• gene
  • Several infants with severe forms of long-QT syndrome (LQTS) who displayed life-threatening ventricular arrhythmias together with delayed neurodevelopment and epilepsy were found to have mutations in either this gene or another member of the calmodulin gene family (PMID:23388215). (nih.gov)
  • Pseudogenes of this gene are found on chromosomes 10, 13, and 17. (nih.gov)
  • The first Raf gene, v-Raf was found in 1983. (wikipedia.org)
  • A year later, another transforming gene was found in the avian retrovirus MH2, named v-Mil - that turned out to be highly similar to v-Raf. (wikipedia.org)
  • Normal cellular homologs of v-Raf and v-Mil were soon found in both the mouse and chicken genome (hence the name c-Raf for the normal cellular Raf gene), and it became clear that these too had a role in regulating growth and cell division. (wikipedia.org)
  • One gene of particular interest is ras, which is found mutated at high frequency in a number of malignancies. (embl.de)
  • stimulation
  • Moreover, we found that cdk5 phosphorylates dopamine and cAMP-regulated phosphoprotein at Thr75, whereas CaMK II is responsible for the activation of cAMP response element-binding protein in response to SKF83959 stimulation. (aspetjournals.org)
  • focal
  • The disruption of organelles is evidenced by the loss of Nissl substances, the formation of ribosomal rosettes, and swelling are reversible, DNH fragmentation is a characteristic of apoptosis, has been demonstrated after both focal and global Ischemic insult, found in CA1 region of hippocampus. (blogspot.com)
  • calcium
  • In comparison to calcium (Ca), the most abundant cation in the human body, Mg 2+ displays higher affinity for oxygen donor ligands, that is negatively charged carboxylates and phosphates or enolate moieties (WOLF, CITTADINI 2003). (docplayer.net)
  • The present study, introducing calcium influx and calcium release from internal store into the tristable system, further show that significant elevation of cytoplasmic calcium concentration switches activation of both kinase and phosphatase to their basal states, thereby depotentiate the synaptic strength. (frontiersin.org)
  • receptors
  • 12 Activation of the inotropic receptors causes a postsynaptic membrane depolarization and Ca +2 entry, whereas metabotropic receptors activate various kinases and also indirectly increase [Ca +2 ] in dorsal horn neurons of the spinal cord. (asahq.org)
  • effects
  • It should also not be confused with AMP-activated protein kinase - which, although a member of the protein kinase superfamily and a Ser/Thr kinase, may have opposite effects - nor be confused with cyclin-dependent kinases (Cdks), nor be confused with the acid dissociation constant pKa. (wikipedia.org)
  • domain
  • On its N-terminal segment, a Ras-binding domain (RBD) and a C-kinase homologous domain 1 (C1 domain) are found next to each other. (wikipedia.org)
  • Historically, this autoinhibitory block was labelled as the CR1 region ("Conserved Region 1"), the hinge region being named CR2, and the kinase domain CR3. (wikipedia.org)