvironment from its domain. (erik-mill.de)
  • gp130 associates with different ligand-specific receptors to form signaling receptor complexes for the other IL-6 family ligands (1). (rndsystems.com)
  • These receptors bind to various ligands on target cells, both endogenous and exogenous, and have an important role in regulating the NK-cell response. (wikidoc.org)
  • In general, Janus family tyrosine kinases (JAKs) bind to the intracellular components of cytokine receptors, and are, in turn, bound by STATs upon cytokine signaling. (medscape.com)
  • 5 4 Succinate functions as a competitive inhibitor for prolyl hydroxylase domain (PHD) proteins that are central to degradation of hypoxia-inducible factor (HIF)-1α subunit. (haematologica.org)
  • also known as IL-6 signal transducer, IL-6 receptor beta, oncostatin-M alpha subunit) is a ubiquitously expressed, 130 kDa type I transmembrane glycoprotein and member of the type II subfamily, type I cytokine receptor family. (rndsystems.com)
  • It belongs to the type Icytokine receptors, and has been shown to form a heterodimeric receptor complex with the common gamma-chain, areceptor subunit also shared by the receptors for interleukin 2, 4, 7, 9, and 15. (creativebiomart.net)
  • [ 1 , 2 ] Although the chief target of the autoimmune attack in most cases is the skeletal muscle nicotinic acetylcholine receptor (nAChR), other antigenic targets that are components of the neuromuscular junction (NMJ) have also been implicated. (medscape.com)
  • In separate work, my team identified a set of secreted proteins overexpressed in the tumor microenvironment, and developed antibodies to block their cognate receptors for therapeutic gain. (gene.com)
  • Functionally, it is responsible for transduction of the IL-6 signal across the plasma membrane (1). (rndsystems.com)
  • Indeed, Toll-like receptors are a class of membrane receptors that sense extracellular microbes and trigger anti-pathogen signalling cascades. (nature.com)
  • ADAM17 is a metalloprotease and disintegrin that lodges in the plasmatic membrane of several cell types and is able to cleave a wide variety of cell surface proteins. (frontiersin.org)
  • A Disintegrin and Metalloproteases (ADAM), originally named metalloproteinases disintegrin cystein-rich (MDC), are membrane-anchored cell surface proteins containing both disintegrin and metalloproteinase domains. (frontiersin.org)
  • They discovered that changes in blood pressure, or alterations in Angiotensin II, provoke rapid trafficking of renal sodium transporters between membrane domains, associated with phosphorylation and pool size regulation. (usc.edu)
  • Normal neuromuscular junction showing a presynaptic terminal with a motor nerve ending in an enlargement (bouton terminale): Synaptic cleft and postsynaptic membrane with multiple folds and embedded with several acetylcholine receptors. (medscape.com)
  • Adoptive cell therapy (ACT) with chimeric antigen receptor T (CAR-T) cells can restore the activity of exhausted T cell through reprogramming and is widely used in the treatment of relapsed/refractory (r/r) hematological malignancies. (hindawi.com)
  • The most active T cell endogenous inhibitory pathway is the immunoglobulin superfamily such as CD28/cytotoxic T lymphocyte antigen-4 (CTLA-4): B7-1/B7-2 receptor/ligand grouping, which plays a central role in coordinating immune responses [ 7 , 8 ]. (hindawi.com)
  • NK-cells are defined as large granular lymphocytes that do not express T-cell antigen receptors (TCR) or Pan T marker CD3 or surface immunoglobulins (Ig) B cell receptor but that usually express the surface markers CD16 (FcγRIII) and CD56 in humans, and NK1.1/NK1.2 in certain strains of mice. (wikidoc.org)
  • Interleukin-1 receptor-associated kinase 4, also known as Renal carcinoma antigen NY-REN-64, IRAK-4 and IRAK4, is a member of the protein kinase superfamily, TKL Ser/Thr protein kinase family and Pelle subfamily. (betalifesci.com)
  • IRAK4 contains onedeath domain and oneprotein kinase domain. (betalifesci.com)
  • A member of the IL-1 receptor (IL-1R)-associated kinase (IRAK) family, IRAK4, has been shown to play an essential role in Toll-like receptor (TLR)-mediated signaling. (betalifesci.com)
  • IL-1-mediated IRAK4 kinase activity in T cells is essential for induction of IL-23R expression, Th17 differentiation, and autoimmune disease. (betalifesci.com)
  • Pharmacological blocking of IRAK4 kinase activity will retain some levels of host defence, while reducing the levels and duration of inflammatory responses, which should provide beneficial therapies for sepsis and chronic inflammatory diseases. (betalifesci.com)
  • Its activation is tightly controlled by numerous other signaling proteins including protein kinase C (PKC), Sab/SH3BP, and caveolin-1. (medscape.com)
  • This protein binds interleukin-1α (IL1A), interleukin-1β (IL1B), and interleukin 1 receptor antagonist (IL1Ra), preventing them from binding to their regular receptors and thereby inhibiting the transduction of their signaling. (wikipedia.org)
  • NK-cells, along with macrophages and several other cell types, express the FcR molecule, an activating biochemical receptor that binds the Fc portion of antibodies . (wikidoc.org)
  • IL-10 binds specifically and with high affinity to cell-surface receptors. (bio-techne.com)
  • Building on these findings, the lab addressed the coordinated and concerted control of extracellular potassium by skeletal muscle, kidney and gut in response to altered metabolic and electrolyte demands and have begun to use these findings to address the mechanisms responsible for the cardiovascular benefit of raising dietary K/Na ratio. (usc.edu)
  • GPR91 is a G protein-coupled cell surface receptor for extracellular succinate (Sucnr1). (haematologica.org)
  • Here, we report that the guanine nucleotide-binding protein (G protein)-coupled receptor-activated WD-repeat Gβ interacts with the glucocorticoid receptor (GR), comigrates with it into the nucleus and suppresses GR-induced transactivation of the glucocorticoid-responsive genes. (rupress.org)
  • Human synovial fibroblasts coexpress IL-1 receptor type I and type II mRNA. (wikipedia.org)
  • The IL-10 R mRNA has been detected in all cell types that are known to respond to IL-10. (bio-techne.com)
  • IRAK4 is required for the efficient recruitment of IRAK1 to the IL-1 receptor complex following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization. (betalifesci.com)
  • Recently, intracellular microbial sensors have also been identified, including NOD-like receptors and the helicase-domain-containing antiviral proteins RIG-I and MDA5. (nature.com)
  • Medzhitov, R. Toll-like receptors and innate immunity. (nature.com)
  • Innate immunity offers the first defense in mammals, depending on its capacity to rapidly detect invading pathogens and then eliminating the 'foreign danger' ( 1 ). (spandidos-publications.com)
  • 1 Similarly, succinate may derive from the γ-aminobutyric acid shunt pathway that correlates with levels of expression of the γ-aminobutyric acid transporters solute carrier family 6 members 12 and 13 (SLC6A12, SLC6A13). (haematologica.org)
  • We report an unanticipated transcriptional activity triggered in stigma upon incompatible pollination and show that following compatible interaction, components of the pattern-triggered immunity (PTI) pathway are induced on the female side. (biomedcentral.com)
  • Another pathway, TGF-β signaling pathway, appears to play a part in the progression of diabetes, insulin resistance, and autoimmunity in both type 1 and 2 diabetes and complications in diabetes. (frontiersin.org)
  • The LIF R alpha /gp130 receptor complex also transduces Oncostatin M signals, although LIF R alpha alone does not interact with Oncostatin M (6). (rndsystems.com)
  • This receptor transduces thegrowth promoting signal of IL21, and is important for the proliferation and differentiation of T cells, B cells,and natural killer (NK) cells. (creativebiomart.net)
  • Recent evidence obtained in mouse models shows its essential role regulating blood cell function through various mechanisms that include pseudohypoxia responses by hypoxia-inducible factor-1α activation, post-translational modifications like succinylation, and communication mediated by succinate receptor 1. (haematologica.org)
  • Given their strong cytolytic activity and the potential for auto-reactivity, Natural Killer cell activity is tightly regulated. (wikidoc.org)
  • Most of these receptors are not unique to NK cells and can be present in other T cell subsets as well. (wikidoc.org)
  • heterodimers) - a C-type lectin family receptor, conserved in both rodents and primates and identifies non-classical (also non-polymorphic) MHC I molecules like HLA E . Though indirect, this is a way to survey the levels of classical (polymorphic) HLA molecules, however, because expression of HLA-E at the cell surface is dependent upon the presence of classical MHC class I leader peptides. (wikidoc.org)
  • The structure and structure-based modulation of ADAM17 are also described for better understanding of the various ADAM17 regulatory pathways in different cell types or tissues. (frontiersin.org)
  • Some labile cell types whose numbers are normally or all severe infections that could be targets for pharmaco- controlled through programmed cell death are subject to logic intervention. (cdc.gov)
  • Extensive lymphocyte severe infections is a massive loss of lymphocytes, den- apoptosis has also occurred in humans and animals infect- dritic cells, gastrointestial epithelial cells, and other cell ed with several exotic agents, including Bacillus anthracis , types through apoptosis, or programmed cell death. (cdc.gov)
  • Prevention of lymphocyte apoptosis, same process by which these cell populations are regulat- through either genetic modification of the host or treatment ed during normal health ( 1 , 2 ). (cdc.gov)
  • These include members of the Bcl-2 protein family, course, and extent of programmed cell death will aid man- which have both proapoptotic and antiapoptotic activity agement of patients with severe infections. (cdc.gov)
  • Following compatible pollination, the dry pollen grain hydrates on the stigma papilla and ultimately germinates, producing a tube that penetrates the wall of the stigmatic cell and grows down to convey the male gametes towards the ovules for fertilization [ 1 , 2 ]. (biomedcentral.com)
  • My postdoc studies on neurotransmitter receptors led to papers in Science, Nature and Cell, and earned the 1988 Boeringer Ingelheim Award. (gene.com)
  • The signaling mechanisms of IL-21 in different cell types have been identified. (intechopen.com)
  • IL-10 is also a pleiotropic cytokine with multiple immunostimulatory as well as immunosuppressive effects on a variety of other cell types. (bio-techne.com)
  • This entry represents a subtype of the immunoglobulin domain, and is found in a diverse range of protein families that includes glycoproteins, fibroblast growth factor receptors, vascular endothelial growth factor receptors, interleukin-6 receptor, and neural cell adhesion molecules. (embl.de)
  • Extracellular stimuli that activate cell surface receptors modulate glucocorticoid actions via as yet unclear mechanisms. (rupress.org)
  • In the fetal bone marrow, the first committed cell in B-cell lineage is the early pro-B cell, which is identified by its ability to proliferate in the presence of interleukin (IL)-7. (medscape.com)
  • Interleukin (IL)-9-producing subset called Th9 cell, Th22 cells which primarily secrete IL-22, IL-13 and tumor necrosis factor- and Th25 cells via producing IL-25 are believed to be important for initiating allergic reactions and developing airway inflammation. (cdc.gov)
  • This rejection mechanism is initiated by a ligand-receptor interaction and is genetically controlled by a single polymorphic locus, called the S -locus [ 4 ]. (biomedcentral.com)
  • Nod2, a Nod1/Apaf-1 family member that is restricted to monocytes and activates NF-κB. (nature.com)
  • IL-21R is a type-1 cytokine receptor and belongs to the IL-2R and IL-15R family. (intechopen.com)
  • IL-1R2 protein also interacts non-productively with the second component of the signaling IL-1 receptor, namely IL-1RAcP, and a complex of the IL-1R2 and IL-1RAcP extracellular domains with interleukin-1 beta has been solved by X-ray crystallography. (wikipedia.org)
  • Gβ2 was associated with GR/glucocorticoid response elements (GREs) in vivo and suppressed activation function-2-directed transcriptional activity of the GR. We conclude that the Gβγ complex interacts with the GR and suppresses its transcriptional activity by associating with the transcriptional complex formed on GR-responsive promoters. (rupress.org)
  • Mature mouse LIF R alpha consists of a 785 amino acid (aa) extracellular domain (ECD) with two cytokine receptor homology domains, one WSxWS motif, and three fibronectin type III repeats, followed by a 25 aa transmembrane segment and a 239 aa cytoplasmic domain (2, 3). (rndsystems.com)
  • Rat gp130 is synthesized as a 918 amino acid (aa) precursor with a 22 aa signal sequence, a 596 aa extracellular domain (ECD), a 22 aa transmembrane region, and a 278 aa cytoplasmic tail. (rndsystems.com)
  • The deduced amino acid sequence of human IL-10 R is approximately 60% identical to mouse IL-10 R. Although human IL-10 has cross-species activities and is active on mouse cells, mouse IL-10 is species-specific in its actions and does not bind to the human IL-10 receptor. (bio-techne.com)
  • Caspase-1 is a proteolytic enzyme that processes the inactive precursor of IL-1β into the mature form, and is termed IL-1β converting enzyme (ICE). (spandidos-publications.com)
  • Under conditions of tissue stress or injury biglycan can be released from the extracellular matrix by proteolytic enzymes such as bone morphogenic protein (BMP)-1 matrix metalloproteinase (MMP)-2 -3 and -13 [58]. (researchdataservice.com)
  • [ 8 , 9 ] STAT3 is one of 7 human STAT (signal transducer and activator of transcription) proteins, which are critical second messengers for many cytokine, hormone, and growth factor receptors. (medscape.com)
  • The mutations are predominantly missense and in-frame deletions that lead to production of proteins with dominant negative activity. (medscape.com)
  • In type 1 diabetes, the lowered expression of adhesion proteins within the intestinal epithelium favours a greater immune response that may result in destruction of pancreatic β cells by CD8+ T-lymphocytes, and increased expression of interleukin-17, related to autoimmunity. (biomedcentral.com)
  • Proteins are sensitive to heat, and freeze-drying can preserve the activity of the majority of proteins. (betalifesci.com)
  • Ig molecules are highly modular proteins, in which the variable and constant domains have clear, conserved sequence patterns. (embl.de)
  • There are 363480 IGc2 domains in 114582 proteins in SMART's nrdb database. (embl.de)
  • Taxonomic distribution of proteins containing IGc2 domain. (embl.de)
  • The complete taxonomic breakdown of all proteins with IGc2 domain is also avaliable . (embl.de)
  • Click on the protein counts, or double click on taxonomic names to display all proteins containing IGc2 domain in the selected taxonomic class. (embl.de)
  • The CNTF receptor is a ternary complex that contains CNTF R alpha and gp130 as well as LIF R alpha (8, 9). (rndsystems.com)
  • Eleven potential N-linked glycosylation sites are found within the rat gp130 ECD (1). (rndsystems.com)
  • The ECD also contains an N terminal immunoglobulin (Ig)-like C2-type domain, followed by the cytokine receptor homology region (CHR) which is made up of two fibronectin type III-like domains and a WSXWS motif, and three additional fibronectin type III-like domains (2). (rndsystems.com)
  • Aside from the Fc receptor, Natural Killer cells express a variety of receptors that serve to either activate or suppress their cytolytic activity. (wikidoc.org)
  • The most abundant surfactant elongation is TACC3, a translocated model type transcribed in viral family storm. (erik-mill.de)
  • Transient overexpression of UBCv1 impaired activation of NF-κB and AP-1 transcription factors induced by several agonists of these pathways. (mdpi.com)
  • Natural killer cells (or NK cells ) are a type of cytotoxic lymphocyte that constitute a major component of the Innate immune system . (wikidoc.org)
  • Nucleotide-binding oligomerization domain (NOD)-like receptors (NLRs) have recently been identified as innate immune receptors that play a pivotal role in initiating the inflammatory response ( 4 ). (spandidos-publications.com)
  • The IL-1 family has been recognized to play important roles in inflammation with pro-inflammatory properties, associated with acute and chronic inflammation, and plays a significant role in the innate immune defense ( 12 ). (spandidos-publications.com)
  • Schematic diagram indicating the complementary activities of cytotoxic T-cells and NK cells. (wikidoc.org)
  • These inhibitory receptors recognize MHC class I alleles , which could explain why NK cells kill cells possessing low levels of MHC class I molecules. (wikidoc.org)
  • Our results suggest that the NLRP3/ASC/caspase-1 axis participates in the regulation of pro-imflammatory cytokine secretion in RAW264.7 cells, particularly the generation of IL-1β and IL-18. (spandidos-publications.com)
  • The two mainstreams of cells that build up the central nervous system are neurons and glia, the latter of which for quite a long time are supposed to act as the background of the former, supporting, nourishing and protecting the neurons [ 1 ]. (degruyter.com)
  • Our research further revealed that inhibiting IRE1 activity in cancer-surveilling dendritic cells augments anti-tumor immunity. (gene.com)
  • Interleukin-21 (IL-21) is produced by activated T cells and it plays many diverse roles by regulating the functions of normal and abnormal cells. (intechopen.com)
  • Interleukin-21 (IL-21) was first identified in 2000 through screening of a cDNA library from CD3+ human T cells [ 1 ]. (intechopen.com)
  • In turn this leads to the secretion of a series of chemoattractants for T cells neutrophils and macrophages including Chemokine (C-X-C motif) ligand PAC-1 2 (CXCL2) Chemokine (C-C motif) ligand (CCL3) CCL2 and CCL5 with the attracted macrophages further synthesizing biglycan and amplifying the proinflammatory response PAC-1 [60]. (researchdataservice.com)
  • In UUO biglycan is overexpressed in the epithelial cells of distal tubules and collecting ducts followed by macrophage infiltration [83 101 109 Biglycan-deficient (mice showing increased albuminuria expanded mesangial matrix impaired renal function and higher levels of macrophage infiltration compared to wild type animals [84]. (researchdataservice.com)
  • L-Serine is required in tailor-made activity in C-terminal responses as ubiquinone to same domains fatty as transcripts, cells and the systems fork and D-serine. (erik-mill.de)
  • Leukemia Inhibitory Factor Receptor alpha (LIF R alpha ), also known as LIFR beta (due to its participation in signal transduction) and CD118, is a 190 kDa type I transmembrane protein in the Interleukin-6 receptor family. (rndsystems.com)
  • Mouse and human cDNA clones encoding the ligand-binding IL-10 receptor (IL-10 R) have been isolated. (bio-techne.com)
  • 2.2 SLRPs in renal inflammation and diabetic nephropathy Several studies have shown that biglycan acts as a proinflammatory danger molecule by signaling through the LRR-containing receptors TLR2 and TLR4 [24 106 For a comprehensive review of the literature on the subject see our recent publication [60]. (researchdataservice.com)
  • In type 2 diabetes, receptor activation and recognition by microorganisms from the intestinal lumen may trigger inflammatory responses, inducing the phosphorylation of serine residues in insulin receptor substrate-1, reducing insulin sensitivity. (biomedcentral.com)
  • protruding of the MRN leukemia to DNA DSBs is ATM-dependent DNA government mimicking type, by signaling KAT5( Tip60) found 5-pyrophosphate of side and interleukin-12 exchanger phosphorylation. (erik-mill.de)
  • negative ER of large reviews to such proteases of the critical phosphorylation is known professions to two phosphatase-1 reactions( Waizenegger et al. (erik-mill.de)
  • Encapsulated bacteria, most commonly Streptococcus pneumoniae, followed by Haemophilus influenzae type b and staphylococcal species, are the typical pathogens. (medscape.com)
  • This gene and three other genes form a cytokine receptor gene cluster on chromosome 2q12. (wikipedia.org)
  • download history Thanks and genes Activation include the acid of and precursor between targets with exciting regulated students and SRC-phosphorylated types. (erik-mill.de)
  • Immunoglobulin-like domains that are related in both sequence and structure can be found in several diverse protein families. (embl.de)
  • Succinate further inhibits several dioxygenases involved in epigenetic regulation like ten-eleven translocation methylcytosine dioxygenase (TET) and jumonji C domain-containing histone lysine demethylases (JMJD3). (haematologica.org)
  • Department of Pharmacology and Toxicology, School of Medicine, Universidad Complutense de Madrid (UCM), Instituto de Investigación Sanitaria Hospital 12 de Octubre (Imas12), Instituto de Investigación Neuroquímica (IUINQ-UCM), Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Avda. (mdpi.com)
  • The domains in the CHR are the structural hallmarks of the hematopoietic cytokine receptor family (2). (rndsystems.com)
  • The NLR family, pyrin domain-containing 3 (NLRP3) inflammasome is currently one of the most fully characterized inflammasomes. (spandidos-publications.com)
  • Additionally biglycan can autonomously engage the activation of the NLR family pyrin domain-containing 3 (NLRP3) inflammasome and trigger the activation of caspase-1. (researchdataservice.com)
  • Human whole blood was stained with Alexa Fluor™ 647 Mouse Anti-Human NCAM-1 (CD56) antibody (Cat. (bdbiosciences.com)
  • Autosomal dominant hyperimmunoglobulin E (IgE) syndrome (AD-HIES) was first described as Job syndrome in 1966[1, 2] and included the triad of eosinophilia, eczema, and recurrent skin and pulmonary infections. (medscape.com)
  • Defects in IRAK4 are the cause of recurrent isolated invasive pneumococcal disease type 1 (IPD1) which is defined as two episodes of IPD occurring at least 1 month apart, whether caused by the same or different serotypes or strains. (betalifesci.com)
  • Thus, XLA is most likely to be diagnosed when unusually severe or recurrent sinopulmonary infections occur in a male infant younger than 1 year. (medscape.com)
  • Defects in IRAK4 are also the cause of IRAK4 deficiency which causes extracellular pyogenic bacterial and fungal infections in otherwise healthy children. (betalifesci.com)
  • 1] Such infections that begin in male infants as maternal IgG antibodies, acquired transplacentally, are lost. (medscape.com)
  • that regulate several pathophysiological processes including fibrosis inflammation and tumor PAC-1 progression. (researchdataservice.com)
  • Quite contrarily a recent study shows a decrease in decorin levels in glomerulonephritides caused by overexpression of the Ovarian-tumor-domain-containing protease OTUB1 [117]. (researchdataservice.com)
  • The protein encoded by this gene is a cytokine receptor for interleukin 21 (IL21). (creativebiomart.net)
  • Phosphorylated STATs dimerize within the cytosol via their phosphotyrosines and Src-homology 2 (SH2) domains. (medscape.com)
  • Pulmonary fibrosis is caused by a variety of insults to the lung, such as acute lung injury, irradiation and drugs [ 1 ]. (ersjournals.com)
  • An important issue for the long-term survival of patients with ARDS is the degree of parenchymal fibrosis and loss of pulmonary function [ 1 ]. (ersjournals.com)
  • Sterile solution in PBS containing 2.5% (v/v) 2-propanol, 25mM n-octyl-β-D-glucopyranoside and 1% (wt/v) human serum albumin. (enzolifesciences.com)
  • Human and mouse IL-10 receptors are structurally related to the IFN-gamma receptor. (bio-techne.com)
  • A DNA sequence encoding the full length of human IRAK4 (Q9NWZ3-1) (Met 1-Ser 460) was expressed with a His tag at the N-terminus. (betalifesci.com)
  • SwissProt sequences and OMIM curated human diseases associated with missense mutations within the IGc2 domain. (embl.de)
  • Nod1, an Apaf-1-like activator of caspase-9 and nuclear factor-κB. (nature.com)