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  • differ
  • Expression of the two transporters in internal organs seems to differ between species: only VMAT1 is expressed in the rat adrenal medulla cells whereas VMAT2 is the major transporter in the bovine adrenal medulla cells. (wikipedia.org)
  • generate
  • The mystery was solved when KCNQ1 was cloned and found to co-assemble with KCNE1, and it was shown that Xenopus laevis oocytes endogenously express KCNQ1, which is upregulated by exogenous expression of KCNE1 to generate the characteristic slowly activating current. (wikipedia.org)
  • mice
  • No detectable motor behavior impairments, autonomic abnormalities, olfactory dysfunction, dopaminergic deficits, Lewy body inclusions or neurodegeneration are associated with α-synuclein expression in these mice. (jax.org)
  • liver
  • Glutathione S -transferase Mu 1 (GSTM1) has been regarded as one of the key enzymes involved in phase II reactions in the liver, because of its high expression level. (aspetjournals.org)
  • Women with a single-nucleotide polymorphism (SNP) in the binding site for let-7 (rs7963551), that causes reduced binding of let-7, likely have increased expression of RAD52 (as was shown for this SNP in liver). (wikipedia.org)
  • horses
  • Decreased expression of TRPM1 in the eye and the skin may alter bipolar cell signaling as well as melanocyte function, thus causing both CSNB and LP in horses. (genetics.org)
  • found
  • No effects were observed upon oocyte co-expression of KCNE1 and Kv4.2, but KCNE1 was found to slow the gating and increase macroscopic current of Kv4.3 in HEK cells. (wikipedia.org)
  • mouse
  • As homozygotes, expression of endogenous mouse α-synuclein is abolished and replaced by human α-synuclein from the two total insertions of the PAC-Tg(SNCA WT ). (jax.org)
  • dosage
  • The combination of homozygote lethality and dosage compensation in heterozygotes may explain why POU4F1 mutations have not been identified in any human disease, whereas diseases are associated with several other members of the POU domain transcription factor class. (wikipedia.org)
  • cell
  • Female homozygotes had a decreased respiratory quotient, increased circulating alkaline phosphatase level and increased leukocyte cell number. (wikipedia.org)
  • activity
  • These findings suggest that the remarkable variability in CYP2B6 expression and activity may be a major determinant of the efficacy and toxicity of these widely used drugs that are characterized by narrow therapeutic indices. (aspetjournals.org)
  • response
  • Claudin multigene family in channel catfish and their expression profiles in response to bacterial infection and hypoxia as revealed by meta-analysis of RNA-Seq datasets. (auburn.edu)
  • influence
  • Sequence analysis of these mutations purported that a number of them may influence CYP2B6 expression by altering consensus transcription factor binding sites. (aspetjournals.org)
  • known
  • H19 is also known as BWS because aberrant H19 expression can be involved in Beckwith-Wiedemann Syndrome ("BWS"), as well as Silver-Russell syndrome. (wikipedia.org)