• Dive into the research topics of 'Rice phytochrome-interacting factor protein OsPIF14 represses OsDREB1B gene expression through an extended N-box and interacts preferentially with the active form of phytochrome B'. Together they form a unique fingerprint. (unl.pt)
  • To provide insight into the molecular mechanisms of their activity and selectivity, we determined the crystal structures of the ERalpha ligand-binding domain (LBD) and a peptide from the glucocorticoid receptor-interacting protein 1 (GRIP1) coactivator complexed with the ligands OBCP-3M, OBCP-2M, and OBCP-1M. (rcsb.org)
  • Transcription factors attach to noncoding DNA, regulating the expression of protein-coding genes. (stanford.edu)
  • Their regulation may be carried out either through direct binding to DNA as peroxisome proliferator-activated receptors or via modulation in an indirect manner of signaling pathway molecules (e.g., protein kinase C) and other transcription factors (nuclear factor kappa B and sterol regulatory element binding protein). (springer.com)
  • The groups used very different isolation methods (i.e., expression cloning, protein purification, genomics), yet all identified the same enzyme and concurred that it possessed all the known characteristics of β-secretase ( Fig. 1 ) ( Cole and Vassar, 2008 ). (jneurosci.org)
  • Intersecting analysis, molecular docking, and pathway validation analysis showed that risperidone influences the adipocytokine signaling pathway by targeting MAPK14 (mitogen-activated protein kinase 14), MAPK8 (mitogen-activated protein kinase 8), and RXRA (retinoic acid receptor RXR-alpha), thereby inhibiting long-chain fatty acid β-oxidation by decreasing STAT3 (signal transducer and activator of transcription 3) expression and phosphorylation. (frontiersin.org)
  • Risperidone upregulates fatty acid synthase (FASN) and sterol regulatory element-binding protein 1 (SREBP1) expression in hepatocyte cultures and mouse liver by targeting the hepatic SREBP-1c/FASN couple, which is also one of the mechanisms by which risperidone induces weight gain ( 24 ). (frontiersin.org)
  • In addition to RNA-binding activity, this protein interacts directly and highly specifically with subunit 2 of the splicing factor 3B. (nih.gov)
  • NRL interacts with homeodomain protein CRX and numerous other regulatory factors to control expression of most rod-expressed genes. (nih.gov)
  • Enrichment analysis for protein localization showed that mainly intracellular and cell-associated interacting proteins were identified. (degruyter.com)
  • Scope includes mutations and abnormal protein expression. (cancerindex.org)
  • Immunoflourescence images of expression of Nrf2 and HO-1 showing thealteration of key protein markers of antioxidant gene expression, read more in 'Melatonin targets ferroptosis through bimodal alteration of redox environment and cellular pathways in NAFLD model' from Saha et al, in this edition of Bioscience Reports. (portlandpress.com)
  • In short, from a total of 437 high-confidence interacting proteins that bind to one or more SARS-CoV-2 genes, the researchers have identified several gene products, M protein, NSP6, ORF3a, ORF6 and ORF7b that interacted with host cell membrane proteins and complexes. (news-medical.net)
  • The SALL1 protein helps turn off (repress) gene activity by interacting with other proteins that alter how tightly regions of DNA are packaged. (medlineplus.gov)
  • The malfunctioning protein may also interact with other proteins, disrupting their function. (medlineplus.gov)
  • rsos from in silico dynamical modelling by tuning parameters for protein concentrations and other factors .r o y involved in the rate equations describing the systems. (lu.se)
  • Non-GPI anchored CD59 interacts with SNARE protein: VAMP2 and rescues insulin secretion. (lu.se)
  • Induction of glucotoxicity in primary, healthy human islets led to a significant decrease in IRIS-1 protein-level expression. (lu.se)
  • Here we show that phytochrome-interacting factor 1 (PIF1) and other transcription factors of the phytochrome-interacting factor (PIF) family down-regulate the accumulation of carotenoids by specifically repressing the gene encoding phytoene synthase (PSY), the main rate-determining enzyme of the pathway. (lancs.ac.uk)
  • In addition, we showed that OsPIF14 is indeed a phytochrome interacting factor, which preferentially binds to the active form (Pfr) of rice phytochrome B. This raises the possibility that OsPIF14 activity might be modulated by light. (unl.pt)
  • For decades, scientists have known that, despite its name, "junk DNA" in fact plays a critical role: While the coding genes provide blueprints for building proteins, which direct most of the body's functions, some of the noncoding sections of the genome, including regions previously dismissed as "junk," seem to turn up or down the expression of those genes. (stanford.edu)
  • To solve the puzzle of why transcription factors go to some places in the genome and not to others, we needed to look beyond the highly preferred motifs," Fordyce said. (stanford.edu)
  • Genome-wide identification and expression analysis of the bZIP transcription factor family genes in response to abiotic stress in Nicotiana tabacum L. (biomedcentral.com)
  • How do numerous non-coding variations in the human genome affect gene expression in the retina? (nih.gov)
  • Because we showed that integration neither affects the levels of viral genes, nor those of virally disrupted human genes, a genome-wide screen was performed to identify human genes which expression is influenced by viral integration and have clinical relevance. (cancerindex.org)
  • Overall, our analyses provide novel opportunities for the normalisation of genome-wide expression profiling data. (biorxiv.org)
  • Given that the basic genome of a differentiated organism is constant between cells (and we here ignore epigenomics), what mainly discriminates one cell type from another is its expression profile. (biorxiv.org)
  • His recent research on Citrus tristeza virus has revealed its genome stability, unusual for an RNA virus, and the promiscuous recombination between viral strains as the major factor driving Citrus tristeza virus evolution. (bio5.org)
  • Epigenetic changes affect the expression or activity of genes without changing the underlying DNA sequence - they are believed to be one mechanism by which the environment can interact with the genome. (kcl.ac.uk)
  • Genome annotation disclosed 29 SARS-CoV-2 gene products - including 16 non-structural proteins, 4 structural proteins and 9 accessory factors. (news-medical.net)
  • One way the exposome and genome interact is through gene-environment interactions . (cdc.gov)
  • Another way the exposome interacts with the genome is through epigenetics , the process of altering gene expression without changing the DNA Sequence. (cdc.gov)
  • Interacting DNA-encoded regulatory subsystems in the GENOME that coordinate input from activator and repressor TRANSCRIPTION FACTORS during development, cell differentiation, or in response to environmental cues. (bvsalud.org)
  • Both in vitro and in vivo evidence demonstrate that PIF1 directly binds to the promoter of the PSY gene, and that this binding results in repression of PSY expression. (lancs.ac.uk)
  • Our results also suggest a role for PIF1 and other PIFs in transducing light signals to regulate PSY gene expression and carotenoid accumulation during daily cycles of light and dark in mature plants. (lancs.ac.uk)
  • PIF1 binds to a G-box (CACGTG) DNA sequence element present in its direct target genes (e.g., protochlorophyllide oxidoreductase C, PORC) in darkness and regulates their expression. (utexas.edu)
  • Using a targeted systems biology approach, we identified new factors, HECATE proteins that promote photomorphogenesis by negatively regulating the function of PIF1. (utexas.edu)
  • The cloning and characterization of these mutants will help identify the factors, such as the kinase and E3 ligase, responsible for the light-induced degradation of PIF1. (utexas.edu)
  • The gene expression of Ppargc1a varied during scleral growth from week 1 to 2, week 2 to 3, week 3 to 6, and week 6 to 8 and was found to interact with a different set of genes at different scleral growth stages. (molvis.org)
  • In addition, we propose that Ppargc1a might play a role in regulating postnatal scleral development by interacting with a different set of genes at different scleral growth stages. (molvis.org)
  • interacting genes at different noise levels or temperatures. (lu.se)
  • For the study, the researchers looked at how STRs interact with proteins called transcription factors. (stanford.edu)
  • The ability of NRs to drive gene activation is directed by specific interacting proteins called cofactors. (ku.edu)
  • Estrogen receptors alpha (ERalpha) and beta (ERbeta) have distinct functions and differential expression in certain tissues. (rcsb.org)
  • 4 Upon polarization, macrophages react to the respective stimulus with the expression of a distinct phenotype. (haematologica.org)
  • How do distinct transcriptional regulatory proteins coordinate their job with extrinsic factors and the microenvironment? (nih.gov)
  • Overall, 477 proteins were found interacting with at least one of four distinct sGAGs. (degruyter.com)
  • This includes the expression of distinct antigens on subsets of MSCs, which was utilized recently to define and separate functionally different subsets from bulk MSCs. (hindawi.com)
  • Our data introduce a new paradigm of BMP antagonism during limb development mediated by Dach1, which is now proven to function in different signaling cascades with distinct interacting partners. (biologists.com)
  • Light-triggered degradation of PIFs after interaction with photoactivated phytochromes during deetiolation results in a rapid derepression of PSY gene expression and a burst in the production of carotenoids in coordination with chlorophyll biosynthesis and chloroplast development for an optimal transition to photosynthetic metabolism. (lancs.ac.uk)
  • The basic leucine zipper (bZIP) transcription factor (TF) is one of the largest families of transcription factors (TFs). (biomedcentral.com)
  • We previously discovered that that Maf-family bZIP transcription factor NRL is critical for rod photoreceptor fate and functional differentiation, and that loss of NRL leads to S-cones instead of rods. (nih.gov)
  • The high expressed CBY1 in non-BCSC interacts with 14-3-3 and β-catenin to form a ternary complex, which leads a translocation of the ternary complex into cytoplasm from nucleus and degradation of β-catenin in phosphorylation-dependent pattern. (nature.com)
  • In shortly, these findings highlight that the novel lnc408 functions as an oncogenic factor by recruiting SP3 to inhibit CBY1 expression and β-catenin accumulation in nucleus to maintain stemness properties of BCSCs. (nature.com)
  • Classical polarization is usually associated with a proinflammatory response, including the increased production of tumor necrosis factor (TNF)-α, IL-1, and IL-6. (haematologica.org)
  • Knockdown of GSTO1 expression abrogates carboplatin-induced BCSC enrichment, decreases tumor initiation and metastatic capacity, and delays tumor recurrence after chemotherapy. (nih.gov)
  • however, restoration of CBY1 expression in tumor cells reduces BCSC and its enrichment, thus lnc408 plays an essential role in maintenance of BCSC stemness. (nature.com)
  • More broadly, adding genomics to public health investigations of environmental risk factors could strengthen the causal interpretation of associations between exposures and health outcomes and lead to preventive interventions focused on modifiable risk factors. (cdc.gov)
  • Clinicians should therefore emphasize strategies to reduce cardiovascular risk even further among low-risk adults by treating modifiable risk factors (smoking, diabetes, blood pressure, hyperlipidemia, overweight, and exercise). (medscape.com)
  • HSPGs interact with growth factors and receptors through heparan sulfate (HS) chains. (scielo.br)
  • 7 In contrast, alternatively activated macrophages are characterized by increased expression of IL-10 and of scavenger receptors. (haematologica.org)
  • However, it is becoming increasingly clear that these factors and their receptors are also widely found to express across many different cancers with further research. (medsci.org)
  • In summary, these results demonstrate ZNF513 + KIF3C as an important genetic combination in HGF manifestation and suggest that ZNF513 mutation may be a major risk factor for HGF. (nature.com)
  • The researchers concluded that the transcription factors directly interact with the repetitive genetic code, attaching to it and the motif with the DNA binding domain. (stanford.edu)
  • Because identical twins share the same genetic code, this suggests non-genetic, or epigenetic, factors may be involved. (kcl.ac.uk)
  • DNA methylation acts to block the genetic sequences that drive gene expression, silencing gene activity. (kcl.ac.uk)
  • The submissions were part of the company's research of epigenetics, or how lifestyle habits and environmental factors alter genetic expression. (startribune.com)
  • The company is applying technology developed by a leading scientist, at the University of California-Los Angeles, to verify how genetic expressions can reliably identify people's habits, such as smoking, and predict their longevity. (startribune.com)
  • The recent skyway research was intended to determine whether genetic expressions could be easily identified in saliva, which is easier to obtain than blood. (startribune.com)
  • Parker said epigenetics is not just about identifying genetic actions, or expressions, that predict future health problems. (startribune.com)
  • Epigenetic testing can identify smoking-related genetic expressions that don't go away as quickly. (startribune.com)
  • Insurance decisions won't be made based on an individual's hard-wired genetic codes, Parker said, but rather on the genetic expressions that reflect lifestyles. (startribune.com)
  • Many diseases, such as birth defects and developmental disabilities, type 2 diabetes and cancer, are influenced by both environmental and genetic factors. (cdc.gov)
  • Epigenetics is a dynamic process that can be influenced by both genetic and environmental factors, such as smoking and air pollution. (cdc.gov)
  • The specific causes of autism spectrum disorders are not fully understood, although they are often related to genetic factors. (msdmanuals.com)
  • Using a yeast one-hybrid screening, we identified a putative Phytochrome-Interacting bHLH Factor (OsPIF14), as binding to the OsDREB1B promoter. (unl.pt)
  • Phys transduce light signals via a sub-family of the basic Helix-Loop-Helix (bHLH) transcription factors called Phytochrome Interacting Factors (PIFs). (utexas.edu)
  • We also showed that OsPIF14 down-regulates OsDREB1B gene expression in rice protoplasts, corroborating the OsPIF14 repressor activity observed in the transactivation assays using Arabidopsis protoplasts. (unl.pt)
  • Identification of transcription factors interacting with a 1274 bp promoter of MaPIP1;1 which confers high-level gene expression and drought stress Inducibility in transgenic Arabidopsis thaliana. (bvsalud.org)
  • Nonverbal cues: Human communication involves nonverbal cues, such as facial expressions, body language, and eye contact. (earth.com)
  • Children with autism spectrum disorder (ASD) show impairment in producing facial expressions adapted to social contexts. (scirp.org)
  • Search the gene expression profiles from curated DataSets in the Gene Expression Omnibus (GEO) repository. (cancerindex.org)
  • Differentially expressed genes (DEGs) were seared by combing the TCGA database and the Gene Expression Omnibus (GEO) database, and the key molecule AKR1B10 was identified by weighted gene coexpression network analysis (WGCNA). (portlandpress.com)
  • Researchers have spent a lot of time characterizing these transcription factors and figuring out which sequences - called motifs - they like to bind to the most," Fordyce said. (stanford.edu)
  • But current models don't adequately explain where and when transcription factors bind to noncoding DNA to regulate gene expression. (stanford.edu)
  • Other times, transcription factors bind to stretches of DNA that aren't motifs. (stanford.edu)
  • Important regulatory factors, TFs bind to the promoter regions of target genes and activate or inhibit their transcription. (biomedcentral.com)
  • These proteins are transcription factors, which means they attach (bind) to specific regions of DNA and help control the activity of particular genes. (medlineplus.gov)
  • ZNF513 , a transcription factor, binds to KIF3C exon 1 and participates in the positive regulation of KIF3C expression in gingival fibroblasts. (nature.com)
  • In addition, we found that ZNF513 binds to the SOS1 promoter and plays an important positive role in regulating the expression of SOS1 . (nature.com)
  • For example, lncRNA nuclear paraspeckle assembly transcript 1 (NEAT1) is highly expressed in GBM tissues and perturbed expression of NEAT1 suppresses cell proliferation and invasion ( 10 ). (spandidos-publications.com)
  • One of the largest transcription factor families is the nuclear receptor (NR) superfamily. (ku.edu)
  • Altered expression of shelterin regulatory proteins, tripeptidyl-peptidase 1 (TPP1) and TERF1-interacting nuclear factor 2 (Tin2), was observed in PBMCs and lung tissues. (cdc.gov)
  • To determine their possible roles in tissues and satellite cells in vitro, their expression pattern was examined in tissues from 40-day-old chickens and in satellite cells from the breast muscles of 1-week-old and 2-week-old chickens using RT-PCR and immunocytochemistry analyses. (scielo.br)
  • Gene expression of eye diseases should be studied as early as postnatal weeks 1-2 to ensure that any changes in gene expression pattern during disease development are detected. (molvis.org)
  • When interacting with robots, these norms and expectations may not apply or may need to be adjusted, which can lead to a different type of interaction. (earth.com)
  • Based on the available public RNA-Seq data, the expression patterns of PgGRF and PgGIF genes were analysed from 14 different tissues. (biomedcentral.com)
  • RT‑PCR demonstrated that the expression levels of DLEU1 and TRAF4 were increased in GBM tissues. (spandidos-publications.com)
  • We analyse two comprehensive transcriptome datasets from human tissues and human-derived cell lines in terms of the expression profiles of the SLC and ABC families of membrane transporters. (biorxiv.org)
  • The Gini index (coefficient) characterises inequalities of distributions, and is used in a novel way to describe the distribution of the expression of each transporter among the different tissues and cell lines. (biorxiv.org)
  • Similar trends hold true for the expression profiles of transporters in different cell lines, suggesting that cell lines exhibit largely similar transport behaviour to that of tissues. (biorxiv.org)
  • Transforming growth interacting factor (TGIF) is a potential repressor of TGF-β pathways in myometrial cells. (wikipedia.org)
  • We are now focused on delineating the transcription factors and signaling pathways that are responsible for generating photoreceptors from retinal progenitor cells. (nih.gov)
  • Correlation analysis revealed that mRNA TNF receptor associated factor 4 (TRAF4) was associated with DLEU1 expression. (spandidos-publications.com)
  • Thirty-three fresh-frozen HPV-16 positive OPSCC samples with known integration status were analyzed by mRNA expression profiling. (cancerindex.org)
  • He was one of the first researchers to discover ribosomal frameshifting as a gene expression mechanism in plant RNA viruses and to demonstrate recombination between transgene mRNA and genomic RNA of an infecting virus. (bio5.org)
  • In this study, we examined POT1 mRNA expression and telomere length and regulation by shelterin complex proteins in peripheral blood mononuclear cells (PBMCs) and non-lavaged whole lung tissue in male Sprague-Dawley rats following exposure, by intratracheal instillation, to 2 mg/rat of manual metal arc-stainless steel welding fume (WF) particulate or saline (vehicle control). (cdc.gov)
  • The expression of the PgGRF gene was significantly upregulated under GA3 induction and three weeks of heat treatment. (biomedcentral.com)
  • Functional studies demonstrated that the ZNF513 p.R250W and KIF3C p.R410H variants significantly increased the expression of ZNF513 and KIF3C in vitro and in vivo. (nature.com)
  • TcMYC2a overexpression also led to significantly increased expression of TASY , tat , dbtnbt, t13h , and t5h genes. (frontiersin.org)
  • Upon increasing culture times in chicken´s primary skeletal muscle satellite cells, SULF1 and SULF2 expression in 1-week-old chickens was significantly higher than in 2-week-old chickens, suggesting that sulfatases play a key role in satellite cell development. (scielo.br)
  • The expression of HOX transcript antisense RNA lncRNA is increased in GBM and is significantly associated with high grade brain tumors ( 13 ). (spandidos-publications.com)
  • 6 ], the transforming growth factor beta 1 ( Tgfβ1 ) gene and several collagen genes were significantly downregulated in 8-week-old B6 mice scleras when compared with 3-week-old B6 mice scleras. (molvis.org)
  • However, qPCR analysis showed that POT1 expression levels in the lung tissue of the WF group relative to those in the control group (T/N ratio) was significantly lower, leading to the activation of ATR expression that was not observed in PBMCs. (cdc.gov)
  • In paper II, we showed that silencing of CD59 expression in rat β cells significantly suppressed insulin secretion. (lu.se)
  • We found that IRIS-1 expressing cells displayed significantly higher expression levels of Urocortin 3 and Pdx 1 (markers of mature β cells, which loss marks the beginning of β cells dedifferentiation), suggesting that IRIS-1 may be required for maintaining β cells identity and function. (lu.se)
  • This region of the promoter also confers high levels of gene expression in response to mannitol treatment . (bvsalud.org)
  • In an dual luciferase assay for complementarity verification, the transcription factor MADS3 positively regulated MaPIP1;1 transcription when combined with the banana promoter. (bvsalud.org)
  • TcMYC2a was able to affect the expression of GUS reporter gene by binding with the T/G-box, G-box, and E-box, which were the key cis -elements of TASY and TcERF12/15 promoter. (frontiersin.org)
  • Lnc408 can recruit transcript factor SP3 to CBY1 promoter to serve as an inhibitor in CBY1 transcription in BCSCs. (nature.com)
  • The weak uterotrophic activity of these ligands in immature rats and their ability to stimulate expression of an ERbeta regulated gene in human U2OS osteosarcoma cells provides more physiological evidence of their ERbeta-selective nature. (rcsb.org)
  • In contrast to monocytes, human macrophages did not show increased tissue factor expression upon stimulation with lipopolysaccharide and interferon-γ. (haematologica.org)
  • Here we used an affinity-purification mass spectrometry-based (AP-MS) approach to identify novel and particularly intracellular sGAG-interacting proteins in human bone marrow stromal cells (hBMSC). (degruyter.com)
  • Human bmMSCs were described in the late nineties as well [ 6 ] and at the same time a breakthrough study investigated the expression of typical cell surface markers and the proliferation and differentiation properties of human MSCs in more detail [ 7 ]. (hindawi.com)
  • HER2/neu (also called ERB B2 ) is the gene that encodes the human epidermal growth factor receptor type 2. (cancerquest.org)
  • Cognitive processes: As mentioned in the table tennis study, human brains react differently when interacting with robots compared to humans. (earth.com)
  • By conducting a state-of-the-art interactome study between the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and host cells, researchers from the University of Texas MD Anderson Cancer Center in Houston identified 437 human proteins as the high-confidence interacting proteins - with substantial implications for understanding coronavirus disease 2019 (COVID-19) pathology and potential treatments. (news-medical.net)
  • However, abnormal expression or aberrant activation of these molecules may convert normal growth signals to undesirable signals inducing overgrowth, becoming an important contributor to a variety of human cancers. (medsci.org)
  • In paper I, we revealed a high expression of C3 in human pancreatic islets. (lu.se)
  • The WRC domain can be combined with the cis-acting regions of downstream genes to regulate their expression. (biomedcentral.com)
  • Among all JA downstream transcription factors, MYC2 is considered as the fatal point of the entire JA signaling pathway ( Kazan and Manners, 2013 ). (frontiersin.org)
  • In darkness, PIFs regulate downstream gene expressions to inhibit photomorphogenesis. (utexas.edu)
  • A leading contributing factor to metastasis and treatment resistance is the heterogeneity and plasticity of the cells within tumors 6 . (nature.com)
  • Increased cytosolic calcium levels activate PYK2 → SRC → STAT3 signaling, leading to increased expression of pluripotency factors and BCSC enrichment. (nih.gov)
  • HIF inhibition blocks chemotherapy-induced GSTO1 expression and BCSC enrichment. (nih.gov)
  • However, we did not observe any regulation of the OsDREB1B gene expression by light under control conditions. (unl.pt)
  • The identification of the intracellular sGAG-interacting proteins could help to unravel these functions. (degruyter.com)
  • Effect of dietary fatty acids on inflammatory gene expression in healthy humans. (springer.com)
  • Humans interacting with robots is going to be different than when they interact with other humans. (earth.com)
  • Knowledge of the mechanisms by which fatty acids control specific gene expression may identify important risk factors for cancer and provide insight into the development of new therapeutic strategies for a better management of whole body lipid metabolism. (springer.com)
  • These side effects are high-risk factors for diabetes, cardiovascular disease, and cerebrovascular disease ( 8 - 10 ), leading to poor treatment compliance. (frontiersin.org)
  • Other recognized risk factors include smoking, the intake of pickled vegetables in the diet, and the clinical management of obesity [ 2 ].The treatment of GC mainly includes surgery, chemotherapy, radiotherapy, and targeted therapy [ 3 ]. (hindawi.com)
  • When activated by injury, satellite cells reenter the cell cycle and proliferate in response to extracellular growth factors ( Relaix & Zammit, 2012 Relaix F, Zammit PS. (scielo.br)
  • Alternative polarization with interleukin-4 and IL-13 led to a macrophage phenotype characterized by increased tissue factor (TF) production and release and by an increase in extracellular vesicle production. (haematologica.org)
  • In conclusion, we provide evidence that proinflammatory polarization of macrophages does not lead to enhanced procoagulatory function, whereas alternative polarization of macrophages leads to an increased expression of TF and increased production of TF bearing extracellular vesicles by these cells suggesting a procoagulatory phenotype of alternatively polarized macrophages. (haematologica.org)
  • His recent collaboration with Dr. Martha Hawes has led to the discovery that extracellular DNA, secreted DNases, and proteins are important immunity and pathogenicity factors in the plant-microbe interactions in the rhizosphere. (bio5.org)
  • Studies have also shown that most members of the GRF family have higher expression levels in the meristem. (biomedcentral.com)
  • But it's been unclear how certain noncoding regions influence gene-expression levels - that is, the number of times a gene is copied into RNA and used to make proteins. (stanford.edu)
  • This receptor is found in moderate levels on some normal cells and as the gene's name implies, it is involved in cellular responses to growth factors. (cancerquest.org)
  • After 3 weeks, we compared body weight, food intake, plasma levels of lipids and glucose, and the expression patterns of the clock genes and the genes involved in lipid metabolism in the liver and WAT. (researchgate.net)
  • More notably, LL markedly decreased not only the amplitude but also the average levels of the expression of the genes in the liver, but not in the WAT, suggesting that transcription in the liver is sensitive to constant light exposure. (researchgate.net)
  • This spectrum of expression of hypogonadism among obese men originates from multiple interacting factors including reduced levels of gonadotropins and testosterone, altered androgen-to-estrogen ratios, insulin resistance, and sleep apnea. (medscape.com)
  • Furthermore, stable viral gene expression was done in cells and subsequently verified by immunoblotting technique. (news-medical.net)
  • Changes in dietary fatty acids, specifically the polyunsaturated fatty acids of the ω-3 and ω-6 families and some derived eicosanoids from lipoxygenases, cyclooxygenases, and cytochrome P-450, seem to control the activity of transcription factor families involved in cancer cell proliferation or cell death. (springer.com)
  • In Xenopus embryos, enforced expression of Tbx20a, but not Tbx20b, led to induction of mesodermal and endodermal lineage markers as well as cell migration, indicating that the long Tbx20a isoform uniquely bears functional domains that can alter gene expression and developmental behaviour in an in vivo context. (nih.gov)
  • How do post-transcriptional events modulate the expression of functional macromolecules, including proteins and non-coding RNAs? (nih.gov)
  • Glial cell line-derived neurotrophic factor family receptor alpha (GFRα) members have been widely connected to the mechanisms contributing to cell growth, differentiation, cell migration and tissue maturation. (medsci.org)
  • We report that chick Dach1 interacts with the Smad complex and the corepressor mouse Sin3a, thereby acting as a repressor of BMP-mediated transcriptional control. (biologists.com)
  • Here, we find that chemotherapy induces the expression of glutathione S-transferase omega 1 (GSTO1), which is dependent on hypoxia-inducible factor 1 (HIF-1) and HIF-2. (nih.gov)
  • Low AKR1B10 expression induces M2 macrophage polarization and promotes the malignant transformation of GC. (portlandpress.com)
  • Quantitative real-time polymerase chain reaction analysis identified that expression patterns of bZIP s differed, including in different organs and under various abiotic stresses. (biomedcentral.com)
  • It was suggested that Tgfβ1 could possibly act as a signaling molecule in controlling collagen gene expression and modulate ECM during ocular growth. (molvis.org)
  • Objective Eating out of phase with the endogenous biological clock alters clock and metabolic gene expression in rodents and can induce obesity and type 2 diabetes mellitus. (researchgate.net)
  • SOX9 expression was found to colocalize with a proportion of so-called scattered tubular cells in the uninjured kidney, a cell population previously shown to be involved in kidney injury and regeneration. (lu.se)
  • They colocalize with insulin granules and interact with SNARE exocytotic machinery, allowing for insulin secretion. (lu.se)
  • We've known for a while that short tandem repeats, or STRs, aren't junk because their presence or absence correlates with changes in gene expression," Fordyce said. (stanford.edu)
  • We report here analysis of Tbx20 expression during murine cardiac development and assessment of DNA-binding and transcriptional properties of Tbx20 isoforms. (nih.gov)
  • Past studies have shown that growth-regulating factors ( GRFs ) and GRF -interacting factors ( GIFs ) are involved in regulating plant growth and development, responding to environmental stress, and responding to the induction of exogenous hormones. (biomedcentral.com)
  • In recent years, studies have shown that GRF transcription factors play essential roles in plant growth development and defence responses to biological and abiotic stresses. (biomedcentral.com)
  • We explore the method on three circuits for haematopoiesis and embryonic stem cell development for commitment and reprogramming scenarios and illustrate how the method can be used to determine sequential steps for onsets of external factors, essential for efficient reprogramming. (lu.se)
  • Tbx20 physically interacted with cardiac transcription factors Nkx2-5, GATA4, and GATA5, collaborating to synergistically activate cardiac gene expression. (nih.gov)
  • Among cardiac GATA factors, there was preferential synergy with GATA5, implicated in endocardial differentiation. (nih.gov)
  • It is also related to increased adiponectin (APN) expression associated with adipocyte differentiation, as well as the expression of adipogenic genes such as peroxisome proliferator-activated receptor ( PPAR) ( 22 , 23 ). (frontiersin.org)
  • The glial cell line-derived neurotrophic factors (GDNFs), a family of neurotrophic factors, were initially thought to be able to regulate the growth, survival, and differentiation of neural-derived cell types. (medsci.org)
  • Certain aspects of the aforementioned diseases have been linked to the aberrant expression and activity of selected gene-expression-programs. (ku.edu)
  • GSTO1 interacts with the ryanodine receptor RYR1 and promotes calcium release from the endoplasmic reticulum. (nih.gov)
  • High expression of lncRNA H19 promotes cell migration and enhances angiogenesis ( 11 , 12 ). (spandidos-publications.com)
  • During its long growth period, it is affected by various environmental factors. (biomedcentral.com)
  • In the animation below, these signals would be represented by the the 'X' shaped growth factor and the foot in the video portion. (cancerquest.org)
  • This growth can occur in the absence of normal pro-growth signals such as those provided by growth factors. (cancerquest.org)
  • As shown below, binding of the growth factor can lead to cell division. (cancerquest.org)