• acute
  • Expression of a distinctive BCR-ABL oncogene in Ph1-positive acute lymphocytic leukemia (ALL). (atcc.org)
  • CD19 is an ideal target antigen for immunotherapy because it is expressed on nearly all leukemia cells in most patients with B-cell acute lymphoblastic leukemia (ALL) and chronic lymphoblastic leukemia (CLL) , . (plos.org)
  • phenotype
  • Moreover, a patient-derived PPI 3-11 -specific CD8 T-cell clone shows a proinflammatory phenotype and kills surrogate β-cells and human HLA-A*24 + islet cells in vitro. (diabetesjournals.org)
  • Although antiquated and partial information about the HLA phenotype of some of the NCI-60 cell lines is available through the American Type Culture Collection (ATCC), Rockville, MD, no high-resolution information obtained by definitive sequence-based typing (SBT) has ever been published. (biomedcentral.com)
  • confer
  • More recent, further weight has been added to the importance of the CD8 T-cell autoantigen/HLA class I pathway by the discovery in a large-scale single nucleotide polymorphism study of allelic forms of HLA class I genes that confer significant type 1 diabetes risk ( 6 ). (diabetesjournals.org)
  • targets
  • This study suggests that ( a ) BAX-δ may serve as a widely expressed TAA in B-ALL and ( b ) gene expression profiling can be a generalizable tool to identify immunologic targets for cancer immunotherapy. (aacrjournals.org)
  • class
  • The HLA-A*24 class I gene confers significant risk of disease and early onset. (diabetesjournals.org)
  • HLA-C belongs to the HLA class I heavy chain paralogues. (usc.edu)
  • Rheumatology international 2009 29(11):1293-9, HLA-Cw*06 class I region rather than MICA is associated with psoriatic arthritis in Czech population. (usc.edu)
  • gene expression
  • Recent studies suggest that the risk of AAD development can be also affected by processes influencing gene expression, such as common copy number variation and epigenetic modification. (springer.com)
  • viral
  • In addition, there are several HLA-A*02 haplotypes that appear to contribute heavily to higher or lower viral loads in HIV patients. (wikipedia.org)
  • HLA-A*02-C*16 and HLA-A*02-B*45 have been shown to contribute to significantly increased viral loads (greater than 100,000 copies per milliliter). (wikipedia.org)
  • patients
  • Among patients with EBV+ HL, only 35.5% of people expressed HLA-A*02 compared to 50.9% in the EBV-HL group and 53% in the control group. (wikipedia.org)
  • study
  • In essence, there are indicators, albeit from a small study comparing HLA expression in fertile and infertile couples, that HLA-A*02 may induce increased maternal immune response to the fetus. (wikipedia.org)
  • 2009, Genomewide Association Study of an AIDS-Nonprogression Cohort Emphasizes the Role Played by HLA Genes (ANRS Genomewide Association Study 02). (usc.edu)
  • identification
  • Serotyping can identify as far as HLA-A*02, which is typically enough to prevent transplant rejection (the original motivation for HLA identification). (wikipedia.org)
  • Accurate information about the HLA genotype of each cell line may, in addition, help their identification, validation and qualification among different laboratories excluding possible errors related to switching of cell lines or culture contamination. (biomedcentral.com)
  • positive
  • HLA-A*02 has been linked with decreased risk of developing Epstein-Barr virus (EBV)-positive Hodgkin lymphoma(HL). (wikipedia.org)
  • effective
  • In summation, HLA-A*02 appears to be somewhat less effective than other HLA-As at protecting against HIV infections. (wikipedia.org)
  • studies
  • Studies on T-cell responses in healthy virus carriers have demonstrated a hierarchy of immunodominance among EBV latent antigens. (aacrjournals.org)