Nasal mucosal inflammation induces remodeling processes within the mucosa characterized by changes in extracellular matrix (ECM) protein deposition, macrophage and lymphocyte infiltration, and histological structure. (molcells.org)
They are expressed on endothelial cells and bind to the integrins CD 11a/CD 18 (lymphocyte function-associated antigen-1) and VLA-4, respectively. (medscape.com)
Protein3
Collagen XVII, previously called BP180, is a transmembrane protein which plays a critical role in maintaining the linkage between the intracellular and the extracellular structural elements involved in epidermal adhesion, identified by Diaz and colleagues in 1990. (wikipedia.org)
Collagen XVII is a homotrimer of three alpha1(XVII)-chains and a transmembrane protein in type II orientation. (wikipedia.org)
The predominant form of the protein is comprised of two alpha1(IV) subunits and one alpha2(IV) subunit, however, at least six different alpha subunits can be incorporated into the heterotrimer. (lookformedical.com)
The membrane proximal part of the ectodomain, within amino acids 506-519, is responsible for binding to alpha 6 integrin, this binding seems to be important for the collagen XVII integration into hemidesmosomes[citation needed]. (wikipedia.org)
Collagen type IV molecules assemble to form a sheet-like network which is involved in maintaining the structural integrity of basement membranes. (lookformedical.com)
A fibrillar collagen consisting of three identical alpha1(III) chains that is widely distributed in many tissues containing COLLAGEN TYPE I. It is particularly abundant in BLOOD VESSELS and may play a role in tissues with elastic characteristics. (lookformedical.com)
This classification was based on the notion that "collagen" was equivalent to "connective tissue", but with the present recognition of the different types of collagen and the aggregates derived from them as distinct entities, the term "collagen diseases" now pertains exclusively to those inherited conditions in which the primary defect is at the gene level and affects collagen biosynthesis, post-translational modification, or extracellular processing directly. (lookformedical.com)
The C-terminal end of the alpha1 chain of collagen type XVIII contains the ENDOSTATIN peptide, which can be released by proteolytic cleavage. (lookformedical.com)
Collagen type XI is heterotrimer containing alpha1(XI), alpha2(XI) and alpha3(XI) subunits. (lookformedical.com)
Structural alterations in the nasal epithelium include goblet cell hyperplasia, squamous metaplasia, epithelial-mesenchymal transition (EMT), epithelial barrier disruption, epithelial exfoliation, and basement membrane thickening. (molcells.org)
Skin3
Clinical hallmarks, in addition to blisters and erosions of the skin and mucous membranes, include nail dystrophy, loss of hair, and dental anomalies. (wikipedia.org)
It is a major constituent of bone (BONE AND BONES) and SKIN and consists of a heterotrimer of two alpha1(I) and one alpha2(I) chains. (lookformedical.com)
Skin and mucous membranes2
Clinical hallmarks, in addition to blisters and erosions of the skin and mucous membranes, include nail dystrophy, loss of hair, and dental anomalies. (wikipedia.org)
The integrin α1 subunit is predominantly present in stromal and smooth muscle cells and fibroblasts and is generally absent from normal epithelia although it has been reported to be expressed in developing organs such as the kidney and skin [ 11 ]. (biomedcentral.com)
In this study, as a first step to test this hypothesis, we investigated α1 integrin subunit expression in a set of colorectal adenocarcinoma specimens. (biomedcentral.com)
In the digestive system, α1 integrin subunit expression in epithelia has only been reported in the small intestine and found to be confined to the lower crypts which contain the progenitor cells [ 12 , 13 ]. (biomedcentral.com)
8. Variants of integrin beta 4 subunit in human endometrial adenocarcinoma cells: mediators of ECM-induced differentiation? (nih.gov)
Transmembrane3
Collagen XVII, previously called BP180, is a transmembrane protein which plays a critical role in maintaining the linkage between the intracellular and the extracellular structural elements involved in epidermal adhesion, identified by Diaz and colleagues in 1990. (wikipedia.org)
Collagen XVII is a homotrimer of three alpha1(XVII)-chains and a transmembrane protein in type II orientation. (wikipedia.org)
Integrins are a family of cell surface αβ heterodimeric transmembrane receptors for extracellular matrix components and cell-cell interactions. (biomedcentral.com)
Matrix7
3. Extracellular matrix induces hormone responsiveness and differentiation in RUCA-I rat endometrial adenocarcinoma cells. (nih.gov)
5. Extracellular matrix regulates steady-state mRNA levels of the proliferation associated protein Ki-67 in endometrial cancer cells. (nih.gov)
7. Extracellular matrix-induced changes in expression of cell cycle-related proteins and proteasome components in endometrial adenocarcinoma cells. (nih.gov)
A) Longitudinal sections of elastin‐rich extracellular matrix sheets stained with acid Orcein at 0% strain (top) and 30% uniaxial strain in the horizontal direction (bottom). (comprehensivephysiology.com)
Specifically, it regulates the organization of apical plasma membrane in epithelial cells, disk morphogenesis during early retinal development, MAPK and Akt signaling pathways, and in cholesterol metabolism. (nih.gov)
They are expressed on endothelial cells and bind to the integrins CD 11a/CD 18 (lymphocyte function-associated antigen-1) and VLA-4, respectively. (medscape.com)
Expression3
Indeed, over-expression of the αvβ3, α5β1, αvβ5 and α6β4 integrins in various cancer types and correlation with the metastatic behaviour of breast, prostate and lung cancers as well as melanomas are well documented [ 4 ]. (biomedcentral.com)
Indeed, nothing is known about integrin α1β1 expression in CRC. (biomedcentral.com)
19. Characterization of the functional progesterone receptor in an endometrial adenocarcinoma cell line (Ishikawa): progesterone-induced expression of the alpha1 integrin. (nih.gov)
Cell3
Integrins are a family of heterodimeric glycoproteins involved in bidirectional cell signaling and participate in the regulation of cell shape, adhesion, migration, differentiation, gene transcription, survival and proliferation. (biomedcentral.com)
9. A novel basement membrane-induced gene identified in the human endometrial adenocarcinoma cell line HEC1B. (nih.gov)
The cell line is positive for KERATIN, can synthesize LECITHIN, and contains high levels of POLYUNSATURATED FATTY ACIDS in its PLASMA MEMBRANE. (nih.gov)