Expression role muscle proteins. Medical search. Frequent questions

The protein regulates muscle creatine kinase, indicating a role in the establishment of diverse mesodermal muscle types. (wikipedia.org)
We aim to study the coupling between LTCC and β adrenergic receptors in different cardiomyocyte microdomains, the distinct involvement of PKA and CAMKII (Ca2+/calmodulin-dependent protein kinase II) and explore how this functional complex is disrupted in heart failure.Methods:Global signaling between LTCCs and β adrenergic receptors was assessed with whole-cell current recordings and western blot analysis. (imperial.ac.uk)
Predicted to enable protein kinase C binding activity. (nih.gov)
It is well known that smooth-muscle contraction is regulated by the cytosolic Ca2+ concentration and by the Ca2+ sensitivity of myofilaments: the former activates myosin light-chain kinase, and the latter is achieved partly by the inhibition of myosin phosphatase. (jefferson.edu)
The small GTPase RhoA, Rho-associated kinase (the target of RhoA), and Protein kinase C (PKC)-potentiated inhibitory protein of 17 kDa (CPI-17) participate in the calcium sensitization mechanism. (jefferson.edu)
We hypothesized that BMP4 might exert beneficial effects through modulation of p16 and p18 expression in transduced MDSCs since the cyclin-dependent kinase inhibitors p16INK4A (p16) and p18INK4C (p18) cause early G1-phase cell cycle blockade. (pitt.edu)
Myostatin binding to type IIB activin receptor (ActRIIB) on muscle surface induces the recruitment and activation of activin receptor-like kinase 5 (ALK5), and eventually leads to forkhead box O3 (FoxO3a)-dependent transcription to promote muscle protein breakdown via the ubiquitin-proteasome system ( 23 ). (spandidos-publications.com)
In the poster section, Joanna Shisler (University of Illinois at Urbana-Champaign [UIUC], Urbana) reported that the modified virus, Ankara, activates nuclear factor κB through the mitogen-activated protein kinase, extracellular signal–regulated kinase (MEK)/extracellular signal–regulated kinase (ERK) pathway, possibly facilitating the host immune response. (cdc.gov)

Furthermore, calreticulin modulates gene expression, is a chaperone and affects cell adhesion. (bio.net)
The grant from NINDS funds a gene expression analysis core for an existing project on type 1 regulatory T-cell development. (genomeweb.com)
an effect which may be explained by an increased expression of adipose tissue lipolysis-related gene expression patterns following chronic supplementation [ 12 ], an increase in protein-induced thermogenesis (reviewed in [ 15 ]), and/or a consistent reduction in food intake given its satiety-stimulatory effects as discussed above. (biomedcentral.com)
TEA domain-1 (TEAD1) transcription factor participates in both slow oxidative fiber type gene expression and plays a role in satellite cell biology. (missouri.edu)
In summary, we demonstrate that C3G enrichment in the HFHS diet attenuates short-term weight gain, decreases hepatic lipid content by suppressing key lipogenic gene expression and improves glucose homeostasis during obesity development, supporting the therapeutic utility of C3G as a bioactive phytonutrient to manage obesity-related complications. (researchgate.net)
Luciferase assay showed miR-214 substantially inhibited wild type, but not the mutant version of QKI-3-UTR-luciferase activity in differentiating ESCs, further confirming a negative regulation role of miR-214 in QKI gene expression. (oncotarget.com)
Mechanistically, our data showed that miR-214 regulated VSMCs gene expression during VSMCs differentiation from ESCs through suppression of QKI. (oncotarget.com)
Improved net protein balance, lean mass, and gene expression changes with oxandrolone treatment in the severely burned. (uams.edu)
Gene expression profiles and protein balance in skeletal muscle of burned children after beta-adrenergic blockade. (uams.edu)
Cardiac hypertrophy and failure are characterized by transcriptional reprogramming of gene expression. (ca.gov)
Here we show that Brg1, a chromatin-remodelling protein, has a critical role in regulating cardiac growth, differentiation and gene expression. (ca.gov)
Our studies show that Brg1 maintains cardiomyocytes in an embryonic state, and demonstrate an epigenetic mechanism by which three classes of chromatin-modifying factors-Brg1, HDAC and PARP-cooperate to control developmental and pathological gene expression. (ca.gov)
The differences in gene expression profiles induced by the two predators suggest that there are functional differences between the altered tail tissues of the two groups of tadpoles. (biomedcentral.com)
Morphological, functional, and gene expression studies have established the phenotypic plasticity of smooth muscle cells (SMCs). (tubitak.gov.tr)
Gene expression refers to how often or when proteins are created from the instructions within your genes. (cdc.gov)
While genetic changes can alter which protein is made, epigenetic changes affect gene expression to turn genes "on" and "off. (cdc.gov)
Epigenetic changes affect gene expression in different ways. (cdc.gov)
Non-coding RNA helps control gene expression by attaching to coding RNA, along with certain proteins, to break down the coding RNA so that it cannot be used to make proteins. (cdc.gov)
Berry intake changes hepatic gene expression and DNA methylation patterns associated with high-fat diet. (lu.se)

2002). Divergence in species and regulatory role of beta -myosin heavy chain proximal promoter muscle-CAT elements. (missouri.edu)
2001). Multiprotein complex formation at the beta myosin heavy chain distal muscle CAT element correlates with slow muscle expression but not mechanical overload responsiveness. (missouri.edu)

Thus EPA antagonizes loss of skeletal muscle proteins in cancer cachexia by down-regulation of proteasome expression, and this may also be the mechanism for inhibition of tumor growth. (aacrjournals.org)
Cachexia has two well-known features: weight loss (mainly due to loss of skeletal muscle and body fat) and inflammation. (spandidos-publications.com)

Dystrophin is part of a protein complex that connects the cytoskeleton to the extracellular matrix. (frontiersin.org)
Perlecan helps make the extracellular matrix, the proteins and other molecules that surround cells, stable and flexible so that cells can develop and function in an environment that is supportive without being rigid. (neurosciencenews.com)
Extracellular matrix proteins play a role in promoting exercise responses, leading to adaptation, regeneration, and repair. (lu.se)

For example, Stathmin is expressed at high levels in endothelial cells and vascular smooth muscle cells. (prospecbio.com)
However, very little is known about its functional role in vascular smooth muscle cells (VSMCs) differentiation from ESCs. (oncotarget.com)
In this study, we intended to investigate the effects of growth factor-rich medium on the protein expression of vascular SMCs in culture. (tubitak.gov.tr)

Alternative splicing yields two isoforms that differ in abundance and expression patterns. (wikipedia.org)
Muscle biopsies of affected patients display impaired membranetrafficking of both POPDC isoforms. (imperial.ac.uk)
T, p.V183F) displayed only askeletal muscle pathology and a mild impairment of membrane trafficking of both POPDC isoforms. (imperial.ac.uk)
The correlation between slow fibre phenotype and strength of innervation suggests a relationship between synaptic structure and expression of troponin isoforms. (biologists.com)
Slightly different versions (called isoforms) of titin are made from the TTN gene in different muscles. (medlineplus.gov)
These variants result in the production of an abnormal titin protein, particularly isoforms that are found in cardiac muscle. (medlineplus.gov)
Differential splicing of the titin gene results in numerous species- and muscle-specific titin isoforms. (frontiersin.org)

Emerin is a 34-kd protein that belongs to a family of nuclear proteins that bind a variety DNA regulatory molecules and to molecules thought to be important in maintaining nuclear membrane structure. (medscape.com)
Moreover, the expression of some molecules was altered in the muscles from the LCC mice but not in those from the ECC mice compared with their CN mice. (spandidos-publications.com)
In conclusion, the molecules with altered expression in the muscles from the ECC and LCC mice were not exactly the same. (spandidos-publications.com)
Our data indicate that proteins playing a role in energy metabolism (glycolysis), translation, and folding of proteins are affected, along with regulatory molecules and cytoskeletal proteins. (tubitak.gov.tr)
A cardiomelic developmental field has also been postulated to relate the genetic heterogeneity of HOS (and other similar syndromes) to a cascade of molecules, including the brachyury, sonic hedgehog, bone morphogenetic protein, retinoic acid receptor, and transforming growth factor beta families. (medscape.com)

The protein functions as a transcription coactivator, enhancing the DNA-binding activity of serum response factor, a protein required for the induction of genes by growth and differentiation factors. (wikipedia.org)
These include gene activity (expression), repair of damaged DNA, cell specialization (differentiation), and cell growth and division (proliferation). (medlineplus.gov)
Mutations in the YY1AP1 gene likely disrupt the function of the complex, which leads to reduced proliferation and differentiation of smooth muscle cells. (medlineplus.gov)
Despite extensive genetic analysis, the function of TEAD factors in muscle differentiation has proved elusive due to redundancy amongst the family members. (nih.gov)
Expression of the TEA/ATTS DNA binding domain that acts a dominant negative repressor of TEAD factors in C2C12 myoblasts inhibits their differentiation, while selective shRNA knockdown of TEAD4 results in abnormal differentiation characterised by the formation of shortened myotubes. (nih.gov)
In contrast, TEAD4 represses expression of the growth factor CTGF and Cyclin D1 to promote differentiation. (nih.gov)
Together these results show that TEAD factor activity is essential for normal C2C12 cell differentiation and define a novel and non-redundant role for TEAD4 in regulating expression of the unfolded protein response genes. (nih.gov)
Knocking down Akt expression increased the amount of dephosphorylated MSY3 and reduced myogenin expression and muscle differentiation. (biomedcentral.com)
In the present study, we assessed the hypothesis that miR-214 and its target genes play an important role in VSMCs differentiation. (oncotarget.com)
Taken together, we have uncovered a central role of miR-214 in ESC-VSMC differentiation, and successfully identified QKI as a functional modulating target in miR-214 mediated VSMCs differentiation. (oncotarget.com)
All-trans retinoic acid (RA) is the most active metabolite of vitamin A. Several studies have described a pivotal role for RA signalling in different biological processes such as cell growth and differentiation, embryonic development and organogenesis. (mdpi.com)
Evidence is accumulating that small G proteins are involved in the regulation of cell growth and differentiation. (nii.ac.jp)

MSY3 (MSY4, YB-2, CSDA, dbpA, ZONAB) is a member of the cold shock domain (CSD) family of proteins also known as Y-box proteins, which are evolutionarily conserved proteins that function as transcription factors and regulators of RNA metabolism and protein synthesis. (biomedcentral.com)
Stathmin is a member of the stathmin family of proteins, which are characterized as having a molecular weight of approximately 20-30 kDa, and a molecular mass of about 21.5 kilodaltons. (prospecbio.com)

Far more so than any other amino acids (the building blocks of structures within the body), BCAAs play many indispensable roles in muscle metabolism, particularly during and after intense exercise. (ast-ss.com)
Measurement of protein metabolism in epidermis and dermis. (uams.edu)
Quantification of protein metabolism in vivo for skin, wound, and muscle in severe burn patients. (uams.edu)
Insulin resistance of muscle protein metabolism in aging. (uams.edu)
Leg glucose and protein metabolism during an acute bout of resistance exercise in humans. (uams.edu)

These studies demonstrate that the capsid protein of WNV may be responsible for aspects of viral pathogenesis through induction of the apoptotic cascade. (cdc.gov)
Here we report on an unexpected role for WNV capsid (Cp) in viral-induced pathogenesis. (cdc.gov)
These results provide evidence of a link between WNV-Cp protein and WNV pathogenesis in vivo. (cdc.gov)
MicroRNAs participate in the regulation of asthma, the goal of this study is to summarize recent researches on the roles of microRNAs in the pathogenesis of asthma. (cdc.gov)
Understanding the roles of Asthma is a worldwide problem, the prevalence of miRNAs in asthma pathogenesis may also aid to asthma ranged from 1% to 18% of the population in explore new therapeutic targets. (cdc.gov)
Although more and animals and plants and regulate gene/protein expression more progressions have been made about the through direct complementarity between their 5' region pathogenesis of asthma in recent years, the increasing and the 3' untranslated region of target mRNAs. (cdc.gov)
He also showed that double-stranded (ds)RNA- and ZDNA binding proteins had a role in poxvirus pathogenesis. (cdc.gov)

Adenosine triphosphate (ATP) and phosphocreatine are the immediate substrates for processes involved in muscle contraction and relaxation, Ca2+ handling, and phosphorylation. (jefferson.edu)
Skeletal muscle and myogenic C2C12 cells were used to study the effects of MSY3 phosphorylation in vivo and in vitro on its sub-cellular localization and activity, by blocking the IGF1/PI3K/Akt pathway, by Akt depletion and over-expression, and by mutating potential MSY3 phosphorylation sites. (biomedcentral.com)
Furthermore, forced expression of Akt in adult skeletal muscle induced MSY3 phosphorylation and myogenin derepression. (biomedcentral.com)
These results support the hypothesis that MSY3 phosphorylation by Akt interferes with MSY3 repression of myogenin circuit activity during muscle development. (biomedcentral.com)

By contrast, at a cellular "global" level PKA plays a major role downstream β1AR and results in an increase in LTCC current.Conclusions:Regulation of the LTCC activity by proximity coupling mechanisms occurs only via β2AR, but not β1AR. (imperial.ac.uk)
These results suggest that EPA induces an attenuation of the up-regulation of proteasome expression in cachectic mice, and this was correlated with an increase in myosin expression, confirming retention of contractile proteins. (aacrjournals.org)
Skeletal muscle constitutes 40% of the body's mass and is designed to generate force for locomotor activity, postural maintenance, and plays an important role in the regulation of systemic energy balance. (missouri.edu)
Given the significance of myogenin regulation in adult muscle, the Akt/MSY3/myogenin regulatory circuit is a potential therapeutic target to counteract muscle degenerative disease. (biomedcentral.com)
Hurst SM, McLoughlin RM, Monslow J, Owens S, Morgan L, Fuller GM, Topley N, Jones SA, Secretion of oncostatin M by infiltrating neutrophils: regulation of IL-6 and chemokine expression in human mesothelial cells. (tcd.ie)
Chromatin regulation by Brg1 underlies heart muscle development and disease. (ca.gov)
The higher expression of gremlin 1 and HIF1a genes after exposure to dragonfly larvae indicated an in vivo hypoxic reaction, while down-regulation of syndecan-2 may indicate impairment of angiogenesis. (biomedcentral.com)
The purpose of this review article is to provide an update on current findings regarding the nutritional regulation of MPS and highlight nutrition based strategies that may serve to maximize skeletal muscle protein anabolism with resistance exercise. (biomedcentral.com)
Such factors include timing of protein intake, dietary protein type, the role of leucine as a key anabolic amino acid, and the impact of other macronutrients (i.e. carbohydrate) on the regulation of MPS after resistance exercise. (biomedcentral.com)
As binding of miRNAs to a target mRNA may result in an airway inflammatory disease closely correlates with either mRNA degradation or inhibition of protein immune regulation, more and more evidences suggest translation.1 More than 2000 miRNAs have been discovered in humans. (cdc.gov)

Mitochondria and smooth muscle contraction: Role of desmin cytoskeleton protein. (jefferson.edu)
The second major area of investigation is to understand the role of cytoskeleton proteins, desmin and vimentin in smooth muscle contraction and mitochondrial respiration. (jefferson.edu)

Most athletes know that the BCAAs are indispensable to the synthesis of new proteins. (ast-ss.com)
MPB assists in maintenance of intracellular amino acid levels, and likely plays a role in maintaining muscle protein quality by removing damaged proteins and allowing their constituent amino acids to be used for the synthesis of new functional muscle proteins. (biomedcentral.com)

We determined if basal HSP expression (HSP70, HSP60, HSP25) was impaired in sedentary or exercised rats following the onset of diet-induced obesity. (lidsen.com)

Therefore, it's easy to see how the BCAAs end up in a constant state of "tug- o -war" between providing energy to fuel intense workouts and the building blocks that are indispensable to muscle repair and anabolism (growth). (ast-ss.com)
Hypercortisolemia alters muscle protein anabolism following ingestion of essential amino acids. (uams.edu)
Essential amino acids are primarily responsible for the amino acid stimulation of muscle protein anabolism in healthy elderly adults. (uams.edu)
Optimal nutrition, exercise, and hormonal therapy promote muscle anabolism in the elderly. (uams.edu)
Exogenous amino acids stimulate human muscle anabolism without interfering with the response to mixed meal ingestion. (uams.edu)

The TEAD (1-4) transcription factors comprise the conserved TEA/ATTS DNA binding domain recognising the MCAT element in the promoters of muscle-specific genes. (nih.gov)
HFHS + CE mice had lower hepatic diacylglycerols and triacylglycerols content and reduced expression of key lipogenic transcription factors. (researchgate.net)
The Y-box protein MSY3/Csda represses myogenin transcription in skeletal muscle by binding a highly conserved cis-acting DNA element located just upstream of the myogenin minimal promoter (myogHCE). (biomedcentral.com)
During myogenesis, the muscle transcription factor Myogenin plays a pivotal role in orchestrating the expression of other muscle-specific genes. (kcl.ac.uk)
Consequent abnormal expression of the cardiac and limb-specific T-box transcription factors lead to the malformations described in HOS. (medscape.com)
The transcription of COX-1 yields a 2.7-kilobase (kb) messenger ribonucleic acid (mRNA) that encodes a 576-residue, 65-kd protein. (medscape.com)
Conversely, the transcription of COX-2 yields a 4.5-kb mRNA that encodes a 70-kd protein with roughly 70-75% homology to the COX-1 protein. (medscape.com)

The ATP-ubiquitin-dependent proteolytic pathway is considered to play a major role in muscle catabolism in cachexia, and functional proteasome activity, as determined by "chymotrypsin-like" enzyme activity, was significantly elevated in gastrocnemius muscle of mice bearing the MAC16 tumor as weight loss progressed. (aacrjournals.org)
When animals bearing the MAC16 tumor were treated with EPA, functional proteasome activity was completely suppressed, together with attenuation of the expression of 20S proteasome α-subunits and the p42 regulator, whereas there was no effect on the expression of the ubiquitin-conjugating enzyme (E2 14k ). (aacrjournals.org)
It is aggravated by acute disease-induced muscle wasting, precipitating functional decline during and after hospitalization. (biomedcentral.com)
In a paper published in Nature Communications, the authors found that Myogenin is a master regulator of muscle cell fusion, therefore controlling the formation of functional muscle fibres and sustaining normal muscle growth during both embryonic and adult muscle development. (kcl.ac.uk)

Functionally, dystrophin expressed in the CNS plays an important role in the clustering of neurotransmitter receptors and water- and ion channels to the cellular membrane. (frontiersin.org)
Voltage-dependent anion channel (VDAC) located at the mitochondrial outer membrane play a crucial role in regulating the metabolic and energetic functions of mitochondria and are primarily responsible for the ATP/ADP flux across the outer mitochondrial membrane. (jefferson.edu)
The human cellular prion protein (PrP C ) is a glycosylphosphatidylinositol (GPI) anchored membrane glycoprotein with two N-glycosylation sites at residues 181 and 197. (mdpi.com)
Outer mitochondrial membrane permeabilization and cytochrome c release are typically achieved by pro-apoptotic Bcl-2 proteins, such as Bax and Bak. (nature.com)
They have been defined as monotropic integral membrane proteins located primarily in the endoplasmic reticulum (COX-1) and the perinuclear envelope (COX-2). (medscape.com)

These biological mechanisms compromise the muscle repair mechanism, alter the kinetics of muscle contraction, and compromise musculoskeletal function. (nutraceuticalsworld.com)
Both calcium- and Ca2+ sensitization- mediated contraction plays role in G-protein signaling during smooth-muscle contraction. (jefferson.edu)
The long-term goals of this project are to elucidate the role of GPCR mediated signaling in smooth muscle contraction and proliferation under pathophysiological conditions. (jefferson.edu)
Its central position in the sarcomere and the tight association to myosin are the basis for titin's role in maintaining the structural integrity of the sarcomere during the relaxation-contraction cycle. (frontiersin.org)
Each muscle is composed of bundles of individual muscle fibres capable of physical contraction. (kcl.ac.uk)

The authors said that the role of vitamin D in the musculoskeletal system is one of the main mechanisms by which they believe this risk occurs. (nutraceuticalsworld.com)
Y-box proteins act via diverse mechanisms, as they work by DNA binding and non-DNA binding mechanisms. (biomedcentral.com)
Protein-interactions e.g., with muscle ankyrin repeat proteins or muscle LIM-protein link titin to hypertrophic signaling and via p62 and Muscle Ring Finger proteins to mechanisms that control protein quality control. (frontiersin.org)
Underlying mechanisms may include modifications in the cytokine network and increases in monocytic expression of cytoprotective Hsp27. (biomedcentral.com)

Higher amounts of whey versus egg protein stimulate the greatest post-treatment anabolic skeletal muscle response, though test proteins with higher amounts of WPH more favorably affected post-treatment markers related to adipose tissue lipolysis. (biomedcentral.com)
Leucine supplementation has an anabolic effect on proteins in rabbit skin wound and muscle. (uams.edu)
Superdrol is an anabolic substance, meaning it promotes protein synthesis, and thus muscle strength. (thedollpalace.com)

Capsid gene delivery into the striatum of mouse brain or interskeletal muscle resulted in cell death and inflammation, likely through capsid-induced apoptosis in vivo. (cdc.gov)
We also observed that expression of Cp protein in mouse muscle resulted in apoptosis and inflammation of muscle cells. (cdc.gov)
Performance of repetitive tasks induces decreased grip strength and increased fibrogenic proteins in skeletal muscle: role of force and inflammation. (cdc.gov)
BACKGROUND: This study elucidates exposure-response relationships between performance of repetitive tasks, grip strength declines, and fibrogenic-related protein changes in muscles, and their link to inflammation. (cdc.gov)
To examine the role of inflammation, results from 6-week HRHF rats were compared to rats receiving ibuprofen or anti-TNF-a treatment in HRHF weeks 4-6. (cdc.gov)
Sarcopenia and cancer cachexia involve excessive and prolonged inflammation that can cause further damage to tissues and organs, including increased muscle protein breakdown and lower muscle protein synthesis. (dsm.com)
Effects on muscle performance of NSAID treatment with Piroxicam versus placebo in geriatric patients with acute infection-induced inflammation. (biomedcentral.com)
Inflammation is the main cause of disease-associated muscle wasting. (biomedcentral.com)
We hypothesized that NSAID treatment would preserve muscle performance better than antibiotic treatment alone, by reducing infection-associated inflammation and by increasing expression of cytoprotective Hsp. (biomedcentral.com)
Piroxicam improves clinically relevant measures of muscle performance and mobility in geriatric patients hospitalized with acute infection-induced inflammation. (biomedcentral.com)
Inflammation with its accompanying cytokine production is seen as a predominant cause of muscle wasting due to chronic or acute disease [ 2 ]. (biomedcentral.com)

After incubation under conditions that modify different proteolytic systems, lysosomal, calcium-dependent, and ATP-dependent proteolysis were found to contribute to the elevated protein catabolism. (aacrjournals.org)
Treatment of mice bearing the MAC16 tumor with the polyunsaturated fatty acid, eicosapentaenoic acid (EPA), attenuated loss of body weight and significantly suppressed protein catabolism in soleus muscles through an inhibition of an ATP-dependent proteolytic pathway. (aacrjournals.org)
Influence of metformin on glucose intolerance and muscle catabolism following severe burn injury. (uams.edu)
Amino acid repletion does not decrease muscle protein catabolism during hemodialysis. (uams.edu)
Activation of myostatin signaling in muscle tissue has been demonstrated to be critical to enhancing muscle catabolism, which causes muscle wasting in cancer cachexia ( 22 ). (spandidos-publications.com)

5% false discovery rate) between risk of MACE and eight proteins: matrix metalloproteinase (MMP)-12, IL-27 subunit α (IL-27a), kidney injury molecule (KIM)-1, fibroblast growth factor (FGF)-23, protein S100-A12, TNF receptor (TNFR)-1, TNFR-2 and TNF-related apoptosis-inducing ligand receptor (TRAIL-R)2. (springer.com)

It is unclear how the altered protein causes familial dilated cardiomyopathy, but it likely impairs sarcomere function and disrupts chemical signaling. (medlineplus.gov)

Soleus muscles from mice bearing a cachexia-inducing tumor (MAC16) showed an increased protein degradation in vitro , as measured by tyrosine release, when compared with muscles from nontumor-bearing animals. (aacrjournals.org)
EPA also inhibited growth of the MAC16 tumor in a dose-dependent manner, and this correlated with suppression of the expression of the 20S proteasome α-subunits in tumor cells, suggesting that this may be the mechanism of tumor growth inhibition. (aacrjournals.org)
Stathmin expression levels are associated with tumor recurrence and growth in prostate cancer cells. (prospecbio.com)

Dietary protein intake impacts human skeletal muscle protein fractional synthetic rates after endurance exercise. (uams.edu)

Mutations in the PIEZO2 gene in two individuals with undiagnosed muscle, sensory, and skeletal conditions suggest the protein product plays a role in touch perception. (genomeweb.com)
Several variants (also known as mutations) in the TTN gene have been found to cause centronuclear myopathy, a condition that is characterized by muscle weakness (myopathy) in the skeletal muscles. (medlineplus.gov)
Mutations of this gene introduce a premature stop codon and result in truncated protein versions. (medscape.com)

Satellite cells are considered adult skeletal muscle stem cells that are responsible for the majority of post-birth skeletal muscle growth (maturation and hypertrophy) and adult skeletal muscle homeostasis. (missouri.edu)
Seems to play a role in vesicle maturation during exocytosis. (lu.se)

Publications] Katayama,M.: 'The postーtranslationally modified Cーterminal structure of bovine aortic smooth muscle rhoA p21. (nii.ac.jp)

Cancer patients with cachexia show a specific depletion of their skeletal muscle mass, whereas the visceral protein compartment remains unchanged (1) . (aacrjournals.org)
As a fundamentally necessary process in the enhancement of muscle mass, strategies to enhance rates of MPS would be beneficial in the development of interventions aimed at increasing skeletal muscle mass particularly when combined with chronic resistance exercise. (biomedcentral.com)
We contend that nutritional strategies that serve to maximally stimulate MPS may be useful in the development of nutrition and exercise based interventions aimed at enhancing skeletal muscle mass which may be of interest to elderly populations and to athletes. (biomedcentral.com)

Protein turnover and amino acid transport kinetics in end-stage renal disease. (uams.edu)
Effect of an amino acid, protein, and carbohydrate mixture on net muscle protein balance after resistance exercise. (uams.edu)
Amino acid ingestion improves muscle protein synthesis in the young and elderly. (uams.edu)
Differential stimulation of muscle protein synthesis in elderly humans following isocaloric ingestion of amino acids or whey protein. (uams.edu)
Quantification of amino acid transport through interstitial fluid: assessment of four-compartment modeling for muscle protein kinetics. (uams.edu)
Essential amino acid and carbohydrate supplementation ameliorates muscle protein loss in humans during 28 days bedrest. (uams.edu)
Amino acid control of muscle protein turnover in renal disease. (uams.edu)
Reduced amino acid availability inhibits muscle protein synthesis and decreases activity of initiation factor eIF2B. (uams.edu)
Human muscle protein synthesis is modulated by extracellular, not intramuscular amino acid availability: a dose-response study. (uams.edu)
Protein and amino acids for athletes. (uams.edu)
Method for the determination of the arteriovenous muscle protein balance during non-steady-state blood and muscle amino acid concentrations. (uams.edu)
Aging is associated with diminished accretion of muscle proteins after the ingestion of a small bolus of essential amino acids. (uams.edu)
A high proportion of leucine is required for optimal stimulation of the rate of muscle protein synthesis by essential amino acids in the elderly. (uams.edu)
Muscles provide an amino acid store for the body, where they can be mobilized quickly if a stressor is present, such as infection, surgical intervention or disease. (dsm.com)
Provision of dietary amino acids increases skeletal muscle protein synthesis (MPS), an effect that is enhanced by prior resistance exercise. (biomedcentral.com)
Consuming dietary amino acids after resistance exercise stimulates an increase in MPS and is necessary to shift net protein balance (defined as MPS minus muscle protein breakdown (MPB)) from negative (net protein loss) to positive (net protein gain) [ 3 ]. (biomedcentral.com)

It helps in building blocks of protein which improves the recovery of muscles and assists in muscle retention. (thedollpalace.com)

Cancer cachexia is characterized by selective depletion of skeletal muscle protein reserves. (aacrjournals.org)
This loss of muscle protein forms part of the syndrome of cancer cachexia, which results in the loss of function of the cancer patient and eventually death from hypostatic pneumonia, attributable to the loss of respiratory function. (aacrjournals.org)
Cancer-induced muscle wasting, which commonly occurs in cancer cachexia, is characterized by impaired quality of life and poor patient survival. (spandidos-publications.com)
Thus far, studies on muscle wasting using cancer cachectic models have generally focused on early cancer cachexia (ECC), before severe body weight loss occurs. (spandidos-publications.com)
These findings may provide some clues for therapy which could prevent the muscle wasting in cancer cachexia from progression to the late stage. (spandidos-publications.com)
This syndrome is prevalent in cancer patients, and muscle wasting is the most prominent symptom of cancer cachexia. (spandidos-publications.com)
It is well known that muscle wasting in cancer cachexia is directly related to the poor quality of life of cancer patients and even impacts their survival ( 1 ). (spandidos-publications.com)

Titin is a giant scaffold protein with multiple functions in striated muscle physiology. (frontiersin.org)

Titin interacts with other muscle proteins, including actin and myosin, to keep the components of sarcomeres in place as muscles contract and relax. (medlineplus.gov)
The backbone of the sarcomere is composed of three filament systems: the myosin-based thick filament, the actin-based thin filament, supplemented with the regulatory protein tropomyosin and the troponin complex, and the titin filament. (frontiersin.org)
Non-muscle cofilin (n-cofilin) is a member of the ADF/cofilin family of actin depolymerizing proteins. (nature.com)
5 Actin dynamics critically depend on members of the ADF/cofilin family that comprises muscle cofilin (m-cofilin), non-muscle cofilin (n-cofilin), and ADF (actin depolymerizing factor). (nature.com)

Without that protein in Drosophila fruit flies, researchers at The Picower Institute for Learning and Memory found axonal segments can break apart during development and the connections, or synapses, that they form end up dying away. (neurosciencenews.com)

They also lead to decreases in muscle strength and mass and cause atrophy, especially for type II muscle fibers. (nutraceuticalsworld.com)
Preventing Brg1 re-expression decreases hypertrophy and reverses this MHC switch. (ca.gov)
Early decreases in IL-6 serum levels with piroxicam correlated with better muscle performance at week 2. (biomedcentral.com)

Poor dietary habits can lead to obesity and insulin resistance-both of which can impair basal heat shock protein (HSP) expression and the HSP stress response in skeletal muscle. (lidsen.com)

My long term goal of this project is to elucidate our understanding of the mechanism by which desmin and vimentin induces mitochondrial and muscle dysfunction under pathological conditions in smooth muscle. (jefferson.edu)

We examined the acute effects of different dietary protein sources (0.19 g, dissolved in 1 ml of water) on skeletal muscle, adipose tissue and hypothalamic satiety-related markers in fasted, male Wistar rats (~250 g). (biomedcentral.com)
Role of dietary protein in the sarcopenia of aging. (uams.edu)

We have purified and characterized several GDP/GTP exchange proteins (GDP dissociation stimulator (GDS) and GDP dissociation inhibitor (GDI)) and GTPase activating Proteins (GAP) for small G proteins. (nii.ac.jp)

We observed that the WNV-Cp protein is a pathogenic protein, which drives apoptosis in vitro through the mitochodrial/caspase-9 pathway. (cdc.gov)

Patients typically develop weakness of peroneal muscles with toe-walking late in the first decade or in the early teenage years. (medscape.com)
Our current studies are designed to identify potential signaling pathways connecting increased TEAD-1 expression in skeletal muscle to activation of genes encoding proteins typically restricted to slow-twitch fibers, as well as satellite cell numbers that exceed homeostatic numbers associated with slow-fibers. (missouri.edu)
Typically, this group is added to specific places on the DNA, where it blocks the proteins that attach to DNA to "read" the gene. (cdc.gov)
Patients typically present with slowly progressive, symmetric, proximal muscle weakness with or without facial involvement and diminished or absent tendon reflexes. (msdmanuals.com)

Low serum 25(OH)D concentrations decrease the expression of genes responsible for myogenesis and reduce the synthesis of muscle contractile proteins and the influx of [calcium] into the sarcoplasmic reticulum of muscle cells," the authors said. (nutraceuticalsworld.com)
Altered contractile-protein expression and increased smooth-muscle cell (SMC) proliferation are characteristics of various disease conditions including hypertension, asthma, and intestine and bladder pathologies. (jefferson.edu)
Overexpression of TEAD-1 in transgenic mouse striated muscles produces a slower skeletal muscle contractile phenotype. (missouri.edu)

A second area if interest is how initial satellite cell number is determined during skeletal muscle formation (myogenesis). (missouri.edu)
To grow large and strong, each fibre is formed by the fusion of several muscle precursor cells in a process called myogenesis. (kcl.ac.uk)

A further 80 genes showed greater than 5 fold differences in expression after exposure to dragonfly larvae and 81 genes showed altered expression after exposure to larval salamanders. (biomedcentral.com)

Mitochondrial desmin and vimentin interacts with the VDAC and this interaction disrupts VDAC/MtCK/ANT complex formation, thereby inhibiting the ATP synthesis and promoting ROS production under pathological conditions in smooth muscle. (jefferson.edu)
Researchers from the Randall Centre for Cell & Molecular Biophysics believe they have reached a new milestone in the understanding of muscle formation that could help define new cellular and molecular approaches in pathological conditions affecting muscle wellness. (kcl.ac.uk)

A new role for the muscle repair protein dysferlin in endothelial cell adhesion and angiogenesis. (nih.gov)
Perhaps the most obvious feature of a neuron is the long branch called an axon that ventures far from the cell body to connect with other neurons or muscles. (neurosciencenews.com)
Stathmin may play a role in the modulation of cell growth, migration, and invasion. (prospecbio.com)
The pathways related to cell protein folding and degradation need to be elucidated because of training was set. (ijpsonline.com)
The results showed that chaperonin containing tailless complex polypeptide the large number of proteins involved, the complex relationship between proteins and the lack of research on the effects of movement and cell protein folding and degradation. (ijpsonline.com)
Importantly, the mitochondrial association of n-cofilin and ADF had no impact on apoptosis signaling because ablation of either n-cofilin, ADF, or both proteins together did not change cell death progression. (nature.com)
In order to understand what kind of intracellular molecular changes should be expected to occur during the medium change, we analyzed global protein expression changes using nano-LC-MS/MS in smooth muscle cell cultures that were isolated and grown in one medium formulation and temporarily switched to the other. (tubitak.gov.tr)
A muscle cell has a structure that aids in your body's ability to move. (cdc.gov)
Epigenetics allows the muscle cell to turn "on" genes to make proteins important for its job and turn "off" genes important for a nerve cell's job. (cdc.gov)

G-protein-coupled receptors (GPCR) mediated signaling smooth muscle. (jefferson.edu)

The protein produced from this gene is part of a group of proteins (a complex) that helps regulate several critical functions within cells. (medlineplus.gov)

In this research project, we have investigated the C-terminal structures of small G proteins, purified the regulatory proteins for small G proteins, and made monoclonal antibodies against small G proteins and their regulatory proteins. (nii.ac.jp)
Among these regulatory proteins, we have cloned the cDNAs of smg p21 GDS, smg p25A GDI, and rho GDI, and made monoclonal antibodies against them. (nii.ac.jp)

Researchers believe that this protein complex plays a particularly important role in smooth muscle cells, which line the walls of blood vessels . (medlineplus.gov)
Calreticulin plays a central role in intracellular Ca homeostasis. (bio.net)
Since epilepsy is also supposed to constitute a comorbidity of DMD, it is hypothesized that dystrophin plays a role in neuronal excitability. (frontiersin.org)
This protein plays an important role in skeletal muscles, which the body uses for movement, and in heart (cardiac) muscle. (medlineplus.gov)
Additionally, researchers have found that titin plays a role in chemical signaling and in assembling new sarcomeres. (medlineplus.gov)
In this paper, we discuss the current available information about the role that different phenotypes of macrophages plays after injury and during the remodelling phase in different tissue types, with particular attention to the skeletal muscle. (hindawi.com)
A new study discovered the critical role that Perlecan, a protein, plays in maintaining the structural integrity of neurons, particularly the long branches called axons. (neurosciencenews.com)
With higher expression in undifferentiated myoblast cells than muscle tissue, it is likely that TNC plays a role in muscle tissue remodelling in humans. (lu.se)
VEGF) plays a crucial role in physiological relations between them were analysed. (who.int)
Demographic and that this particular family of angiogenic clinical data were collected during routine proteins plays an important role in placental obstetric visits. (who.int)

Increasing evidence indicates that pro-inflammatory mediators, protein degradation-associated factors, and some other circulating mediators drive this process ( 18 ). (spandidos-publications.com)
Chaperonin Containing Tailless Complex Polypeptide 1 (CCT-1) is one of the important elements of protein folding pathway in cells and proteasome is an important component of Adenosine Triphosphate (ATP) dependent protein degradation pathway in cells. (ijpsonline.com)
They are involved in the formation of protein folding/degradation signalling pathway, maintaining the normal spatial structure and normal biological function of protein [ 3 ]. (ijpsonline.com)

3 Pro-apoptotic proteins, such as cytochrome c and second mitochondria-derived activator of caspase (SMAC), are released from mitochondria into the cytosol where they participate in the activation of execution caspases. (nature.com)

Your genes play an important role in your health, but so do your behaviors and environment, such as what you eat and how physically active you are. (cdc.gov)

Les concentrations sériques de sCD40L circulant et d'interleukine 10 circulante ont été analysées à l'aide de la méthode immuno-enzymatique chez 30 patients positifs pour le VHC avec un CHC, chez 30 patients patients positifs pour le VHC avec une cirrhose du foie, et chez 30 volontaires d'âge correspondant en bonne santé avec des anticorps anti-VHC négatifs servant de groupe témoin. (who.int)

In addition to its role in muscle tissue, it functions as an anchoring protein within the central nervous system such as in hippocampus and cerebellum. (frontiersin.org)
Heterogeneity and plasticity of macrophages could explain these apparently contrasting roles in tissue healing. (hindawi.com)
TNC RNA expression is higher in myoblasts and myotubes compared to skeletal muscle tissue. (lu.se)
In 1930, American gynecologists Kurzok and Lieb first described the stimulatory effects of seminal fluid on human uterine muscle tissue. (medscape.com)
A few years later, von Euler of Sweden independently discovered similar effects of human seminal fluid on smooth muscle tissue. (medscape.com)

More importantly, direct in vivo expression of WNV-Cp protein in mouse brain resulted in an induction of apoptosis similar to what is observed in natural infection. (cdc.gov)
Myoblasts were isolated from the muscle biopsies and differentiated to myotubes ex vivo. (lu.se)

Variants in the TTN gene have been identified in people with early-onset myopathy with fatal cardiomyopathy (EOMFC), an inherited disease that affects both skeletal and cardiac muscle. (medlineplus.gov)
The defective protein disrupts the function of sarcomeres, preventing skeletal and cardiac muscle from developing and working normally. (medlineplus.gov)
Changes in sarcomere function reduce the heart's ability to contract, weakening cardiac muscle and leading to the signs and symptoms of familial dilated cardiomyopathy. (medlineplus.gov)
It is unclear why these effects are usually limited to certain skeletal muscles and respiratory muscles, and do not involve cardiac muscle. (medlineplus.gov)
Cardiac stress triggers adult hearts to undergo hypertrophy and a shift from alpha-MHC to fetal beta-MHC expression. (ca.gov)

We also investigated the effects of BotoxA-induced paralysis on the sprouting capacity of NMJs in the K108N-SEMA3A mutant mouse, and observed no change in the differential neuronal plasticity found at NMJs on fast-fatigable or slow muscle fibers due to the presence of the SEMA3A mutant protein. (nih.gov)

MSY3 is a DNA binding protein, which acts as a transcriptional repressor. (biomedcentral.com)
We further demonstrated that QKI down-regulated the expression of SRF, MEF2C and Myocd through transcriptional repression and direct binding to promoters of the SRF, MEF2c and Myocd genes. (oncotarget.com)

Supplementation with Muscle Energy BCAAs can prevent CNS fatigue by competing with free-tryptophan for uptake from the plasma into the brain. (ast-ss.com)
Metabolic response of muscle to alanine, glutamine, and valine supplementation during severe illness. (uams.edu)

A multifunctional DNA-binding protein that promotes the formation of serum response factor/homeodomain complexes: identity to TFII-I". Genes Dev. (wikipedia.org)
Bone morphogenetic protein 4 (BMP4) promotes the osteogenic potential & the bone regenerative potential of muscle-derived stem cells (MDSCs). (pitt.edu)
In embryos, Brg1 promotes myocyte proliferation by maintaining Bmp10 and suppressing p57(kip2) expression. (ca.gov)
Their findings also revealed that another molecule, named Hedgehog, promotes the formation of multinucleated muscle fibres via a second, Myogenin-independent, pathway. (kcl.ac.uk)

Conclusions: Adiponectin, leptin, and FABP4 were demonstrated to be associated with the severity of DR and maybe good predictors for STDR, suggesting that adipokines may play an important role in the pathophysiology of DR development. (bvsalud.org)
Dr. Barbara Troesch, DSM's Nutrition Science & Advocacy Lead Scientist, explains why sarcopenia has become an increasingly important area within the medical nutrition field, the role of muscle health in clinical settings and how EPA and DHA can support patient outcomes. (dsm.com)
It is well-known that muscle health is important for normal physical movement and overall health throughout life, helping to maintain our quality of life and independence. (dsm.com)
Atrogin1 and muscle RING-finger 1 (MuRF1) are two important muscle-specific ubiquitin ligases that are induced in almost all types of muscle wasting ( 28 - 30 ). (spandidos-publications.com)
The results of the present study indicate that microRNAs play important roles in regulating asthma immune responses. (cdc.gov)

The claw and leg opener muscles in the crayfish and lobster provide preparations in which regional differences in synaptic strength and muscle fibre phenotype can be compared, since the postsynaptic responses differ among regions of the muscle even though it is innervated by a single excitatory tonic motor neuron. (biologists.com)

Anatomy52

Organisms16

Diseases24

Chemicals and Drugs85

Analytical, Diagnostic and Therapeutic Techniques and Equipment26

Psychiatry and Psychology3

Phenomena and Processes47

Disciplines and Occupations1

Anthropology, Education, Sociology and Social Phenomena6

Technology, Industry, Agriculture7

Information Science3

Health Care4

Kinase8

Gene expression19

Myosin heavy2

Loss of skeletal muscle2

Extracellular matrix3

Vascular3

Isoforms7

Molecules5

Differentiation12

Family of proteins2

Metabolism5

Pathogenesis7

Phosphorylation4

Regulation10

Cytoskeleton2

Synthesis of new2

Exercised rats1

Anabolism5

Transcription7

Functional4

Membrane5

Contraction5

Mechanisms4

Anabolic3

Inflammation11

Catabolism5

Ligand1

Altered protein1

Tumor3

Human skeletal muscle1

Mutations3

Maturation2

Aortic1

Skeletal muscle mass3

Amino16

Improves1

Cancer cachexia7

Physiology1

Actin4

Drosophila1

Decreases3

Insulin1

Induces1

Dietary protein2

Inhibitor1

Vitro1

Typically4

Contractile3

Myogenesis2

Larval1

Pathological2

Cell9

Receptors1

Regulate1

Antibodies2

Plays10

Degradation3

Mitochondria1

Genes play an important role1

Concentrations1

Tissue5

Vivo2

Cardiac5

Differential1

Transcriptional2

Supplementation2

Promotes4

Important5

Phenotype1