• Expression patterns and correlations between LINE-1 ORF1 and c-Met proto-oncogene proteins were analyzed by immunofluorescence staining using both LINE-1 ORF1 and c-Met antibodies. (kosinmedj.org)
  • The expression patterns of LINE-1 ORF1 and c-Met showed significant individual differences, and the expression of both proteins was correlated in all colorectal cancer patients. (kosinmedj.org)
  • Bortoluzzi S, Alessi FD, Romualdi C, Danieli GA: Differential expression of genes coding for ribosomal proteins in different human tissues. (karger.com)
  • Six proto-oncogenes (K-ras, c-myc, c-fos, c-jun, c-sis, and erbB), as well as the p53 tumor suppressor, were investigated for gene amplification using differential polymerase chain reaction (PCR), while the expression of the proteins produced by these genes was evaluated by Western blot analysis. (cdc.gov)
  • The GENE for myeloid-lymphoid leukemia protein is commonly disrupted in LEUKEMIA and combines with over 40 partner genes to form FUSION ONCOGENE PROTEINS. (bvsalud.org)
  • In humans, mRNA expression of hTERT ( hEST2 ), the candidate telomerase catalytic subunit gene, appears to parallel the levels of telomerase enzyme activity, suggesting that induction of hTERT is necessary and perhaps sufficient for expression of telomerase activity in tumor cells. (nature.com)
  • Back in 2014, they discovered that ecDNA plays a central role in the drug resistance of certain brain tumors by enabling tumors to rapidly change the amount of oncogenes they contain-and thereby determine whether a cell transforms into a tumor cell. (genengnews.com)
  • The altered gene expression may enhance several cancer-related events such as cell division (proliferation), cell movement, and the development of new blood vessels (angiogenesis) that nourish a growing tumor. (medlineplus.gov)
  • It plays a role in proliferation, apoptosis, angiogenesis, and tumor invasion ( 12 - 14 ), and its expression may be related to resistance to cytotoxic-, antiestrogen-, and HER2 / neu -targeted therapy ( 15 - 18 ). (snmjournals.org)
  • Thus far, studies on IGF-1R expression have been performed mainly on tumor tissue sections using immunohistochemistry. (snmjournals.org)
  • However, this technique cannot be used to measure the expression in different tumor lesions and different regions within a tumor, because this would require multiple invasive procedures. (snmjournals.org)
  • Furthermore, the expression of IGF-1R may change in the course of time (e.g., because of tumor growth and therapy). (snmjournals.org)
  • This led us to hypothesize that the absence of SMAD1 expression in HRS cells may mechanistically be linked to their resistance to the tumor-suppressive effects of TGF-β. (haematologica.org)
  • Ectopic expression of DOCK8 regulates lysosome-mediated pancreatic tumor cell invasion. (mayo.edu)
  • The paper also presents evidence that oncogenes encoded on ecDNA are among the most highly expressed genes in the transcriptome of the tumors. (genengnews.com)
  • abstract = "The influence of cell shape on the expression of proto‐oncogenes was examined in normal and malignant human cells that varied in their sensitivities to contact‐inhibition of proliferation. (psu.edu)
  • LINE-1 hypomethylation induces the activation of proto-oncogenes in human colorectal cancer metastasis. (kosinmedj.org)
  • Western blotting was performed to detect the protein levels of cyclin‑dependent kinase inhibitor P21 (P21), B‑cell lymphoma‑2 (Bcl‑2), matrix metalloproteinase 9 (MMP9) and E26 oncogene homolog 1 (ETS1). (spandidos-publications.com)
  • Genetic alterations of BCL2 (B-cell CLL/lymphoma 2), MYC [v-myc myelocytomatosis viral oncogene homolog (avian)] and CCND1 (cyclin D1) are the most frequently found alterations in human B-cell lymphomas. (haematologica.org)
  • The activation of AKT1 suppressed the expression of phosphatase and tensin homolog and increased the activation of Notch1. (spandidos-publications.com)
  • Subsequent mechanism investigations revealed that AKT1 served a notable function in cell proliferation and anti-apoptosis by directly regulating the expression of phosphatase and tensin homolog (PTEN) and Notch1. (spandidos-publications.com)
  • We have studied the expression of this protein in different subtypes of Hodgkin's disease using monoclonal antibodies directed against a formalin-resistant epitope of the bcl-2 protein and also have investigated these cases by polymerase chain reaction for evidence of the t(14;18) translocation. (ox.ac.uk)
  • Western blotting and reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR) to evaluate the expression levels of AKT1 in HCC SMMC‑7721 cell line. (spandidos-publications.com)
  • Moreover, inability to regulate c‐myc and c‐ras oncogene expression is associated with loss of shape‐dependent growth controls and contact inhibition but that loss of this regulation alone is not sufficient to release cells from contact‐inhibited controls. (psu.edu)
  • The inhibition of AKT1 effectively suppressed the expression of Notch1. (spandidos-publications.com)
  • Wnt/β-catenin pathway regulates MGMT gene expression in cancer and inhibition of Wnt signalling prevents chemoresistance. (lu.se)
  • Expression of the bcl-2 oncogene product and chromosomal translocation t(14;18) in Hodgkin's disease. (ox.ac.uk)
  • The reciprocal chromosomal translocation t(14;18), leading to overexpression of this oncogene, can be found in the majority of follicular lymphomas and much less frequently in B-cell leukemias and diffuse lymphomas. (ox.ac.uk)
  • Thus chromosomal translocations invoicing the Ig loci may not only contribute to transformation by deregulating oncogene expression but could also act by potentiating subsequent oncogene hypermutation. (lu.se)
  • We isolated mouse cDNA clones containing the entire coding region of the putative oncogene Akt2. (nih.gov)
  • In the present study we show that p95 is a product of the mdm2 putative proto-oncogene. (nih.gov)
  • Long noncoding RNA H19 competitively binds miR-17-5p to regulate YES1 expression in thyroid cancer. (atlasgeneticsoncology.org)
  • Moreover, zebrafish is very well-suited for systematic analysis of gene expression patterns at transcript level by whole-mount in situ hybridization (WISH), and at protein level by immunohistochemistry/immunofluorescence (IHC/IF). (frontiersin.org)
  • By using immunohistochemistry we investigated the expression of EphA2 and EphrinA-1 in 217 early squamous cell cervical carcinomas and examine their prognostic relevance. (medsci.org)
  • In situ hybridization (ISH) was used to investigate the presence of HPV-16, while immunohistochemistry (IHC) was used to estimate the expression level of TIMP-2. (bvsalud.org)
  • Quantification of transcription rates by the nuclear run‐off assay showed that shape modulation of c‐myc and c‐ras oncogene expression occurred at the transcriptional level. (psu.edu)
  • According to recent studies, the long interspersed element-1 (LINE-1) retrotransposon open reading frame (ORF) is located in the intron of the c-Met proto-oncogene, which is involved in cancer progression and metastasis, and regulates its expression. (kosinmedj.org)
  • However, no study has compared the expression patterns of LINE-1 ORF1 and c-Met, which are closely related to cancer progression and metastasis, and their correlation in primary and recurrent cancers. (kosinmedj.org)
  • Specifically, the activation of proto-oncogene c-Met is involved in liver metastasis of colorectal cancer patients [ 7 ]. (kosinmedj.org)
  • Alternative splicing of the oncogene murine double minute 2 (MDM2) is induced in response to genotoxic stress . (bvsalud.org)
  • The B-cell lymphoma/leukemia oncogene bcl-2 takes part in crucial regulatory events in B-cell maturation and differentiation. (ox.ac.uk)
  • We further demonstrate that the induction of mdm2 expression by t p53 activity is at the mRNA level. (nih.gov)
  • Our data provide evidence that constitutive MDM2-ALT1 expression is itself an oncogenic lesion that aggravates the tumorigenesis induced by p53 loss. (bvsalud.org)
  • Our data suggest that the B- cell loss is p53 dependent and is a response mounted to persistent MDM2-ALT1 expression in a wild-type p53 background. (bvsalud.org)
  • The protein expression levels of LINE-1 ORF1 and c-Met were correlated, but did not change significantly in cases of recurrent colorectal cancer in the same patient. (kosinmedj.org)
  • Importantly, a precise temporal description of RPRM protein expression during the development of neuronal structures is still missing. (frontiersin.org)
  • Scope includes mutations and abnormal protein expression. (cancerindex.org)
  • In summary, BCL9-2 induces ER positive breast cancers in vivo , regulates ER expression by a novel ß-catenin independent mechanism in breast cancer cells, and might predict the therapy response to tamoxifen treatment. (oncotarget.com)
  • Alterations in the activity (expression) of the SEPTIN9 gene are associated with certain cancers. (medlineplus.gov)
  • However, the expression levels of LINE-1 ORF1 and c-Met were not significantly different between primary and recurrent colorectal cancers. (kosinmedj.org)
  • In various human cancers poor outcome for the patients has been associated with increase expression of EphA2 and EphrinA-1 [ 16 , 17 , 19 , 24 , 26 ]. (medsci.org)
  • we found that the expression of cartilage protein COMP is associated with metastases and a poor prognosis for patients with various types of solid cancers. (lu.se)
  • Proto-oncogene activation and genomic instability of cadmium -induced cell transformation in BALB/c-3T3 cells. (cdc.gov)
  • Therefore, the aim of the present study was to develop a noninvasive, in vivo imaging method, using radiolabeled antibodies, to visualize IGF-1R expression. (snmjournals.org)
  • 111 In-R1507 and 89 Zr-R1507 are new tracers to noninvasively determine IGF-1R expression in vivo in breast cancer xenografts using SPECT and PET. (snmjournals.org)
  • Chromosome painting was performed to confirm that this amplification was not simply due to additional copies of the chromosomes carrying these oncogenes. (cdc.gov)
  • In contrast, transcriptional regulation of the ESR1 gene promoter was described in a number of studies to be an important mechanism for overexpression and maintenance of ER expression in breast tumors [ 1 ]. (oncotarget.com)
  • Expression of CD44 3'-untranslated region regulates endogenous microRNA functions in tumorigenesis and angiogenesis. (sunnybrook.ca)
  • However, reprogramming fibroblasts to a liver progenitor fate, induced hepatocytes (iHeps), makes them sensitive to transformation by the same oncogenes. (biorxiv.org)
  • In this study, amplification, expression, and point mutation of cancer-related genes associated with Cd-induced cell transformation in BALB/c-3T3 cells were studied. (cdc.gov)
  • Expression of nuclear estrogen receptor alpha (ER) predicts the prognosis and the therapy response to anti-estrogens of human breast cancer [ 1 ]. (oncotarget.com)
  • Gene expression profiling of ErbB receptor and ligand-dependent transcription. (rochester.edu)
  • Therefore, patient selection for IGF-1R-targeted therapy may be based on receptor expression. (snmjournals.org)
  • Moreover, aged BCL9-2 transgenic mice developed ductal-like mammary tumors with high nuclear ER expression. (oncotarget.com)
  • For EphA2 expression, 21 tumors (10%) showed negative, 108 (50%) weak positive, 69 (32%) moderate positive and 19 (9%) strong positive, whereas for EphrinA-1 expression, 33 tumors (15%) showed negative, 91 (42%) weak positive, 67 (31%) moderate positive and 26 (12%) strong positive. (medsci.org)
  • The expression of telomerase, the enzyme that synthesizes telomeric DNA de novo , is suppressed in normal somatic human cells but is reactivated during tumorigenesis. (nature.com)
  • Here we describe the role of BCL9-2, a proto-oncogene previously characterized as co-activator of Wnt/ß-catenin signaling, for mammary tumorigenesis in mice and human. (oncotarget.com)
  • These data suggest that changes in cell shape can modulate expression of certain oncogenes and that these changes correlate with the cell's ability to proliferate. (psu.edu)
  • In addition, reverse-transcription PCR (RT-PCR) was performed to confirm increased expression of c-myc and c-jun. (cdc.gov)
  • Akt2 expression was low in a multipotent fibroblast cell line, but it was upregulated when these cells were transformed with Myod and induced to differentiate into myocytes. (nih.gov)
  • Moreover, BCL9-2 regulated the expression of ER and the proliferation of human breast cancer cells independently of ß-catenin. (oncotarget.com)
  • High SEPT9_v1 expression in human breast cancer cells is associated with oncogenic phenotypes. (medlineplus.gov)
  • Northern analysis revealed that expression of c‐myc and c‐ras was highly sensitive to cell shape in the normal CUA‐1 cells but not in the malignant HT‐1080 or variant HT‐IFNr cells. (psu.edu)
  • Expression of c‐fos and c‐fes oncogenes were independent of cell shape in all cells tested. (psu.edu)
  • Characterization of the S-benzyldithiocarbazate effects on cell proliferation and oncogene expression in human breast cancer cells. (grmrc.org)
  • Figure 2: The expression profile of a novel non-protein coding transcript known as Nrgn antisense transcript in different adult mouse brain cells. (grmrc.org)
  • Propofol could inhibit Bcl‑2 and MMP9 expression, and increase P21 expression in GC cells. (spandidos-publications.com)
  • The expression levels of circ‑PVT1 and ETS1 were increased in GC tissues and cells, and miR‑195‑5p was decreased. (spandidos-publications.com)
  • Additionally, the treatment with propofol could lead to decreased circ‑PVT1 expression in GC cells. (spandidos-publications.com)
  • Results Primary B cells exogenously expressing Bcl2 , Myc and Ccnd1 showed factor-independent growth ability, enhanced colony-forming capability and aggressive oncogenicity, unlike the cases observed with the expression of any combination of only two of the genes. (haematologica.org)
  • High expression of activated AKT can be detected in HCC, and AKT may promote cell proliferation and regulation of cells apoptosis in HCC ( 20 , 21 ). (spandidos-publications.com)
  • GLI1 interaction with p300 modulates SDF1 expression in cancer-associated fibroblasts to promote pancreatic cancer cells migration. (mayo.edu)
  • Format: Text / Subject: Mutagenesis and Gene Expression Regulation / Genre: Articles / Publisher: Cold Spring Harbor Laboratory. (nih.gov)
  • This proto-oncogene may play a role in the regulation of embryonic development and cell growth. (wikipedia.org)
  • Farrell, RE & Greene, JJ 1992, ' Regulation of c‐myc and c‐Ha‐ras oncogene expression by cell shape ', Journal of Cellular Physiology , vol. 153, no. 2, pp. 429-435. (psu.edu)
  • The up-regulation of proto-oncogene may be the consequence of epigenetic control of gene expression by demethylase, and mbd2 is involved in the regulation of hMSH2 expression in human gastric cancer. (wjgnet.com)
  • Molecular mechanisms and the influences of different regulation the expression of AKT1 on HCC cell growth, proliferation were determined by western blotting, MTT and colony formation assays, cell cycle and apoptosis were investigated by flow cytometry. (spandidos-publications.com)
  • 7 Importantly, it is believed that other hitherto unknown genes also play important roles in lymphomagenesis in addition to the synergistic effects of the aforementioned two oncogenes since human B-cell lymphomas often show a variety of genes subject to alterations and/or deregulated expression. (haematologica.org)
  • Here we show that a combination of oncogenes that is characteristic of liver cancer (CTNNB1, TERT, MYC) induces senescence in human fibroblasts and primary hepatocytes. (biorxiv.org)
  • In the present study, we compared the expression patterns of LINE-1 ORF1 and c-Met in both primary and recurrent colorectal cancer tissues from 10 patients. (kosinmedj.org)
  • Stable disease and objective responses have been reported in patients treated with these new agents, but no relationship with the IGF-1R expression has been tested in a structured way ( 22 ). (snmjournals.org)
  • Les concentrations sériques de sCD40L circulant et d'interleukine 10 circulante ont été analysées à l'aide de la méthode immuno-enzymatique chez 30 patients positifs pour le VHC avec un CHC, chez 30 patients patients positifs pour le VHC avec une cirrhose du foie, et chez 30 volontaires d'âge correspondant en bonne santé avec des anticorps anti-VHC négatifs servant de groupe témoin. (who.int)
  • To determine the expression of tissue inhibitors of metalloproteinases (TIMP-2) in oral squamous cell carcinoma (OSCC) and the difference in its expression level between positive and negative HPV-16 (human papilloma virus- 16) OSCC patients. (bvsalud.org)
  • The transformed iHeps are highly proliferative, tumorigenic in nude mice, and bear gene expression signatures of liver cancer. (biorxiv.org)
  • 3 ]. However, the molecular mechanisms that maintain ER expression in breast cancer are not well understood [ 1 ]. (oncotarget.com)
  • A recent study of the disparity in breast cancer mortality between AA and EA women concluded that differences in mortality are driven by higher hazard rates of breast cancer death in AA women, irrespective of ER expression [9]. (cdc.gov)
  • We were particularly interested to determine whether nodular paragranuloma (lymphocyte-predominant, nodular), which differs from other subtypes of Hodgkin's disease by virtue of the B-cell nature of its malignant cell population, is characterized by expression of the bcl-2 protein. (ox.ac.uk)
  • ARVCF expression is significantly correlated with the malignant phenotype of non-small cell lung cancer. (nih.gov)
  • We examined eye lesions in five lines of transgenic mice carrying the human rasT24 oncogene driven by the type I γ glutamyl transferase (γGT) promoter. (houstonmethodist.org)
  • Expression levels of mouse Akt2 mRNA and Akt2 protein varied among tissues, with the highest levels in skeletal muscle. (nih.gov)
  • Herein we examine the temporal and spatial expression patterns of RPRM gene-products (mRNA and protein) during neural development. (frontiersin.org)
  • These data demonstrate that Akt2 expression is activated during cellular differentiation and suggest that it functions in the signaling pathways of some adult tissues. (nih.gov)
  • The new findings appeared November 20 in Nature , in an article titled, " Circular ecDNA promotes accessible chromatin and high oncogene expression . (genengnews.com)
  • We found very high levels of expression of the central complement protein, C3, and complement inhibitor CD59 in human pancreatic islets. (lu.se)
  • Once the oncogene is transfected back into a chicken, it can lead to cancer. (wikipedia.org)
  • To explore the effect of DNA methyltransferase, demethylase and methyl-CpG binding protein MeCP2 on the expressions and methylation of hMSH2 and proto-oncogene in human gastric cancer. (wjgnet.com)
  • The authors suggest that ecDNA, because of its increased DNA copy numbers and in association with enhanced chromatin accessibility, promotes massively increased transcription of the oncogenes. (genengnews.com)
  • With ecDNA, oncogenes are more likely to be expressed at high levels. (genengnews.com)
  • In univariate analysis high expression (strong staining) of EphrinA-1 was associated with poor disease-free ( P = 0.033) and disease-specific ( P = 0.039) survival. (medsci.org)
  • The percentage of samples that appeared to accommodate detectable HPV-16 was high, but no significant difference was observed in relation to TIMP-2 expression level. (bvsalud.org)
  • Myeloid-lymphoid leukemia protein is a transcription factor that maintains high levels of HOMEOTIC GENE expression during development. (bvsalud.org)
  • Among the 17 tissues, the highest similarity in gene expression patterns was between human brain and testis, based on DDD and clustering analysis. (karger.com)
  • In our previous study of cervical carcinomas FIGO stage I-IV we found that increase expression of EphA2 and EphrinA-1 was significantly associated with shorter overall survival in multivariate analysis [ 22 ]. (medsci.org)
  • The expression of these Src family members are not the same throughout all tissues and cell types. (wikipedia.org)