• Results: Our immortalized SC line (iPS) proliferated stably and had a phenotype similar to NPSC, as indicated by the immunoexpression of follicle stimulating hormone receptor (FSHR), and mRNA expression of androgen receptor (AR), and Wilms' tumor antigen (WT1). (johnshopkins.edu)
  • The team has developed two prostate cancer vaccines, which activate the immune system against two prostate cancer associated proteins - the androgen receptor (AR), and prostatic acid phosphatase (PAP). (pcf.org)
  • On the other hand, the proliferation of oncolytic viruses into target cells and subsequent recognition of viral elements by pattern recognition receptors (PRRs) such as toll-like receptors can positively affect the development of the innate and adaptive immune responses against tumor cells (Fig. 1 ) [ 6 ]. (biomedcentral.com)
  • Interestingly, NPSC and iPS expressed mRNA of complement regulatory proteins (CRP) such as membrane cofactor protein (CD46), decay accelerating factor (DAF or CD55), and protectin (CD59), but CD59 mRNA expression was negligible in iPS. (johnshopkins.edu)
  • Effector proteins interacting with the Fc portion of immunoglobulin M (IgM) include complement and complement receptors. (medscape.com)
  • Partial or complete deficiencies of the components of the complement system, including its receptors and regulatory proteins, are now described in humans and may be of a genetic or familial origin or acquired. (medscape.com)
  • Defects in the expression of complement or complement receptors may result in loss of tolerance to self-proteins and the development of immune complex-mediated autoimmune diseases such as systemic lupus erythematosus (SLE). (medscape.com)
  • Explore our comprehensive collection of recombinant Fc receptor proteins! (acrobiosystems.com)
  • The affected patients' genetic backgrounds revealed significant genetic heterogeneity in several genes involved in complement regulation, including the complement factor H, complement factor H-related proteins, complement factor I, complement factor B, complement component 3, and CD46 genes in the alternative complement pathway. (ekjt.org)
  • Granzyme B is crucial for rapid induction of cell death and apoptosis through interaction with mannose-6-phosphate receptor. (biolegend.com)
  • Our results indicate that an Arg279Glu substitution is sufficient to convert the Ad11p receptor-interaction phenotype to that of Ad7p and abolish sB2AR and CD46 interaction. (grandlacs-med-journal.com)
  • The efficacy of a therapeutic antibody depends on the Fab fragment and its binding activity to the target antigen, but also depends on the Fc fragment and its interaction with key Fc receptors.Therefore, candidates must be tested against a panel of receptors during antibody engineering. (acrobiosystems.com)
  • The expression of these receptors are often increased in tumor cells. (wikipedia.org)
  • Viruses can also be engineered to target specific receptors on tumor cells as well. (wikipedia.org)
  • extended and triggered with SIINFEKL peptide antigen pulsed tumor cells as focuses on. (grandlacs-med-journal.com)
  • The majority of our de novo radiotracer development focuses on small molecule organic chemistry, and our antibody radiotracer development programs involves new bioconjugation chemistry, and defining and exploiting the biological mechanisms that underwrite the aberrant expression of cell surface receptors in cancer. (ucsf.edu)
  • The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. (wikidoc.org)
  • Human sodium/iodide symporter (hNIS) is considered as one of the most prevalent nuclear imaging reporter transgenes that provides precise information regarding the kinetics of gene expression, viral biodistribution, toxicity, and therapeutic outcomes using the accumulation of radiotracers at the site of transgene expression. (biomedcentral.com)
  • However, as TRIM7 is not immune regulated and has restricted tissue expression, its natural function may not be as a viral restriction factor. (mdpi.com)
  • Instead of developing your own assays, explore our kits and services to quickly quantify viral antigens! (acrobiosystems.com)
  • Mice with C5a receptor-deficient dendritic cells promote induction of Treg and Th17 cells. (medscape.com)
  • This stress condition can also lead to the attraction of immune cells, notably antigen presenting cells (APCs) (i.e. immature dendritic cells), natural killer cells (NK cells), and cytotoxic T-cells to the site of infection [ 5 , 6 ]. (biomedcentral.com)
  • SELPLG codes for PSGL-1, the high affinity counter-receptor for P-selectin on myeloid cells and stimulated T lymphocytes. (wikidoc.org)
  • The CD8 antigen, acting as a coreceptor, and the T-cell receptor on the T lymphocyte recognize antigen displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. (wikidoc.org)
  • B-lymphocyte antigen CD20 or CD20 is an activated- glycosylated phosphoprotein expressed on the surface of all B-cells beginning at the pro-B phase ( CD45 R+, CD117 +) and progressively increasing in concentration until maturity. (wikidoc.org)
  • Gene knockout uses RNA methods to silence or reduce expression of disease-causing genes. (wikipedia.org)
  • Methods: SC line was established following the transfection of primary SC (NPSC) from the testis of neonatal pig with plasmid pRNS-1 carrying genes for neomycin resistance and the SV40 large T antigen. (johnshopkins.edu)
  • The complement system, interacting with its regulatory molecules and cellular receptors, plays a central role in the induction and regulation of immunity. (medscape.com)
  • 8 , 11 - 14 Numerous stimuli can drive the activation of the complement system, including apoptotic debris, pathogens, and antibody-antigen complexes, in addition to ischemia-reperfusion injuries associated with organ transplantation. (jrheum.org)
  • generated in vitro from the same individual blood donors were exposed to five different pathogens, and gene expression profiles were assessed by microarray analysis. (gsea-msigdb.org)
  • Her study in Immunology concentrates on Complement, Inflammation, Complement receptor, Classical complement pathway and Complement membrane attack complex. (research.com)
  • Defective gene expression of the membrane complement inhibitor CD46 in patients with progressive immunoglobulin A nephropathy. (edu.pl)
  • However, inflammation causes the expression of cell adhesion molecules (CAM) such as P-selectin on the surface of the blood vessel wall. (wikidoc.org)
  • To study how humoral tolerance is normally maintained to organ-specific membrane antigens, transgenic mice were generated selectively expressing membrane-bound hen egg lysozyme (mHEL) on the thyroid epithelium. (silverchair.com)
  • The primary cell cultures, obtained from four human pleural mesotheliomas, were expanded in vitro in a low serum proliferation-permissive medium and the expression of different markers as well as the tumorigenicity in immunodeficient mice was evaluated. (biomedcentral.com)
  • Proliferating cell nuclear antigen (PCNA) expression in CNV mice without or with YAP siRNA intravitreal injection and the colocalization of PCNA and CD31 were measured with western blotting and immunofluorescent double staining, respectively. (molvis.org)
  • This study aimed to investigate the role of LTα in MOG 35-55 -induced EAE using mice deficient in LTα or its membrane receptor, LTβR. (rusimmun.ru)
  • Surprisingly, LTα-deficient mice with normal TNF expression developed EAE clinically comparable to wild-type mice. (rusimmun.ru)
  • Patients will be evaluated for safety, clinical responses, immune system responses against the vaccine antigens (PAP and AR), as well as immune system changes that correlate with clinical responses. (pcf.org)
  • Her Innate immune system research focuses on Classical complement pathway and how it connects with T cell, Complement receptor and Acquired immune system. (research.com)
  • 00:01:59.26 However, pigs, and most mammalian species, and also non-mammalian species, in fact, 00:02:07.05 express an antigen that is quite ubiquitous and that causes. (ibiology.org)
  • The role of an intact endothelial barrier in sequestering organ-specific antigens from circulating preimmune B cells is discussed. (silverchair.com)
  • YAP expression increased following laser exposure, in accordance with vascular endothelial growth factor (VEGF) expression. (molvis.org)
  • Additionally, after laser exposure, YAP siRNA inhibited the increased expression of PCNA, which was colocalized with endothelial cells. (molvis.org)
  • Complex immunobiology of lymphotoxin (LTα) is due to multiple modalities of signal transduction, involving a soluble homotrimer and membrane-bound heterotrimers that engage at least three different receptors. (rusimmun.ru)
  • Viruses are chosen because they can target specific receptors expressed by cancer cells that allow for virus entry. (wikipedia.org)
  • One example of this is the targeting of CD46 on multiple myeloma cells by measles virus. (wikipedia.org)
  • Tumor antigens and danger-associated molecular patterns are also released during the lysis process which helps recruit host immune cells. (wikipedia.org)
  • Because of their high numbers, red blood cells express an average of 90% of the CR1 receptors despite their having a lower number of antigenic sites per cell. (medscape.com)
  • Among healthy individuals, the number of CR1 receptors on the red blood cells varies widely, yet the phenotypic expression, regulated by 2 codominant alleles, is stable. (medscape.com)
  • In this manner, the reduced detection of self MHC-I molecules by NK cell-inhibitory receptors coupled with an increase in activating signals by recognition of stress-induced surface ligands promote the cytolytic activity of NK cells. (biomedcentral.com)
  • Virus-based immunostimulatory cytokine and chemokine expression can recruit and activate T cells, antigen-presenting cells (APCs), and natural killer (NK) cells, and subsequently, improve the therapeutic activity of OVs. (biomedcentral.com)
  • Graves' Disease results from the production of autoantibodies against receptors for thyroid stimulating hormone (TSH) on thyroid epithelial cells, and represents the prototype for numerous autoimmune diseases caused by autoantibodies that bind to organ-specific cell membrane antigens. (silverchair.com)
  • 353:765-769), selective expression of mHEL autoantigen on thyroid cells did not trigger elimination or inactivation of circulating HEL-reactive B cells. (silverchair.com)
  • However all the cell lines established so far were grown in medium containing at least 10% serum, and it has been shown that primary cell lines cultured under these conditions lose their ability to differentiate, acquire gene expression profiles that differ from that of tissue specific stem cells or the primary tumor they derive from, and in some cases are neither clonogenic nor tumorigenic. (biomedcentral.com)
  • Moreover, HSV engineered in gH of a scFv targeting the cancer-specific HER2 receptor, scFv-HER2-gH chimera, can enter, replicate and kill cancer cells efficiently [ 14 ]. (biomedcentral.com)
  • In melanocytic cells Glycophorin C gene expression may be regulated by MITF . (wikidoc.org)
  • Members of this nascent protein family are characterized by common structural features and similar intron / exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. (wikidoc.org)
  • Conclusion: These results suggest that iPS, immortalized by the introduction of SV40 T, retain their original characteristics, except for the relatively low expression of CD59, and that they may be useful for future in vitro and in vivo studies of immune privilege mechanisms related to SC. (johnshopkins.edu)
  • These results provide evidence that tolerance is not actively acquired to organ-specific antigens in the preimmune B cell repertoire, underscoring the importance of maintaining tolerance to such antigens by other mechanisms. (silverchair.com)
  • Each distinct CD4 + T-cell subset has a specific function and can mainly be distinguished by its cytokine profile, the expression pattern of cell surface molecules, and the activation of specific transcription factors 8 . (nature.com)
  • The density of CR1 receptors on cell surfaces varies with the cell type and with the activation of the cell for neutrophils and monocytes. (medscape.com)
  • HHV-6A was found to both enhance expression and inhibit degradation of amyloid precursor protein in vitro. (hhv-6foundation.org)
  • This result is comparable to Cytochalasin H another non-coxsackie-adenovirus receptor binding Ad (Ad37p), where substitution of one amino acid abolishes virus-cell connection. (grandlacs-med-journal.com)
  • Four distinct complement receptors, CR1, CR2, CR3, and CR4, have been described for the surface-bound complement fraction C3 and its cleavage fragments. (medscape.com)
  • Complement and complement receptors play a critical role in immune defense by initiating the rapid destruction of invading microorganisms, amplifying the innate and adaptive immune responses, and mediating solubilization and clearance of immune complexes. (medscape.com)
  • Conclusions: Our outcomes demonstrated that focusing on EZH2 improved antigen demonstration and could circumvent anti-PD-1 level of resistance. (grandlacs-med-journal.com)
  • The human interferon-gamma receptor. (wikidoc.org)
  • An violence of the considerable novel of vital antigen in Latin America draws to better deny browser women that several host acids or human chemistry Chemistry products should take the drainage of lonely chatter, considerably incremental factors per se, to write the course and section of promotional walls that may or may n't read making in domestic issues. (yvonne-unden.de)
  • The JUN protein is a transcription factor that plays a crucial role in regulating gene expression in response to a variety of signals, including growth factors, cytokines, and stress. (cusabio.com)
  • In conjunction with earlier results, our findings Cytochalasin H also strongly suggest that sB2AR is equivalent to CD46. (grandlacs-med-journal.com)
  • Our cell cultures were strongly positive for CD46, CD47, CD56 and CD63 and were also strongly positive for some markers never described before in mesothelioma cell lines, including CD55, CD90 and CD99. (biomedcentral.com)
  • Using RNA sequencing (RNA-seq) data from primary and xenograft SCLC samples, we identified seizure-related homolog 6 (SEZ6) as a surface-expressed SCLC target with broad expression in SCLC and minimal normal tissue expression by both RNA-seq and IHC. (aacrjournals.org)
  • Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. (cusabio.com)
  • For example, production of autoantibodies that bind to and stimulate the thyroid-stimulating hormone (TSH) receptor cause the thyrotoxicosis of Graves' Disease, and anti-thyroid peroxidase antibody in Graves' and Hashimoto's thyroiditis is thought to inhibit thyroid function and promote complement deposition and thyroid destruction ( 2 ). (silverchair.com)
  • [ 2 ] T cell-derived complement C3a and CD46 activation is required for Th1 induction. (medscape.com)
  • Her Factor H study combines topics from a wide range of disciplines, such as Complement factor I, Complement factor B and CD46. (research.com)
  • As a part of the same scientific study, she usually deals with the Cell biology, concentrating on Decay-accelerating factor and frequently concerns with Complement receptor 1. (research.com)
  • CD46 is frequently linked to Factor H in her study. (research.com)
  • This study intends to reveal the expression and functions of YAP during the CNV process. (molvis.org)
  • [1] The following year a new but related antigen was discovered in a Mrs Yus for whom an antigen in this system is also named. (wikidoc.org)
  • In 1972 a numerical system for the antigens in this blood group was introduced. (wikidoc.org)