Expression disease autoantigens. Medical search. Frequent questions

Understanding the mechanism underlying EBV's role in autoimmunity could lead to the development of targeted therapies for these diseases. (lupusresearch.org)
Animal studies have demonstrated potentiated autoimmunity, arthritis, and profibrotic/inflammatory lung disease with combination of airborne exposures and collagen-induced arthritis (CIA). (cdc.gov)
Graves' orbitopathy (GO) is the main extrathyroidal manifestation of GD, potentially involving autoimmunity against the IGF1 receptor (IGF1R: We tested for autoantibodies against the IGF1R (IGF1R-Abs) in sera of GD patients and controls and elucidated their possible implication in the disease. (thyroidmanager.org)
Many of the autoantigens generated by neutrophils in NETs, including double-stranded deoxyribonucleic acid (DNA), citrullinated peptides, histones, myeloperoxidase (MPO), and proteinase 3 (PRTN3), are known to be attacked by the adaptive immune system observed in systemic autoimmunity. (news-medical.net)
In Graves disease, B and T lymphocyte-mediated autoimmunity are known to be directed at 4 well-known thyroid antigens: thyroglobulin, thyroid peroxidase, sodium-iodide symporter and the thyrotropin receptor. (medscape.com)
The genetic predisposition to thyroid autoimmunity may interact with environmental factors or events to precipitate the onset of Graves disease. (medscape.com)
The overall focus of our laboratory investigates how the immune system is involved in the pathogenesis of human diseases, including asthma, autoimmunity and cancer, and novel ways to treat disease including nanotechnology based approaches. (boisestate.edu)
An active area of research in our lab is investigating the potential applications of metal oxidenanomaterials on the immune response and treatment of human diseases including cancer and autoimmunity. (boisestate.edu)
Shepshelovich D and Shoenfeld Y (2006) Prediction and prevention of autoimmune diseases: additional aspects of the mosaic of autoimmunity. (nature.com)
In 1983, a hypothesis concerning the relevance of class II expression and antigen presentation to the induction and maintenance of endocrine autoimmunity was published. (ox.ac.uk)

However, the pathogenesis of autoimmune diseases has not been clearly elucidated. (frontiersin.org)
MiRNAs also play a role in the pathogenesis of these diseases and several known miRNAs that are involved in these diseases have also been shown to play a role in CD8+ regulation. (frontiersin.org)
It is becoming evident that both the innate and the adaptive immune response are involved in the pathogenesis of autoimmune diseases ( 4 ), especially adaptive immune response. (frontiersin.org)
However, mounting evidence has suggested that CD8+ T cells, in particular, play an important role in the induction, progression, pathogenesis, and protection for autoimmune diseases ( 5 ). (frontiersin.org)
He identified a link between autoantigen gene expression and ANCA mediated neutrophil activation that supports the model that ANCA pathogenesis involves regulation of the autoantigen, not just the presence of autoantibody. (unc.edu)
Autoantibodies directed against molecules that are unique to the surface of cells in the parenchyma of discrete organs underlie the pathogenesis of a variety of organ-specific autoimmune diseases ( 1 ). (silverchair.com)
In addition to the TSH receptor, the IGF-I receptor (IGF-IR) has been proposed to be a second autoantigen that plays a role in the pathogenesis of GO. (thyroidmanager.org)
As a chronic autoimmune disease, the pathogenesis of SS remains insufficiently identified. (hindawi.com)
Although the nature of the antigens responsible for RA pathogenesis is unknown, there is evidence that the disease-associated HLA-DR (B1*0401, 0404, 0405 and 0101) molecules are involved in disease pathogenesis [ 2 ]. (biomedcentral.com)
The role of the immune system and cytokines involved in the pathogenesis of autoimmune thyroid disease (AITD). (scienceopen.com)
However, the pathogenesis of VKH disease is uncertain, although the wide spectrum of findings in this disorder suggests a central mechanism to account for the multisystemic manifestations. (medscape.com)
The possibility that VKH disease has an autoimmune pathogenesis is supported by the statistically significant frequency of HLA-DR4, an antigen commonly associated with other autoimmune diseases. (medscape.com)

Autoimmune diseases are usually complex and multifactorial, characterized by aberrant production of autoreactive immune cells and/or autoantibodies against healthy cells and tissues. (frontiersin.org)
Autoimmune diseases are complex diseases characterized by the loss of immunological tolerance to self-antigens and sustained aberrant immunological response against healthy cells and tissues, leading ultimately to the overproduction of autoreactive immune cells and/or autoantibodies ( 1 , 2 ). (frontiersin.org)
In autoimmune diseases, these target cells killed by autoreactive CD8+ T cells can release numerous autoantigens to induce the overproduction of autoantibodies, and finally lead to the death of self-cells. (frontiersin.org)
Graves disease is an autoimmune disorder characterized by hyperthyroidism due to circulating autoantibodies. (medscape.com)
Graves' Disease results from the production of autoantibodies against receptors for thyroid stimulating hormone (TSH) on thyroid epithelial cells, and represents the prototype for numerous autoimmune diseases caused by autoantibodies that bind to organ-specific cell membrane antigens. (silverchair.com)
For example, production of autoantibodies that bind to and stimulate the thyroid-stimulating hormone (TSH) receptor cause the thyrotoxicosis of Graves' Disease, and anti-thyroid peroxidase antibody in Graves' and Hashimoto's thyroiditis is thought to inhibit thyroid function and promote complement deposition and thyroid destruction ( 2 ). (silverchair.com)
Autoantibodies against the encoded protein may be markers for scleroderma and Crohn's disease. (nih.gov)
Autoantibodies against ubiquitination factor E4A (UBE4A) are associated with severity of Crohn's disease. (nih.gov)
In diseases and conditions in which autoantibodies are generated (e.g., autoimmune disease, cancer), the adaptive immune system escapes "tolerance", the internal checks and balances that would normally prevent the generation of antibodies that bind to self-antigens, and results in chronic inflammation, fibrosis, progressive tissue damage or a combination of the foregoing. (justia.com)
The present invention addresses this need, by providing methods for identifying such autoantigens and autoantibodies. (justia.com)
Systemic lupus erythematosus (SLE) is a systemic autoimmune disease which is classically characterised by a variety of autoantibodies to deoxyribonucleic acid (DNA), ribonucleic acid (RNA), other nuclear and cytoplasmic antigens. (openrheumatologyjournal.com)
Graves disease, named after Robert J. Graves, MD,[1] circa 1830s, is an autoimmune disease characterized by hyperthyroidism due to circulating autoantibodies. (medscape.com)
Direct proof of an autoimmune disorder that is mediated by autoantibodies is the development of hyperthyroidism in healthy subjects by transferring thyrotropin receptor antibodies in serum from patients with Graves disease and the passive transfer of thyrotropin receptor antibodies to the fetus in pregnant women. (medscape.com)
6] Moreover, strong associations of thyroid-stimulating hormone receptor and major histocompatibility complex class II variants with persistently thyroid stimulating hormone receptor autoantibodies (TRAb)-positive Graves disease were found. (medscape.com)
Production of autoantibodies directed against nuclear Ags and myriad other autoantigens characterize SLE. (researchdataservice.com)

In each of these diseases, genes that play a role in the proliferation or activation of CD8+ T cells have been found to be affected by epigenetic modifications. (frontiersin.org)
They went on to identify differences in chromatin modifications between healthy individuals and patients with ANCA disease, which implicates epigenetic control of expression of autoantigen genes. (unc.edu)
4, 5] Some of these susceptibility genes are specific to either Graves disease or Hashimoto thyroiditis, while others confer susceptibility to both conditions. (medscape.com)
The human leukocyte antigen class II genes DRB1, DQB1, and DQA1 are associated with Graves disease (GD), but, because of strong linkage disequilibrium within this region, the primary etiological variant(s) remains unknown. (lincoln.ac.uk)
Total RNA from tumors the expression of thousands of genes (3) to address complex questions was isolated using two successive rounds of Trizol. (lu.se)

He has Identified an association between a genetic variant and expression of the PRTN3 gene, which encodes the autoantigen PR3, and increased risk of relapse in patients with PR3-ANCA vasculitis who carry the genetic variant. (unc.edu)
Dr. Cotsapas has developed a set of diagnostic tools to compare genetic information from different diseases and identify the regions in the genome (DNA) associated with the disease risks. (lupusresearch.org)
This highlights the areas that we do not yet understand, namely the interplay of genetic susceptibility, extrinsic agents or disorders of immune regulation which permit the autoimmune process to become sufficiently pronounced as to engender a clinical autoimmune disease. (ox.ac.uk)
Autoimmune rheumatic diseases are considered to be influenced by both genetic and environmental factors. (nature.com)
Tobacco smoking has been linked to the development of rheumatic diseases, namely systemic lupus erythematosus and rheumatoid arthritis, and has been shown to interact with genetic factors to create a significant combined risk of disease. (nature.com)
VKH disease occurs more commonly in patients with a genetic predisposition to the disease, including those from Asian, Middle Eastern, Hispanic, and Native American populations. (medscape.com)
Host genetic risk factors for West Nile virus infection and disease progression. (cdc.gov)
Identification of genetic variants associated with susceptibility to West Nile virus neuroinvasive disease. (cdc.gov)

These relationships have been studied in various autoimmune diseases, including multiple sclerosis (MS), systemic sclerosis (SSc), type 1 diabetes (T1D), Grave's disease (GD), systemic lupus erythematosus (SLE), aplastic anemia (AA), and vitiligo. (frontiersin.org)
Type 1 diabetes is an autoimmune disease that causes loss of pancreatic beta cells, which produce endogenous insulin. (sciencedaily.com)
Thus, serum CHGA seems to reflect changes in beta cell function in response to verapamil treatment or Type 1 diabetes progression and therefore may provide a longitudinal marker of treatment success or disease worsening," Shalev said. (sciencedaily.com)
Immunohistopathological studies of pancreases from individuals with type 1 diabetes are generally compatible with these observations made in mice (see references below) but have exposed additional phenomena peculiar to the natural history of the disease in humans. (springer.com)

The protein can act as an autoantigen in pemphigus diseases, and it is also considered to be a biomarker for some cancers. (nih.gov)
Human thyroid peroxidase (TPO) isoforms, and TPO-2: analysis of protein expression in Graves' tissue. (rusmedserv.com)
In 1997 Haneji and colleagues recognized a 120 kDa fragment of the ubiquitous cytoskeletal protein -fodrin as an autoantigen in the NFS/sld mouse model of human SS [1]. (asiatox.org)
Large-scale bacterial expression and fusion protein purification A 5 ml saturated culture of pGEX-4T-2C-fodrin-transformed bacteria produced in Luria-Bertani(LB) medium supplemented with ampicillin (100. (asiatox.org)
Our laboratory, in collaboration with Dr. Ann Marshak-Rothstein, is defining the protein and nucleic acid composition of these immunostimulatory autoantigens and determining whether different forms of apoptosis are capable of selectively releasing these autoantigens from cells, thereby making them accessible to autoreactive B cells. (bu.edu)
Scope includes mutations and abnormal protein expression. (cancerindex.org)
Beta-agonists, by increasing cAMP levels in the cell, can elevate the expression of CD40L protein on T cells from asthmatics. (boisestate.edu)
The goal of our research is to determine the molecular and cellular mechanisms leading to dysregulated CD40L protein expression in asthma. (boisestate.edu)
Loss of expression of the double strand break repair protein ATM is associated with worse prognosis in colorectal cancer and loss of Ku70 expression is associated with CIN. (ox.ac.uk)
Here we have shown that a known nuclear matrix binding protein SMAR1 is selectively expressed more in colonic Treg cells and is required for their ability to accumulate at inflammatory site and to sustain high levels of Foxp3 and IL-10 expression during acute colitis. (ozgene.com)
The myelin-associated stress protein αB-crystallin triggers strong proliferative responses and IFN-γ production by human T cells and it is considered a candidate autoantigen in multiple sclerosis. (tno.nl)
The myelin-associated protein, αB-crystallin, is considered a candidate autoantigen in multiple sclerosis (MS). In the present study, we examined the potential of αB-crystallin to induce experimental autoimmune encephalomyelitis (EAE) in Lewis rats. (tno.nl)
We will also analyze the peptides presented by dendritic cells from healthy donors expressing T1D-associated HLA alleles pulsed with b-cells protein extracts and/or soluble autoantigens. (uab.cat)

Through his investigations, he proposed a pathogenic role for autoantigen gene expression by demonstrating autoantigen gene expression correlated with ANCA mediated neutrophil activation. (unc.edu)
As the condition worsens, neutrophil-specific gene expression is enriched in the neutrophil populations of SLE patients relative to healthy controls. (news-medical.net)
Recent findings have demonstrated that activation of certain nuclear receptors (NR), including peroxisome proliferator activated receptor (PPAR), liver X receptor (LXR), and glucocorticoid receptor (GR)) potently inhibits TLR-induced inflammatory gene expression in MØ, LC/DC, and epithelial cells. (bu.edu)
Search the gene expression profiles from curated DataSets in the Gene Expression Omnibus (GEO) repository. (cancerindex.org)
The regulatory deficiency of NKT cells in T1D patients can be related to a differentiated gene expression pattern compared to NKT cells from healthy controls (ongoing research). (uab.cat)

The DNAseII x IFNaR double-deficient mice develop a systemic autoimmune disease associated with hepatic inflammation and fibrosis. (umassmed.edu)
Sjögren's syndrome (SS) is well-recognized as a systemic autoimmune disease, and it is characterized by manifestations of sicca (dryness) of the oral, ocular mucosa, and genital taking diverse exocrine glands as targets [ 1 ]. (hindawi.com)
SLE is a type I interferon response-heavy systemic autoimmune disease that displays high autoreactivity against nucleic acids and other nuclear and intracellular components. (news-medical.net)
Systemic lupus erythematosus is a systemic autoimmune disease with diverse clinical manifestations which are often complex and occur as a result of inflammation in target organs. (openrheumatologyjournal.com)

In animal models, it has been suggested to be a potent autoantigen that induces the airway disease of RPC, but the expression of matrilin-1 in tracheobronchial tissue in humans is unclear. (medjournal360.com)

Dr. Steere currently serves as Professor of Medicine at Harvard Medical School and Director of Translational Research in Rheumatology at Massachusetts General Hospital, where he studies basic pathologic features of Lyme disease and rheumatoid arthritis. (massgeneral.org)
Graves disease is associated with pernicious anemia , vitiligo , diabetes mellitus type 1 , autoimmune adrenal insufficiency , systemic sclerosis , myasthenia gravis , Sjögren syndrome , rheumatoid arthritis , and systemic lupus erythematosus . (medscape.com)
Respiratory-related diseases are a leading cause of death in rheumatoid arthritis (RA) and are disproportionately higher in men, which may be attributable to environmental risk factors. (cdc.gov)
Symptoms of secondary SS are aggravated accompanying with additional autoimmune diseases including systemic lupus erythematosus, systemic sclerosis, or rheumatoid arthritis [ 3 ]. (hindawi.com)
Particularly in the initial phases of the disease, rheumatoid arthritis patients have an abundance of neutrophils in their inflamed joints that might produce NETs locally. (news-medical.net)
The authors found coexisting disorders in 9.7% of patients with Graves disease and in 14.3% of those with Hashimoto thyroiditis, with rheumatoid arthritis being the most common of these (prevalence = 3.15% and 4.24% in Graves disease and Hashimoto thyroiditis, respectively). (medscape.com)
in other diseases such as rheumatoid arthritis the evidence is increasing. (ox.ac.uk)
Smoking increases the risk of dermatologic features and nephritis in systemic lupus erythematosus, rheumatoid nodules and multiple joint involvement in rheumatoid arthritis and digital ischemia in systemic sclerosis, as well as further increasing the risk of accelerated atherosclerosis in these diseases. (nature.com)

They have higher concentrations of modified autoantigens and immunostimulatory molecules. (news-medical.net)

CIA+LPS-induced lung histopathology changes and the expression of lung autoantigens including malondialdehyde acetaldehyde (MAA)- and citrulline (CIT)-modified proteins and vimentin were reduced in castrated animals. (cdc.gov)
Loss of expression of the DSB repair proteins have previously been shown to be associated with poorer survival in colorectal cancer. (ox.ac.uk)
We wished to ascertain the relationship of altered expression of the DSB repair proteins γ-H2AX (gamma-H2AX), ATM and Ku70 with biological and clinico-pathological features of colorectal cancer. (ox.ac.uk)
Respect to the recognition of proteins by T cells, our approach, following our previous experience with T1D and other autoinmune diseases, is to find T cell ligands that are present in the periphery but are not found in the thymus. (uab.cat)

Other conditions that can produce similar symptoms include Graves' disease and nontoxic nodular goiter. (wikipedia.org)
Graves disease , along with Hashimoto thyroiditis , is classified as an autoimmune thyroid disorder . (medscape.com)
In some patients, Graves disease represents a part of more extensive autoimmune processes leading to dysfunction of multiple organs (eg, polyglandular autoimmune syndromes ). (medscape.com)
[ 2 ] Moreover, advances in cancer immunotherapy with immune checkpoint inhibitors (anti-CTLA-4, anti-PD-1, and anti-PD-L1 antibodies) have led to immune-related adverse effects, including problems affecting the thyroid glands (ie, thyroiditis [typically with a transient hyperthyroid phase followed by a permanent hypothyroid phase] and Graves disease). (medscape.com)
Graves disease may be associated with normocytic anemia, low-normal to slightly depressed total white blood cell (WBC) count with relative lymphocytosis and monocytosis, and low-normal to slightly depressed platelet count. (medscape.com)
In Graves disease, the radioactive iodine uptake is increased, and the uptake is diffusely distributed over the entire gland. (medscape.com)
Zanelli E, Henry M, Charvet B, Malthiery Y. Evidence alternate splicing in the thyroperoxidase messenger patients with Graves' disease. (rusmedserv.com)
Graves' disease (GD) is maintained by stimulating antibodies against the TSH receptor. (thyroidmanager.org)
This leads to infiltration of the gland by T cells and B cells that produce antibodies specific for clinical manifestations of hyperthyroidism in Graves' disease (GD) and chronic autoimmune thyroiditis (cAIT). (scienceopen.com)
Boelaert et al investigated the prevalence of and relative risks for coexisting autoimmune diseases in patients with Graves disease (2791 patients) or Hashimoto thyroiditis (495 patients). (medscape.com)
The authors also reported a tendency for parents of patients with Graves disease or Hashimoto thyroiditis to have a history of hyperthyroidism or hypothyroidism, respectively. (medscape.com)
However, the thyrotropin receptor itself is the primary autoantigen of Graves disease and is responsible for the manifestation of hyperthyroidism. (medscape.com)
The anti-sodium-iodide symporter, antithyroglobulin, and antithyroid peroxidase antibodies appear to have little role in the etiology of hyperthyroidism in Graves disease. (medscape.com)
This article reviews the evidence that has been marshalled to support this concept, both in man, chiefly in Graves' disease, and in murine systems. (ox.ac.uk)

AITD development occurs due to loss of immune tolerance and reactivity to thyroid autoantigens: thyroid peroxidase (TPO), thyroglobulin (TG) and thyroid stimulating hormone receptor (TSHR). (scienceopen.com)

Various cytokines, transcription factors, and other regulatory molecules have been found to be differentially methylated in CD8+ T cells in autoimmune diseases. (frontiersin.org)
The activation, differentiation, and development of CD8+ T cells is accompanied by large-scale changes in the coordinated expression of numerous inflammatory cytokines, transcription factors (TFs) and chemokines that are correlated with their survival, effector function, and self-renewal ( 7 ). (frontiersin.org)
so far, however, the only viruses that have been etiologically connected with the disease are the human retroviruses human immunodeficiency virus (HIV) and human T-cell lymphotrophic virus type I (HTLV-I), the simian retroviruses, and coxsackievirus B. Those viruses may directly invade the muscle tissue, damaging the vascular endothelium and releasing cytokines, which then induce abnormal expression of the major histocompatibility complex (MHC) and render the muscle susceptible to destruction. (medscape.com)
Besides being the source of autoantigens, the thyroid cells express molecules that mediate T cell adhesion and complement regulation (Fas and cytokines) that participate and interact with the immune system. (medscape.com)
We have developed a genosensor (doi: 10.1016/j.bios.2018.05.030) and a rapid flow test (lateral flow) for the detection of proinflammatory cytokines in the context of infectious diseases as tuberculosis or COVID 19. (uab.cat)

In the skin the invariably observed keratinocyte apoptosis may result in the cell surface expression and release of self-Ags including DNA Ro/Sj?gren syndrome A La/Sj?gren syndrome B and histones (10). (researchdataservice.com)

Disease severity-specific neutrophil signatures in blood transcriptomes stratify COVID-19 patients. (ega-archive.org)
Neutrophil extracellular traps in systemic autoimmune and autoinflammatory diseases. (news-medical.net)
Autoantigens can be altered and presented to the adaptive immune system due to dysregulated neutrophil cell death. (news-medical.net)
Since patients with GPA have augmented neutrophil PR3 expression, and PR3-expressing apoptotic cells frustrate macrophage phagocytosis and cellular clearance, we investigated the role of PR3 in stimulating giant cell and granuloma formation. (bmj.com)

2) Autoimmune diseases such as systemic lupus erythematosus (SLE) are characterized by the overproduction of antibodies, many of which recognize ribonucleoprotein and/or chromatin related autoantigens. (bu.edu)

An autoimmune response to nuclear and cytoplasmic autoantigens is detected in about 60-80% of patients with polymyositis and dermatomyositis. (medscape.com)

Hashimoto's thyroiditis, also known as chronic lymphocytic thyroiditis and Hashimoto's disease, is an autoimmune disease in which the thyroid gland is gradually destroyed. (wikipedia.org)
Patients with goiters who have had autoimmune thyroiditis for many years might see their goiter shrink in the later stages of the disease due to destruction of the thyroid. (wikipedia.org)
Anyone may develop this disease, but autoimmune thyroiditis affects women more often than men by about 10 times. (wikipedia.org)
Autoimmune thyroiditis (AIT) is the most common autoimmune thyroid disease. (scienceopen.com)
It is also associated with a number of non-neurologic diseases, including diabetes mellitus and thyroiditis. (medscape.com)

We have also developed a model of cutaneous lupus induced by the adoptive transfer of T cells specific for a pseudo-autoantigen. (umassmed.edu)
Autoimmune and immune-mediated diseases are chronic disorders in which the immune system produces a harmful response against its own cells, tissues and/or organs that results in inflammation and organ damage. (lupusresearch.org)
He will use genome engineering-a way to make changes in the DNA-to determine the effect of a specific alteration of the DNA on the function of immune cells and uncover the biological basis for risk shared across autoimmune diseases, and find specific pathways that can be targeted for drug development. (lupusresearch.org)
Dendritic cells in psoriasis lesions are marked by increased expression of TNF and the enzyme iNOS, which makes nitrous oxide. (dermatologytimes.com)
353:765-769), selective expression of mHEL autoantigen on thyroid cells did not trigger elimination or inactivation of circulating HEL-reactive B cells. (silverchair.com)
Numerous experiments have shown that B cells collaborate with T cells to activate in response to autoantigens in this disease, resulting in lymphocyte infiltration and immune complex deposition [ 6 ]. (hindawi.com)
In both human and animal disease models, these immune cells are frequently located at the areas of tissue inflammation where they support inflammatory response. (news-medical.net)
Expansion of circulating NKG2D+ effector memory T-cells and expression of NKG2D-ligand MIC in granulomaous lesions in Wegener's granulomatosis. (ox.ac.uk)
Cluster-like formations of "Wegener's autoantigen" PR3 were surrounded by NKG2D+ and NKG2D-ligand MIC+ cells in WG-granulomata, but not in disease controls. (ox.ac.uk)
On the other hand, the discovery that the thymus contains a broad representation of self-antigens and that this depends on the expression of the product of the gene [[AIRE]] by the medullary thymic epithelial cells opens the possibility of manipulating central tolerance. (transhumanist.ru)
Even with our limited understanding of the disease process, it is apparent that there are many opportunities for newer approaches at therapy, based on interfering with the immune cells or their mediators. (ox.ac.uk)
Treg cells are not only crucial for controlling immune responses to autoantigens but also prevent those directed towards commensal pathogens. (ozgene.com)
The evidence for an autoimmune etiology includes pathological findings of infiltrating T cells, the presence of antigen-antibody complexes in affected cartilage, cellular and humoral responses against collagen type II and other collagen antigens, and the observation that immunosuppressive regimens most often suppress the disease. (medscape.com)
New data concerning the multiplicity of thyroid autoantigens recognized by in vivo activated thyroid infiltrating T cells are compatible with this concept since the thyroid epithelial cells are the source of these antigens. (ox.ac.uk)
Further, little is known about local lipid ligands for NKT cells that may be influencing the disease outcome. (uab.cat)
In T1D patients NKT cells seem to lose their regulatory capacity which can be associated to a poor IL13 production at disease onset. (uab.cat)
Additionally, the expression of Foxp3 in the CD25high Treg cell population was significantly greater compared with the CD25inter Treg cells in both HNSCC patients and healthy controls, P ≤ 0·01. (c-kitinhibitors.com)
Dividing the HNSCC patient cohort by tumour subsite demonstrated that patients with cancer of the larynx and oropharynx had similar percentages of circulating Treg cells irrespective of whether the level of expression of CD25 was intermediate or high (Fig. 2a). (c-kitinhibitors.com)
BT-474 cells, obtained expression of the receptor has important implications for their biology from American Type Culture Collection, were maintained in RPMI 1640 and therapy (1). (lu.se)
Cells which lack ER expression at diagnosis arise from an ER compart- were harvested at 60 - 80% confluency and used as a reference in all hybrid- ment within the mammary epithelium or represent evolution from an izations. (lu.se)

RESULTS: The loss of Hes1 expression in the adult pancreas did not induce phenotypic alterations. (bvsalud.org)

Combined repetitive inhalant endotoxin and collagen-induced arthritis drives inflammatory lung disease and arthritis severity in a testosterone-dependent manner. (cdc.gov)

However, problems with recognition of auto-antigens and the subsequent cell elimination are at the root of numerous autoimmune diseases. (umontreal.ca)

The present invention relates to methods for isolating the sequences of an antibody that reacts with a disease related antigen, e.g., an autoantigen, without knowing the identity of the antigen (sequence or structural epitope) a priori. (justia.com)

In some of these diseases, autoantigens that are associated with pathology, or which are prognostic of disease occurrence and/or disease progression have also been discovered. (justia.com)
It is the principal underlying pathology of coronary heart disease and stroke. (ac.ir)

Traditionally, the roles of B lymphocytes and CD4+ T lymphocytes in autoimmune diseases have already been widely studied and are well recognized. (frontiersin.org)
The increased Fas expression in intrathyroidal CD4 T lymphocytes may be the cause of CD4 lymphocyte reduction in these individuals. (medscape.com)
The observation that the local site of autoimmune responses over-expressed HLA class II led to the formulation that tissue antigen-presenting capacity contributes significantly to the mechanism of autoimmune disease perpetuation, by continually reactivating auto-antigen-reactive T lymphocytes. (ox.ac.uk)
This analysis is consistent with the possibility that position B74 of exon 2 of the DRB1 molecule may have a specific and central role in autoantigen presentation by DRB1 to T lymphocytes. (lincoln.ac.uk)

While their role in the initial destruction of the follicles is unclear, antibodies against thyroid peroxidase or thyroglobulin are relevant, as they serve as markers for detecting the disease and its severity. (wikipedia.org)
Anti-nucleoporin antibodies can be also found in systemic connective tissue diseases. (openrheumatologyjournal.com)
Intrathyroidal lymphocytic infiltration is the initial histologic abnormality in persons with autoimmune thyroid disease and can be correlated with the titer of thyroid antibodies. (medscape.com)
The antifetal cartilage antibodies were found in 6 of 9 patients and only 4 (1.5%) of 260 patients with RA, exclusively in long-standing disease. (medscape.com)

During his faculty period at Yale and subsequently at Tufts, he detailed the clinical features of Lyme disease, identified the spirochetal etiology of the infection in human patients, developed serologic, culture and PCR tests for diagnosis, conducted antibiotic trials, and was principal investigator of the SmithKline Beecham Phase III Lyme disease vaccine trial. (massgeneral.org)
Expression analysis of the gene encoding for the U-box-type ubiquitin ligase UBE4A in human tissues. (nih.gov)
Chromosomal gene structure of human myeloperoxidase and regulation of its expression by granulocyte colony-stimulating factor. (rusmedserv.com)
A diagnostic assay for IGF1R-Ab was established with recombinant human IGF1R as autoantigen. (thyroidmanager.org)
The forkhead box D3 ( FOXD3 ) gene encodes a forkhead transcription factor that plays an important role in neural crest specification in vertebrates and therefore may be involved in human eye disease. (molvis.org)
Nevertheless, implementing and main- human, microbial, and environmental factors often deter- taining infection control measures is shifting disease pat- mine risk for exposure and chronic outcome. (cdc.gov)
Molecular mechanisms involved in human autoimmune diseases: relevance of chronic antigen presentation. (ox.ac.uk)
The concept also relates the human autoimmune diseases to the normal mechanisms of immune induction and immunoregulation. (ox.ac.uk)
Several human leukocyte antigen (HLA) associations have been found in patients with VKH disease, including HLA-DR4, HLA-DR53, and HLA-DQ4. (medscape.com)

We have generated murine models of SAVI that recapitulate many of the clinical manifestations exhibited by SAVI patients, including interstitial lung disease. (umassmed.edu)
Here, we describe a patient who, despite two heterozygous mutations in COL17A1, has an extremely mild form of the disease missing most of the characteristic clinical features. (nih.gov)
Immunofluorescence of skin sections showed diminished, but correctly localised expression of BP180, and this, in concert with the mild clinical phenotype, suggests that this COL15 mutated BP180 is still partly functional. (nih.gov)
however, many patients present with metastatic disease with or without any clinical symptoms. (msdmanuals.com)
title=Determining the cost-effectiveness of preventing cardiovascular disease: are estimates calculated over the duration of a clinical trial adequate? (transhumanist.ru)
908 tumours from the VICTOR clinical trial of stage II/III colorectal cancer were analysed for expression of γ-H2AX, ATM and Ku70 using immunohistochemistry. (ox.ac.uk)
The molecular and cellular mechanisms involved in the expression of cutaneous LE remain unclear (3 6 7 There are three clinical subtypes of cutaneous LE: acute cutaneous LE (ACLE) subacute cutaneous LE and chronic cutaneous LE (also known as discoid LE). (researchdataservice.com)

In both diseases, they are researching basic immune abnormalities, knowledge of which may lead to improved diagnosis and treatment of these diseases. (massgeneral.org)
Patients taking the oral blood pressure medication not only required less daily insulin two years after first diagnosis of the disease, but also showed evidence of surprising immunomodulatory benefits. (sciencedaily.com)
To help clarify the diagnostic features of VKH disease, the International Committee on Nomenclature established revised criteria for the diagnosis of VKH disease. (medscape.com)
will allow us to assess the effects of early diagnosis, environmen- tal control, and therapy on the outcome of this disease. (cdc.gov)

From 1973-1975, he served in the Epidemic Intelligence Service at the Centers for Disease Control. (massgeneral.org)
Centers for Disease Control and Prevention. (cdc.gov)
The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. (cdc.gov)

Prednisone and prednisolone [ 386 ] act powerfully to suppress the inflammation accompanying a rejection crisis, and also appear to reduce the expression of class II histocompatibility antigens, thus reducing the immunogenicity of the transplant. (nanomedicine.com)

The true potential to avoid or mini- reduce the impact of chronic disease by preventing or treat- ing infection. (cdc.gov)
As the concept is progressively accepted, mize chronic disease by preventing or treating infections advances in laboratory technology and epidemiology facili- may yet be substantially underestimated. (cdc.gov)
To capi- determinants of chronic diseases, in which 1 infectious talize on these opportunities, clinicians, public health agent(s) causes, precipitates, or drives the chronic disease practitioners, and policymakers must recognize that many or its long-term sequelae. (cdc.gov)
Together, this group affects all populations sure to chronic disease. (cdc.gov)

Some patients in the early stage of the disease may experience symptoms of hyperthyroidism due to the release of thyroid hormones from intermittent thyroid destruction. (wikipedia.org)
His lab discovered that a change in DNA methylation at a specific gene in patients with ANCA vasculitis was associated with a probability of patients to relapse and identified an alternative gene isoform for the ANCA autoantigen, PR3, that is expressed in patients with ANCA disease. (unc.edu)
More than three consecutive samples were available from 11 of the 15 positive GO patients spanning an average disease period of 2 years. (thyroidmanager.org)
IGF1R-Ab concentrations were constantly elevated in these patients demonstrating relatively stable IGF1R-Ab expression over time. (thyroidmanager.org)
Ectopic expressions of CXC chemokines (CXCL9, CXCL10, CXCL11, and CXCL13), interleukins (IL-1/2/4/6/10/12/17/22/23), IFN- γ, and TNF- α occur in the minor salivary glands of SS patients as compared to healthy individuals [ 10 , 11 ]. (hindawi.com)
This could be done in women who wish to become pregnant and those with an increased risk per se who are pregnant (to predict first trimester hypothyroidism, and postpartum thyroid dysfunction), patients with other autoimmune diseases, subjects on amiodarone, lithium, or interferon-alpha, and in relatives of patients with autoimmune thyroid diseases. (scienceopen.com)
It is found in a particularly large subset of patients with diabetes, and endocrinologists hoped that it would be the major breakthrough needed to cure this disease in millions of patients worldwide. (medscape.com)
Since that time, the antibody has been found in patients with a number of neurologic diseases, a scenario that is easier to understand because the pathophysiologic link to neurologic disease is easier to explain. (medscape.com)
The range of diseases encountered includes seizures, cerebellar dysfunction, cortical dysfunction, and myelopathy, but the association between function of the enzyme and the consequence of the disease is most clear in patients with stiff person syndrome. (medscape.com)
In the two-year study, subjects who stopped daily doses of verapamil at one year saw their disease at two years worsen at rates similar to those of the control group of diabetes patients who did not use verapamil at all. (sciencedaily.com)
Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by high levels of autoantibody and multiorgan tissue damage including kidney and skin (1 2 Skin is involved in three quarters of patients with SLE (3) whereas in one fifth skin lesions represent the first manifestation (4). (researchdataservice.com)
ACLE typically presents abruptly in the context of a systemic disease and almost all patients develop Trichodesmine SLE (9). (researchdataservice.com)
Anti-Ro Abs are associated with photosensitive skin disease (3) and have been found deposited in the skin of patients with SLE (15). (researchdataservice.com)
Patients with AE differ in the stage of their skin disease (acute, subacute, chronic). (tno.nl)
Despite differences in their patients, the manifestations appeared to represent a spectrum of disease, and several authors suggested that the disorder should be termed Vogt-Koyanagi-Harada syndrome (see the image below). (medscape.com)
Patients with complete VKH disease must also have evidence of neurologic and auditory manifestations, as well as integumentary signs. (medscape.com)
Patients with incomplete VKH disease have either neurologic and auditory manifestations or integumentary signs, but not both. (medscape.com)
Patients with probable VKH disease include those with isolated ocular disease. (medscape.com)

Enhanced expression of immune checkpoint receptors during SARS-CoV-2 viral infection. (ega-archive.org)

This response is predicted to promote the underlying inflammatory responses contributing to disease. (boisestate.edu)

Ongoing studies are exploring how endosomal TLRs modulate disease severity. (umassmed.edu)

Autoimmune thyroid disease (AITD) is the most common organ-specific autoimmune disorder. (scienceopen.com)

In systemic autoimmune diseases, the immune system cannot distinguish between self and non-self and subsequently responds to and harms several tissues and organs, including joints, kidneys, and blood vessels. (news-medical.net)

The pathophysiology of the disease is autoimmune. (medscape.com)

Each study will investigate the immune system's role in the development of lupus, T1D and/or MS. The 2021 awardees are examining possible common mechanisms that could cause or contribute to the development of at least two of the three autoimmune diseases. (lupusresearch.org)
and 2) the role of endogenous nucleic acid autoantigens as mediators of systemic lupus erythematosus. (bu.edu)
To investigate the role of T(EM) in WG, we analyzed the expression of the activating NK-receptor NKG2D and its ligand MIC on circulating T(EM) and in granulomatous lesions, respectively. (ox.ac.uk)
However, we cannot yet exclude a primary role for DQA1 or for other polymorphisms that affect DRB1 function or expression. (lincoln.ac.uk)
Study of the specificity and contribution on the HLA peptide repertoires of different proteasomes and its role in tolerance and disease. (uab.cat)
Analysis of the role of the autoimmune regulator (AIRE) in antigen expression, processing and presentation. (uab.cat)

Thyroid peroxidase (TPO) is a key enzyme in the formation of thyroid hormones and a major autoantigen in autoimmune thyroid diseases. (scienceopen.com)

Controlling infectious diseases remains paramount to nized microbial origins. (cdc.gov)
The Journal of infectious diseases 2005 Nov 192 (10): 1741-8. (cdc.gov)
The Journal of infectious diseases 2008 Jan 197 (2): 262-5. (cdc.gov)
The Journal of infectious diseases 2010 Jan 201 (2): 178-85. (cdc.gov)
The Journal of infectious diseases 2011 Oct 204 (7): 1031-7. (cdc.gov)

Lymphocytic infiltration and expression of -fodrin in the salivary glands was decreased in -fodrin-treated groups. (asiatox.org)

Relapsing polychondritis (RPC) is a rare progressive autoimmune disease that causes inflammation in the cartilage of multiple organs, with tracheobronchial involvement appearing in nearly half of all cases. (medjournal360.com)
The patient's expression level of matrilin-1 in a tracheal and auricular specimen were evaluated and Immunohistochemical staining with anti-matrilin-1 antibody showed matrilin-1 in the tracheal but not in the auricular cartilage. (medjournal360.com)

Anatomy15

Organisms7

Diseases29

Chemicals and Drugs57

Analytical, Diagnostic and Therapeutic Techniques and Equipment16

Phenomena and Processes18

Disciplines and Occupations2

Information Science2

Health Care1

Autoimmunity10

Pathogenesis12

Autoantibodies15

Genes5

Genetic8

Type 1 diabet4

Protein13

Gene expression5

Systemic autoimm4

Humans1

Rheumatoid arthritis8

Immunostimulatory1

Proteins4

Graves Disease14

Reactivity1

Cytokines5

Apoptosis1

Neutrophil4

Chromatin1

Cytoplasmic1

Thyroiditis5

Cells20

Induce1

Collagen1

Numerous autoimmune diseases1

Epitope1

Pathology2

Lymphocytes4

Antibodies4

Human9

Clinical7

Diagnosis4

Centers3

Suppress1

Chronic Disease4

Patients18

Receptors1

Inflammatory responses1

Severity1

Organ-specific autoimmune1

Distinguish1

Pathophysiology1

Role6

Thyroid diseases1

Infectious diseases5

Infiltration1

Cartilage2