Expression gene encodes alcohol aldehyde dehydrogenase. Medical search. Frequent questions

Aldehyde dehydrogenase family 3 member B2 is an enzyme that in humans is encoded by the ALDH3B2 gene. (wikipedia.org)
Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. (nih.gov)
Young males who have experienced a traumatic event can develop low levels of MAO‑A expression (an enzyme that breaks down serotonin), and this decrease in MAO‑A levels correlates with an increase in antisocial behaviour, which is a risk factor for alcohol dependence. (psychscenehub.com)
Sjögren-Larsson syndrome (SLS) is diagnosed by demonstrating the enzyme deficiency or by mutation analysis of the FALDH gene. (medscape.com)
Sjögren-Larsson syndrome (SLS) is due to deficient activity of fatty aldehyde dehydrogenase (FALDH), an enzyme required to oxidize fatty alcohol to fatty acid. (medscape.com)
TaqMan qRT-PCR detection and enzyme activity determination showed that S. scitamineum rapidly proliferated and incurred significant enzyme activity changes in the reactive oxygen species metabolic pathway and phenylpropanoid metabolic pathway at 2 d and 5 d after inoculation, which was the best time points to study target gene degradation during sugarcane and S. scitamineum interaction. (biomedcentral.com)
Diminished activity of aldehyde dehydrogenase (ALDH), a major enzyme in the alcohol-metabolizing pathway, causes the flushing syndrome associated with alcoholic consumption. (bvsalud.org)
Chrysanthemyl diphosphate synthase (CDS), the first enzyme involved in the synthesis of trans-chrysanthemic acid, was characterized previously and its gene isolated. (rhea-db.org)
encodes an enzyme that oxidizes trans-chrysanthemal into trans-chrysanthemic acid. (rhea-db.org)
First, berberine bridge enzyme (BBE), an enzyme not encoded by the cluster, forms the fused four-ring structure in ( S )- scoulerine . (cloudfront.net)
Another cytochrome P450 enzyme (CYP82X1) catalyzes the hydroxylation of C8, and the newly formed hemiaminal spontaneously cleaves, yielding a tertiary amine and aldehyde. (cloudfront.net)

Most ethanol is broken down in the liver in two steps by alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH2) enzymes, which metabolize down ethanol into acetaldehyde and then acetate. (uchile.cl)
Some individuals from the Asian population who carry a mutation in the aldehyde dehydrogenase gene (ALDH2*2) cannot metabolize acetaldehyde as efficiently, producing strong effects, including facial flushing, dizziness, hypotension, and palpitations. (uchile.cl)
The large prevalence of this mutation in the human population strongly suggests that modulation of ALDH2 expression by genetic technologies could result in a similar phenotype. (uchile.cl)
scAAV2 vectors encoding ALDH2 small hairpin RNA (shRNA) were utilized to validate this hypothesis by silencing ALDH2 gene expression in human cell lines. (uchile.cl)
Human cell lines HEK-293 and HepG2 were transduced with scAAV2/shRNA, showing a reduction in ALDH2 RNA and protein expression with the two viral concentration assayed (1 x 10(4) and 1 x 10(5) vg/cell) at two different time points. (uchile.cl)
In both cell lines, ALDH2 RNA levels were reduced by 90% and protein expression was inhibited by 90% and 52%, respectively, 5 days post infection. (uchile.cl)
These results suggest that gene therapy could be a useful tool for the treatment of alcoholism by knocking down ALDH2 expression using shRNA technology delivered by AAV vectors. (uchile.cl)
In addition, alcohol consumption can interact with the polymorphisms of ALDH2 and CYP2E1-RsaI genes to increase OSCC risk [ 12 ]. (biomedcentral.com)

This protein belongs to the aldehyde dehydrogenase family of proteins. (nih.gov)
The pathogenesis of amyotrophic lateral sclerosis (ALS) has not been unclear yet, it might be associated with the abnormal expression and distribution of certain proteins. (ijbs.com)
Interestingly, there was no significant difference in the expression of genes encoding heat shock proteins or antioxidant enzymes in L. trifolii treated with microwave radiation as compared to the untreated control. (bvsalud.org)
There is growing evidence that regions of the genome that cannot encode proteins play an important role in diseases. (biomedcentral.com)
Genes encoding proteins involved in processing of drugs and other xenobiotics. (gsea-msigdb.org)
It binds and inactivates the 140 kDa subunit of RNA polymerase II, blocking all gene expression leading to proteins. (helmberg.at)

Metabolism of ethanol in the human body is a two-step process (Equation 1), mediated by the enzymes alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH). (justia.com)
For example, acetaldehydemia-related facial flushing after light drinking, or upon administration of ethanol-containing pharmaceutical compositions, is experienced by individuals possessing inactive or inefficient aldehyde dehydrogenase (ALDH). (justia.com)
We establish a microbial biosynthetic pathway for PAA production from the simple substrate phenylalanine in E. coli with heterologous coexpression of aminotransferase (ARO8), keto acid decarboxylase (KDC) and aldehyde dehydrogenase H (AldH) gene. (springeropen.com)
In this study, we establish a microbial biosynthetic pathway for PAA production from the simple substrate phenylalanine through overexpression of an aminotransferase gene ARO8, a keto acid decarboxylase gene KDC from S. cerevisiae and an aldehyde dehydrogenase H gene aldH from E. coli in E. coli (Fig. 1 ). (springeropen.com)
This study is the first to report associations between genetic variants in 19 ALDH isoforms, their interaction with alcohol consumption and NPC in an East Asian population. (bvsalud.org)
The remaining MEHP is excreted directly in the urine or is oxidized by cytochrome P450 4A, then further oxidized by alcohol dehydrogenase (ADH) or aldehyde dehydrogenase (ALDH) to dicarboxylic acid or ketones. (who.int)

In these experiments it was found that a glutathione-dependent formaldehyde dehydrogenase that oxidizes formaldehyde 6 was found to be encoded by a gene, which can be transferred between the microorganisms via plasmids, and the mechanisms of resistance can be transferred to unrelated strains of the same bacterial species, such as Escherichia coli. (basicmedicalkey.com)

Gene Ontology (GO) annotation and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis indicated that the predicted target genes were involved in various regulatory processes, such as signal transduction mechanisms, inorganic ion transport and metabolism, defense mechanisms, translation, posttranslational modifications, energy production and conversion, and glycerolipid metabolism. (biomedcentral.com)
Transcriptomic studies of L. trifolii indicated significant enrichment of differentially expressed genes (DEGs) in 'post-translational modification, protein turnover, chaperones', 'sensory perception of pain/transcription repressor complex/zinc ion binding' and 'insulin signaling pathway' when analyzed with the Clusters of Orthologous Groups, Gene Ontology and the Kyoto Encyclopedia of Genes and Genomes databases, respectively. (bvsalud.org)

Pharmacological inhibition of the embryonic alcohol dehydrogenase activity, prevents the oxidation of ethanol to acetaldehyde that in turn functions as a RALDH2 inhibitor. (xenbase.org)
Aldehyde dehydrogenase are a superfamily enzymes which catalyze the oxidation of a large variety of aldehydes (Jo et al. (springeropen.com)
Sjögren-Larsson syndrome can also be diagnosed by directly demonstrating defective fatty alcohol oxidation in a skin-biopsy sample using a histochemical staining method. (medscape.com)

In the embryo , RA production by RALDH2 (ALDH1A2), the main retinaldehyde dehydrogenase expressed at that stage, is inhibited by ethanol exposure. (xenbase.org)
Ethanol-dependent retinoic acid inhibition requires middle-chain alcohol dehydrogenases. (xenbase.org)
On chronic ethanol consumption, ethanol is mainly metabolized in perivenous hepatocytes with high expression of CYP2E1, inducing metabolic stress-mediated death and regeneration of hepatocytes at zone 3. (e-cmh.org)
The engineered strain converts glucose to ethanol via acetate and acetaldehyde, catalyzed by the host-encoded aldehyde ferredoxin oxidoreductase AOR and heterologously expressed AdhA, in an energy-conserving, redox-balanced pathway. (brenda-enzymes.info)
deletion of the hypoxanthine phosphoribosyltransferase gene in ethanol tolerant strain adhE*(EA), carrrying mutation P704L/H734R in the alcohol dehydrogenase gene, and deletion of lactate dehydrogenase (ldh) to redirect carbon flux towards ethanol reults in a strain producing 30% more ethanol than wild type on minimal medium. (brenda-enzymes.info)

Formaldehyde is the simplest of the aldehydes and is also known as methanal. (basicmedicalkey.com)
Some microorganisms have been found to have increased resistance to formaldehyde due to the expression of formaldehyde dehydrogenase. (basicmedicalkey.com)
5 Formaldehyde is oxidized by formaldehyde dehydrogenase. (basicmedicalkey.com)
7 , 8 However, Azachi et al 9 described that formaldehyde dehydrogenase was not the sole reason for increased resistance to formaldehyde in two gram-negative bacteria. (basicmedicalkey.com)

The positive reinforcing action of alcohol comes from the activation of the dopaminergic reward pathway in the limbic system . (psychscenehub.com)
However, chronic alcohol consumption decreases GSH generation through cysteine deficiency by suppressing the methionine cycle and trans-sulfuration system, whereas it turns on an alternative defense pathway, such as the xCT transporter, to compensate for GSH shortage. (e-cmh.org)
construction of a synthetic pathway for bioalcohol production at 70°C by insertion of the gene for alcohol dehydrogenase AdhA into the archaeon Pyrococcus furiosus. (brenda-enzymes.info)
The AOR/AdhA pathway also converts exogenously added aliphatic and aromatic carboxylic acids to the corresponding alcohol using glucose, pyruvate, and/or hydrogen as the source of reductant. (brenda-enzymes.info)
We found significant dysregulation of genes encoding drug-metabolizing enzymes and stress response components of the NRF2- mediated oxidative damage pathway, potentially representing key genes in African-American esophageal squamous carcinogenesis. (biomedcentral.com)
The remainder of the noscapine biosynthetic pathway is largely governed by a single biosynthetic 10-gene cluster. (cloudfront.net)

Furthermore, the results proved that the Hsf1, an upstream transcription factor of Hsps, had a positive effect on alleviating the unfolded protein response and that overexpression of Hsf1 reprogramed the pattern of ATF1 gene transcript levels. (biomedcentral.com)
It is beneficial to improve the protein expression and product yield by controlling the promoter strength to fine regulate the transcription level of the target gene and maximize the transcription efficiency. (biomedcentral.com)
In order for a cell to respond to changes in internal and external environmental factors, a broad range of protein co- and post-translational modifications have evolved to expand upon the relatively static properties encoded in protein side-chains. (biologists.com)
The expression of DEGs encoding cuticular protein and protein takeout were silenced by RNA interference, and the results showed that knockdown of these two DEGs reduced the survival of L. trifolii exposed to microwave radiation. (bvsalud.org)
Differential expression of polycytosine-binding protein isoforms in adrenal gland, locus coeruleus and midbrain. (rochester.edu)
What does this gene/protein do? (cancerindex.org)
What pathways are this gene/protein implicaed in? (cancerindex.org)
Scope includes mutations and abnormal protein expression. (cancerindex.org)
Stable expression of GFP-fused OsbHLH035 in rice transgenic plants revealed that this protein is predominantly localized to the nucleus. (springeropen.com)
Immunoflourescence images of expression of Nrf2 and HO-1 showing thealteration of key protein markers of antioxidant gene expression, read more in 'Melatonin targets ferroptosis through bimodal alteration of redox environment and cellular pathways in NAFLD model' from Saha et al, in this edition of Bioscience Reports. (portlandpress.com)
The p53 protein is a transcription factor that normally inhibits cell growth and stimulates cell death in response to myriad stressors, including DNA damage (induced by either UV or chemical agents such as hydrogen peroxide), oxidative stress, and deregulated oncogene expression [6-10]. (bioinf.org)

It is well established that acetaldehyde is the culprit in hangovers and in alcohol-induced facial flushing, and it is the principal suspect in alcohol-associated cancers as well vide infra. (justia.com)
It is a drug that modifies the metabolism of alcohol, which causes a considerable increase in the level of acetaldehyde in the blood. (essentialhospitals.org)
The Disulfiram effect is due to the accumulation of acetaldehyde in the body (one of the components resulting from the metabolism of alcohol). (essentialhospitals.org)
Acetaldehyde inhibits retinoic acid biosynthesis to mediate alcohol teratogenicity. (xenbase.org)

dehydrogenase/reductase 1 [Source:HGNC. (gsea-msigdb.org)

Variation in genes encoding enzymes involved in the metabolism of alcohol dehydrogenase or aldehyde dehydrogenase has been shown to influence the risk of alcohol dependence. (psychscenehub.com)

Alcohol consumption during pregnancy induces Fetal Alcohol Spectrum Disorder (FASD), which has been proposed to arise from competitive inhibition of retinoic acid (RA) biosynthesis. (xenbase.org)
The enzymatic requirements for EtOH to inhibit RA biosynthesis were studied using inhibitors of the middle-chain alcohol dehydrogenases (ADH), 4-methylpyrazole (4MP), or the short-chain dehydrogenase/reductases, carbenoxolone (CBX) and chloral hydrate (CH). Late blastula stage embryos were treated with EtOH alone or in combination with 4MP (a,b), CH (c,d) or CBX (e,f). (xenbase.org)
In this study, an Escherichia coli K-12 MG1655 strain with reduced aromatic aldehyde reduction (RARE) that does duty for a platform for aromatic aldehyde biosynthesis was used to prompt more PAA biosynthesis. (springeropen.com)
In contrast, Annong1589 showed a passive prevention of the spread of toxins into cells by the upregulation of genes involved in tyramine biosynthesis at the early stage (5 DPA), which may be involved in cell wall strengthening. (biomedcentral.com)

Acamprosate used in the treatment of alcohol dependence has demonstrated that its mechanism of action is through its inhibition of the NMDA receptor. (psychscenehub.com)

alpha-ketoisovalerate decarboxylase Kivd from Lactococcus lactis combined with alcohol dehydrogenase Adh3 from Zymomonas mobilis are the optimum candidates for 3-methyl-1-butanol production in Corynebacterium glutamicum. (brenda-enzymes.info)

The Arabidopsis phyB-9 mutant has a second-site mutation in the VENOSA4 gene that alters chloroplast size, photosynthetic traits, and leaf growth. (umh.es)

Two major liver isoforms of aldehyde dehydrogenase, cytosolic and mitochondrial, can be distinguished by their electrophoretic mobilities, kinetic properties, and subcellular localizations. (nih.gov)
A remarkably higher frequency of acute alcohol intoxication among East Asians than among Caucasians could be related to the absence of a catalytically active form of the mitochondrial isozyme. (nih.gov)
This gene encodes a mitochondrial isoform, which has a low Km for acetaldehydes, and is localized in mitochondrial matrix. (nih.gov)

Furthermore, the C. difficile toxin genes (tcdA and tcdB) and their regulators (tcdR and tcdC) are direct CcpA targets. (studyres.com)

RNA-sequencing analysis showed that the overexpression of differential gene HSP30 increased the transcriptional abundance of ATF1 gene and production of ethyl acetate. (biomedcentral.com)

2016 ). However, aldehyde dehydrogenase involved in the last step to generate PAA has not yet been experimentally characterized and this knowledge gap limits the process development for producing PAA from phenylalanine. (springeropen.com)

Nasopharyngeal carcinoma (NPC) and alcohol flush syndrome are thought to be strongly influenced by genetic factors and are highly prevalent amongst East Asians. (bvsalud.org)

Aldehyde dehydrogenase 2 rs671 genetic polymorphisms are associated with chemotherapy-induced nausea and vomiting]. (nih.gov)

The gene is part of a cluster of MMP genes on chromosome 11. (cancerindex.org)

The gene encoding FALDH is called the ALDH3A2 gene (or ALDH10 ) and has been mapped to the Sjögren-Larsson syndrome locus on band 17p11.2. (medscape.com)

We used an RNA sequencing-based approach and coexpression correlation analysis to identify several candidate genes encoding putative trans-chrysanthemol and trans-chrysanthemal dehydrogenases. (rhea-db.org)
Differentially expressed genes (DEGs) were seared by combing the TCGA database and the Gene Expression Omnibus (GEO) database, and the key molecule AKR1B10 was identified by weighted gene coexpression network analysis (WGCNA). (portlandpress.com)

Whereas, microorganic synthesis of PAA is impeded by the formation of by-product phenethyl alcohol due to quick, endogenous, and superfluous conversion of aldehydes to their corresponding alcohols, which resulted in less conversation of PAA from aldehydes. (springeropen.com)
Accumulation of long-chain fatty alcohols and modification of macromolecules by an excess of fatty aldehydes are thought to be the pathophysiologic mechanisms causing the manifestations of Sjögren-Larsson syndrome. (medscape.com)

Alcohol dependence is characterised by deficits in the physiological dysregulation of motivation and reward systems , such as those in the limbic system, hippocampus, amygdala, caudate nucleus, frontal lobe and nucleus accumbens. (psychscenehub.com)
Tumor initiation and progression often involve the dysregulation of developmentally important genes in cancer cells, endowing them with stem cell-like features such as enhanced self-renewal, invasiveness, and an aberrant differentiation state [ 1 ]. (nature.com)

Several studies have shown that the presence of ADH2*2 alleles, which encode hyper-active forms of alcohol dehydrogenase (W. F. Bosron, T. K. Li, Hepatology, 1986 6:502-510), also contributes to alcohol flushing and a predisposition to esophageal cancer (A. Shibuya et al. (justia.com)

moreover, these polymorphisms also have an impact on the risk of alcohol-related cancers, such as esophageal cancer. (nih.gov)
This gene exhibits elevated expression levels in multiple human cancers. (cancerindex.org)
In the context of aberrant growth control, many important genes responsible for the genesis of various cancers have been discovered and the pathways through which they act characterized. (bioinf.org)

more recently, however, modern advances in genotyping have resulted in widespread use of genome-wide association studies for alcohol dependence. (nih.gov)
Genome-wide association studies now offer a host of emerging opportunities, as well as challenges, for discovering the genetic etiology of alcohol dependence and for unveiling new treatment strategies. (nih.gov)
Recent genome-wide association studies, gene expression profiling, DNA methylation and proteomic studies conducted in Japanese and Chinese ESCCs (reviewed in [ 6 ]) have identified multiple risk variants and gene signatures associated with ESCC. (biomedcentral.com)

However, the results of many researches proved that excessive transcription levels of target genes actually reduced the yield of the target product. (biomedcentral.com)
However, to date, there is no report on the identification of microRNA (miRNA) target genes of sugarcane in response to smut pathogen infection by degradome technology. (biomedcentral.com)
A total of 309 target genes were predicted in sugarcane, corresponding to 97 known miRNAs and 112 novel miRNAs, and 337 degradation sites, suggesting that miRNAs can efficiently direct cleavage at multiple sites in the predicted target mRNAs. (biomedcentral.com)
qRT-PCR analysis of the expression level of 13 predicted target genes and their corresponding miRNAs revealed that there was no obvious negative regulatory relationship between miRNAs and their target genes. (biomedcentral.com)
In addition, a number of putative resistance-related target genes regulated by miRNA-mediated cleavage were accumulated in sugarcane during S. scitamineum infection, suggesting that feedback regulation of miRNAs may be involved in the response of sugarcane to S. scitamineum infection. (biomedcentral.com)
This study elucidates the underlying response of sugarcane to S. scitamineum infection, and also provides a resource for miRNAs and their predicted target genes for smut resistance improvement in sugarcane. (biomedcentral.com)
The understanding of how miRNAs regulate the expression of their target genes in response to S. scitamineum infection is limited. (biomedcentral.com)

Alcohol acts presynaptically at the GABA neuron,, increasing GABA release and postsynaptically enhancing GABA receptor action. (psychscenehub.com)
Liang H, Wu C, Deng Y, Zhu L, Zhang J, Gan W, Tang C, Xu R. Aldehyde Dehydrogenases 1A2 Expression and Distribution are Potentially Associated with Neuron Death in Spinal Cord of Tg(SOD1*G93A)1Gur Mice. (ijbs.com)
The expression decrease of ALDH1A2 followed with the increase of neuron cells death. (ijbs.com)

Loss of activity of drug metabolizing enzymes would confer increased sensitivity of esophageal cells to xenobiotics, such as alcohol and tobacco smoke, and may account for the high incidence and aggressiveness of ESCC in this ethnic group. (biomedcentral.com)

The purified ReBDH in the native form was found to exist as a monomer with a calculated subunit size of 37180, belonging to the family of the zinc-containing alcohol dehydrogenases. (mdpi.com)

The dysfunction of these systems is responsible for acute alcohol intoxication, alcohol dependence, and withdrawal syndrome. (psychscenehub.com)

Genetic predisposition plays a role, with certain individuals having a higher susceptibility to alcohol addiction. (anormed.com)

The definitive test for Sjögren-Larsson syndrome (SLS) is measurement of FALDH or fatty alcohol:NAD oxidoreductase in cultured skin fibroblasts. (medscape.com)

The GWD gene, which is known to regulate starch phosphorylation-dephosphorylation, participates in the regulation of a number of morphological traits, rather than one specific trait. (peerj.com)
By whole transcriptome analyses, we characterized glucosedependent and CcpA-dependent gene regulation in Clostridium difficile. (studyres.com)
About 18% of all C. difficile genes are regulated by glucose, for which 50% depend on CcpA for regulation. (studyres.com)
In synthetic biology, the strength of promoter elements is the basis for precise regulation of target gene transcription levels, which in turn increases the yield of the target product. (biomedcentral.com)
Hsp26, Hsp78, Hsp82) decreased the production of ethyl acetate, suggesting that the Hsp family was also involved in the regulation of ATF1 gene transcription. (biomedcentral.com)
Posttranscriptional regulation of adrenal TH gene expression contributes to the maladaptive responses triggered by insulin-induced recurrent hypoglycemia. (rochester.edu)
Post-transcriptional regulation of tyrosine hydroxylase expression in adrenal medulla and brain. (rochester.edu)

In 2018, the World Health Organization reported that 3 million people per year die as a result of the abuse of alcohol [ 1 - 3 ]. (e-cmh.org)

To date, more than 70 different FALDH gene mutations have been found in patients with Sjögren-Larsson syndrome. (medscape.com)

This gene encodes a member of the aldehyde dehydrogenase family, a group of isozymes that may play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. (wikipedia.org)

Virulence is controlled by a set of transcriptional regulators that directly bind to DNA promoter regions of toxin-encoding genes. (cipsm.de)

The CcpA regulon comprises genes involved in sugar uptake, fermentation and amino acids metabolism, confirming the role of CcpA as a link between carbon and nitrogen pathways. (studyres.com)
p53 is a master gene regulator controlling diverse cellular pathways, by either activating or repressing downstream genes. (bioinf.org)

Search the gene expression profiles from curated DataSets in the Gene Expression Omnibus (GEO) repository. (cancerindex.org)

In this study, promoters PGK1p and TDH3p with different strengths were used to regulate the transcription level of alcohol acetyl transferase encoding gene ATF1 . (biomedcentral.com)
for example, they provide structural stability to cells and tissues, give motility to individual cells, carry messages within and between cells, and regulate gene expression and metabolism. (biologists.com)

Chronic alcohol consumption induces the development of alcoholic steatosis in the liver, which is one of the most widespread liver diseases worldwide. (e-cmh.org)
Low AKR1B10 expression induces M2 macrophage polarization and promotes the malignant transformation of GC. (portlandpress.com)

Aldehyde dehydrogenases 1A2 (ALDH1A2) was thought to be one of potential candidates. (ijbs.com)
Therefore, in this study we observed and analyzed the alteration of the expression and distribution of ALDH1A2 in the spinal cord of wild-type (WT) and Tg(SOD1*G93A)1Gur mice. (ijbs.com)
We compared the expression and distribution of ALDH1A2 in the different segments, anatomic regions and neural cells of spinal cord at the different stages of WT and Tg(SOD1*G93A)1Gur mice applied the methods of fluorescent immunohistochemistry and western blot. (ijbs.com)
The expression and distribution of ALDH1A2 in the white matter including the anterior, posterior and lateral funiculus were more than that in the gray matter including the central canal, the anterior and dorsal horn. (ijbs.com)
The ALDH1A2 expression significantly decreased and redistributed in some anatomic regions of spinal cord at the onset and progression stages of Tg(SOD1*G93A)1Gur mice. (ijbs.com)
This study suggested that the alteration of expression and distribution of ALDH1A2 was potentially associated with the pathogenesis of ALS. (ijbs.com)

The compositions of the invention are expected to ameliorate some of the negative side effects associated with the consumption of alcohol, such as hangover and facial flushing. (justia.com)
In the latter case, they appeared due to the simultaneous consumption of alcohol and cyanamide. (essentialhospitals.org)
It is a chronic and progressive disorder characterized by an individual's inability to control or stop their consumption of alcohol, despite negative consequences. (anormed.com)

Early exposure to alcohol, including parental drinking behaviours, can increase the risk of alcohol addiction in individuals. (anormed.com)

Therefore, when plants are exposed to salt, the phytohormone ABA, TFs, and transporters act as key components that integrate cellular signal transduction and stress-responsive gene expression to confer salt tolerance. (springeropen.com)

Disulfiram clearly improves the results of psychosocial therapy (the most effective to solve alcohol dependence). (essentialhospitals.org)

DNA tests can detect mutations in the ALDH3A2 gene and are considered a diagnostic test of choice. (medscape.com)

The pathogenesis in the early stages of ALD, including alcoholic steatosis, also varies with oxidative stress, alcohol metabolite-mediated toxicity, and activation of diverse inflammatory signals. (e-cmh.org)

Alternative splicing results in multiple transcript variants encoding distinct isoforms. (nih.gov)

Anatomy7

Organisms5

Diseases7

Chemicals and Drugs112

Analytical, Diagnostic and Therapeutic Techniques and Equipment9

Psychiatry and Psychology4

Phenomena and Processes25

Disciplines and Occupations1

Technology, Industry, Agriculture2

Information Science3

Enzyme11

ALDH28

Proteins6

ALDH6

Glutathione-dependent formaldehyde dehydrogenase1

Kyoto Encyclo2

Oxidation3

Ethanol5

Formaldehyde4

Pathway6

Protein11

Acetaldehyde4

Reductase1

Metabolism of alcohol1

Biosynthesis4

Inhibition1

ADH31

Mutation1

Mitochondrial3

Toxin genes1

Overexpression1

20161

East Asians1

Rs6711

Chromosome1

Locus1

Coexpression2

Alcohols2

Dysregulation2

ADH21

Cancers3

Genome-wide as3

Target genes7

Neuron3

Activity1

Subunit1

Acute alcohol into1

Susceptibility1

Fatty alcohol1

Regulation7

20181

FALDH1

Detoxification1

Transcriptional1

Pathways2

Datasets1

Regulate2

Induces2

ALDH1A26

Consumption of alcohol3

Risk of alcohol1

Signal transduction1

Improves1

ALDH3A21

Oxidative stress1

Isoforms1