Expression antigens cd44. Medical search. Frequent questions

Stimulation of naive CD4 cells by specific antigen results in proliferation and changes in cell surface marker expression as the cells differentiate into effector and memory cells. (unboundmedicine.com)
CD4(+) T cells from DO11.10 TCR transgenic mice were labeled with the fluorescent dye carboxyfluorescein diacetate succinimidyl ester (CFSE) and were stimulated with specific antigen (OVA323-339). (unboundmedicine.com)
AU - Lee,W T, AU - Pelletier,W J, PY - 1998/9/23/pubmed PY - 1998/9/23/medline PY - 1998/9/23/entrez SP - 1 EP - 11 JF - Cellular immunology JO - Cell Immunol VL - 188 IS - 1 N2 - Stimulation of naive CD4 cells by specific antigen results in proliferation and changes in cell surface marker expression as the cells differentiate into effector and memory cells. (unboundmedicine.com)
Androgen induced expression of androgen receptor (AR), and co-culture with rat urogenital sinus further induced expression of prostate-specific antigen, a hallmark of secretory cells, suggesting that E-PZ-iPS-like cells have the capacity to differentiate into prostatic basal and secretory epithelial cells. (nih.gov)
After 6 weeks, the subcutaneous tissues were processed for alizarin red staining and immunohistochemistry of human specific antigen. (ncku.edu.tw)
The specific antigen that triggers lichen planus is unknown, although it may be a self-peptide (or altered self-peptide), in which case lichen planus would be a true autoimmune disease. (medscape.com)

Although changes in some markers (L-selectin) occurred independently of cell division, changes in other markers were either strictly related to cell division (CD45RB) or were a prerequisite to cell division (CD4, CD44). (unboundmedicine.com)
Upregulation of activation and costimulatory markers in antigen presenting cells are key events in the sensitization process and have been reported to serve as indicators of skin sensitization. (cdc.gov)
The antigen-specific CD8 + T cell repertoire in unimmunized mice includes memory phenotype cells bearing markers of homeostatic expansion. (nature.com)
Importantly, E-PZ-iPS-like cells re-expressed basal epithelial cell markers (CD44, p63, MAO-A) in response to prostate-specific medium in spheroid culture. (nih.gov)
Finally, when injected into mice, E-PZ-iPS-like cells expressed basal epithelial cell markers including CD44 and p63. (nih.gov)
Finally, mononuclear cells isolated from lung (L-MCs), which are used as precursors for L-DCs, expressed more antigen-presenting cell-associated markers such as MHC class II and CD172α compared to their counterparts from blood. (biomedcentral.com)
Morphology, growth characteristics, and expression of endothelial surface antigens and other cellular markers were evaluated. (nih.gov)
However, the intensity of expression of the DC-restricted markers NLDC 145, 33D1, and N418, and the macrophage marker F4/80, intercellular adhesion molecule 1, and Fc gamma RII was low to moderate, whereas the cells were negative for CD3, CD45RA, and NK1.1. (silverchair.com)
Splenocytes prepared in the same way also had a similar range and intensity of expression of these immunophenotypic markers. (silverchair.com)
Aims: To determine the validation of the CSC model for cell surface markers such as CD44 and CD24 and their clinical significance. (nbuv.gov.ua)
1 2 Cell surface antigens CD38 and CD138 can be used to distinguish normal cells from clonal plasma cells, but more extensive use of immunophenotyping has been limited by a lack of universally accepted markers of MM. 3-5 Once diagnosed, the current standard-of-care for MM includes immunomodulatory drugs, proteasome inhibitors, steroids, and antibody therapies. (bmj.com)
To study the correlation between the putative cancer stem cell (CSC) markers aldehyde dehydrogenase 1 (ALDH1), cluster of differentiation 44 (CD44), sex-determining region Y-box 2 (SOX2), and octamer-binding protein 4 (OCT4) and human papilloma virus (HPV) infection using p16, the surrogate marker of HPV in oral epithelial dysplasia (OED) and normal mucosa. (rmmj.org.il)
This is the first study to evaluate the expression of putative CSC markers in HPV-associated OED. (rmmj.org.il)
It is also considered a marker of multipotent mesenchymal stem cells when expressed in association with other markers (CD29, CD44, CD73, CD105) [33, 34]. (islamophobiacon.com)
To this end, we investigated cell markers expression related to this proliferative stimulus. (islamophobiacon.com)
The expression level of CD24 and CD44 as CSC markers was measured by flow cytometry in secondary mammospheres, and the expression of NANOG, SOX2, and OCT4 genes in CSCs was also analyzed using the real-time polymerase chain reaction (PCR). (celljournal.org)
Objective: To establish cultures of cells from the pulp of permanent teeth by the explant method assessing parameters usually presented by stem cells, such as the expression of certain markers and the differentiation ability into osteogenic, adipogenic, and chondrogenic lineages. (bvsalud.org)
Cells were tested for the expression of surface markers and for ALDH1 enzyme activity, by flow cytometry. (bvsalud.org)
The isolated cells may be considered stem cells, based on the current criteria for their characterization, such as plastic adherence, expression of certain markers, and the absence of others, as well as multi-differentiation potential, which showed to be promising for the application in tissue regeneration. (bvsalud.org)

In breast cancer cells expressing CD44 and CD24, DHRS7B expression was observed to be down regulated. (wikipedia.org)
While innate immune cells are important for early tumor immune surveillance, T cells are fundamentally recognized for their crucial role in the antigen-specific recognition and elimination of malignantly transformed cells ( 2 ). (frontiersin.org)
In the early 2000's, large and persistent populations of antigen (Ag)-specific CD8 T cells in peripheral tissues were initially classified as T EM cells in recirculation from the blood ( 8 , 11 ). (frontiersin.org)
Several of the marker changes (e.g., differences in CD45RB, CD44, and L-selectin levels) appear to be relatively stable and permit the identification of memory T cells. (unboundmedicine.com)
The present study evaluated the effect of hapten and prohapten exposure on cell surface marker expression (CD86, CD54, CD44 and CD40) on THP-1 cells. (cdc.gov)
Flow cytometry data demonstrated a consistent dose-dependent increase of surface expression of the Tcell costimulatory molecule CD86 when cells were dosed with a hapten or prohapten in the presence of S9. (cdc.gov)
Expression of the adhesion molecule CD54 (ICAM-1) and the antigen presenting cell costimulatory molecule CD40 were also significantly elevated in both hapten and prohapten (+ S9) treated cells, however S9 alone also upregulated CD54. (cdc.gov)
However flat mounts of HCECs from organ-culture preserved corneas showed a mosaic-like distribution pattern of VCAM-1 and ELAM-1 positive cells and garland-like clusters of CD44 positive cells. (bmj.com)
Virtual memory T (T VM ) cells are a T cell subtype with a memory phenotype but no prior exposure to foreign antigen. (nature.com)
Mechanistically, CD44 s-hi CD49d lo CD8 + T cells could be induced from conventional T VM cells by interleukin (IL)-12, IL-15 and IL-18 stimulation. (nature.com)
Pathogenic activity of CD44 s-hi CD49d lo CD8 + T cells was mediated by NKG2D-dependent innate-like cytotoxicity, which was further augmented by IL-15 stimulation and triggered disease onset. (nature.com)
Fig. 2: CD44 s-hi CD49d lo CD8 + T cells originate from T VM cells. (nature.com)
Fig. 3: CD44 s-hi CD49d lo CD8 + T cells are derived from T VM cells by cytokine stimulation. (nature.com)
Fig. 4: CD44 s-hi CD49d lo CD8 + T cells have strong effector functions with T RM cell features. (nature.com)
Fig. 5: Cytolytic activity of CD44 s-hi CD49d lo CD8 + T cells is abrogated by NKG2D blockade. (nature.com)
White, J. T., Cross, E. W. & Kedl, R. M. Antigen-inexperienced memory CD8 + T cells: where they come from and why we need them. (nature.com)
CD8α + dendritic cell trans presentation of IL-15 to naive CD8 + T cells produces antigen-inexperienced T cells in the periphery with memory phenotype and function. (nature.com)
These E-PZ-iPS-like cells with normal karyotype gained expression of pluripotent genes typical of iPS cells (Tra-1-81, SSEA-3, Nanog, Sox2, and Oct4) and lost gene expression characteristic of basal prostatic epithelial cells (CK5, CK14, and p63). (nih.gov)
When co-injected with rat urogenital mesenchyme, E-PZ-iPS-like cells expressed AR and expression of p63 and CD44 was repressed. (nih.gov)
Rapamycin enhanced expansion of peripheral antigen-specific CD8 T cells and IFNγ production following ex vivo antigen stimulation. (aacrjournals.org)
The latter is a tool previously developed by Jacopo, 2020, able to identify tumor antigens similar to pathogen antigens in order to exploit molecular mimicry and tumor pathogen cross-reactive T cells in cancer vaccine development. (elifesciences.org)
Dendritic cells (DCs) are professional antigen-presenting cells that have multiple subpopulations with different phenotypes and immune functions. (biomedcentral.com)
Dendritic cells (DCs) are the most important antigen-presenting cells (APCs) in the body. (biomedcentral.com)
The purpose of this study was to investigate the expression pattern of Mage-D1 in rat tooth germ development and its differential mineralization ability to ectomesenchymal stem cells (EMSCs), and to explore its potential mechanism. (researchsquare.com)
Right: EpCAM+ cells from histogram gates shown on left stained with CD133-APC (y-axis) and CD44-PE (x-axis). (gardos-channel.com)
Evidence reported to date suggests overlapping functions for these ligands and their constitutive expression on some normal tissues and upregulation on activated antigen-presenting cells. (thermofisher.com)
Cell-mediated immune responses are initiated by T lymphocytes that are themselves stimulated by cognate peptides bound to MHC molecules on antig en-presenting cells (APC). (thermofisher.com)
The expression of biomarkers can be detected intracellularly or on the cell membrane of melanoma cells or noncancer cells in association with the melanoma. (hindawi.com)
However, when 7-d cultured GM-CSF-stimulated liver cells were maintained additionally for three or more days on type-1 collagen-coated plates in the continued presence of GM-CSF, they exhibited characteristics of mature DC: MHC class II expression was markedly upregulated, mixed leukocyte reaction stimulatory activity was increased, and phagocytic function was decreased. (silverchair.com)
Immunotherapies with antibody-drug-conjugates (ADC) and CAR-T cells, targeted at tumor surface antigens (surfaceome), currently revolutionize clinical oncology. (lu.se)
In the short-term AN model, iPS-MSCs conferred a substantial anti-apoptotic effect on tubular cells, associated with a downregulation of Bax and Bax/Bcl2 ratio and an upregulation of survivin expression. (oncotarget.com)
Are CD44⁺/CD24⁻ cells the assumed cancer stem cells in breast cancer? (nbuv.gov.ua)
CD44 and CD24 antigens expression was evaluated by the percentage of positive cells using different chromogens and the MultiVision detection system by immunohistochemical method. (nbuv.gov.ua)
positive - expression in ≥10% of cells. (nbuv.gov.ua)
The content of CD44 cells did not differ statistically between groups A and B (p = 0.18), but there was a tendency for increasing in OS with the existence of CD44+ cells (p = 0.056). (nbuv.gov.ua)
Conclusions: As a result of our research, the analysis of the quantity of assumed stem cells of the BC, which were identified by immunohistochemistry as CD44 and CD24 cells, failed to detect a statistically significant relation between groups of patients with different prognosis, and the identification of their expression is not enough for the characteristics of CSC. (nbuv.gov.ua)
CD44 is expressed on leucocytes, erythrocytes, epithelial cells and weakly on platelets. (bdbiosciences.com)
Nine of these proteins were identified as potential immunotherapeutic targets, including five that were validated by FCM, confirming their expression on the cell surface of primary MM patient cells. (bmj.com)
In the thymus, DOCK8-deficient mice lack a terminally differentiated subset of NK1.1(+) NKT cells expressing the integrin CD103, whereas in the liver, DOCK8-deficient NKT cells express reduced levels of the prosurvival factor B-cell lymphoma 2 and the integrin lymphocyte function-associated antigen 1. (ox.ac.uk)
Up regulation of endoglin expression has been demonstrated in tumor vasculature and proliferating cells, suggesting that it is a proliferation associated endothelial marker. (thermofisher.com)
Taking advantage of the diverse γδ TCR repertoire or other ligand-receptor interactions, γδ T cells can recognize a broad spectrum of tumor-associated antigens (TAAs) in a major histocompatibility complex (MHC)-independent manner, thereby activating downstream pleiotropic effects. (explorationpub.com)
Dendritic cells (DCs) are hematopoietic-derived highly specialized antigen-presenting cells (APCs) that display potent ability to induce both specific immune responses and deletion of potentially autoreactive T cells. (ashpublications.org)
We investigated whether CD44 is involved in the mineralization of dental pulp cells. (ncku.edu.tw)
Dental pulp cells isolated from another 5 human third molars were assayed for their viability, alkaline phosphatase activity, and alizarin red staining in vitro after silencing stably their expression of CD44 by using the short hairpin RNA technique. (ncku.edu.tw)
The CD44 knockdown cells were cultured on a collagen sponge and transplanted subcutaneously into the dorsal surfaces of immunocompromised mice. (ncku.edu.tw)
Results: CD44 is expressed in odontogenic cells with active mineral deposition during tooth development. (ncku.edu.tw)
When CD44 expression was stably suppressed in dental pulp cells, their mineralization activities were substantially decreased in both in vitro and in vivo assays. (ncku.edu.tw)
Therefore, early in the formation of oral lichen planus lesions, CD8 + T cells may recognize an antigen associated with the major histocompatibility complex (MHC) class I on keratinocytes. (medscape.com)
After antigen recognition and activation, CD8 + cytotoxic T cells may trigger keratinocyte apoptosis. (medscape.com)
Kb-17 tetramer positive liver CD8+ T cells (panel 1) harvested 7?days postboost have phenotype of antigen experienced CD11a+ (panel 2) CD44+CD62L? (bibf1120.com)
In this study, we sought to determine fine antigen (Ag) specificities of CD8 T cells that target LS malaria parasites. (bibf1120.com)
The expression of class II MHC molecules by mucosal epithelial cells has generated interest in the role that these cells may have in mucosal immunity. (utmb.edu)
Since in classical antigen-presenting cells (APC) the biology of class II MHC is regulated by Ii, it is necessary to bring into perspective the known functions of Ii in conventional APC to understand the role that Ii may play in mucosal epithelial cells as potential regulators of local immune responses. (utmb.edu)
A third marker of cell proliferation is usually CD90 (Thy1, thymocyte differentiation antigen-1), a glycophosphatidylinositol cell surface protein expressed by thymocytes, CD34+ cells, mesenchymal stem cells, endothelial cells, and cardiac fibroblasts. (islamophobiacon.com)
Mouse anti Human CD44 antibody, clone F10-44-2 ( MCA89 ) used for the identification of mesenchymal stem cells in mixed bone marrow cell populations by flow cytometry. (bio-rad-antibodies.com)
Moreover, proliferating cell nuclear antigen (PCNA) and CD31 showed co-localization with α-SMA, suggesting the differentiation of hBMSCs into epithelial cells and myofibroblasts/fibroblasts. (ijbs.com)
This study also aimed to assess the expression of ALDH1 (aldehyde dehydrogenase 1) enzyme activity on the isolated cells. (bvsalud.org)
Results: The isolated cells showed high expression of CD44 (98.8%), CD73 (100%), and CD90 (97.2%), and moderate expression of STRO-1 (18.4%) and ALDH1 (16.2%), by flow cytometry. (bvsalud.org)

dashed line histogram) or PE Mouse Anti-Human CD44 (Cat. (bdbiosciences.com)
Staining of human peripheral blood granulocytes with Mouse anti Human CD44:Alexa Fluor ® 647 ( MCA89A647 ). (bio-rad-antibodies.com)
Staining of human peripheral blood lymphocytes with Mouse anti Human CD44:FITC ( MCA89F ). (bio-rad-antibodies.com)
Formalin fixed, paraffin embedded human breast cancer biopsy stained with Mouse anti Human CD44 antibody ( MCA89 ) followed by HRP-polymer detection and DAB substrate development (low power) following antigen retrieval using citrate buffer at pH6.2. (bio-rad-antibodies.com)

We analysed the expression of CD44, CD24 and CD44⁺/CD24⁻ for different patients with dividing them into two groups. (nbuv.gov.ua)

Since leucocyte-endothelial cell interactions involve various adhesion receptors we have analysed the expression and distribution pattern of the neural cell adhesion molecule (NCAM), the intercellular adhesion molecule-1 (ICAM-1), the vascular cell adhesion molecule-1 (VCAM-1), the endothelial leucocyte adhesion molecule-1 (ELAM-1), and the cluster of differentiation antigen-44 (CD44) on flat preparations of normal and organ-cultured HCECs. (bmj.com)

Analysis of the underlying mechanism showed that 6-S and PTE decreased the expression of the surface antigen CD44 on BCSCs and promoted β-catenin phosphorylation through the inhibition of hedgehog/Akt/GSK3β signaling, thus decreasing the protein expression of downstream c-Myc and cyclin D1 and reducing BCSC stemness. (tmu.edu.tw)
The most advanced BMS-354825 tyrosianse inhibitor malaria vaccine, RTS,S, based on the Pf circumsporozoite protein (CSP), BMS-354825 tyrosianse inhibitor the major sporozoite (spz) surface antigen (Ag), induces but a modicum of protection from clinical malaria and protection is usually short-lived (2C4). (bibf1120.com)

Flow cytometric analysis of CD44 on human peripheral blood lymphocytes. (bdbiosciences.com)

The isolated hBMSCs expressed the phenotype of CD11b low /CD14 low /CD34 low /CD45 low /CD29 high /CD44 high /CD90 high /CD105 high /CD146 high /STRO-1 low . (ijbs.com)
Resultados: as células isoladas mostraram alta expressão para CD44 (98,8%), CD73 (100%) e CD90 (97,2%) e uma expressão moderada para STRO-1 (18,4%) e ALDH1 (16,2%), por meio da citometria de fluxo. (bvsalud.org)

These peptides were then tested in our previously described oncolytic cancer vaccine platform PeptiCRAd, a vaccine platform that combines an immunogenic oncolytic adenovirus (OAd) coated with tumor antigen peptides. (elifesciences.org)
They act as a surveillance system to detect foreign antigens and shape immunogenic or tolerogenic responses [ 1 ]. (biomedcentral.com)
Conclusion: Altogether, we found that heat-induced upregulated expression of gp96 in CSCs enriched mammospheres from breast tumor tissue might be used as a complementary procedure to generate more immunogenic antigens in immunotherapy settings. (celljournal.org)

CD44 has functional roles in cell migration, lymphocyte homing and adhesion during hematopoiesis and lymphocyte activation. (bdbiosciences.com)
CD44 is an integral cell membrane glycoprotein with a postulated role in matrix adhesion lymphocyte activation and lymph node homing. (wdv.com)
1989) demonstrated that the lymphocyte homing receptor is identical to the human leukocyte surface glycoprotein called CDw44, on the basis of studies at the Third International Workshop on Human Leukocyte Differentiation Antigens. (wdv.com)
The major histocompatibility complex (MHC) on chromosome 6, which contains the human lymphocyte antigens (HLA), was the first described genetic link to SLE. (medscape.com)

Glycoprotein 96 (gp96) is a well-known HSP that promotes the cross-presentation of tumor antigens. (celljournal.org)

CD44 percentage values in peripheral T-lymphocytes were significantly higher in patients than controls, as detected by flow cytometry. (who.int)

The 515 monoclonal antibody specifically binds to CD44. (bdbiosciences.com)
1983) used a murine monoclonal antibody (A3D8) to identify an erythrocyte antigen inhibited by the In(Lu) gene. (wdv.com)

CD44 is an 80-95 kDa type I transmembrane glycoprotein, also known as Phagocytic glycoprotein-1 (Pgp-1), or Extracellular matrix receptor type III (ECMR-III). (bdbiosciences.com)
Introduction: CD44 is a transmembrane glycoprotein with various biological functions. (ncku.edu.tw)
1989)' 'demonstrated' 'sameness' 'the human leukocyte surface glycoprotein' 'is called' 'CDw44' 'studies' 'were conducted at' 'the Third International Workshop on Human Leukocyte Differentiation Antigens. (wdv.com)

Conversely, CD44 and E-cadherin expressions were significantly lower in the ectopic endometrial tissue samples of women with endometrioma than in the control endometrial tissue samples ( p = 0.0137 and p = 0.0060, respectively). (biomedcentral.com)

Another marker Gabazine of cell proliferation is usually proliferating cell nuclear antigen (PCNA). (islamophobiacon.com)

It is likely that L-DCs play an important role in antigen uptake and processing of respiratory pathogens and are major contributors to respiratory tract immunity and may be ideal tools for future in vitro or ex vivo studies. (biomedcentral.com)

MSCs used in this study were characterized for marker expression by flow cytometric analysis. (bio-rad-antibodies.com)

Five sections each from 40 histopathologically diagnosed cases of different grades of OED and 10 cases of normal oral mucosa without dysplasia were immunohistochemically stained with p16, ALDH1, CD44, SOX2, and OCT4, respectively. (rmmj.org.il)
Expression of ALDH1 and SOX2 was significantly increased in OED cases, whereas CD44 and OCT4 expression was increased in normal mucosa. (rmmj.org.il)
Real-time PCR indicated that OCT4, NANOG, and SOX2 expression in mammospheres were increased by 3.8 ± 0.6, 17.8 ± 0.6, and 7.7 ± 0.8 fold respectively in comparison to the MCF-7 cell line. (celljournal.org)

In vitro , conditioned medium from iPS-MSCs (iPSMSC-CM) significantly limited albumin-induced tubular apoptosis and enhanced tubular proliferation, accompanied by a reduced expression of tubular Bax and an elevated expression of Bcl2 and survivin. (oncotarget.com)
Herein, the growth and proliferation, gene expression, multipotency and phenotype of cultured hBMSCs were compared with those incubated with CTX. (ijbs.com)

Acetylation at Lys-42 of PbrPPA5 by the acetyltransferase GCN5-related N-acetyltransferase 1 (GNAT1) drives accumulation of PbrPPA5 in the nucleus, where it binds to the transcription factor PbrbZIP77, forming a transcriptional repression complex that inhibits the expression of the pectin methylesterase (PME) gene PbrPME44. (bvsalud.org)

Moreover, colon length, histological changes, myeloperoxidase and catalase activities, metalloproteinase (MMP) 2 and 9 expression and endoplasmic reticulum (ER) stress related proteins were evaluated on day 7. (biomedcentral.com)
CD44 is a member of the hyaladherin family of hyaluronan-binding proteins, with structural similarities to selectins. (bdbiosciences.com)

Schlemm's canal cell isolates reacted with antibodies specific for CD44 (hyaluron receptor), CD54 (intercellular adhesion molecule-1, ICAM-1), tissue-type plasminogen activator, and TM-inducible glucocorticoid-responsive protein-myocilin (TIGR-MYOC). (nih.gov)
1983) showed that the antigens defined by monoclonal antibodies A3D8 and A1G3 are determined by genes on 11p. (wdv.com)

Concurrent with this observation, L-MCs possessed significantly more antigen-uptake capacity compared to their counterparts from blood. (biomedcentral.com)
Alix knockdown did not influence the number of EVs released by HLSCs, but it significantly decreased miRNA expression levels in the EVs and consequently their transfer to the endothelium. (spandidos-publications.com)
Immunohistochemical expression of Oct-4 was significantly higher in the ectopic endometrial tissue samples of women with endometrioma than in the control endometrial tissue samples ( p = 0.0002). (biomedcentral.com)

Methods: Ten human third molars with incomplete root formation were collected and processed for immunohistochemistry of CD44. (ncku.edu.tw)

More recent studies suggested that DCs derived from tissues without "danger" signal stimulation should be regarded as immature DCs, based on their major role in antigen uptake and endocytosis of antigens [ 11 , 14 ]. (biomedcentral.com)
The aim of this study was to investigate the expression patterns of Oct-4, CD44, and E-cadherin in eutopic and ectopic endometrial tissues from women with endometrioma compared to control endometrial tissues from women without endometrioma. (biomedcentral.com)
Increased expression of Oct-4 and decreased expression of adhesion molecules in endometriotic tissues may contribute to the development and progression of endometriosis. (biomedcentral.com)

CVO and DMBA, but not BaP, induced inconsistent increases in the adhesion molecule CD44. (cdc.gov)
CD44 is a multifunctional cell surface adhesion molecule that acts as an integral cell membrane protein and plays a role in cell-cell and cell-matrix interactions. (biomedcentral.com)

CD44 is an antigen found on the surface of most cell types and functions as a receptor that binds tissue macromolecules. (wikipedia.org)
A segment of Ii designated as CLIP (class II-associated Ii peptide) binds into the antigen binding site of class II MHC molecules until class II MHC reach intracellular compartments that contain peptides from internalized antigens. (utmb.edu)

showed that knocking out Mage-D1 can induce the expression of autophagy-related genes by enhancing the activity and differentiation of osteoclasts, thereby accelerating the process of periodontitis 23 . (researchsquare.com)

Further studies confirmed that p75NTR participates in the regulation of tooth development maybe by changing the activity of the key factor distal-less homeobox/msh homeobox (Dlx/Msx), and melanoma-associated antigen D1 (Mage-D1) seems to be play a role in the differentiation and mineralization of EMSCs 5 , 6 . (researchsquare.com)

The removal of CLIP from class II MHC catalyzes the binding of antigenic peptides and their subsequent cell surface expression. (utmb.edu)

DOCX) Figure S4 Histogram plots from antigens in Table 2. (gardos-channel.com)

Conclusions: CD44 may play a crucial role in the initial mineralization of tooth-associated structures. (ncku.edu.tw)

This goal is accomplished by tagging an antibody with a uniquely identifiable agent that is a surrogate for the level of expression of a given cellular constituent. (nature.com)
To generate a heatmap of the expression of antigens,(XLSX)Multiplexed FACS Antibody Array in Colon CancerTable S2 Complete SW620 profiling results. (gardos-channel.com)
Dashed histograms indicate staining with isotype-matched control antibody and solid histograms denote the specific expression of each indicated marker. (bio-rad-antibodies.com)

[ 19 ] Research published in 2015 also suggests that osteopontin, CD44, and survivin may be involved in the pathogenesis of oral lichen planus. (medscape.com)

CD44 is the receptor for hyaluronic acid. (bdbiosciences.com)

Le pourcentage de CD44 dans les lymphocytes T périphériques était significativement plus élevé chez les patients que chez les témoins, comme détecté par la cytométrie en flux. (who.int)
and finally live single lymphocytes are analyzed for their CD3 and CD8 expression. (bibf1120.com)

Histologic studies have shown that CD44 is strongly expressed in odontoblasts at the appositional stage of tooth development. (ncku.edu.tw)

1990) demonstrated that CD44 is the main cell surface receptor for hyaluronate. (wdv.com)

Nevertheless, the comparison of the clinical outcomes did not reveal a statistically significant difference in the survival curves in the groups with existence and absence of CD44⁺/CD24⁻ expression (p = 0.08). (nbuv.gov.ua)

The distribution of the expression of CD24 marker did not differ between the groups (p = 0.36) as well as the OS curves (p = 0.59). (nbuv.gov.ua)
The present study indicated a suggestive link between p16 and cancer stem cell marker expression in HPV-associated OED, and that p16 has a significant role in CSC progression in OED. (rmmj.org.il)

The immunohistochemical results showed prominent expression of CD44 in 13 of the patients and CD117 in 9 of the patients with new blister formation. (who.int)
Results showed that the expression of Mage-D1 during rat tooth germ development was temporally and spatially specific. (researchsquare.com)

These effects were associated with a significant reduction of NF-κB activation and monocyte chemotactic protein-1 (MCP-1) expression in the carotid arteries of rats treated with the peptide. (unina.it)
As proof-of-concept, the established target antigen CD44 was identified as a commonly and abundantly expressed surface protein with high endocytic activity. (lu.se)
The nucleotide sequence of CD44 cDNAs predicts a 37-kD polypeptide with homology to cartilage link protein (115435) in a phylogenetically conserved amino-terminal domain. (wdv.com)

Following in vitro exposure to CTX, hBMSCs showed decreased cell growth in a dose- and time-dependent manner, accompanied by increased expressions of collagen-I/III, and CD31. (ijbs.com)

Odontoblasts in the root ends of immature teeth express a stronger CD44 signal compared with those in the crown portion. (ncku.edu.tw)

Green shading: antigen was two-fold increased (SW620/ SW480.2) by mean fluorescence intensity. (gardos-channel.com)

The obtained data demonstrating the worst clinical outcome in the cases of absence of CD44⁺/CD24⁻ expression apparently require further investigations and the validation of the immunohistochemical method with the determination of the cut-off line in defining of CD44 and CD24 status. (nbuv.gov.ua)
Although the initial NKT cell response to antigen is intact in the absence of DOCK8, their ongoing proliferative and cytokine responses are impaired. (ox.ac.uk)

T RM responses against tumor/self-antigens can concurrently result in the development of pathogenic T RM responses to self, with a growing number of autoimmune diseases and inflammatory pathologies being attributed to T RM responses. (frontiersin.org)

Anatomy29

Organisms10

Diseases3

Chemicals and Drugs157

Analytical, Diagnostic and Therapeutic Techniques and Equipment27

Phenomena and Processes31

Disciplines and Occupations1

Information Science3

Health Care3

Specific antigen6

Markers19

Cells58

Mouse Anti-Human CD444

CD24 and CD441

Cluster of differentiat1

Surface antigen2

Human peripheral blood lymph1

CD902

Immunogenic3

Lymphocyte4

Tumor antigens1

Peripheral1

Monoclonal antibody2

Glycoprotein3

Conversely1

PCNA1

Vivo1

Cytometric analysis1

Oct43

Proliferation2

Inhibits1

Proteins2

Antibodies2

Significantly3

Immunohistochemistry1

Tissues3

Adhesion2

Binds2

Genes1

Differentiation1

Peptides1

Histogram1

Conclusions1

Antibody3

Survivin1

Hyaluronic1

Lymphocytes2

Strongly expressed1

Cell surface1

Survival1

Marker2

Results2

Protein3

Exposure1

Immature1

Fluorescence1

Absence2

Responses1