Expression in tumor heterogeneous tumors adenocarcinoma. Medical search. Frequent questions

Cancerous tumors are complex mixtures of malignant and non-malignant cells shaping the tumor microenvironment (TME). (nature.com)
Past research has mainly used 2D-cultured cell line models to investigate the role of EVs in tumors, which poorly simulate the tumor microenvironment. (bvsalud.org)
Cancer research has been conducted using cultured cells as part of drug discovery testing, but conventional two-dimensional culture methods are unable to reflect the complex tumor microenvironment. (medsci.org)
However, the cellular environment under 2D culture is very different and often a poor reflection of the complex tumor microenvironment (TME) in vivo [ 1 ]. (medsci.org)
Stromal fibroblasts are a dominant but heterogenous population within the tumor microenvironment and therapeutic targeting of stromal subsets may have therapeutic utility. (elifesciences.org)
The plasticity and heterogeneity of fibroblasts in the tumor microenvironment of pancreatic ductal adenocarcinoma (PDAC) has emerged as a key factor in determining tumor growth and therapeutic response. (elifesciences.org)
In the metabolic symbiosis model, these cells have been proposed to overexpress MCT4 to release high amounts of lactate produced during anaerobic glycolysis into the tumor microenvironment. (hindawi.com)
Regardless of the therapeutic approach, the heterogeneity of pancreatic cancer cells and the complexity of its tumor microenvironment contribute to the emergence of drug resistance. (frontiersin.org)
Wang H , Han G , Chen J , . Heterogeneity of tumor immune microenvironment in malignant and metastatic change in LUAD is revealed by single-cell RNA sequencing. (aging-us.com)
Plenty of research had reported that the tumor immune microenvironment (TIME) impacts cancer progression and metastases, as well as affects patient prognoses and outcomes [ 6 , 7 ], which emphasizes the important role of immune cells, vital components of the tumor microenvironment, impacting on patient survival and tumor progression [ 8 , 9 ]. (aging-us.com)
Previous studies unraveled that extracellular adenosine concentration was elevated in the tumor microenvironment [ 8 ]. (biomedcentral.com)
Recently, CD73-adensine was found to be a significant pathway involved in the formation of immunosuppressive microenvironment in distinct tumors [ 3 ]. (biomedcentral.com)
However, the tumour may evade immune responses through regulatory T-cell-mediated immune suppression in the tumour microenvironment, defective antigen presentation, and production of immunosuppressive cytokines (5). (cambridgemedicine.org)
We laid particular focus on those researches that reveal how exosomes regulate the tumor immune microenvironment (TIME) and how exosomal cargos affect the progression of HCC. (hindawi.com)
HCC-derived exosomes participate in changing tumor progression by regulating the tumor microenvironment and tumor immune status [ 14 , 15 ]. (hindawi.com)

The role of EVs in tumors has been extensively studied, and they have been shown to play a crucial role in tumor growth, progression, and metastasis. (bvsalud.org)
It unlocks novel dimensions by uncovering elusive cell populations and tumor heterogeneities for early detection, unraveling mechanisms of treatment resistance, tailoring therapies to individuals, and illuminating metastasis and cachexia pathways, thereby opening fresh avenues for preventive strategies. (frontiersin.org)
Firstly, the transcriptome landscape of heterogeneous cell types in LUAD was analyzed and memory T cells, NK cells, and helper T cells were revealed to be the common immune cells in tumor, normal, and metastasis tissue, respectively. (aging-us.com)
Next, the results of cell-cell communication analysis suggested that pericytes interact with broad immune cells via MDK-NCL pathways in metastasis samples, MIF-(CD74+CXCR4) and MIF-(CD74+CC44) interaction especially occurred between different cell types in tumor and normal samples. (aging-us.com)
A number of studies have proved that exosomes are important mediators for the initiation, progression, angiogenesis, and metastasis of tumors [ 10 ]. (hindawi.com)
Overexpression of tumor markers in Extracellular vesicles (EV), especially in tumor-derived exosomes (TDEs), is implicated in metastasis. (researchsquare.com)
We explored molecular markers shared between TDEs and circulating tumor cells (CTCs) in the blood of cancer patients to identify candidate genes involved in CRC metastasis. (researchsquare.com)

Significance of expression of CD109 in osteosarcoma and its involvement in tumor progression via BMP signaling. (nagoya-u.ac.jp)
In this paper, we reviewed the recent researches on the multiple roles of tumor-associated exosomes in the progression of HCC. (hindawi.com)
Ectopic expression of CDX2 is associated with the development and progression of gastric cancer. (biomedcentral.com)
Metabolic reprogramming plays an important role in tumor progression and antitumor immunity. (medsci.org)

Finally, MCT4 inhibition mitigates the induction of angiogenesis, suggesting that MCT4 also plays a crucial role in tumor-related angiogenesis. (hindawi.com)
Recent studies revealed that CD73 plays a pivotal role in tumor escape from immune surveillance. (biomedcentral.com)

In this study, we investigated the expression of the two types of TGF-beta1 receptors, R-I and R-II, in a normal human prostate, primary prostate adenocarcinoma and lymph nodes with metastatic deposits. (nih.gov)
These lesions are accessible through endoscopic/endobronchial ultrasound-guided or computed tomography-guided fine-needle aspiration cytology and represent a wide range of primary and metastatic tumors. (allenpress.com)
Tumors metastatic to mediastinal lymph nodes represent the most common mediastinal lesions and must be differentiated from primary lesions. (allenpress.com)
To identify operable lung cancer patients with risk for metastatic relapse we search for new prognostic biomarkers based on analysis of genome-wide gene expression data and conventional protein marker validation based on analysis of primary tumor tissue. (lu.se)

1 The most frequent primary tumor types of anterior mediastinal masses are thymic tumors and lymphoma, with approximate proportions of 35% and 25% among mediastinal lesions, respectively. (allenpress.com)
PDGFA and RAF1 mRNA are higher in CSC-EXOs than in HT-29-EXOs, which correlates with higher expression in CSC than the primary tumor. (researchsquare.com)
Oien] Unfortunately in 20-50% of CUP cases the primary tumor is never found. (biogenex.com)

Here, we combine spatial transcriptomics and scRNA-Seq datasets to define the transcriptome of tumor-proximal and tumor-distal cancer-associated fibroblasts (CAFs) and link this to clinical outcome. (elifesciences.org)

Scope includes mutations and abnormal protein expression. (cancerindex.org)
Earlier methods used cell sorting methods such as FACS (fluorescence-activated cell sorting) based on the flow cytometry technique, which separates the populations of cells belonging to different cell types based on their cell sizes, morphologies (shape), and surface protein expressions. (wikipedia.org)
Western blotting was used for protein expression analysis of the collected cell masses (spheroids), and H-E staining was used for structural observation. (medsci.org)
Moreover, there was a significant decrease in the expression of R-I and R-II mRNA, in all 20 primary prostatic tumors and 4 lymph nodes positive for metastases, indicating that the decreased protein expression was due to down-regulation of gene expression for the two receptors. (nih.gov)
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Wilms Tumor Protein (WT1) in tissue homogenates, cell lysates and other biological fluids. (kits-elisa.com)
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Wilms Tumor Protein (WT1) in samples from tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species. (kits-elisa.com)
Description: A sandwich ELISA kit for detection of Wilms Tumor Protein from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (kits-elisa.com)
Description: Quantitative sandwich ELISA for measuring Human Wilms tumor protein (WT1) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. (kits-elisa.com)
Gene ID: 5925, OMIM 614041 ) gene, which encodes a tumor suppressor protein. (molvis.org)
To define the incidence and characteristics of Lynch syndrome-related small-intestinal adenocarcinomas, meticulous familial and clinical histories were obtained from 195 patients with small-intestinal adenocarcinoma, and MMR protein immunohistochemistry, microsatellite instability, MLH1 methylation, and germline mutational analyses were performed. (oncotarget.com)
A meticulous patient history taking, MMR protein immunolabeling, and germline MMR gene mutational analysis are important for the diagnosis of Lynch syndrome-related small-intestinal adenocarcinomas. (oncotarget.com)
In chemically induced mouse lung tumors, the p16INK4a gene is a target of inactivation, and Rb is reduced at the mRNA level (Northern blot) although similar at the protein level (Western blot) when compared to normal lung tissues. (jax.org)
The expression of cyclin D1, cdk4, p16INK4a, and Rb protein was examined by immunohistochemistry in 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-induced mouse lung tumors. (jax.org)
Western blot analysis indicated the presence of both hypophosphorylated and hyperphosphorylated Rb protein in lung tumors and in normal lung tissues. (jax.org)
A positive correlation was observed between CDX2 and Reg IV expression at the mRNA and protein levels in gastric cancer tissues. (biomedcentral.com)
Neither Reg IV silencing nor overexpression had any effect on CDX2 protein expression in AGS or MKN-45 cells, even though both affected the expression of CDX2 mRNA. (biomedcentral.com)

Variation in tumor purity (proportion of cancer cells in a sample) can both confound integrative analysis and enable studies of tumor heterogeneity. (nature.com)
Overall, PUREE is a highly accurate and versatile method for estimating tumor purity and interrogating tumor heterogeneity from bulk tumor gene expression data, which can complement genomics-based approaches or be used in settings where genomic data is unavailable. (nature.com)
These findings demonstrate the extreme transcriptional heterogeneity of CAFs and its determination by apposition to tumor. (elifesciences.org)

Malignant gliomas are the most common primary malignant brain tumors with an increasing incidence of up to nine per 100,000 habitants over the last years [ 1 , 2 ]. (hindawi.com)
In pediatric solid tumors and brain tumors, PLK1 inhibition leads to apoptosis in vitro and in tumor xenografts. (childrenscolorado.org)

Terris et al evaluated 1,092 consecutive radical prostatectomy specimens, and pelvic lymph nodes, if available, removed for prostatic adenocarcinoma. (medscape.com)

Children born with germline mutations tend to have bilateral tumors. (molvis.org)

Relatively recent case reports exist of an elderly Indian male with synchronous bladder urothelial carcinoma and prostatic carcinoma with CLL (triple cancer),[4] a senior Serbian patient with synchronous mantle cell lymphoma and prostate adenocarcinoma,[5] and an elderly Czech patient with mantle cell lymphoma and prostate adenocarcinoma. (medscape.com)
Prostate adenocarcinoma (PRAD) is one of the most common types of malignancy in males and at present, effective prognostic indicators are limited. (spandidos-publications.com)

found that pyroptosis-related genes can be used for prognostic prediction of skin cutaneous melanoma and lung adenocarcinoma, respectively. (nature.com)
Lung adenocarcinoma (LUAD) is the most common type of non-small cell lung cancer and accounts for approximately 40% of all lung cancer cases. (aging-us.com)
Lung adenocarcinoma (LUAD) is the most common histological type of lung cancer and has the highest cancer mortality rate worldwide [ 1 ]. (aging-us.com)
However, the underlying functions of STARDs in lung adenocarcinoma (LUAD) have not been clarified yet. (medsci.org)
Non-small cell lung cancer (NSCLC) accounts for 85-90% of cases, while lung adenocarcinoma (LUAD) is the most common subtype [ 2 ]. (medsci.org)
[ 3 , 4 ] The term "pseudomesotheliomatous carcinoma" was first applied by Harwood and colleagues in 1976 to 6 cases of peripheral lung adenocarcinoma that closely mimicked mesothelioma. (medscape.com)

relied on tumour samples obtained from pancreatic cancer patients. (elifesciences.org)
Besides, upregulated MCT4 has been linked to altered tumor metabolism as well as to increased growth and survival in breast and pancreatic cancer [ 33 , 34 ]. (hindawi.com)

Not only do these wrap pancreatic tumours in a dense, protective layer, they also foster complex relationships with the cancerous cells: some fibroblasts may fuel tumour growth, while other may help to contain its spread. (elifesciences.org)
Medulloblastoma is the most common cancerous childhood brain tumor. (childrenscolorado.org)

PUREE was trained on gene expression data and genomic consensus purity estimates from 7864 solid tumor samples. (nature.com)
PUREE predicted purity with high accuracy across distinct solid tumor types and generalized to tumor samples from unseen tumor types and cohorts. (nature.com)
Compared with solid tumor sampling, the bone marrow or peripheral blood of leukemia patients is easier to access, and therefore an accurate and practical prognostic signature for leukemia patients has potential for more direct clinical application. (nature.com)

Lung cancer is the first leading diagnosed malignant tumor globally [ 1 ]. (medsci.org)

Consistent with its function as lactate and proton exporter, MCT4 expression levels correlated inversely with extracellular pH and proportionally with extracellular lactate concentrations. (hindawi.com)
In line with this observation, elevated extracellular lactate concentrations up to 40 mM and corresponding low extracellular pH (pH e ) have been found in solid tumors under hypoxic conditions [ 18 - 22 ]. (hindawi.com)
In the present study, we examined the relationship between MCT4 expression, alterations in pH e , and extracellular lactate concentrations. (hindawi.com)

Poor clinical outcome was correlated with elevated HIF-1α and podoplanin expression whilst expression of inflammatory and complement genes was predictive of extended survival. (elifesciences.org)
Specifically, elevated expression of HIF-1a and podoplanin predicted worse outcome while inflammatory gene expression correlated with increased survival, suggesting future interventions targeting proximal fibroblast populations to mitigate against PDAC. (elifesciences.org)
However, there has only been one previous functional study investigating MCT4 in glioblastoma (GBM) neurospheres, mainly focusing on tumor growth and survival dependent on the oxygen level [ 14 ]. (hindawi.com)
For this purpose, we designed an MCT4 overexpression and knockdown/inhibition model to explore the functional consequences of MCT4 expression on cancer cell metabolism, survival, proliferation, migration, invasion potential, and angiogenesis as well as on cell cycle profiles and cell death mechanisms. (hindawi.com)
Survival analysis showed high STARD12 expression was associated with favorable overall survival, disease special survival as well as disease free survival, while STARD14 showed the opposite. (medsci.org)

Myeloid immune cells, specifically tumor-associated macrophages (TAMs), may represent potential novel therapeutic targets in HCC, complementing current ablative or immune therapies. (cancerindex.org)
Consequently, immune cells fail to recognise and kill tumour cells. (cambridgemedicine.org)

A family of mesenchymal tumors composed of histologically and immunohistochemically distinctive perivascular epithelioid cells. (curehunter.com)

The incidence of high CD73 expression was 0.50 (95% CI: 0.36-0.63). (biomedcentral.com)
Incidence rates and tumour localisation vary considerably between geographical regions thus implying genetic and environmental factors in disease pathophysiology. (docksci.com)

The worst prognosis is in Group 3 patients, who often have high MYC expression, a transcription factor that triggers or blocks any array of target genes. (childrenscolorado.org)
An examination of PLK1 and Ki67 expression in medulloblastoma subtypes demonstrated high expression of PLK1 is associated with high malignancy and poor prognosis in Group 3. (childrenscolorado.org)
We aimed to provide an overview of the current status of CD73 expression and its relationship with clinicopathlogical features and prognosis in different cancers. (biomedcentral.com)
CD73 expression level in distinct cancers and its relationship with clinicopathlogical characteristics and prognosis were investigated using online database. (biomedcentral.com)
High CD73 expression was often associated with poor prognosis in different cancers. (biomedcentral.com)
However, several studies demonstrated that high CD73 expression was not correlated with the prognosis of patients with breast cancer [ 10 ]. (biomedcentral.com)
To date, there is no study to comprehensively investigate the correlation between high CD73 expression and prognosis in cancer patients. (biomedcentral.com)

In summary, our data highlight MCT4 /SLC16A3 as a key gene for distinct hallmarks of tumor malignancy in glioma cells. (hindawi.com)
We investigated the impact on tumor malignancy in F98 glioma cells using in silico analysis, in vitro cell culture assays, and ex vivo vascular organotypic glioma impact model (VOGIM) [ 35 ] by implanting F98 cells into rat brain slices. (hindawi.com)
Breast cancer is the most common malignancy in women and a heterogeneous disease at the molecular level. (lu.se)

Therefore, many downstream analyses such as differential gene expression might be confounded by the variations in cell type proportions when using the output of high-throughput technologies applied to bulk samples. (wikipedia.org)
These approaches are labeled as reference-based (also called supervised) and reference-free (also called unsupervised) methods Reference-based methods require an a priori defined reference matrix consisting of the expected value (also called profile or signature) of gene expression (or DNA methylation) for a group of genes (or CpG sites) known to have a differential expression (or methylation) across the cell types. (wikipedia.org)

The novel PLK1 inhibitor, onvansertib, is the first available for oral administration and has shown tumor growth inhibition in hematologic tumors, osteosarcoma, ovarian carcinoma, breast cancer and colon adenocarcinoma cells. (childrenscolorado.org)

Since most high-throughput technologies use bulk samples and measure the aggregated levels of molecular information (e.g. expression levels of genes) for all cells in a sample, the measured values would be an aggregate of the values pertaining to the expression landscape of different cell types. (wikipedia.org)
Most cellular deconvolution algorithms consider an input data in a form of a matrix X m × n {\displaystyle X_{m\times n}} , which represents some molecular information (e.g. gene expression data or DNA methylation data) measured over a group of n {\displaystyle n} samples and m {\displaystyle m} marks (e.g. genes or CpG sites). (wikipedia.org)
Using a robust gene pairing approach, which effectively eliminates batch effects across heterogeneous patient cohorts and transcriptomic data, we developed an immunity and pyroptosis-related prognostic (IPRP) signature that consists of 15 genes. (nature.com)
Investigators used CRISPR-Cas9 screening to determine which genes were essential for medulloblastoma tumor growth. (childrenscolorado.org)
We investigated the expression of genes of interest using quantitative reverse transcription PCR. (molvis.org)
Studies are underway to improve the safety of CAR T-cell therapy by limiting their expression, producing switchable CAR T-cells, and producing genetically engineered T-cells that are equipped with genes to reduce adverse effects. (cambridgemedicine.org)
In blood samples from 20 CRC patients, the expression of candidate genes was assessed by real-time polymerase chain reaction (PCR) in CTC, TDEs, and microvesicles (MVs), and the expression levels were correlated with clinicopathological features. (researchsquare.com)
To further confirm, the expression of candidate genes was investigated in exosomes derived from the parental HT-29 colorectal cancer cell line (HT-29-EXOs), and cancer stem cells (CSCs) -enriched spheroids (CSC-EXOs) derived thereof. (researchsquare.com)

Parathyroid adenoma Most parathyroid tumors are benign. (msdmanuals.com)

The cultures were exposed to cisplatin and cetuximab and the morphological changes of spheroids over time and the expression changes of target proteins were compared. (medsci.org)
Expression of receptor proteins was examined by immunohistochemical analysis in paraffin-embedded prostatic tissue sections, and mRNA expression was determined by Northern blot and RT-PCR analysis. (nih.gov)
Expression of cell cycle proteins in 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced mouse lung tumors. (jax.org)

P =0.04) and more likely to have mucinous adenocarcinomas ( P= 0.003), and tended to survive longer ( P =0.11) than those with sporadic cases. (oncotarget.com)
Sample from an esopho-gastrectomy, of mucinous adenocarcinoma, gastroesophageal junction. (lab-ally.com)

Conversely, several studies have indicated that CDX2 may act as a tumor suppressor. (biomedcentral.com)

Overview of Multiple Endocrine Neoplasias (MEN) The multiple endocrine neoplasia (MEN) syndromes comprise 4 genetically distinct familial diseases involving adenomatous hyperplasia and malignant tumors in several endocrine glands. (msdmanuals.com)

Tumor-proximal fibroblasts comprise large populations of myofibroblasts, strongly expressed podoplanin, and were enriched for Wnt ligand signaling. (elifesciences.org)
Here the authors use innovative approaches to combine spatial profiling with single cell transcriptomics to define tumor-proximal populations of fibroblasts that predict clinical outcome. (elifesciences.org)

DeMixT uses probabilistic modeling to infer proportions of stromal and cancer-cell components from a set of input samples, comprising both tumor and normal-tissue samples 8 . (nature.com)
H-E staining showed tumor tissue-like structures specific to each cell line. (medsci.org)
In the future, it may become possible to produce tumor spheroids from tissue samples of oral cancer patients, and then apply them to drug screening and to develop individualized diagnostic and treatment methods. (medsci.org)
Therefore, it is difficult to propose that 2D culture accurately reflects the original growth state of tumor tissue. (medsci.org)
World Health Organization Classification of Tumors: Pathology and Genetics of Tumors of Soft Tissue and Bone, 2002). (curehunter.com)
Adenocarcinomas develop from the stomach mucosa (its innermost layer) that is composed of glandular tissue. (lab-ally.com)

Selective targeting of tumor-proximal subsets, potentially combined with HIF-1α inhibition and immune stimulation, may offer a multi-modal therapeutic approach for this disease. (elifesciences.org)

GSEA analysis found STARD12 and STARD14 were associated with glycolysis, oxidative phosphorylation and tumor related signaling pathways. (medsci.org)

Gene features of PUREE were further validated using single-cell RNA-seq data from distinct tumor types. (nature.com)
However, the functional consequences of MCT4 expression on the distinct hallmarks of cancer have not yet been explored at the cellular level. (hindawi.com)

Previous studies showed that CDX2 may be an upstream regulator of Reg IV expression in gastric cancer, and our previous report showed that Reg IV upregulated SOX9 expression and enhanced cell migration and invasion in gastric cancer cells. (biomedcentral.com)
To verify their relationship, knockdown and exogenous expression of CDX2 or Reg IV were performed in AGS and MKN-45 gastric cancer cells, and their expression was subsequently analyzed via a real-time PCR and western blotting. (biomedcentral.com)
Our findings demonstrate that CDX2 expression was positively correlated with that of Reg IV in gastric cancer, and CDX2 promoted cell migration and invasion through upregulation of Reg IV expression in AGS and MKN-45 cells. (biomedcentral.com)

iii) to accelerate the conversion of anti-tumor type 1 macrophages into pro-tumor type 2 macrophages [ 9 ]. (biomedcentral.com)

Compared with normal cells, tumor cells secrete more exosomes, and the number of exosomes secreted by different tumor cells varies dramatically [ 6 ]. (hindawi.com)
Parathyroid tumors secrete parathyroid hormone (PTH). (msdmanuals.com)

High CD73 expression was significantly associated with lymph node metastases and a promising prognostic factor in different types of cancers. (biomedcentral.com)

In the NHS, he is Director of the Charing Cross/ Imperial College Trophoblastic Disease and Malignant Ovarian Germ Cell Tumour (MOGCT) Centre and supraregional tumour marker assay service. (imperial.ac.uk)

Search the gene expression profiles from curated DataSets in the Gene Expression Omnibus (GEO) repository. (cancerindex.org)
We reviewed published microarray and RNA sequencing studies in which gene expression profiles were compared between human RB and normal retina tissues. (molvis.org)
Common markers were analyzed in gene expression profiles of two studies (GSE31023 and GSE72577). (researchsquare.com)

Tumor cells typically infiltrate the prostatic stroma in a nonperiglandular manner, and they may infiltrate between normal prostate glands. (medscape.com)
Low-grade tumors may recur and infiltrate adjacent structures. (medscape.com)

Stable F98 glioma cell lines with MCT4 overexpression, normal expression, and knockdown were generated. (hindawi.com)
CDX2 silencing significantly downregulated Reg IV expression, and CDX2 overexpression significantly upregulated Reg IV expression in AGS and MKN-45 cells. (biomedcentral.com)

Immunohistochemical staining revealed exclusive nuclear staining of both cyclin D1 and cdk4 that was light to moderate in normal mouse lung tissues, but intense in lung adenomas and adenocarcinomas. (jax.org)

Oncomine, UALCAN, TCGA and CPTAC were used to explore the expression landscape and clinicopathological characteristics of STARDs in LUAD. (medsci.org)

The proportion of malignant cancer cells in the tumor mass, herein referred to as tumor purity, also impacts genomic analysis such as the estimation of clonal composition 6 and tumor mutation burden 7 , critical for predicting treatment outcomes and selecting patients for immunotherapy. (nature.com)
Treatment responses of patients with acute myeloid leukemia (AML) are known to be heterogeneous, posing challenges for risk scoring and treatment stratification. (nature.com)
Even though developed for AML patients, our pan-cancer analyses demonstrate a wider application of the IPRP signature for prognostic prediction and analysis of tumor-immune interplay also in multiple solid tumors. (nature.com)
This brain tumor type is highly proliferative and shows an infiltrative growth pattern, accounting for the high recurrence rates in patients. (hindawi.com)
Small-intestinal adenocarcinomas were the first clinical manifestation in 37% (3/8) of Lynch syndrome patients, and second malignancies developed within 5 years in 63% (5/8). (oncotarget.com)

Spheroids made from oral cancer cell lines appeared to have tumor-like characteristics that may reflect their clinical significance. (medsci.org)
Pancreatic ductal adenocarcinoma has a poor clinical outcome and responses to immunotherapy are suboptimal. (elifesciences.org)
Since most hematological malignancies are very heterogeneous diseases, robust patient-specific prognostic signatures are required for clinical applications. (nature.com)
In this pre-clinical study led by Rajeev Vibhakar, MD , investigators from multiple departments at Children's Hospital Colorado, including the Morgan Adams Foundation Pediatric Brain Tumor Research Program and the Neuro-Oncology Program for Children with Central Nervous System Tumors , sought to determine the effects of onvansertib on MYC-driven medulloblastoma as a monotherapy or in combination with radiation. (childrenscolorado.org)

Her research has redefined the molecular map of breast cancer and led to new paradigms in understanding how human tumors evolve and metastasize. (stanford.edu)

Lung cDC2s from CD109-/- mice had a poor ability to induce cytokine production in ex vivo DC-T cell cocultures with high expression of RUNX3, resulting in suppression of Th2 differentiation. (nagoya-u.ac.jp)
Chimeric antigen receptor (CAR) T-cell therapy is a novel therapeutic T-cell engineering option, where T-cells obtained from a patient's blood are engineered ex vivo to express specific tumour antigen receptors. (cambridgemedicine.org)
The second-generation CAR T-cells consist of one additional co-stimulatory component (mainly CD28, CD137 or CD134) in the intracellular domain, which amplifies anti-tumour responses in vivo (8). (cambridgemedicine.org)

For example, samples collected from the human brain are a mixture of various neuronal and glial cell types (e.g. microglia and astrocytes) in different proportions, where each cell type has a diverse gene expression profile. (wikipedia.org)
There are two broad categories of methods aiming at estimating the proportion of cell types in samples using some type of omics data (bulk gene expression or DNA methylation data). (wikipedia.org)
There are a variety of approaches for isolating different cell types to measure their gene expression or DNA methylation levels to be used as references in the deconvolution algorithms. (wikipedia.org)
Cisplatin showed concentration-dependent antitumor effects due to loss of cell adhesion and spheroid disruption in each cell line, while cetuximab exhibited antitumor effects that correlated with EGFR expression in each cell line. (medsci.org)
Therefore, cell pyroptosis is closely related to the immune process, but it is also essential for tumor development. (nature.com)
An investigation of PLK1 expression in DepMap found PLK1 is a critical mediator in 55 central nervous system cell lines, including eight medulloblastoma cell lines. (childrenscolorado.org)
The regulatory elements required for this cell-specific gene expression are likely located within its proximal promoter. (molvis.org)
Following this, in 1971, Sir Frank Mac Farlane Burnet hypothesised that tumour cell antigens induced immunological reaction against cancer and postulated the "immune surveillance theory" (4). (cambridgemedicine.org)
Furthermore, they demonstrate the importance of immunohistochemical studies to examine expression in tissues that contain multiple cell types, such as the lung, and in tumors that by nature are heterogeneous. (jax.org)

Tumors are complex masses composed of malignant and non-malignant cells. (nature.com)
This process enables tumor cells, including those within the core of the heterogeneous tumor mass to survive, despite being at a distance from blood vessels that supply their metabolic needs [ 16 , 17 ]. (hindawi.com)
Circulating tumor cells provide excellent prognostic evaluation of PRAD, but their use is limited by high equipment requirements and costs ( 9 ). (spandidos-publications.com)
Expression of DCT was absent or barely detected in retina tissues, various human ocular cells, and major organs. (molvis.org)
In 1959, Lewis Thomas suggested that the human immune system can recognise tumour-specific antigens on the surface of newly developing tumour cells as 'foreign' and eliminate them (3). (cambridgemedicine.org)
The immune system interacts closely with tumour cells via complex mechanisms and can result in either eradication of the tumour or immune evasion by the tumour (5). (cambridgemedicine.org)
CAR T-cells are T-cells that have been engineered to express receptors that specifically target tumour-associated antigens (8). (cambridgemedicine.org)
Exosomes were first described in 1981 as ATPase-containing vesicles exfoliated from cells and were found in various normal cells and tumor cells [ 16 ]. (hindawi.com)
Tumor-derived EV modulates cellular activities in recipient cells by transferring genetic information from cancer cells. (researchsquare.com)

These studies indicate the importance of the pyroptosis process in tumor development and treatment responses. (nature.com)

There is also no study to dissect the CD73 expression level in different cancers and the relationship between high CD73 expression and clinicopathlogical characteristics. (biomedcentral.com)
Adenocarcinoma - About 90-95% of all stomach cancers are of this type and therefore the greatest availability of stomach cancer samples will be for this indication. (lab-ally.com)

Anatomy14

Organisms8

Diseases104

Chemicals and Drugs43

Analytical, Diagnostic and Therapeutic Techniques and Equipment48

Phenomena and Processes42

Disciplines and Occupations1

Information Science5

Health Care11

Microenvironment15

Metastasis7

Progression4

Role in tumor2

Metastatic4

Primary tumor3

Transcriptome1

Protein16

Heterogeneity3

Brain tumors2

Lymph nodes1

Mutations1

Prostate adenocarcinoma2

Lung adenocarcinoma6

Pancreatic Cancer2

Cancerous2

Solid tumor3

Malignant tumor1

Extracellular3

Survival5

Immune cells2

Mesenchymal1

Incidence2

Prognosis7

Malignancy3

Differential2

Osteosarcoma1

Genes8

Benign1

Proteins3

Mucinous2

Suppressor1

Hyperplasia1

Populations2

Tissue6

Inhibition1

Signaling1

Distinct2

Gastric cancer3

Macrophages1

Secrete2

Metastases1

Ovarian1

Gene expression profiles3

Infiltrate2

Overexpression2

Adenomas1

LUAD1

Patients5

Clinical4

Molecular1

Vivo3

Cell9

Cells9

Responses1

Cancers2