Individuals expressing certain[specify] human leukocyte antigen (i.e. (wikipedia.org)
Individuals possessing human leukocyte antigen (HLA)-B12 are 3 times more likely to develop this disorder. (medscape.com)
Antibodies3
bacterial or viral similarity with self-antigens (molecular mimicry) leading to production of cross-reactive antibodies. (pocketdentistry.com)
ABSTRACT We have raised a panel of 15 monoclonal antibodies (MAbs) recognizing cell surface antigens of the rat osteoblast-like cell line ROS 17/2.8. (docksci.com)
Transcriptome analysis of mouse spleen cells cultured with miso and its raw material revealed that the expression of genes, including interleukin (IL)-10, IL-22 and CD86, was upregulated. (bvsalud.org)
Cell6
HLA) serotypes (i.e. genetic alleles), genetical-based T cell receptors, or variations in their efficiency to absorb, distribute to tissues, metabolize, or excrete (this combination is termed ADME) a drug are predisposed to develop SJS. (wikipedia.org)
The antigens appear to be localized to the cell surface of the osteoblast, with no apparent staining of bone matrix in either undecalcified or decalcified sections. (docksci.com)
In vitro, these MAbs recognize cell surface antigens present on two additional cell lines, ROS 24/1 and Rat 2 cells, and on the adherent cell population cultured from rat long bone marrow. (docksci.com)
This study has also identified cell surface antigens of ROS 17/2.8 cells that are not expressed by osteoblasts in vivo. (docksci.com)
4.5)The object of our study was to raise MAbs to antigens restricted to the plasma membrane of the normal rat OB and to use these MAbs to further characterize the cell surface phenotype of the OB. (docksci.com)
This technique has produced a MAb specific to the cell surface of the chick osteOcyte,'6) to the murine PTH receptor,") and to OB-restricted antigens. (docksci.com)
ERAP1 is a gene that encodes an endoplasmic reticulum amino peptidase, which acts on amino acid terminals in peptides that are then involved in HLA class I molecules, affecting their length for optimum major histocompatibility complex (MHC)-I binding. (medscape.com)
therefore, the association between MICA6 and Behçet disease may be a secondary phenomenon related to HLA-B51. (medscape.com)
Function2
Although HLA-B51 transgenic mice do not develop any manifestations of Behçet disease, their neutrophils show excessive function. (medscape.com)
NKG2D expression on iDNT cells enhanced the regulatory function of these cells. (bvsalud.org)
Class I molecules2
ERAP1 is a gene that encodes an endoplasmic reticulum amino peptidase, which acts on amino acid terminals in peptides that are then involved in HLA class I molecules, affecting their length for optimum major histocompatibility complex (MHC)-I binding. (medscape.com)
Likewise, low expression of inhibitory human leukocyte antigen (HLA) class I molecules is an important prerequisite for successful natural killer cell triggering. (biomedcentral.com)
Molecules2
ERAP1 isoforms may affect some HLA molecules' properties. (medscape.com)
Cancer immunotherapy harnesses a patient's CD4+ and CD8+ T cell responses toward peptide neoantigens, which are displayed on the surface of tumor cells by major histocompatibility complex molecules [MHC, termed human leukocyte antigen (HLA) in humans] ( 1 ). (frontiersin.org)
Alleles3
HLA) serotypes (i.e. genetic alleles), genetical-based T cell receptors, or variations in their efficiency to absorb, distribute to tissues, metabolize, or excrete (this combination is termed ADME) a drug are predisposed to develop SJS. (wikipedia.org)
Here, we employ a bioinformatics method, Prediction of T Cell Epitopes for Cancer Therapy, to analyze sequencing data from neuroblastoma patients and identify a recurrent anaplastic lymphoma kinase mutation ( ALK R1275Q) that leads to two high affinity neoepitopes when expressed in complex with common HLA alleles. (frontiersin.org)
To evaluate the range of HLA alleles that could display the ALK neoepitopes, we used structure-based Rosetta comparative modeling calculations, which accurately predict several additional high affinity interactions and compare our results with commonly used prediction tools. (frontiersin.org)
Peptides1
Analysis of the X-ray structures of the two peptides bound to HLA-B*15:01 reveals drastically different conformations with measurable changes in the stability of the protein complexes, while the self-epitope is excluded from binding due to steric hindrance in the MHC groove. (frontiersin.org)
Human4
Individuals expressing certain[specify] human leukocyte antigen (i.e. (wikipedia.org)
The identification of recurrent human leukocyte antigen (HLA) neoepitopes driving T cell responses against tumors poses a significant bottleneck in the development of approaches for precision cancer therapeutics. (frontiersin.org)
Individuals possessing human leukocyte antigen (HLA)-B12 are 3 times more likely to develop this disorder. (medscape.com)
BACKGROUND AND OBJECTIVES: Human neutrophil antigens (HNAs) are categorized into five systems: HNA-1 to HNA-5. (bvsalud.org)
Tumor2
Through this process, a large and heterogeneous pool of p/MHC antigens is continuously generated in healthy, pathogen infected, or tumor cells as a means of displaying a cell's peptide repertoire to the immune system ( 4 ). (frontiersin.org)
a pipeline for the identification of personalized Variant Antigens by Cancer Sequencing (pVAC-Seq) that integrates tumor mutation and expression data (DNA- and RNA-Seq) ( original article ). (sixthresearcher.com)
Subsequent determination of the X-ray structure of an HLA-A*01:01 bound neoepitope validates atomic features seen in our Rosetta models with respect to key residues relevant for MHC stability and T cell receptor recognition. (frontiersin.org)
This work provides a rational approach toward high-throughput identification and further optimization of putative neoantigen/HLA targets with desired recognition features for cancer immunotherapy. (frontiersin.org)
Pathway2
Using ATM/ATR inhibitor caffeine, the contribution of the DNA damage response pathway to histone deacetylase inhibitor-induced ligand expression was assessed. (biomedcentral.com)
For example, pre-conditioning of various cancer cell types by agents that activate the DNA damage response pathway may sensitize for natural killer cell cytotoxicity via induction of activating natural killer cell receptor ligands and/or death receptor expression. (biomedcentral.com)
Genetic1
CONCLUSION: Physicians' awareness of LAD-I considering delayed separation of umbilical cord marked neutrophilic leukocytosis, and variability in CD11 and CD18 expression levels, and genetic analysis leads to early diagnosis and defining disease severity. (bvsalud.org)
Association2
The evidence of association between HLA-B(∗)1502 and anticonvulsant induced Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) from the Indian population is scant. (nih.gov)
therefore, the association between MICA6 and Behçet disease may be a secondary phenomenon related to HLA-B51. (medscape.com)
Region1
The genes that confer actions, are likely to provide important information susceptibility to IDDM are located in the HLA region regarding the causes of IDDM and lead to approaches of chromosome 6. (nih.gov)
Sensitivity of tumours to natural killer cells critically depends on expression of ligands for activating receptors. (biomedcentral.com)
Finally, MHC tetramer staining of peripheral blood mononuclear cells from HLA-matched donors shows that the two neoepitopes are recognized by CD8+ T cells. (frontiersin.org)
High1
Low-resolution DNA typing for HLA-B and high resolution HLA-B(∗)15 typing was performed. (nih.gov)
Patients2
In a study of 57 Egyptian patients with Behçet disease, it was found that Behçet disease was associated with HLA-A*24 and HLA-B*42 and highly associated with HLA-A*68 and B*15 and B*51, while HLA-A*03 and B*52 were protective against Behçet disease. (medscape.com)
They were found to be risk factors in Behçet disease patients, while HLA-A03 and B49 were found to be protective for Behçet disease. (medscape.com)
Develop1
Although HLA-B51 transgenic mice do not develop any manifestations of Behçet disease, their neutrophils show excessive function. (medscape.com)