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Gene Expression ProfilingGene ExpressionGene Expression RegulationOligonucleotide Array Sequence AnalysisRNA, MessengerGene Expression Regulation, DevelopmentalTranscription, GeneticPromoter Regions, GeneticGene Expression Regulation, NeoplasticReverse Transcriptase Polymerase Chain ReactionTranscription FactorsBase SequenceGene Expression Regulation, EnzymologicGene Expression Regulation, PlantMolecular Sequence DataGene Expression Regulation, BacterialGene Expression Regulation, ViralDNA-Binding ProteinsSignal TransductionCell LineCells, CulturedCluster AnalysisTranscriptomeGene Expression Regulation, FungalGenes, ReporterMicroarray AnalysisUp-RegulationBlotting, NorthernTransfectionCell DifferentiationRNATranscriptional ActivationMutationDNA PrimersDown-RegulationIn Situ HybridizationCell Line, TumorTrans-ActivatorsNuclear ProteinsGene Regulatory NetworksRepressor ProteinsPolymerase Chain ReactionMice, Inbred C57BLDNA, ComplementaryPhenotypeReal-Time Polymerase Chain ReactionTime FactorsModels, GeneticLiverComputational BiologyAmino Acid SequenceLuciferasesDNAHomeodomain ProteinsTumor Cells, CulturedBinding SitesBlotting, WesternModels, BiologicalOrgan SpecificityCell NucleusAlgorithmsProtein BindingDatabases, GeneticHistonesPlasmidsMicroRNAsReproducibility of ResultsEpigenesis, GeneticGenetic VectorsMice, TransgenicRats, Sprague-DawleyCloning, MolecularRegulatory Sequences, Nucleic AcidImmunohistochemistryGene SilencingEnhancer Elements, GeneticExpressed Sequence TagsResponse ElementsChromatin ImmunoprecipitationDNA MethylationMultigene FamilyNF-kappa BArabidopsisChromatinRNA InterferenceBacterial ProteinsSequence Analysis, DNARNA, Small InterferingCell ProliferationGene LibraryGenes, PlantFibroblastsGenomicsMice, KnockoutHeLa CellsGreen Fluorescent ProteinsApoptosisProtein BiosynthesisRecombinant Fusion Proteinsbeta-Galactosidase
StudiesTopicReportEffectConditionsRegulationPathway
Studies1
Topic2
  • The aforementioned complex factors have made it difficult to investigate the impact of the DNA length on gene regulation, which has been an unexplored topic. (nature.com)
  • This Special Issue includes 12 research articles and one review on the topic of differential gene expression and coexpression. (mdpi.com)
Report1
  • Here we report the effect of the length of linearized reporter DNAs encoding the firefly luciferase gene so as to exclude the influence of supercoiling. (nature.com)
Effect2
  • We propose an underlying mechanism for the favorable effect of longer DNA on gene expression in terms of the enhancement of access of RNA polymerase to the shrunken conformation. (nature.com)
  • Effect of silymarin on the relative gene expressions of some inflammatory cytokines in the liver of CCl 4 -intoxicated male rats. (bvsalud.org)
Conditions1
  • We used three different conditions: the same luc -gene concentration (Fig. 1 d), the same nucleotide-unit concentration (Fig. 1 e), and a combination of both (the same luc -gene and nucleotide-unit concentration adjusted by the addition of noncoding DNA, nc 2.6k) (Fig. 1 f). (nature.com)
Regulation1
  • In addition, a systems biology approach identified genes involved in ubiquitination, such as UBC and PFDN2 , which may be key players in the regulation of differential gene expression in treatment responders and non-responders. (nature.com)
Pathway2
  • In contrast, we identified genes involved in the Wnt pathway were relatively up-regulated in non-responders. (nature.com)
  • One of these genes was Wnt-5a, a member of the Wnt signaling pathway, known to be involved in the development of neural crest cells. (nih.gov)