Expression carcinoma basal cell. Medical search. Frequent questions

In addition to an inherited (germline) mutation in one copy of the gene, which is found in essentially every cell of the body, a second, non-inherited (somatic) mutation usually occurs in the normal copy of the gene in cells that give rise to tumors. (medlineplus.gov)
Cemiplimab was already approved for use in NSCLC, but the previous indication was for use as monotherapy as a first-line treatment for patients who were similar but whose tumors tested positive for high levels of PD-L1 expression . (medscape.com)
Basal cell carcinoma (BCC) and seborrheic keratosis (SK) are benign and malignant skin tumors, respectively [ 1 ]. (hindawi.com)
We report here that Ptch +/- mice develop primordial follicular neoplasms resembling human trichoblastomas, and that exposure to ultraviolet radiation or ionizing radiation results in an increase in the number and size of these tumors and a shift in their histologic features so that they more closely resemble human basal cell carcinoma. (nature.com)
The mouse basal cell carcinomas and trichoblastoma-like tumors resemble human basal cell carcinomas in their loss of normal hemidesmosomal components, presence of p53 mutations, frequent loss of the normal remaining Ptch allele, and activation of hedgehog target gene transcription. (nature.com)
The Ptch mutant mice provide the first mouse model, to our knowledge, of ultraviolet and ionizing radiation-induced basal cell carcinoma-like tumors, and also demonstrate that Ptch inactivation and hedgehog target gene activation are essential for basal cell carcinoma tumorigenesis. (nature.com)
The gene, known as patched (PTC), is implicated in thenevoid basal cell carcinoma syndrome, a rare disorder that causesnumerous birth defects and an inherited form of basal cell carcinoma.It also appears to play a role in sporadic basal cell carcinoma,since mutations of the gene were also found in a few patientswith noninherited basal cell tumors. (cancernetwork.com)
CaSR expression was weak in colon carcinomas with a more-differentiated histologic pattern, whereas CaSR expression was undetectable in less-differentiated tumors. (aacrjournals.org)
In a series of 175 human adult tumors, gene expression was highest in ovarian serous carcinomas. (nature.com)
In brief, frozen sections of profiled tumors were examined by hematoxylin-and-eosin, and areas rich in neoplastic cells were cut from the frozen blocks. (nature.com)
Libtayo, a monoclonal antibody, has previously been approved to treat metastatic cutaneous squamous cell carcinoma, advanced basal cell carcinoma, and patients with advanced non-small-cell lung cancer whose tumors have high PD-L1 expression. (biospace.com)
For EphA2 expression, 21 tumors (10%) showed negative, 108 (50%) weak positive, 69 (32%) moderate positive and 19 (9%) strong positive, whereas for EphrinA-1 expression, 33 tumors (15%) showed negative, 91 (42%) weak positive, 67 (31%) moderate positive and 26 (12%) strong positive. (medsci.org)
The spectrum of tumors found in Gorlin Syndrome includes basal cell carcinoma, medulloblastoma, and rarely, rhabdomyosarcoma (RMS). (uea.ac.uk)
A previous report utilizing in situ hybridization has provided initial evidence for the expression of Hh targets GLI1 and PTCH in RMS tumors. (uea.ac.uk)
When the different groups of tumors were compared, epithelial-myoepithelial carcinomas (EMEC) showed a stark contrast with the others (83.3% of cases with CD10 expression). (qxmd.com)
However, the gain of this protein is not a sensitive marker for detecting myoepithelial cells in the majority of the tumors, except for EMEC. (qxmd.com)
A number of skin tumors show differentiation toward hair matrix components, including Gardner syndrome cysts, basal cell carcinoma, purely matrical tumors (pilomatricoma, matricoma, melanocytic matricoma, and pilomatrix carcinoma), and even some mixed tumors. (actasdermo.org)
4 Melanocytic matricoma, which was described by Carlson 5 and is included in the World Health Organization classification of skin tumors, is a similar tumor, but with pigmented dendritic melanocytes (i.e., it has a dual population of epithelial and melanocytic cells). (actasdermo.org)
Individuals with MEN1 are at a substantially increased risk of developing neuroendocrine tumors, including cancer of the pancreatic islet cells that secrete insulin. (medindia.net)
To begin to define genetic alterations that occur in African-American ESCC we conducted microarray expression profiling in pairs of esophageal squamous cell tumors and matched control tissues. (biomedcentral.com)
Total RNA from tumors the expression of thousands of genes (3) to address complex questions was isolated using two successive rounds of Trizol. (lu.se)
Resolving the Pathogenesis of Anaplastic Wilms Tumors through Spatial Mapping of Cancer Cell Evolution. (lu.se)

PTCH1 is frequently mutated on one allele in sporadic basal cell carcinomas (BCCs), and according to Epstein, "upregulation of HH signaling is the pivotal abnormality in all BCCs. (medscape.com)
The role of the human homologue of Drosophila patched in sporadic basal cell carcinomas. (nature.com)

Skin cancers are also associated with BAP1 tumor predisposition syndrome, including cutaneous melanoma and basal cell carcinoma . (medlineplus.gov)
Separately, cemiplimab is also approved for use in advanced cutaneous squamous cell carcinoma (CSCC) and basal cell carcinoma (BCC). (medscape.com)
Using the 31-gene expression profile assay may help lead to more personalized treatment strategies in patients with cutaneous melanoma, according to Aaron Farberg, MD. (cancernetwork.com)

Nevoid basal cell carcinoma syndrome (NBCCS), also known as basal cell nevus syndrome (BCNS), represents a series of multiorgan abnormalities known to be the consequence of abnormalities in the PTCH gene. (medscape.com)
Multiple organ systems may be impacted in nevoid basal cell carcinoma syndrome (NBCCS). (medscape.com)
Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome. (nature.com)
Diagnostic Criteria of Nevoid Basal Cell Carcinoma Syndrome. (actasdermo.org)
Complementary Tests for the Diagnosis and Follow-up of Pediatric Patients With Nevoid Basal Cell Carcinoma Syndrome. (actasdermo.org)

In mammals, PTCH1 is an important inhibitor in the so-called hedgehog (HH) signaling pathway, whose downstream proteins can lead to cell growth. (medscape.com)
Although it is unclear exactly how loss of BAP1 function leads to BAP1 tumor predisposition syndrome, researchers speculate that altered activity of proteins normally regulated by BAP1 deubiquitination may promote cell proliferation or survival, resulting in tumor formation. (medlineplus.gov)
They determined that the hh gene encodes a family of hh proteins, which mediate both cell-to-cell interactions and has long-range effects in developing Drosophila embryos. (asu.edu)
The increased levels of EphA2 and EphrinA-1 in a relative high number of early stage squamous cell carcinomas suggested that these two proteins may play an important role in the development of a subset of early cervical cancers. (medsci.org)
Expression of cell cycle proteins in head and neck cancer correlates with tumour site rather than tobacco use. (bvsalud.org)
Furthermore, we found a distinctive type of retinal cells expressing the characteristic proteins of both bipolar cells and amacrine cells at P6, which may be an intermediate state in which amacrine cells were transforming into bipolar cells. (bvsalud.org)

The naevoid basal cell carcinoma syndrome (NBCCS) is an autosomal dominant multisystem disorder with variable expression. (bmj.com)
Human homolog of patched, a candidate gene for the basal cell nevus syndrome. (nature.com)
What's more, treating a mouse model of human MEN1 syndrome with a Hedgehog pathway inhibitor called Erivedge (FDA-approved in 2012 for metastatic or locally advanced basal cell carcinoma) reduced proliferation of tumor cells and blood insulin levels. (medindia.net)

Among 557 invasive oropharyngeal squamous cell carcinomas, 72% were positive for HPV and 62% for vaccine types HPV16 or 18. (cdc.gov)

Cell Death and Differentiation. (wikipedia.org)
Both agents concomitantly induced a series of changes in the CBS cells that influence proliferation and differentiation, but cellular responses to the two agents were not identical. (aacrjournals.org)
It is concluded that CaSR may function in the colon to regulate epithelial differentiation and that loss of CaSR expression may be associated with abnormal differentiation and/or malignant progression. (aacrjournals.org)
The hedgehog signaling pathway is a mechanism that regulates cell growth and differentiation during embryonic development, called embryogenesis, in animals. (asu.edu)
While it is possible that SCCs initially develop in basal cells, it is unclear why such basal cells in SCCs begin to express differentiation markers. (ukri.org)
Our preliminary results show that the tumour suppressor ASPP2 is able to repress p63 expression, is highly expressed in keratin 1-positive and keratin 14-negative stratified epithelial cells, and that differentiation induces ASPP2's expression in vitro. (ukri.org)
Additionally, lumen differentiation, local clear cell-like change, collagen proliferation and sclerosis around the lower tumor tissue were observed. (oatext.com)
Temporal multimodal single-cell profiling of native hematopoiesis illuminates altered differentiation trajectories with age. (lu.se)

No basal cell skin cancer symptoms should ever be ignored, but this one is of particular importance because it can indicate an invasive case of basal cell skin cancer. (gentlecure.com)

The BAP1 protein is thought to be involved in cell growth and division (proliferation), cell death, repair of damaged DNA, and control of gene activity. (medlineplus.gov)
We evaluated the expression and activation of Notch pathway genes in the adult human and murine corneal epithelium during proliferation. (molvis.org)
2005). The vascular endothelial growth factor (VEGF) is a 46 kD dimeric glycoprotein secreted by neoplastic cells, macrophages, plasma cells and lymphocytes, which triggers endothelial cell proliferation by interacting with specific receptors in a paracrine or autocrine fashion (Ferrara 2004). (vin.com)
It has been found to supress proliferation of myeloid progenitor cells and induces calcium flux in THP-1 cells. (conzort.com)
Normal human skin demonstrates marked site-variation of tenascin expression, not correlated to epidermal proliferation (Ki-67 binding). (conzort.com)
Menin mutations lead to increased Hedgehog signaling and cell proliferation. (medindia.net)
The GAS1 protein promotes Hedgehog signaling, and thus by inhibiting Gas1 expression, menin and PRMT5 effectively dial down the pathway's tendency towards cell proliferation. (medindia.net)
Aspects of cell proliferation in oral epithelial dysplastic lesions. (bvsalud.org)
Thymidine analog-retention assays revealed that Sox2 deficiency contributed to reduced survival of SCN neurons during the postnatal period of cell clearance, but did not affect progenitor cell proliferation or SCN specification. (bvsalud.org)
In vitro studies based on MCF-7 cell proliferation and induction of vitellogenin in primary culture of rainbow trout hepatocytes. (cdc.gov)

A form of kidney cancer called clear cell renal cell carcinoma is also associated with the condition. (medlineplus.gov)

We have recently developed an in vivo mouse model system in which the expression of ASPP2, a previously identified tumour suppressor and regulator of p53, is knocked out. (ukri.org)
Of the different tumour types arising in epithelial tissues, squamous cell carcinoma (SCC) is the most malignant and has the highest metastatic potential. (ukri.org)
The extraepithelial presence of Langerin-positive cells forming contacts with dendrite-like protrusions of 175 kD mannose receptor-exhibiting cells was found in connective tissue surrounding the tumour epithelium and indicates possible cooperation of both elements. (archive.org)
SquamouS cell carcinoma for the viability of the tumour cel s once skin lesions are also mutated in the ultraviolet they have become malignant (Rol ison (UV) radiation-induced skin lesions of A large number of HPV types have et al. (who.int)

However, adenocarcinomas of the lung, and occasional breast, transitional cell and pancreatic carcinomas had moderate or high levels of HE4 expression. (nature.com)
Scientists have identified that pancreatic cancer cells growth and spread are fueled by an unusual metabolic pathway that someday might be blocked with targeted drugs to control the deadly cancer. (medindia.net)

Basal cell carcinoma may sometimes show metastatic spread to regional lymph nodes and, occasionally, in-transit metastases. (cancer.org.au)

Combining these new datasets with existing published gene expression and protein expression data have identified selected panels of novel biomarkers which have been evaluated on over 100 cervical cancer and pre-cancer cases using standard immunohistochemistry approaches. (europa.eu)
How Reliable Are Gene Expression-Based and Immunohistochemical Biomarkers Assessed on a Core-Needle Biopsy? (lu.se)

Total 524 mRNA expression profiles including 482 COAD tissues and 42 normal colon tissues were enrolled. (frontiersin.org)
2018). Heritability enrichment of specifically expressed genes identifies disease-relevant tissues and cell types. (harvard.edu)
however, the expression in normal and malignant adult tissues has not been examined in detail. (nature.com)
Here, we examined the expression of the HE4 gene and protein in a large series of normal and malignant adult tissues by oligonucleotide microarray and tissue microarray, respectively. (nature.com)
Using tissue microarrays and full tissue sections of normal and 448 neoplastic tissues, HE4 immunoreactivity was found in normal glandular epithelium of the female genital tract and breast, the epididymis and vas deferens, respiratory epithelium, distal renal tubules, colonic mucosa, and salivary glands, consistent with HE4 gene expression. (nature.com)
Here, we used oligonucleotide and tissue microarrays to survey HE4 gene and protein expression in a large group of malignant and normal tissues from adults. (nature.com)
Western blot was performed using Anti-ATF2 Recombinant Rabbit Monoclonal Antibody (SZ17-01) (Product # MA5-32022) and 60kDa and 40kDa bands corresponding to Cyclic AMP-dependent transcription factor ATF-2 was observed across all the tested cell lines and tissues, except Mouse Skeletal Muscle. (thermofisher.com)
CD10 is a cell surface peptidase expressed in a wide variety of normal and neoplastic tissues, including breast myoepithelial cells. (qxmd.com)
Higher p53 positive cell counts were demonstrated in oral squamous cell carcinoma compared to hyperplastic and dysplastic tissues. (bvsalud.org)
Tissues and Cells. (lu.se)

Expression of Notch1 , Jagged1 , and Hes1 was found predominantly in the basal and immediate suprabasal cells. (molvis.org)
To determine the precise origin of SCC, ASPP2 will be deleted in keratin 14-positive basal cells and keratin 1-positive suprabasal cells using keratin 14-Cre or keratin 1-Cre respectively. (ukri.org)

In some cases of basal cell skin cancer, the symptoms and appearance of the lesion do not match any of those listed above. (gentlecure.com)
We present the case of a 75-year-old woman with a history of basal cell carcinoma and actinic keratoses who presented with an asymptomatic papular lesion on her forehead that had been growing progressively for several weeks and was clinically suggestive of basal cell carcinoma ( Fig. 1 A). The lesion was excised. (actasdermo.org)
preneoplastic oral lesion and oral squamous cell carcinoma. (bvsalud.org)

Hence, wide surgical resection and long-term follow-up are required for this high-risk basal cell carcinoma to prevent a recurrence. (oatext.com)

Knowledge of the expression patterns of HE4 in our survey is useful for application in histopathologic diagnosis, and should be taken into consideration in future studies that examine the role of HE4 as a serological tumor biomarker or as a target for gene-based therapy. (nature.com)
The high expression of CD10 by this carcinoma can be a valuable tool to separate EMEC from the tubular variant of adenoid cystic carcinomas in small incisional biopsies, where the precise diagnosis may be impossible. (qxmd.com)
Two contiguous sections from 30 tissue specimens (10 each from oral hyperplastic epithelium, dysplastic epithelium and squamous cell carcinoma) were subjected to hematoxylin and eosin (H/E) staining for histopathological diagnosis and immunohistochemical (IHC) staining for demonstration of p53. (bvsalud.org)
Cells which lack ER expression at diagnosis arise from an ER compart- were harvested at 60 - 80% confluency and used as a reference in all hybrid- ment within the mammary epithelium or represent evolution from an izations. (lu.se)

Prognosis of basal cell carcinoma and Table 1. (cancer.org.au)

Due to changes in their epigenetic regulation, differentiated keratin 1-positive squamous epithelial cells may start to re-express keratin 14 and p63 to gain a proliferative potential. (ukri.org)
p53 positivity was looked for in each IHC stained slide and the number of positive cells amongst 1,000 epithelial cells were recorded. (bvsalud.org)
The expression of p53 in epithelial hyperkeratosis was mainly localized to basal epithelial cells whereas in epithelial dysplasia, it was predominantly localized to spinous epithelial cells. (bvsalud.org)

Together, the germline and somatic mutations result in a complete loss of BAP1 protein function in tumor cells. (medlineplus.gov)
Basal cell carcinomas, the commonest human skin cancers, consistently have abnormalities of the hedgehog signaling pathway and often have PTCH gene mutations. (nature.com)
Scope includes mutations and abnormal protein expression. (cancerindex.org)
Mutations in PTCH1 influencing the Shh pathway may induce the generation of clear cells with organelle degeneration and glycogen deposition, accompanied by the increased expression of type-I and III procollagen mRNA. (oatext.com)

MicroRNAs function to regulate the expression levels of other genes by several mechanisms. (wikipedia.org)
Differential expression of amino acid metabolism-related genes (AAMRGs) was identified for prognostic gene selection. (frontiersin.org)
HE4 is one of more than 8900 different human genes represented on U95a GeneChips (Affymetrix, Santa Clara, CA, USA), which we used previously to develop a molecular classification of 175 human carcinomas based on patterns of gene expression. (nature.com)
The expression of Notch pathway genes in the limbal and central human corneal epithelium was compared by reverse transcription polymerase chain reaction (RT-PCR). (molvis.org)
We will also examine the mechanism by which ASPP2's suppression of SCC development is achieved, in particular, by examining the expression levels of genes involved in the p63, Notch and Wnt signalling pathways, all of which are known to be affected by ASPP2's activity. (ukri.org)
To determine whether certain genes are uniquely altered in African-American ESCC we performed a meta-analysis of ESCC expression profiles in our African-American samples and those of several Asian samples. (biomedcentral.com)
The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. (ayassbioscience.com)

Metabolic reprogramming is a common feature of tumor cells, which is crucial for rapid tumor growth and adaption to tumor microenvironment ( 5 , 6 ). (frontiersin.org)
The percentage of VEGF-positive tumor cells was scored at 0 to 4 levels (0: less than de 5% of labeled cells to 4: more than 75% of labeled cells). (vin.com)

18 With the exception of the ovarian neoplasms, the same carcinomas analyzed for gene expression were also examined for HE4 by immunohistochemistry on tissue microarrays (see below). (nature.com)

The expression of Notch1 and Jagged1 was higher in the human limbal epithelium while the expression of Hes1 and Hes5 was higher in the central cornea. (molvis.org)
The corneal epithelium is continually losing cells due to desquamation (primarily via the blink reflex) and thus must replace these cells to maintain homeostasis. (molvis.org)
Around 80% of all human cancers develop in the epithelium, and of the different epithelial cancer types, Squamous Cell Carcinoma (SCC) is the most deadly. (ukri.org)
Alternatively, it is possible that SCC instead initially develops from the differentiated keratin 1-positive and keratin 14-negative suprabasal layer of the epithelium, which sits above the basal layer. (ukri.org)
To study oral hyperplastic epithelium, dysplastic epithelium and squamous cell carcinoma todetermine (1) the prevalence of p53 protein immunoreactivity, (2) number of p53 positive cells, and (3) the area of localization of p53 protein immunoreactivity. (bvsalud.org)
The localization of these p53 positive cells within the strata (i.e. basal/suprabasal, spinous and superficial layers) of epithelium between 3 groups, and also within each group according to histological grades was recorded. (bvsalud.org)
However the quantitative analysis of p53 positive cells and their localization in oral epithelium is of importance as a marker for oral squamous cell carcinoma. (bvsalud.org)
Clara cells lining the respiratory epithelium metabolize ST to styrene 7,8- oxide (SO), which is cytotoxic and weakly genotoxic. (cdc.gov)

Patched (ptch)-associated preferential expression of smoothened (smoh) in human basal cell carcinoma of the skin. (nature.com)
We found that Ca 2+ and/or 1,25(OH) 2 D 3 stimulated CaSR promoter activity and CaSR protein expression in the human colon carcinoma CBS cells, which possessed a functional CaSR. (aacrjournals.org)
In various human cancers poor outcome for the patients has been associated with increase expression of EphA2 and EphrinA-1 [ 16 , 17 , 19 , 24 , 26 ]. (medsci.org)
NCC-4 chemoattracts human monocytes and THP-1 cells. (conzort.com)
Alterations of p53, cyclinD1, Rb, and H-ras in human oral carcinomas related to tobacco use. (bvsalud.org)
Location of cells exhibiting a specific marker of Langerhans cells--Langerin, and the 175 kD mannose receptor as a marker of dendritic cells of non-Langerhans type and macrophages, was studied using double staining in the normal human epidermis and in basal cell carcinomas. (archive.org)

NBCCS patients have variable susceptibility to development of basal cell carcinoma (BCC). (bmj.com)

To evaluate CNN models' performance of identifying the clinical images of basal cell carcinoma (BCC) and seborrheic keratosis (SK) and to compare their performance with that of dermatologists. (hindawi.com)
The results were validated both by gene expression analysis and immunohistochemistry study in an independent 55 clinical samples from Fudan University Shanghai Cancer Center. (cancerindex.org)

Recent genome-wide association studies, gene expression profiling, DNA methylation and proteomic studies conducted in Japanese and Chinese ESCCs (reviewed in [ 6 ]) have identified multiple risk variants and gene signatures associated with ESCC. (biomedcentral.com)

2005). The aim of this study was to investigate the expression of VEGF in dogs with lymphoma by means of immunohistochemistry and its relationship to biological behavior of canine lymphomas. (vin.com)
Immunohistochemistry was performed to identify T or B cell origin, using anti-CD3 polyclonal antibody (Dako) and anti-CD79a monoclonal antibody (Dako), respectively. (vin.com)
By using immunohistochemistry we investigated the expression of EphA2 and EphrinA-1 in 217 early squamous cell cervical carcinomas and examine their prognostic relevance. (medsci.org)

It is a highly conserved network that orchestrates cell-fate decisions in the nervous, gastrointestinal, and the hematopoietic systems of many organisms ranging from insects to humans. (molvis.org)
Esophageal carcinoma is the third most common gastrointestinal malignancy worldwide and is largely unresponsive to therapy. (biomedcentral.com)

Prognostic significance of p53 expression in oral squamous cell carcinoma without neck node metastases. (bvsalud.org)

A new approval from the US Food and Drug Administration (FDA) expands the use of the immunotherapy PD-1 inhibitor cemiplimab-rwlc (Libtayo) for patients with non-small cell lung cancer (NSCLC). (medscape.com)
The integrated Gene Expression Omnibus (GEO) dataset with 1,430 colon cancer samples was used for validation. (frontiersin.org)
BETHESDA, Md--Research supported by the National Institutes of Health and the National Cancer Institute has led to discovery of a tumor-suppressor gene involved in basal cell carcinoma. (cancernetwork.com)
Extracellular Ca 2+ and 1,25(OH) 2 D 3 are potential candidates involved in regulating CaSR expression in the colon and the chemopreventive actions of Ca 2+ and 1,25(OH) 2 D 3 in colon cancer may be mediated, in part, through the CaSR. (aacrjournals.org)
The company is hoping BNT111, which used a fixed combination of mRNA-encoded, tumor-associated antigens to target the cancer cells, will demonstrate the same kind of success as the COVID-19 vaccine. (biospace.com)
Basal cell carcinoma (BCC) is a nonmelanocytic skin cancer (ie, an epithelial tumor) that arises from basal cells (ie, small, round cells found in the lower layer of the epidermis). (medscape.com)
What are the Basal Cell Skin Cancer Symptoms? (gentlecure.com)
Basal cell skin cancer is the most common type of skin cancer, making up about 80% of diagnoses. (gentlecure.com)
With that said, it's important to know the basal cell skin cancer symptoms to look for. (gentlecure.com)
Learn more about the different ways basal cell skin cancer may present on the skin in the guide below. (gentlecure.com)
If you have an open sore on your skin that never seems to heal, lasting for weeks or repeatedly healing and then returning as the same open sore, it may be basal cell skin cancer. (gentlecure.com)
Basal cell skin cancer may present as a small pink growth with a raised, rolled edge and a lowered center that is crusted over. (gentlecure.com)
Some individuals don't notice basal cell skin cancer on their skin because it's mistaken for other common skin conditions like eczema or psoriasis. (gentlecure.com)
If you have a skin spot that matches the basal cell skin cancer symptoms, consult with your doctor without delay. (gentlecure.com)
ASPP2: A molecular switch of cancer initiating cells in Squamous Cell Carcinoma? (ukri.org)
Dan LaBarbera received a Cancer League of Colorado research grant with Dr. Reema Wahdan (SOM-Pathology) to fund a collaborative project, "Targeting Thyroid Hormone-Mediated Cancer Stem Cell Expansion and Treatment Resistance in ER+ Breast Cancer Cells. (cuanschutz.edu)
7. Pillay M, Vasudevan DM, Rao CP, Vidya M. p53 expression in oral cancer: observations of a South Indian study. (bvsalud.org)
arations verified the presence of cancer cells in all samples. (lu.se)

This indication specifies that the combination can be used irrespective of PD-L1 expression or histology. (medscape.com)

REG4 is an indicator for KRAS mutant lung adenocarcinoma with TTF-1 low expression. (cancerindex.org)
Recent research has classified lung adenocarcinoma patients with KRAS mutation into three subtypes by co-occurring genetic events in TP53 (KP subgroup), STK11/LKB1 (KL subgroup) and CDKN2A/B inactivation plus TTF-1 low expression (KC subgroup). (cancerindex.org)
REG4, an important regulator of gastro-intestinal carcinogenesis, was highly expressed in KRAS mutant lung adenocarcinoma with low expression of TTF-1 (KC subtype). (cancerindex.org)

Search the gene expression profiles from curated DataSets in the Gene Expression Omnibus (GEO) repository. (cancerindex.org)

The hedgehog signaling pathway works both between cells and within individual cells. (asu.edu)

In vitro, the expression of Hes1 was higher in confluent cells maintained under high calcium conditions. (molvis.org)
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. (thermofisher.com)
Both SAPK and p38 MAPK have been shown to phosphorylate ATF-2 at these sites in vitro and in cells transfected with ATF-2. (thermofisher.com)

About 50% of basal cell skin cancers diagnosed in people with darker skin are pigmented . (gentlecure.com)

PURPOSE: To explore the mechanisms underlying stemness maintenance of retinoblastoma (RB) stem cells (RSCs). (bvsalud.org)

African-Americans have an increased risk for esophageal squamous cell carcinoma (ESCC), the subtype that shows marked variation in geographic frequency. (biomedcentral.com)

Notch signaling is initiated by the interaction between the ligand on one cell and the receptor on a neighboring cell. (molvis.org)
This calcium flux can be desensitized by exposure to RANTES which suggests that NCC-4 and RANTES share the same receptor in THP-1 cells. (conzort.com)
receptor-exhibiting cells were present. (archive.org)
BT-474 cells, obtained expression of the receptor has important implications for their biology from American Type Culture Collection, were maintained in RPMI 1640 and therapy (1). (lu.se)
1994. Ah receptor in embryonic mouse palate and effects of TCDD on receptor expression. (cdc.gov)
Out of 29 liver tissue sections examined, 14 had a low level of expression of insulin receptor type 1 by immunohistochemical studies. (who.int)

The lone study evaluating an African cohort found that only 20% with NBCCS had basal cell carcinoma. (medscape.com)
During neonatal corneal development, NotchIC was detected in occasional cells at P10 while at P15 and P90, it was found in the basal and early suprabasal layers. (molvis.org)
In our previous study of cervical carcinomas FIGO stage I-IV we found that increase expression of EphA2 and EphrinA-1 was significantly associated with shorter overall survival in multivariate analysis [ 22 ]. (medsci.org)
How SCC develops is currently poorly understood, however, it is known that as well as expressing normal basal cell markers such as keratin 14, they also express markers normally found in differentiated squamous cells such as keratin 1. (ukri.org)
In neoplastic myoepithelial cells, CD10 expression was found in 25.71% of benign and 32.43% of malignant neoplasms. (qxmd.com)
Using microarray analysis, his team found that loss of menin results in increased expression of the Gas1 gene. (medindia.net)
We found menin linked to Hedgehog signaling by suppressing expression of GAS1, leading to the suppression of Hedgehog signaling in endocrine tissue. (medindia.net)
A low incidence of Langerin-positive cells was found in tumours and 1/3 of studied carcinomas were even Langerhans cell-free. (archive.org)

Loss of activity of drug metabolizing enzymes would confer increased sensitivity of esophageal cells to xenobiotics, such as alcohol and tobacco smoke, and may account for the high incidence and aggressiveness of ESCC in this ethnic group. (biomedcentral.com)

BABEL enables cross-modality translation between multiomic profiles at single-cell resolution. (stanford.edu)
One explanation is that a selective advantage may be derived from their expression that enables basal cells to gain new properties. (ukri.org)

Cell 85 , 841-851 (1996). (nature.com)

In addition, 14 of the patients were the normal mammary gland and are also important in the development premenopausal (5 ER and 9 ER ) and 33 were postmenopausal (18 ER and progression of breast carcinoma. (lu.se)

Here, we report that the stem/progenitor cell transcription factor, Sex determining region Y-box 2 (Sox2), is required in the embryonic SCN to control the expression of SCN-enriched neuropeptides and transcription factors. (bvsalud.org)

Anatomy26

Organisms5

Diseases109

Chemicals and Drugs42

Analytical, Diagnostic and Therapeutic Techniques and Equipment47

Phenomena and Processes28

Disciplines and Occupations2

Information Science5

Health Care14

Tumors22

Sporadic basal2

Cutaneous3

Nevoid5

Proteins6

Syndrome3

Squamous cell carcinomas1

Differentiation8

Case of basal1

Proliferation10

Renal cell carc1

Tumour4

Pancreatic2

Metastatic1

Biomarkers2

Tissues10

Suprabasal cells2

Lesion3

Recurrence1

Diagnosis4

Prognosis1

Epithelial cells3

Mutations4

Genes7

Tumor cells2

Tissue microarrays1

Epithelium8

Human6

Susceptibility1

Clinical2

Methylation1

Immunohistochemistry3

Gastrointestinal2

Prognostic1

Cancer18

Histology1

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Gene expression profiles1

Signaling pathway1

Vitro3

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19961

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