• Retinoic acid inhibits chondrogenesis of mesenchymal cells by sustaining expression of N-cadherin and its associated proteins. (rush.edu)
  • PEI-al nanocomposites carrying BMP-2 gene could efficiently transfect bone marrow mesenchymal stem cells. (dovepress.com)
  • Our results suggested that PEI-al nanocomposites efficiently deliver the BMP-2 gene to bone marrow mesenchymal stem cells and that BMP-2 gene-engineered cell sheet is an effective way for promoting bone regeneration. (dovepress.com)
  • In this study, we found that BMP-13 inhibited the osteogenic differentiation of human bone marrow multipotent mesenchymal stromal cells (BM MSCs) in vitro. (ijbs.com)
  • Expression of BMP-13 has since been detected in a variety of mesenchymal derivatives such as tendon and cartilage, but its biological function is poorly defined [ 6 ]. (ijbs.com)
  • We subsequently discuss how β-TCP can regulate osteogenic processes to aid bone repair/healing, namely osteogenic differentiation of mesenchymal stem cells, formation of blood vessels, release of angiogenic growth factors, and blood clot formation. (frontiersin.org)
  • The main challenge for large bone defect repair and regeneration remains the inadequate recruitment of mesenchymal stem cells (MSCs), reduced vascularization, and decreased growth factors stimulation within the scaffold construct to support cell viability and tissue growth. (frontiersin.org)
  • Mesenchymal stem cells (MSCs) from bone marrow play a critical role in osteochondral repair. (hindawi.com)
  • Mariano García Arranz has the following conflict of interest: MGA is inventor on 2 patents entitled "Identification and isolation of multipotent cells from non-osteochondral mesenchymal tissue" (10157355957US) and "Use of adipose tissue-derived stromal stem cells in treating fistula" (US11/167061). (wjgnet.com)
  • Because hydrostatic pressure can be a major factor in chondroinduction of mesenchymal stem cells, it was proposed to investigate the importance of the cytoskeleton in transduction of hydrostatic pressure by C3H10T1/2 murine fibroblasts, a model of primary bone marrow mesenchymal stem cells. (openorthopaedicsjournal.com)
  • In this study, we assayed the effect of exogenous mouse recombinant GDF-5 on cell proliferation of dental pulp cells and determined the expression levels of odontoblast differentiation marker genes in the cells of isolated mouse dental pulp tissues in the presence of GDF-5. (ispub.com)
  • An odontogenic medium modified by the addition of recombinant human bone morphogenetic protein 2 was used in the experimental groups to induce differentiation. (scielo.br)
  • Recombinant human BMP-2 and BMP-7 are used clinically to augment bone formation in spinal fusion and many other applications in which bone induction is desired [ 4 ]. (ijbs.com)
  • Herein, we investigated the effect of dovitinib on human recombinant bone morphogenetic protein (BMP)-2-induced osteoblast differentiation in a cell culture model. (molcells.org)
  • Growth/differentiation factor-5 (GDF-5) belongs to the bone morphogenetic protein (BMP) family, which is expressed in dental pulp tissues. (ispub.com)
  • Growth/differentiation factor-5 (GDF-5) is a member of the bone morphogenetic protein (BMP) family, which is a subgroup of the transforming growth factor- (TGF-) superfamily. (ispub.com)
  • Here, we investigated the effect of GDF-5 on the proliferation of dental pulp cells and their differentiation into odontoblasts by assaying the expression levels of odontoblast marker genes. (ispub.com)
  • Bone morphogenetic proteins (BMP), known as active components of odontogenic differentiation and tooth development, have been used as a growth factor in an appropriate medium. (scielo.br)
  • The expression of osteogenesis-related gene was increased, which demonstrated that released BMP-2 could effectively induce the cell sheet osteogenic differentiation in vitro. (dovepress.com)
  • In conclusion, BMP-13 inhibited osteogenic differentiation of MSCs, implying that functional mutations or deficiency of BMP-13 may allow excess bone formation. (ijbs.com)
  • BMP-13, also known as growth differentiation factor 6 (GDF6) and cartilage-derived morphogenetic protein-2 (CDMP-2), was first identified and isolated as a component of bovine cartilage [ 5 ]. (ijbs.com)
  • Dovitinib enhanced the BMP-2-induced alkaline phosphatase (ALP) induction, which is a representative marker of osteoblast differentiation. (molcells.org)
  • Our results suggest that dovitinib has a potent stimulating effect on BMP-2-induced osteoblast differentiation and this existing drug has potential for repositioning in the treatment of bone-related disorders. (molcells.org)
  • Here we show that components of both bone morphogenetic protein/growth differentiation factor and TGF-β/activin/Nodal branches of TGF-β superfamily signaling are expressed in the developing subpallium. (biomedcentral.com)
  • Furthermore, Smad proteins, transcriptional effectors of TGF-β signaling, are co-expressed and physically interact in the basal ganglia with Dlx homeodomain transcription factors, which are critical regulators of the differentiation, migration and survival of telencephalic GABAergic neurons. (biomedcentral.com)
  • It has been demonstrated to induce gremlin expression which in turn is known to inhibit the induction of differentiation by bone morphogenetic proteins . (wikidoc.org)
  • Recently, this cell line has become a valuable tool to study osteoclast differentiation and activity due to its expression of RANK and differentiation to osteoclast in response to RANKL [7]. (sciforschenonline.org)
  • To investigate the efficiency of growth differentiation factor 9 and bone morphogenetic protein 15 during folliculogenesis in a dehydroepiandrosterone-induced mouse Polycystic ovary syndrome model. (balkanmedicaljournal.org)
  • Ovarian tissues were examined for growth differentiation factor 9 and bone morphogenetic protein 15 using immunofluorescent labelling and electron microscopic examinations. (balkanmedicaljournal.org)
  • These results suggest that the decrease in the growth differentiation factor 9 and bone morphogenetic protein 15 expression initiated at the primary follicle stage effect the follicle development and zona pellucida structure and may cause subfertility or infertility in Polycystic ovary syndrome. (balkanmedicaljournal.org)
  • Two related members of the TGFB superfamily are involved in the function and development of the ovary: Growth differentiation factor 9 (GDF9) and bone morphogenetic protein 15 (BMP15) (7). (balkanmedicaljournal.org)
  • Numerous secreted and cell surface proteins relevant to airway inflammation and remodeling are initially synthesized as inactive precursor proteins, including growth/differentiation factors and their associated receptors, enzymes, adhesion molecules, neuropeptides, and peptide hormones. (molcells.org)
  • The protein encoded by this gene is a member of the TGFβ superfamily. (wikipedia.org)
  • Bone morphogenetic proteins (BMPs) are members of the transforming growth factor-β (TGF-β) superfamily, which includes the families of TGF-βs, BMPs, activins and inhibins. (ijbs.com)
  • ALK1 and BMPR1‐2 are receptors of the TGF‐β superfamily and BMP (bone morphogenetic protein) 92. (comprehensivephysiology.com)
  • In that regard, recent studies in non-neural cells have suggested the existence of functional interactions between Dlx proteins and Smad transcription factors, which are critical mediators of transforming growth factor-β (TGF-β) superfamily signaling pathways (Chiba et al. (biomedcentral.com)
  • The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. (wikipedia.org)
  • BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. (wikipedia.org)
  • Along with other BMPs, including BMP-2, -4 and -7, which are well known as potent osteoinductive growth factors, GDF-5 plays important roles in the development of bones, cartilage and tendons, as evidenced by the tendency for the gene and protein expression levels of GDF-5 to increase over time in these tissues. (ispub.com)
  • It may be feasible in the near future for BMPs to replace autologous and allogenic bone grafts. (allenpress.com)
  • BMPs comprise the largest subfamily of TGF-beta and belong to a group of noncollagen proteins. (allenpress.com)
  • BMPs were originally identified because of their ability to induce endochondral bone formation and are important regulators of key events in the process of bone formation during embryogenesis, postnatal growth, remodelling and regeneration of the skeleton [ 1 , 2 , 3 ]. (ijbs.com)
  • Comparisons with other BMPs known for their ability to stimulate bone growth have suggested that BMP-13 is not strongly osteo-inductive [ 9 , 10 , 11 , 12 ]. (ijbs.com)
  • The function of BMPs in bone remodelling and fracture repair is associated with the recruitment of stem cells from surrounding tissues and with effects on the osteogenic lineage commitment of these cells. (ijbs.com)
  • Subsequent regenerative dental procedures include the development of guided tissue or bone regeneration (GTR, GBR) procedures and distraction osteogenesis 2 the application of platelet rich plasma (PRP) for bone augmentation 17 . (bvsalud.org)
  • Nakashima M. Bone morphogenetic proteins in dentin regeneration for potential use in endodontic therapy. (scielo.br)
  • They have become a likely treatment option, given their action on regeneration and remodeling of bone lesions and increasing the bone response around alloplastic materials. (allenpress.com)
  • The application of specific growth factors for osteoinduction without using a bone graft constitutes a real impact on bone regeneration. (allenpress.com)
  • In this review, we will highlight the role of the BMP in bone, periodontal and dental regeneration. (allenpress.com)
  • Grafting with autogenous bone, guided bone regeneration (GBR), distraction osteogenesis, and tissue engineering have been developed to perform intraoral bone augmentation in dentistry. (allenpress.com)
  • A variety of growth factors (GFs)-including bone morphogenetic protein (BMP), platelet-derived growth factor (PDGF), and peptides of the parathyroid hormone (PTH)-have been tested for local bone regeneration. (allenpress.com)
  • Regeneration of large bone defects is a common clinical problem. (dovepress.com)
  • Regeneration of bone remains an important clinical challenge because the regeneration potential of human bone appears to be limited. (dovepress.com)
  • Hence, they are of high interest for supporting bone regeneration and wound healing. (degruyter.com)
  • By way of this review, a deeper understanding of the basic mechanisms of β-TCP for bone repair will be achieved which will aid in the optimization of strategies to promote bone repair and regeneration. (frontiersin.org)
  • Consequently, enhancing the adhesion of MSCs, augmenting the release of growth factors, and promoting angiogenic potential of biomaterial scaffolds after implantation are pivotal for successful bone regeneration. (frontiersin.org)
  • Based on the finding that alcohol alters the circulating levels of dozens of peptides shown to influence bone metabolism, we arrive at the conclusion that no single unifying mechanism adequately explains the diversity of reports or successfully predicts individuals most likely to be impacted favorably or unfavorably by alcohol consumption. (springer.com)
  • Ribosomal protein S6 kinases are activated through phosphorylation in response to a variety of HORMONES and INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS. (bvsalud.org)
  • In addition, development and genetic studies have shown that GDF-5 null mutation or transgenic mice exhibit abnormal growth patterns or overgrowth of limbs, long bones, cartilage, joints and digits (Storm et al. (ispub.com)
  • The concomitant decrease in cartilage fraction supports our prior work showing that β-NGF promotes endochondral conversion of cartilage to bone to accelerate healing. (frontiersin.org)
  • A bone marrow clot forms within the cartilage defect either as a result of marrow stimulation or during the course of the spontaneous repair of osteochondral defects. (hindawi.com)
  • The additional application of a bone marrow aspirate (BMA) to the procedure of marrow stimulation is thought to enhance cartilage repair as it may provide both an additional cell population capable of chondrogenesis and a source of growth factors stimulating cartilage repair. (hindawi.com)
  • If bone marrow fills a cartilage defect either as a result of marrow stimulation for chondral defects or the course of the spontaneous repair of osteochondral defects, a bone marrow clot forms within the cartilage defect. (hindawi.com)
  • In the orthopaedic field, additional application of a bone marrow aspirate (BMA) to the procedure of marrow stimulation has been recently studied, since the bone marrow itself is both a source of MSCs, providing a cell population capable of chondrogenesis and of various growth factors stimulating cartilage repair [ 7 - 10 ]. (hindawi.com)
  • Could be involved in bone and cartilage formation. (abcam.com)
  • The interaction of sGAG with α2-macroglobulin receptor-associated protein (LRPAP1), exportin-1 (XPO1), and serine protease HTRA1 (HTRA1) was confirmed in reverse assays. (degruyter.com)
  • A quantification of the injury-induced changes in central aromatase, estrogenic milieu and steroid receptor expression in the zebra finch. (neurotree.org)
  • The receptor (5‐HTR) and transporter (5‐HTT) of serotonin (5‐HT), and VPAC [the receptors of vasoactive intestinal peptide (VIP)] are all coupled to G‐protein 128,136. (comprehensivephysiology.com)
  • [3] [5] FGF2 binds to and exerts effects via specific fibroblast growth factor receptor (FGFR) proteins which themselves constitute a family of closely related molecules. (wikidoc.org)
  • A cardiomelic developmental field has also been postulated to relate the genetic heterogeneity of HOS (and other similar syndromes) to a cascade of molecules, including the brachyury, sonic hedgehog, bone morphogenetic protein, retinoic acid receptor, and transforming growth factor beta families. (medscape.com)
  • Applying the methodology to four gene families (the chemokine receptor family, the TNF receptor family, the TGF- β gene family, the IL-17 gene family) in nine inflammation related diseases, we identify disease associated genes which exhibit significant dysregulation in gene expression or DNA methylation in the inflammation related diseases, which provides clues for functional associations between the diseases. (biomedcentral.com)
  • Mutations in bone morphogenetic protein receptor type 2 ( BMPR2 ) cause familial pulmonary arterial hypertension (FPAH), but the penetrance is reduced and females are significantly overrepresented. (ersjournals.com)
  • Familial pulmonary arterial hypertension (FPAH) is caused, in 80% of families, by autosomal dominant mutations in the gene encoding bone morphogenetic protein receptor type 2 ( BMPR2 ). (ersjournals.com)
  • Data suggest that, unlike the weak mitogen 2-OHE, 16α-OHE 1 stimulates cellular proliferation by constitutively activating the oestrogen receptor. (ersjournals.com)
  • Expression of mouse zonadhesin mRNA is evident only within the testis, and the protein is found exclusively on the apical region of the sperm head. (embl.de)
  • Results showed that endogenous BMP-13 mRNA expression was higher than BMP-2 or -7 during MSC growth. (ijbs.com)
  • Quantitative RT-PCR was used to determine the expression of BMP-6, E-cadherin, and δEF1 at the mRNA level in MCF-7 and MDA-MB-231 breast cancer cells, as well as in 16 breast cancer specimens. (biomedcentral.com)
  • Further, we found that BMP-6 inhibited δEF1 transcription, resulting in an up-regulation of E-cadherin mRNA expression. (biomedcentral.com)
  • Therefore we examined the effects of drugs which selectively interfere with actin and tubulin polymerization on pressure-induced upregulation of aggrecan and col2a1 (type II collagen) mRNA expression. (openorthopaedicsjournal.com)
  • [ 2 , 3 , 4 ] A full list of the described mutations is available at the TBX5 Gene Mutation Database , an online locus-specific database that contains germline and somatic mutations of the TBX5 gene. (medscape.com)
  • Mutations of this gene introduce a premature stop codon and result in truncated protein versions. (medscape.com)
  • 17 , 19 - 24 BMP-2, −4, and −7 have been shown to stimulate de novo, in vitro, and in vivo bone formation in various animal models. (allenpress.com)
  • To enhance the osteogenic potential of stem cell sheet, we fabricated bone morphogenetic protein 2 ( BMP-2 ) gene-engineered cell sheet using a complex of polyethylenimine-alginate (PEI-al) nanocomposites plus human BMP-2 complementary(c)DNA plasmid, and studied its osteogenesis in vitro and in vivo. (dovepress.com)
  • To further test the osteogenic potential of the cell sheet in vivo, enhanced green fluorescent protein or BMP-2-producing cell sheets were treated on the cranial bone defects. (dovepress.com)
  • We also show that Dlx and Smad proteins localize to promoters/enhancers of a number of common telencephalic genes in vivo and that Smad proteins co-activate transcription with Dlx family members, except with certain mutated human DLX proteins identified in autistic individuals. (biomedcentral.com)
  • This product is an active protein and may elicit a biological response in vivo, handle with caution. (abcam.com)
  • Here, we analyzed the protein levels, activity and role of Rsk in in vivo and in vitro HD models. (biomedcentral.com)
  • Other growth factors involved in vascular remodeling include platelet‐derived growth factor (PDGF), epithelial growth factor (EGF), and fibroblast growth factor (FGF‐2). (comprehensivephysiology.com)
  • FGF2 , also known as basic fibroblast growth factor (bFGF) and FGF-β, is a growth factor and signaling protein encoded by the FGF2 gene . (wikidoc.org)
  • Fibroblast growth factor protein was first purified in 1975, but soon afterwards others using different conditions isolated basic FGF, Heparin-binding growth factor-2, and Endothelial cell growth factor-2. (wikidoc.org)
  • Basic fibroblast growth factor has been shown to interact with casein kinase 2, alpha 1 , [13] RPL6 [14] and ribosomal protein S19 . (wikidoc.org)
  • Nanobody-Based GFP Traps to Study Protein Localization and Function in Developmental Biology. (unibas.ch)
  • Enrichment analysis for protein localization showed that mainly intracellular and cell-associated interacting proteins were identified. (degruyter.com)
  • Postnatal stem cells have been sourced from umbilical cord blood, umbilical cord, bone marrow, peripheral blood, body fat, and almost all body tissues, including the pulp tissue of teeth 8 . (bvsalud.org)
  • Tissue Eng Part A. 2008;14(2):285-94. (scielo.br)
  • Recently, stem cell sheet has been an emerging strategy in bone tissue engineering. (dovepress.com)
  • 2 , 3 Bone tissue engineering (BTE) attempts to solve the referred problems mentioned. (dovepress.com)
  • Importantly, a single injection of β-NGF loaded PEGDMA microrods resulted in improved fracture healing as indicated by a significant increase in the percent bone in the fracture callus, trabecular connective density, and bone mineral density relative to soluble β-NGF control indicating improved drug retention within the tissue. (frontiersin.org)
  • Mobilized pluripotent MSCs from the subchondral bone migrate into the defect filled with the clot, differentiate into chondrocytes and osteoblasts, and form a repair tissue over time. (hindawi.com)
  • Over time, they form a fibrocartilaginous repair tissue in the defect and close the connection with the subchondral bone. (hindawi.com)
  • A focus is on the steps of mobilization of cells from the subchondral bone and repair tissue formation, including adherence of the bone marrow clot to the subchondral bone. (hindawi.com)
  • Despite improved surgical techniques, the tendon-to-bone healing rate is unsatisfactory due to difficulties in restoring the delicate transitional tissue between bone and tendon. (wjgnet.com)
  • Dovitinib also stimulated the translocation of phosphorylated Smad1/5/8 into the nucleus and phosphorylation of mitogen-activated protein kinases, including ERK1/2 and p38. (molcells.org)
  • Altered ERK1/2 and PDK1 phosphorylation have been described in Huntington's disease (HD), characterized by the expression of mutant huntingtin (mhtt) and striatal degeneration. (biomedcentral.com)
  • Analysis of the phosphorylation of Rsk in Hdh mice and STHdh cells showed reduced levels of phospho Ser-380 (dependent on ERK1/2), whereas phosphorylation at Ser-221 (dependent on PDK1) was increased. (biomedcentral.com)
  • Briefly, sequential phosphorylations are initiated by ERK1/2 at Thr-573/574 of CTKD leading to the auto-phosphorylation of Rsk at Ser-380. (biomedcentral.com)
  • Phosphorylation of RIBOSOMAL PROTEIN S6 by enzymes in this class results in increased expression of 5' top MRNAs. (bvsalud.org)
  • Smads 1, 5 and 8 are mainly activated by BMP and GDF receptors, while Smads 2 and 3 are substrates for TGF-β, activin and Nodal receptors. (biomedcentral.com)
  • The tight junctions protein Claudin-5 limits endothelial cell motility. (unibas.ch)
  • Mammalian bone morphogenetic protein-binding (BMP-binding) endothelial regulator protein. (embl.de)
  • Sandy JD, Thompson V, Verscharen C, Gamett D. Chondrocyte-mediated catabolism of aggrecan: evidence for a glycosylphosphatidylinositol-linked protein in the aggrecanase response to interleukin-1 or retinoic acid. (rush.edu)
  • Functional analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis resulted in the differentially expressed proteins in the FM and OA groups are mostly involved in the coagulation and complement system-related pathways, serotonin pathways, dopamine pathways, glutamate pathways and acute phase reactions. (ncl.edu.tw)
  • In vitro release studies showed there is significant retention of protein within the polymer matrix over 168 hours through physiochemical interactions. (frontiersin.org)
  • Rsk activation is regulated by sequential phosphorylations controlled by extracellular signal-regulated kinase (ERK) 1/2 and 3-phosphoinositide-dependent protein kinase 1 (PDK1). (biomedcentral.com)
  • The identification of the intracellular sGAG-interacting proteins could help to unravel these functions. (degruyter.com)
  • A family of protein serine/threonine kinases which act as intracellular signalling intermediates. (bvsalud.org)
  • Alkaline phosphatase (ALP) expression and activity, proteoglycan (PG) synthesis and matrix mineralization were assessed by cytological staining or ALP assay. (ijbs.com)
  • However, there are four alternate start codons which provide N-terminal extensions of 41, 46, 55, or 133 amino acids, resulting in proteins of 22 kDa (196 aa total), 22.5 kDa (201 aa total), 24 kDa (210 aa total) and 34 kDa (288 aa total), respectively. (wikidoc.org)
  • Detrimental effects of alcohol on bone growth. (springer.com)
  • To create a favorable osteogenic environment, β-TCP scaffolds have been modified in a number of ways to boost bone healing, including modulating physical features (e.g., pore sizes, porosity and surface roughness), combining with ionic components, and the addition/delivery of growth factors. (frontiersin.org)
  • 1 , 2 , 3 In each menstrual cycle, the dominant follicle that ovulates its egg originates from a primordial follicle that was recruited to initiate growth almost 1 year earlier (Fig. 2). (glowm.com)
  • Glycosaminoglycans (GAGs) are multifunctional polysaccharides of the extracellular matrix (ECM) responsible for ECM hydration and binding of cations and proteins due to their negative charge. (degruyter.com)
  • A pig sperm protein that binds to the extracellular matrix of the egg in a species-specific manner was recently identified and named zonadhesin (Hardy, D. M., and Garbers, D. L. (1995) J. Biol. (embl.de)
  • Nasal mucosal inflammation induces remodeling processes within the mucosa characterized by changes in extracellular matrix (ECM) protein deposition, macrophage and lymphocyte infiltration, and histological structure. (molcells.org)
  • Transglutaminase 2" Encyclopedia , https://encyclopedia.pub/entry/12976 (accessed December 07, 2023). (encyclopedia.pub)
  • 2023 Feb;25(2):203-206. (caltech.edu)
  • Although specific for RIBOSOMAL PROTEIN S6 members of this class of kinases can act on a number of substrates within the cell. (bvsalud.org)
  • The immunosuppressant SIROLIMUS inhibits the activation of ribosomal protein S6 kinases. (bvsalud.org)
  • 1998). "Bone morphogenetic protein-6 production in human osteoblastic cell lines. (wikipedia.org)
  • By the late 1980s, the active factor responsible for the induction of bone was identified: BMP. (allenpress.com)
  • In addition to down-regulating the expression of δEF1, BMP-6 also physically dislodged δEF1 from E-cadherin promoter to allow the activation of E-cadherin transcription. (biomedcentral.com)
  • Four members of the mouse Dlx protein family (Dlx1, 2, 5 and 6), part of the Antennapedia class of non-Hox homeodomain transcription factors, are expressed in the embryonic subpallium (Panganiban and Rubenstein 2002 ). (biomedcentral.com)
  • In both species, larval expression of BMP2/4 closely resembles the pattern previously reported for B. floridaedthat is, transcription is undetectable in tissues juxtaposed to the forming mouth, but is seen in several other anterior structures (most conspicuously in the lining of the rostral coelom and the club-shaped gland). (sorbonne-universite.fr)
  • Consequent abnormal expression of the cardiac and limb-specific T-box transcription factors lead to the malformations described in HOS. (medscape.com)
  • E7 from human papil omavirus type 16 cooperate to cancer: the European prospective investigation into doi:10.1093/carcin/bgp321 PMID:20047954 target the PDZ protein Na/H exchange regulatory cancer and nutrition study. (who.int)
  • Cell reports, 39 (2). (unibas.ch)
  • Assays on the cell culture showed that the genetically engineered cells released the BMP-2 for at least 14 days. (dovepress.com)
  • The results indicated that the BMP-2-producing cell sheet group was more efficient than other groups in promoting bone formation in the defect area. (dovepress.com)
  • Species diversity in the structure of zonadhesin, a sperm-specific membrane protein containing multiple cell adhesion molecule-like domains. (embl.de)
  • Bioactivity of protein post-loading was confirmed with the TF-1 cell line. (frontiersin.org)
  • Consistent with the fact that higher level of δEF1 expression is associated with more invasive phenotype of breast cancer cells, our collective data suggests that δEF1 is likely the switch through which BMP-6 restores E-cadherin-mediated cell-to-cell adhesion and prevents breast cancer metastasis. (biomedcentral.com)
  • The association between loss or down-regulation of E-cadherin, an epithelial cell-cell adhesion protein, and progression of breast cancer has been extensively documented [ 3 , 4 ]. (biomedcentral.com)
  • Osteoclasts can be obtained by isolating primary bone marrow monocytes or by using macrophage cell lines. (sciforschenonline.org)
  • Cerebellar granule cell precursors are specifically generated within the hindbrain segment, rhombomere 1, which is bounded rostrally by the midbrain/hindbrain isthmus and caudally by the boundary of the Hoxa2 expression domain. (biomedcentral.com)
  • Early global overexpression of Hoxa2 at embryonic day 0 has no effect on the expression of isthmic signalling molecules or the allocation of rhombomere 1 territory, but selectively results in the loss of granule cell markers at embryonic day 6 and the depletion of cell bodies from the external granule cell layer. (biomedcentral.com)
  • Rhombic lip derivatives, normally destined to occupy the external granule cell layer, violate the cerebellar boundary to form a ventrolateral nucleus in a position comparable to that occupied by rhombic lip derived neurons in rhombomere 2. (biomedcentral.com)
  • Indeed, BMP-13 expression was absent from osteoblasts or newly formed osteocytes, rather BMP-13 was strongly detected in chondrocytes in a human osteophyte (bone spur) study [ 13 ]. (ijbs.com)
  • The steps and timing of human folliculogenesis are shown in Fig. 2. (glowm.com)
  • 2. Find values for the kinetic parameters from experimental b pathway have been detected in several human diseases, estimates or by fitting the model to experimental kinetic most notably in many forms of cancer, and in fibrotic diseases data. (lu.se)
  • 0.05), except for the expression of DSPP in the PLDL group with regard to the time variable. (scielo.br)
  • In the United States, these proteins are commercially available INFUSE Bone Graft since its approval by the Food and Drug Administration in July 2002 for its use in anterior lumbar interbody fusion. (allenpress.com)
  • Neuroinflammation induces glial aromatase expression in the uninjured songbird brain. (neurotree.org)
  • Mammalian von Willebrand factor (VWF), a multifunctional protein involved in maintaining homeostasis. (embl.de)
  • XIAP, X-linked mammalian inhibitor of apoptosis protein. (rupress.org)
  • The X-linked mammalian inhibitor of apoptosis protein (XIAP) has been shown to bind several partners. (rupress.org)
  • We demonstrate a novel and translational method wherein β-NGF can be encapsulated within PEGDMA microrods for local delivery and that β-NGF bioactivity is maintained resulting in improved bone fracture repair. (frontiersin.org)
  • To determine which of these interactions are required for it to inhibit apoptosis, we generated point mutant XIAP proteins and correlated their ability to bind other proteins with their ability to inhibit apoptosis. (rupress.org)
  • By identifying many sGAG-specific interacting proteins, our data provide a resource for upcoming studies aimed at molecular mechanisms and understanding of sGAG cellular effects. (degruyter.com)
  • Our finding provides an insight into the molecular mechanisms and the therapeutic potential of BMP-13 in restricting pathological bone formation. (ijbs.com)
  • Injectable therapies designed to stimulate bone healing represent an exciting alternative to surgically implanted biologics, however, the translation of effective osteoinductive therapies remains challenging due to the need for safe and effective drug delivery. (frontiersin.org)
  • Bone loss caused by congenital defects, traumatic injury, cancer, reconstructive surgery, or periodontal disease has aroused widespread concern all over the world. (dovepress.com)
  • They were first isolated from the bone marrow, and the potency of MSCs is currently being employed in the techniques of marrow stimulation for symptomatic small chondral defects. (hindawi.com)
  • Skeletal turnover, bone mineral density, and fractures in male chronic abusers of alcohol. (springer.com)
  • Alcohol consumption and bone mineral density in elderly women. (springer.com)
  • Within this region, their expression overlaps with that of Gad65 and Gad67 , genes encoding different forms of the rate-limiting enzyme required for production of GABA from glutamate. (biomedcentral.com)
  • Members of the gene family whose expression or methylation levels significantly deviate from the model are considered as the potential disease associated genes. (biomedcentral.com)
  • In Dlx1/2 −/− double mutant mice, the tangential migration of GABAergic interneurons into pallial structures is nearly extinguished and neuronal precursors accumulate in the SVZ of the MGE and CGE (Anderson et al. (biomedcentral.com)
  • To examine the role of OPN in vascular calcification, OPN mutant mice were crossed with matrix Gla protein (MGP) mutant mice. (silverchair.com)
  • Knock-in striatal cells expressing full-length mutant huntingtin (mhtt) (STHdh Q111/Q111 ) show increased levels of active PDK1 [ 17 ] and reduced levels of ERK1/2 activity [ 18 ] compared with striatal cells expressing wild-type htt (STHdh Q7/Q7 ). (biomedcentral.com)