Expression phenotype. Medical search. Frequent questions

We found a significantly lower expression of key autophagy- (ATG-) related genes in primary AML as compared to healthy granulocytes, an increased autophagic activity during all- trans retinoic acid- (ATRA-) induced neutrophil differentiation, and an impaired AML differentiation upon inhibition of ATG3, ATG4D, and ATG5. (hindawi.com)
(E and F) represents a Western blot demonstrating WT-ASPH induced activation of Notch signaling as determined by increased levels of Notch1 ICN, JAG2, as well as increased expression of downstream responsive genes HES1, HEY1, EpCAM, CD44, c-Myc, MMP2/9, cyclin D3 and PCNA. (oncotarget.com)
Gene expression changes initially showed a large number of differentially expressed genes in response to an environmental change followed by a return of most genes to a baseline expression level, leaving a relatively small set of differentially expressed genes at the endpoint that varied between evolved populations. (ucsd.edu)
Expression of these genes had no impact on dormancy in murine models, but their expression correlated with disease-free survival in primary human breast cancer tumors, suggesting that these genes have predictive value in determining which patients are likely to recur. (biomedcentral.com)
The expression of dormancy-related genes identified in our analyses was consistently observed among different breast cancer dormancy models and correlated with breast cancer progression in patients. (biomedcentral.com)
Fasting also induced muscle atrophy marker genes Murf1 and Fbxo32 and reduced myogenesis factor Mef2 expression without muscle fibre or gender differences. (hku.hk)
Dysregulated expression of DISC1-interactome genes might, therefore, contribute to schizophrenia susceptibility via disruption of molecular systems required for normal cognitive function. (ed.ac.uk)
We found that DISC1-interactome genes showed correlated expression in the blood of healthy individuals. (ed.ac.uk)
Our findings highlight the importance of the coordinated expression of DISC1-interactome genes for normal cognitive function and suggest that dysregulated DISC1 and NDEL1 expression might, in part, contribute to susceptibility for schizophrenia via disruption of prefrontal cortex-dependent cognitive functions. (ed.ac.uk)
Therefore, these results demonstrate that LsARF3 could promote lettuce bolting in response to the high temperature by directly or indirectly activating the expression of floral genes such as LsCO, which provides new insights into lettuce bolting in the context of ARFs signaling and heat response. (frontiersin.org)
A total of 1,800 genes were responsive to BMP-2 and expression was modulated from 3- to 14-fold for less than 100 genes during the time course. (umassmed.edu)
BMP-2 immediately responsive genes (1-4 h), which exhibited either transient or sustained expression, reflect activation and repression of non-osseous BMP-2 developmental systems. (umassmed.edu)
Commitment to the osteogenic phenotype is recognized by 8 h, reflected by downregulation of most myogenic-related genes and induction of a spectrum of signaling proteins and enzymes facilitating synthesis and assembly of an extracellular skeletal environment. (umassmed.edu)
These genes included collagens Type I and VI and the small leucine rich repeat family of proteoglycans (e.g., decorin, biglycan, osteomodulin, fibromodulin, and osteoadherin/osteoglycin) that reached peak expression at 24 h. (umassmed.edu)
With extracellular matrix development, the bone phenotype was further established from 16 to 24 h by induction of genes for cell adhesion and communication and enzymes that organize the bone ECM. (umassmed.edu)
however, because DEGs from the expression dataset may not be functional genes per se but dysregulated genes perturbed by bona fide functional genes. (molcells.org)
To overcome this shortcoming, we developed network-based GSEA (NGSEA), which measures the enrichment score of functional gene sets using the expression difference of not only individual genes but also their neighbors in the functional network. (molcells.org)
Question: The Process By Which Genotype Becomes Expressed As Phenotype Is Translation Transcription Gene Expression O Gene Regulation Question 57 In Bacteria, What Name Is Given To A Cluster Of Genes With Related Functions, Along With Their DNA Control Sequences? (prowritershub.com)
Prader-Willi syndrome (PWS) is caused by the loss of expression of imprinted genes in chromosome 15q11-q13. (elsevierpure.com)
abstract = "To understand the mechanisms by which glucocorticoids promote differentiation of fetal rat calvaria derived osteoblasts to produce bone‐like mineralized nodules in vitro, a panel of osteoblast growth and differentiation related genes that characterize development of the osteoblast phenotype has been quantitated in glucocorticoid‐treated cultures. (nyu.edu)
Gene expression refers to the process of making proteins using the instructions from genes. (cdc.gov)
Phenotype is how a person looks (on the outside and inside the body) due to his or her genes and the environment (for example, having a certain eye color, being a specific blood type, or being a certain height). (cdc.gov)
Total RNA from tumors the expression of thousands of genes (3) to address complex questions was isolated using two successive rounds of Trizol. (lu.se)
1 In particular, morpholino oligonucleotides (MOs) have been used to block the expression of targeted genes in several invertebrate and vertebrate models. (cdc.gov)

In cell culture systems, the luminal ERα + tumor cells are either outcompeted by other types of cells or the cells rapidly downmodulate ERα expression 5 . (nature.com)
In vivo, stable ERα expression has been reported in patient-derived xenograft (PDX) models, especially in tumor cells introduced via intraductal transplantations 8 , 9 and these findings have suggested a strong microenvironment-dependent dynamic component in the regulation of ERα expression. (nature.com)
As with other aggressive subtypes of breast cancer, these tumors are associated with abnormally high expression of galectin-7 (gal-7), which confers metastatic breast tumor cells with increased invasive behavior. (inrs.ca)
Multiple studies have successfully used this method to analyze different types of high-dimensional data, such as tumor mRNA expression data 28 , and single-cell data 29 , 30 . (nature.com)
Here, we report that CTL-mediated immune selection drives the evolution of tumor cells toward a CSC-like phenotype and that the CSC-like phenotype arises through the Akt signaling pathway via transcriptional induction of Tcl1a by Nanog. (jci.org)
Our findings establish a firm link among immune selection, disease progression, and the development of a stem-like tumor phenotype in human cancer and implicate the Nanog/Tcl1a/Akt pathway as a central molecular target in this process. (jci.org)
Here, we report that in T cell acute lymphoblastic leukemia (T-ALL) the MYC oncogene controls the expression of TET1 and TET2 to maintain 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC) patterns, which is associated with tumor cell-specific gene expression. (biomedcentral.com)
Knockdown of TET1 or ectopic expression of TET2 in T-ALL was associated with genome-wide changes in 5mC and 5hmC enrichment and decreased cell proliferation, suggesting a tumor promoting function of TET1, and a tumor suppressing role for TET2. (biomedcentral.com)
The altered gene expression may enhance several cancer-related events such as cell division (proliferation), cell movement, and the development of new blood vessels (angiogenesis) that nourish a growing tumor. (medlineplus.gov)
Our discovery of a novel independent prognostic factor in breast cancer highlights a correlation between tumor phenotype and immune contexture. (lu.se)

We subsequently demonstrate that basal leptin expression significantly correlates with LPS-induced IL-6 expression and that the same variants at LEP which associate with IL-6 expression are also major determinants of leptin expression in these cells. (ox.ac.uk)
This article is a brief introduction to the study of CMT and correlates the most common different genotypes and phenotypes. (medscape.com)
Multidrug resistance gene (ie, MDR1 ) expression correlates with unfavorable cytogenetic aberrations and is responsible for poor response to chemotherapy and short survival time. (medscape.com)

In the present study, BMP-2 responsive factors involved in the early stages of commitment and differentiation to the osteoblast phenotype were analyzed by microarray gene expression profiling in samples ranging from 1 to 24 h following BMP-2 dependent differentiation of C2C12 premyoblasts into the osteogenic lineage. (umassmed.edu)
Short term (48 h) effects of glucocorticoid on histone H4 (reflecting cell proliferation), alkaline phosphatase, osteopontin, and osteocalcin mRNA levels reveal both up or down regulation as a function of the developmental stage of the osteoblast phenotype. (nyu.edu)

An organism's phenotype results from two basic factors: the expression of an organism's genetic code (its genotype) and the influence of environmental factors. (wikipedia.org)
There is evidence of significant heritability in inter-individual variation in IL6 gene expression but the genetic variants responsible for this remain to be defined. (ox.ac.uk)
The study used granular case and control definitions for the COVID-19 phenotype and identified distinct patterns of genetic association. (cdc.gov)
They identified a new association with a rare genetic variant at the Xp22.2 locus (rs190509934) that downregulates the expression of angiotensin-converting enzyme 2 (ACE2). (cdc.gov)

Some behavioral phenotypes may characterize psychiatric disorders or syndromes. (wikipedia.org)
Another team of researchers characterize "the human phenome [as] a multidimensional search space with several neurobiological levels, spanning the proteome, cellular systems (e.g., signaling pathways), neural systems and cognitive and behavioural phenotypes. (wikipedia.org)

In this study, we used gastrocnemius skeletal muscle RNA sequencing data from fasting male mice in the Gene Expression Omnibus (GEO) database. (hku.hk)
Adopted male and female C57BL/6J mice that fasted for 24 h were included to examine the effect of fasting on myokine expression in slow-twitch soleus and fast-twitch tiabialis anterior (TA) skeletal muscle. (hku.hk)
Fasting reduced Fndc5 and Igf1 gene expression in soleus and TA muscles in both male and female mice without muscle phenotype or gender differences, but Il6, Mstn and Erfe expression was influenced by fasting with fibre type- and gender-dependent effects. (hku.hk)
Compared with wild-type mice, the transgenic mice exhibited a low-anxiety phenotype in plus maze and hyponeophagia tests. (ox.ac.uk)
Furthermore, in the plus maze test, the low-anxiety phenotype of the transgenic mice was reversed by acute administration of paroxetine, suggesting a direct link between the behavior, 5-HTT overexpression, and low extracellular 5-HT. (ox.ac.uk)
In toto, these findings demonstrate that associations between increased 5-HTT expression and anxiety can be modeled in mice and may be specifically mediated by decreases in 5-HT transmission. (ox.ac.uk)
In HSALR mice, intravenous injections of CPP-PMOs improve molecular, histopathological, and functional phenotypes, without signs of toxicity. (ox.ac.uk)

Longitudinal multi-omics measurements are highly valuable in studying heterogeneity in health and disease phenotypes. (nature.com)
Reproducible quantifiable imaging features of GBM heterogeneity that explicitly examine links between the imaging findings and the underlying GBM phenotypes characteristics are identified. (hindawi.com)
Introduced quantitative histogram features can discriminate phenotype heterogeneity from MRI images and thereby strengthen personalized medicine in GBM [ 12 ]. (hindawi.com)
Although the detailed composition of these pools is not completely understood, there is known to be heterogeneity, in particular of CD45 isoform expression. (ox.ac.uk)

The encoded protein can block ES cell differentiation and can also autorepress its own expression in differentiating cells. (nih.gov)
Rayev M.B., Zamorina S.A., Litvinova L.S., Yurova K.A., Khaziakhmatova O.G., Timganova V.P., Bochkova M.S., Kropaneva M.D., Khramtsov P.V. (2017) The influence of chorionic gonadotropin on phenotype conversion and hTERT gene expression by T-lymphocytes of different degrees of differentiation. (msk.ru)

We aimed to determine the significance of detecting expression of some antigens that might be pivotal to the process, namely CD44 and CD117, in patients with active pemphigus vulgaris. (who.int)

RNA binding proteins can control protein expression by regulating transport, localization, splicing, polyadenylation and turnover of mRNA transcripts. (umassmed.edu)
hCG inhibited expression of hTERT mRNA in naive T-cells (CD45RA+) and immune memory T cells (CD45RO+), causing a decrease in the replicative potential of the cells. (msk.ru)

In genetics, the phenotype (from Ancient Greek φαίνω (phaínō) 'to appear, show', and τύπος (túpos) 'mark, type') is the set of observable characteristics or traits of an organism. (wikipedia.org)
Both genetics and environmental factors influence the expression of asthma, and not all asthma is the result of a specific immune response to allergen. (cdc.gov)

It may seem that anything dependent on the genotype is a phenotype, including molecules such as RNA and proteins. (wikipedia.org)
Here, the blood RNA expression levels of DISC1 and DISC1-interacting proteins were measured in 63 control subjects. (ed.ac.uk)
Characterization of the structure and dynamics of protein-RNA complexes is essential for understanding how they function at the molecular level: how these proteins specifically recognize their target RNAs, what are the structure-function relationships, and assess their biological role in regulating gene expression. (umassmed.edu)
Characterization of the structure and dynamics of protein-RNA complexes is essential for understanding how they function at the molecular level: how these proteins specifically recognize their target RNAs, what are the structure-function relationships, and to assess their biological role in regulating gene expression. (umassmed.edu)
This initial response was followed by waves of expression of nuclear proteins and developmental regulatory factors including inhibitors of DNA binding, Runx2, C/EBP, Zn finger binding proteins, forkhead, and numerous homeobox proteins (e.g. (umassmed.edu)
Boosting the endogenous expression of MBNL proteins by inhibiting the natural translational repressors miR-23b and miR-218 has previously been shown to be a promising therapeutic approach. (ox.ac.uk)

We have investigated the developmental expression and subcellular localization of synapsin III, the newest member of the synapsin family, in cultured mouse hippocampal neurons. (jneurosci.org)
We analyzed the developmental expression and subcellular distribution of synapsin III in cultured mouse hippocampal neurons and its role in neurite elongation and synapse formation. (jneurosci.org)
The orthologous mouse gene (Magel2) is located within 150 kb of Ndn, is imprinted with paternal-only expression and is expressed predominantly in late developmental stages and adult brain as shown by northern blotting, RT-PCR and whole-mount RNA in situ hybridization. (elsevierpure.com)
MBNL1/2 depletion interferes with a developmental alternative splicing switch that causes the expression of fetal isoforms in adults. (ox.ac.uk)
IMPROVE-DD: Integrating multiple phenotype resources optimizes variant evaluation in genetically determined developmental disorders. (cdc.gov)

Two thirds of breast cancers express the luminal estrogen receptor-positive (ERα + ) phenotype that is initially responsive to antihormonal therapies, but drug resistance emerges. (nature.com)
About 80% of all newly diagnosed breast cancers have luminal cell phenotype and they express estrogen receptor (ERα). (nature.com)

Mutations in this gene have been associated with adult i blood group phenotype. (nih.gov)
Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene. (jax.org)
Better understanding of new mutations and the wide range of possible phenotypes led to the development of a new nomenclature proposal, based on the gene and inheritance pattern. (medscape.com)
Finally, it seems appropriate to consider the "sodium channel syndrome" (mutations in the gene of the α subunit of the sodium channel, SCN5A gene) as a single clinical entity that may manifest in a wide range of phenotypes, to thus have a better insight on these cardiac syndromes and potential outcomes for their clinical treatment. (bvsalud.org)

Increased expression of the 5-HT transporter confers a low-anxiety phenotype linked to decreased 5-HT transmission. (ox.ac.uk)

Breast cancers are commonly divided into four molecular subtypes based on specific therapeutically actionable biomarkers and gene expression profiles 1 . (nature.com)
Molecular phenotypes of clinical samples have proven useful in disease diagnosis, patient stratification, and drug discovery. (molcells.org)
Gene expression profiling is probably the most accessible strategy for molecular phenotyping of clinical samples. (molcells.org)
For clinical samples, the general purpose of gene set analysis of genome-wide expression profiles is to identify underlying disease-associated molecular processes, which can facilitate disease diagnosis and therapeutic intervention. (molcells.org)
Examples of high molecular environmental factors are known to influence the development weight occupational allergens include proteases used in the and expression of asthma, and a vast array of triggers of asthma detergent industry, laboratory animal allergens, and ovalbumin have been identified. (cdc.gov)

Figure 7: Effect of SMI MO-I-1100 on the PC phenotype induced by exogenous or endogenous high-level of WT-ASPH expression. (oncotarget.com)
Peptide-conjugated antimiRs improve myotonic dystrophy type 1 phenotypes by promoting endogenous MBNL1 expression. (ox.ac.uk)
GXD's primary emphasis is on endogenous gene expression during development. (jax.org)

The effects of chorionic gonadotropin (hCG) on the expression of the hTERT gene in combination with the conversion of the phenotype of naive T-cells and T-cells of immune memory in vitro were studied. (msk.ru)
How mixtures of immune cells associate with cancer cell phenotype and affect pathogenesis is still unclear. (lu.se)
In 15 breast cancer gene expression datasets, we invariably identify three clusters of patients with gradual levels of immune infiltration. (lu.se)

Gene set enrichment analysis (GSEA) is a popular tool to identify underlying biological processes in clinical samples using their gene expression phenotypes. (molcells.org)
New insights on Noonan syndrome's clinical phenotype: a single center retrospective study. (cdc.gov)
Regulation of IFN-γ-mediated PD-L1 expression by MYC in colorectal cancer with wild-type KRAS and TP53 and its clinical implications. (cdc.gov)

In this paper, feature selection based on decision tree is examined to determine the relevant subset of glioblastoma (GBM) phenotypes in the statistical domain. (hindawi.com)
This study demonstrated the ability of statistical features to provide a quantitative, individualized measurement of glioblastoma patient and assess the phenotype progression. (hindawi.com)

MIA PaCa2 cells were stably transfected with empty vector (EV), "wild type" (WT)-ASPH, or H 675 Q-ASPH mutant and the levels of expression were confirmed by Western blot. (oncotarget.com)
We found that a spectrum of phenotypes exists stably, from CD45R0(high)/RA(low) through CD45RA(high)/R0(low), and that expression of other surface markers such as CD28 and CD62L, and also TCR usage, may vary in parallel with CD45 isoform expression. (ox.ac.uk)

The roles of immunomodulatory elements such as microRNAs, which alter gene expression, and regulatory T cells (Tregs), which suppress T cell-mediated responses, in TDI sensitization are unknown. (cdc.gov)

The study replicated associations with eight of the 12 previously reported risk loci (including one in IFNAR2 ) and uncovered specific associations with a range of distinct COVID-19 disease susceptibility and severity phenotypes. (cdc.gov)

Epigenetics is the study of changes in phenotype caused by something other than changes in the underlying DNA sequence (for example, DNA methylation). (cdc.gov)

90 different alleles have been identified and described by protease inhibitor (PI*) phenotype. (msdmanuals.com)

Either way, the term phenotype includes inherent traits or characteristics that are observable or traits that can be made visible by some technical procedure. (wikipedia.org)
Our aim was to establish whether or not major repeaters are a distinctive suicidal phenotype, taking into account a wide range of potential competing risks including sociodemographic characteristics, personal and familial history, psychiatric diagnoses, and personality traits. (psychiatrist.com)
This resulted in four distinct body shapes that may better capture the heterogeneous expression of adiposity and its health consequences compared with single anthropometric traits because of the way they combine. (who.int)

Furthermore, Exogenous application of IAA failed to rescue the late-bolting and -flowering phenotype of lsarf3 mutants. (frontiersin.org)
Gray triangles = other expression annotations only (e.g. absence of expression or data from mutants). (jax.org)
The resulting blockade of RNA splicing or translation allows loss-of-function phenotypes to be determined within days, contrasting the months that can be required to obtain homozygous mutants. (cdc.gov)

Then, we implemented the decision tree to define the optimal subset features of phenotype classifier. (hindawi.com)
Although this may be a subset of all such trans-acting effects, we find that the same ALOX15 variants are associated with induced expression of tumour necrosis factor and IL-1beta consistent with a broader role in acute inflammation for ALOX15. (ox.ac.uk)

In particular, we examined expression of these phenotypic markers in relation to the expression of CD45 isoforms. (ox.ac.uk)

We adopted a combined approach of mapping protein and expression quantitative trait loci in peripheral blood mononuclear cells using high-density single-nucleotide polymorphism (SNP) typing for approximately 2000 loci implicated in cardiovascular, metabolic and inflammatory syndromes to show that common SNP markers and haplotypes of LEP (encoding leptin) associate with a 1.7- to 2-fold higher level of lipopolysaccharide (LPS)-induced IL-6 expression. (ox.ac.uk)

Behaviors and their consequences are also phenotypes, since behaviors are observable characteristics. (wikipedia.org)

A commonly occurring polymorphic variant of the human 5-hydroxytryptamine (5-HT) transporter (5-HTT) gene that increases 5-HTT expression has been associated with reduced anxiety levels in human volunteer and patient populations. (ox.ac.uk)
They showed that this protective variant can reduce expression of the SARS-CoV-2 receptor and decrease COVID-19 risk. (cdc.gov)

Numerous phenotypes of asthma have inflammation, airway hyperresponsiveness and mucus produc- been described, and a better understanding of the pathophysio- tion. (cdc.gov)

The finding that the matrix stiffness is a central cue to the ERα phenotype reveals a mechanobiological component in breast tissue hormonal signaling and enables the development of novel therapeutic interventions. (nature.com)
Some usages of the term suggest that the phenome of a given organism is best understood as a kind of matrix of data representing physical manifestation of phenotype. (wikipedia.org)
DataMatrix object or a matrix of gene expression values where each row corresponds to a gene and each column corresponds to a replicate. (mathworks.com)

Ex vivo analysis of phenotype and TCR usage in relation to CD45 isoform expression on cytomegalovirus-specific CD8+ T lymphocytes. (ox.ac.uk)

Cells which lack ER expression at diagnosis arise from an ER compart- were harvested at 60 - 80% confluency and used as a reference in all hybrid- ment within the mammary epithelium or represent evolution from an izations. (lu.se)

Behavioral phenotypes include cognitive, personality, and behavioral patterns. (wikipedia.org)
Cognitive dysfunction is central to the schizophrenia phenotype. (ed.ac.uk)
Pairwise correlations between gene expression levels and the relationship between gene expression levels and cognitive function and N-back-elicited brain activity were assessed. (ed.ac.uk)
The expression levels of several interactome members were correlated with cognitive performance and N-back-elicited activity in the prefrontal cortex. (ed.ac.uk)

Furthermore, the ectopic expression (EE) of CmNAC1 in Arabidopsis led to ABA hypersensitivity and enhanced tolerance to salinity, drought and cold stress. (frontiersin.org)

and (3) the evolutionary gene expression response involves a large number of compensatory expression changes and a smaller number of adaptively beneficial expression changes common across evolution strains. (ucsd.edu)

These data suggest that gal-7 could potentiate the phenotype of HER-2 positive primary breast cancer. (inrs.ca)
We also observed that NGSEA substantially improved the ability to retrieve known anti-cancer drugs from patient-derived gene expression data using drug-target gene sets compared with another method, Connectivity Map. (molcells.org)
Statistical tools are required to analyze the large and hybridized as described previously (3, 10, 11) and according to standard amount of expression data generated by this methodology. (lu.se)
performed a GWAS using self-reported and electronic health record data to define phenotypes for more than 750,000 individuals. (cdc.gov)

Alkaline phosphatase and type I collagen expression were initially inhibited in proliferating cells, then increased after nodule formation to support further growth and mineralization of the nodule. (nyu.edu)

Immunity against CMV comprises a large population of CD8+ T lymphocytes with heterogeneous potential, a spectrum in which CD45 isoform expression may play a central role. (ox.ac.uk)
dLN Tregs were phenotyped during TDI sensitization and a heterogeneous population was observed. (cdc.gov)

The ERα + phenotype is not stable in cultured cells for reasons not fully understood. (nature.com)
E1A transfection results in the transformation of peripheral lung epithelial cells and normal lung fibroblasts to a phenotype intermediate between that of the two primary cells. (ersjournals.com)
Dormant breast cancer cells exhibit a distinct gene expression signature regardless of metastatic site. (biomedcentral.com)
In this study, we developed an efficient system for isolating rare dormant breast cancer cells in experimental metastases models and performed scRNA-seq comparing gene expression in dormant vs proliferative breast cancer cells. (biomedcentral.com)
Our studies suggest that the gene expression signature we identified in disseminated dormant breast cancer cells exists in the primary site and can be utilized to predict which patients are more likely to experience a breast cancer recurrence. (biomedcentral.com)
E ) Western blot analysis of expression of cyclin A and p21 in P0 versus P3 cells. (jci.org)
We found decreased expression of CD43 on the neutrophils of these patients, and we correlated this finding with the activation status of these cells as it is denned by their phenotypes. (elsevierpure.com)
In conclusion, we believe that the decreased expression of CD43 on the neutrophils of MDS patients is associated with activation of these cells and is probably due to cleavage of the molecule from the cell surface and that the same mechanism is possibly responsible for the parallel down-reeulation of CD44 and CD53. (elsevierpure.com)
High SEPT9_v1 expression in human breast cancer cells is associated with oncogenic phenotypes. (medlineplus.gov)
BT-474 cells, obtained expression of the receptor has important implications for their biology from American Type Culture Collection, were maintained in RPMI 1640 and therapy (1). (lu.se)

An integrated expression phenotype mapping approach defines common variants in LEP, ALOX15 and CAPNS1 associated with induction of IL-6. (ox.ac.uk)

These two cell types differed, however, in their NF-κB and AP-1 binding after lipopolysaccharide stimulation, possibly due to differences in the expression of the subunits that comprise these transcriptional complexes. (ersjournals.com)
The changes that occur during adenoviral E1A transformation of primary guinea pig PLECs were also compared with those occurring during the transformation of the fibroblasts that frequently contaminate primary epithelial cultures, and evidence is presented that both cell types are transformed to an intermediate phenotype. (ersjournals.com)

Numerous asthma phenotypes have been described, including occupational asthma, and therapeutic strategies for asthma control are similar regardless of phenotype. (cdc.gov)

We studied the expression of this molecule on the leukocytes of patients with myelodysplastic syndromes (MDSs) in an effort to detect acquired deficiencies of this molecule. (elsevierpure.com)

In this study, we investigated the reproducibility of growth phenotypes and global gene expression states during adaptive evolution. (ucsd.edu)
In the present study, the hypothesis that adenoviral infection followed by persistent expression of its E1A gene is capable of producing epithelial-mesenchymal transformation was examined by investigating guinea pig PLECs that express adenoviral E1A. (ersjournals.com)

Anatomy2

Organisms6

Diseases1

Chemicals and Drugs7

Analytical, Diagnostic and Therapeutic Techniques and Equipment17

Phenomena and Processes27

Disciplines and Occupations1

Information Science3

Genes24

Tumor10

Correlates3

Osteoblast phenotype2

Genetic4

Characterize2

Mice7

Heterogeneity4

Differentiation2

Antigens1

MRNA2

Genetics2

Proteins6

Developmental5

Estrogen receptor2

Mutations4

Confers1

Molecular5

Endogenous3

Immune3

Clinical3

Glioblastoma2

Stably2

MicroRNAs1

Susceptibility1

Epigenetics1

Alleles1

Traits3

Mutants3

Subset2

Isoforms1

Quantitative1

Consequences1

Variant2

Inflammation1

Matrix3

Vivo1

Diagnosis1

Cognitive4

Ectopic expression1

Strains1

Data4

Initially1

Heterogeneous2

Cells10

Induction1

Cell2

Numerous1

Leukocytes1

Study2