Express zebrafish proteins. Medical search. Frequent questions

He explains that some of these studies use transgenic zebrafish that over-express a protein called Cofilin which is known to play an important role in the formation and modification of connections in the brain. (coherent.com)
Confocal micrograph of the brain of a transgenic zebrafish embryo. (cellimagelibrary.org)
Although Rab11a subcellular localization has been demonstrated by transgenic zebrafish [10], and molecular function of Rab11 proteins in primary cilia membrane assembly in Kupffer Vesicle has been studied [6], the developmental expression profile of Rab11 proteins in zebrafish remains elusive. (researchsquare.com)
16 , 17 In particular, transgenic zebrafish lines that express nfsB in β cells, cardiomyocytes, or other cell types have been established, and their exposure to the metronidazole leads to the targeted loss of these cells. (cdc.gov)

Confocal micrograph of "lost" axons - chick interneurons labeled with green fluorescent protein that were transplanted from older into younger embryos. (cellimagelibrary.org)
The findings could provide new evidences for better understanding the functions of rab11 in the development of zebrafish embryos. (researchsquare.com)
A team of researchers led by Professor Jonathan Rocheleau (BME), has introduced an innovative biosensor, Apollo-NADP + , in living zebrafish embryos to track molecular metabolism. (utoronto.ca)
The study's first phase focused on demonstrating the sensor's functionality within living zebrafish embryos. (utoronto.ca)
Injection of 25-40pg of the TALENs targeting individual exons into zebrafish embryos resulted in efficient mutagenesis of the target sites. (iastate.edu)
We characterize the activation kinetics of these reagents in vitro and demonstrate their efficacy in zebrafish embryos that express NfsB either ubiquitously or in defined cell populations. (cdc.gov)
Results from zebrafish embryos injected with murine Stat3 mRNA and stat3 morpholino suggest that Ambra1b could indirectly regulate this protein through CUL4-DDB1 interaction. (biomedcentral.com)

citation needed] Pole plasm is organized by and contains the proteins and mRNA of the posterior group genes (such as oskar, nanos gene, Tudor, vasa, and Valois). (wikipedia.org)
Of dozens of genes strongly activated by injury, seven coded for proteins that are secreted from cells. (neurosciencenews.com)
Humans and zebrafish share most protein-coding genes, and CTGF is no exception. (neurosciencenews.com)
Conclusions: Our results suggest that rab11 genes play important but distinct roles in the development of the nervous system in zebrafish. (researchsquare.com)
In the present project, we showed that zebrafish rab11 genes are conserved in vertebrate evolution by in silicon analysis. (researchsquare.com)
We study genes, proteins and signaling pathways that might be essential for RGC and optic nerve development, function, survival, and regeneration. (nih.gov)
We are particularly interested in genes encoding olfactomedin domain-containing proteins. (nih.gov)
Several genes encoding olfactomedin domain-containing proteins are expressed in the eye. (nih.gov)
The Popeye domain containing (POPDC) genes encode sarcolemma-localized cAMP effector proteins. (imperial.ac.uk)
Here, we show that the zebrafish Atonal genes neurogenin1 ( neurog1 ) and neurod4 are redundantly required for development of both early-born olfactory neurons (EONs) and later-born olfactory sensory neurons (OSNs). (silverchair.com)
Zebrafish express npy and two agrp genes, agrp1 and agrp2, in the brain. (korea.ac.kr)
Similar to mammals, NPY and AgRP1 act as orexigenic factors in zebrafish, but the exact distribution of NPY and AgRP neurons in the zebrafish brain and the regulation of these genes by metabolic states remain unclear. (korea.ac.kr)
This gene is a member of the mitochondrial carrier subfamily of solute carrier protein genes. (thermofisher.com)
ALS-associated genes display CNS expression in the developing zebrafish. (neuralsci.org)
Although 271 genes linked to hereditary retinal diseases have already been identified, these genes encode diverse functions, including phototransduction, retinol metabolism, and intracellular protein transport. (oist.jp)
The zebrafish genome contains two ambra1 paralogous genes ( a and b ), both involved in development and expressed at high levels in the gonads. (biomedcentral.com)
Characterization of the zebrafish paralogous genes mutant lines generated by CRISPR/Cas9 approach showed that ambra1b knockout leads to an all-male population. (biomedcentral.com)
By exploiting ambra1a and ambra1b knockout zebrafish lines, we prove the sub-functionalization between the two paralogous zebrafish genes and uncover a novel function of Ambra1 in the protection from excessive PGC loss, which seems to require binding with the CUL4-DDB1 complex. (biomedcentral.com)

The zebrafish ( Danio rerio ) is an attractive and versatile model to gain insight into vertebrate brain development and function. (nature.com)
The expression pattern of this gene family has been recently described during zebrafish ( Danio rerio ) embryogenesis, and primarily locates in the nervous system. (frontiersin.org)
To this end, the zebrafish ( Danio rerio ) is an established model to study early nervous system development, which combines the complexity of a vertebrate organism with the easy-to-use and high-throughput capabilities of in vitro models ( MacRae and Peterson, 2015 ). (frontiersin.org)
Gene Expression of CRAL_TRIO Family Proteins modulated by Vitamin E Deficiency in Zebrafish (Danio Rerio). (oregonstate.edu)
Knock-out of vasotocin reduces reproductive success in female zebrafish, Danio rerio. (mennigen-lab.com)
Deleterious effects of PFOS, OBS, and F-53B on dopaminergic health, mitochondrial function, and locomotor behaviour in developing zebrafish (Danio rerio). (mennigen-lab.com)
Acute and long-term metabolic consequences of early developmental Bisphenol A exposure in zebrafish (Danio rerio). (mennigen-lab.com)
morph]] of the zebrafish ''Danio rerio'' caused by a pigment mutation. (wikidoc.org)
ref>Watanabe M, Iwashita M, Ishii M, Kurachi Y, Kawakami A, Kondo S, Okada N. (2006) Spot pattern of leopard Danio is caused by mutation in the zebrafish connexin41.8 gene. (wikidoc.org)

A sensation for inflation: initial swim bladder inflation in larval zebrafish is mediated by the mechanosensory lateral line bioRxiv. (usc.edu)
We detected the expression of agrp1, but not npy, in the hypothalamus of larval zebrafish. (korea.ac.kr)
However, consistent with the findings in larval zebrafish, NPY neurons in the hypothalamus did not coexpress AgRP1. (korea.ac.kr)

Taken together, our results show that the zebrafish NPY/AgRP system is involved in appetite regulation. (korea.ac.kr)

Through molecular characterization and evolutionary-developmental considerations, we delineated the complex amygdala ground plan of zebrafish, whose everted telencephalon has made comparisons to the evaginated forebrains of tetrapods challenging. (frontiersin.org)
Based on molecular and evolutionary-developmental characteristics, the study identifies the elaborate amygdala ground plan in zebrafish and stresses the evolution of a complex emotional system in early vertebrates. (frontiersin.org)
Metabolic consequences of developmental exposure to polystyrene nanoplastics, the flame retardant BDE-47 and their combination in developing zebrafish. (mennigen-lab.com)
42) Huang J, Sun L, Mennigen JA, Liu Y, Liu S, Zhang M, Wang Q, Tu W. Developmental toxicity of the novel PFOS alternative OBS in developing zebrafish:an emphasis on cilia disruption. (mennigen-lab.com)
However, the precise developmental profile of functional zebrafish BBB acquisition and the subcellular and molecular mechanisms governing the zebrafish BBB remain poorly characterized. (elifesciences.org)
Our findings indicate a conserved developmental program of barrier acquisition between zebrafish and mice. (elifesciences.org)
By evaluating TCDD-induced developmental toxicity, mRNA expression changes and CYP1A protein in the AHR2 mutant line, we determined that ahr2(hu3335) zebrafish are functionally null. (oregonstate.edu)
Developmental neurobiology unit uses zebrafish as an animal model and will elucidate genetic program that regulate eye development. (oist.jp)
Since data that can be obtained by knockdown approaches are limited to the first developmental stages, we recently generated a mutant zebrafish line for each paralogous gene. (biomedcentral.com)

She also carried out functional studies in the mouse, and using CRISPR-Cas9 genome editing, in zebrafish. (neuralsci.org)

citation needed] In zebrafish, the PGCs express two CXCR4 transmembrane receptor proteins. (wikipedia.org)
G protein-coupled receptors (GPCRs) constitute a large family of integral transmembrane receptor proteins that play a central role in signal transduction in eukaryotes. (biomedcentral.com)

Identifying the molecular basis of sexual dominance in male zebrafish. (exeter.ac.uk)

Finally, we demonstrate a key mammalian BBB regulator Mfsd2a, which inhibits transcytosis, plays a conserved role in zebrafish, as mfsd2aa mutants display increased BBB permeability due to increased transcytosis. (elifesciences.org)
runx1 expression in the lateral plate mesoderm co-localizes with the hematopoietic transcription factor scl , and expression of runx1 is markedly reduced in the zebrafish mutants spadetail and cloche . (biologists.com)
We focus on zebrafish mutants, in which photoreceptor degeneration is caused by defects in protein synthesis in ER, protein transport from ER to the apical photoreceptive membrane region, and phototransduction. (oist.jp)

Thus, we provide a reference dataset describing the expression patterns of RPRM gene products during zebrafish and mouse development as a first step to approach the physiological role of the RPRM gene family. (frontiersin.org)
Moreover, zebrafish is very well-suited for systematic analysis of gene expression patterns at transcript level by whole-mount in situ hybridization (WISH), and at protein level by immunohistochemistry/immunofluorescence (IHC/IF). (frontiersin.org)
Herein we examine the temporal and spatial expression patterns of RPRM gene-products (mRNA and protein) during neural development. (frontiersin.org)
Gene-nutrient interactions exemplified by the alpha-tocopherol content of tissues from alpha-tocopherol transfer protein-null mice fed different dietary vitamin E concentrations. (oregonstate.edu)
Little is known about proneural gene function during olfactory neurogenesis in zebrafish. (silverchair.com)
Equatorial segment protein (ESP), a novel 349-amino acid concanavalin-A-binding protein encoded by a two-exon gene ( SP-ESP ) located on chromosome 15 at q22, has been localized to the equatorial segment of ejaculated human sperm. (bioone.org)
Gfp refers to the gene that produces green fluorescent protein. (asu.edu)
Using DNA recombinant technology, scientists combine the Gfp gene to a another gene that produces a protein that they want to study, and then they insert the complex into a cell. (asu.edu)
We previously mapped a highly penetrant retinal tumor model to transgene disruption of the zebrafish lncRNAis18 gene. (iastate.edu)
The objective of this project is to isolate a second zebrafish lncRNAis18 allele that contains a deletion of part of the lncRNAis18 gene. (iastate.edu)
A gene coding for a kappa bungarotoxin (K-Bgt) and rat intestinal fatty acid binding fusion protein was previously constructed in an Escherichia coli plasmid in order to allow synthesis of K-Bgt in vitro. (kzoo.edu)
Gene Expr Patterns [Internet]. (neuralsci.org)
The furry ( fry ) gene encodes an evolutionarily conserved protein with a wide variety of cellular functions, including cell polarization and morphogenesis in invertebrates. (nature.com)
The Furry (Fry) gene encodes a large protein (~ 330 kDa) that is evolutionarily conserved from yeast to humans. (nature.com)
We demonstrated that the silencing of the ambra1b gene determines a reduction of primordial germ cells (PGCs), a condition that, in the zebrafish, leads to the development of all-male progeny. (biomedcentral.com)

We observed miR-137 expression and activity in sensory neurons including Rohon-Beard neurons and dorsal root ganglia, two neuronal cell types that confer touch-sensitivity in normal zebrafish, suggesting a role of these cell types in the observed phenotype. (nature.com)
Importantly, a precise temporal description of RPRM protein expression during the development of neuronal structures is still missing. (frontiersin.org)
We demonstrated that Olfm1 interacts with several proteins essential for neuronal and synaptic activity. (nih.gov)
Zebrafish runx1 is expressed in hematopoietic and neuronal cells during early embryogenesis. (biologists.com)

In the zebrafish, rprma mRNA is expressed in the olfactory placodes (OP) and olfactory epithelium (OE), rprmb is observed in the tectum opticum (TeO) and trigeminal ganglion (Tg), whereas rprml is found primarily in the telencephalon (Tel). At protein level, RPRM is present in a subset of cells in the OP, and neurons in the OE, TeO, hindbrain and sensory peripheral structures. (frontiersin.org)
We conclude that the duration of proneural expression in EON progenitors is crucial for correct development of the zebrafish olfactory system. (silverchair.com)

We aim to study the coupling between LTCC and β adrenergic receptors in different cardiomyocyte microdomains, the distinct involvement of PKA and CAMKII (Ca2+/calmodulin-dependent protein kinase II) and explore how this functional complex is disrupted in heart failure.Methods:Global signaling between LTCCs and β adrenergic receptors was assessed with whole-cell current recordings and western blot analysis. (imperial.ac.uk)
AHR2 mutant reveals functional diversity of aryl hydrocarbon receptors in zebrafish. (oregonstate.edu)

The ahr2(hu3335) functional knockout line expands the experimental power of zebrafish to unravel the role of the AHR during development, as well as highlights potential activity of the other AHR paralogues in ligand-specific toxicological responses. (oregonstate.edu)
The block in definitive hematopoiesis is similar to that observed in Runx1 knockout mice, implying that zebrafish Runx1 has a function equivalent to that in mammals. (biologists.com)

This protein is fused to a green fluorescent protein (GFP) enabling it to be observed with fluorescence microscopy. (coherent.com)
Some neurons express the green fluorescent protein (GFP) - shown in green under the control of a specific promotor. (cellimagelibrary.org)
Green fluorescent protein (GFP) is a protein in the jellyfish Aequorea Victoria that exhibits green fluorescence when exposed to light. (asu.edu)
John W. Hasting and James G. Morin, who later researched aequorin, termed the protein as green fluorescent protein in 1971. (asu.edu)

In the adult zebrafish brain, npy mRNA expression was detected in the dorsal area of the periventricular and lateral hypothalamus, but fasting induced upregulation of npy only in the lateral hypothalamus, indicating that NPY neurons in this area are implicated in feeding regulation. (korea.ac.kr)

Apollo-NADP+ sensor expressed in the single pancreatic islet of a living zebrafish embryo. (utoronto.ca)

This molecule is highly conserved in vertebrates enabling the investigation of its function in the developing zebrafish. (nature.com)
CTGF is a large protein, made of four smaller parts, and it has more than one function. (neurosciencenews.com)
To study function of these proteins we also use zebrafish as a model system. (nih.gov)
In addition, we found for the first time that npy- and agrp1-expressing neurons function as GABAergic inhibitory neurons in zebrafish, as they do in mammals. (korea.ac.kr)
The protein is implicated in the function of the permability transition pore complex (PTPC), which regulates the release of mitochondrial products that induce apoptosis. (thermofisher.com)
To further elucidate the role of RUNX1 in hematopoiesis, we cloned the zebrafish ortholog ( runx1 ) and analyzed its function using this model system. (biologists.com)
The lncRNAis18 deletion allele will provide a new genetic tool to study the function of lncRNAis18 in zebrafish development and cancer. (iastate.edu)
Currently, she is working on elucidating the many roles of Stau2, an RNA-binding protein in different aspects of brain development and function. (neuralsci.org)
For example, we have applied light-activatable cMOs to interrogate transcription factor function during zebrafish notochord, pancreas, and vascular patterning. (cdc.gov)

By inserting DNA encoding the sensor into the genome, researchers were able to establish a stable line of zebrafish that express the fluorescence protein-based sensor in the pancreatic islet. (utoronto.ca)
The interaction of POPDC proteins was investigated by co-precipitation, proximity ligation, bioluminescence resonance energy transfer and bimolecular fluorescence complementation. (imperial.ac.uk)
GFP can attach to and mark another protein with fluorescence, enabling scientists to see the presence of the particular protein in an organic structure. (asu.edu)
When they purified aequorin, they also discovered traces of another protein, which showed green fluorescence. (asu.edu)
The paper was about aequorin, but it also described a green protein, which exhibited green fluorescence under sunlight. (asu.edu)

Thus, the study explains how the zebrafish amygdala and the complexly everted telencephalon topologically relate to the corresponding structures in mammals indicating that an elaborate amygdala ground plan evolved early in vertebrates, in a common ancestor of teleosts and tetrapods. (frontiersin.org)
Confocal micrograph of the anterior region of the developing zebrafish brain (consisting of the telencephalon, part of diencephalon and the optic tectum). (cellimagelibrary.org)

Adult zebrafish can regenerate their spinal cords after an injury. (neurosciencenews.com)
In this study, we analyzed the tissue distribution of npy, agrp1, and agrp2 mRNA in the brain of larval and adult zebrafish. (korea.ac.kr)

These experiments may reveal some answers to why zebrafish can regenerate whereas mammals cannot. (neurosciencenews.com)
In mammals, NPY neurons coexpress Agouti-related protein (AgRP) in the arcuate nucleus of the hypothalamus, and NPY/AgRP neurons activate orexigenic signaling to increase food intake. (korea.ac.kr)

He states, "My research is currently focused on social behavior in zebrafish, a model organism for studying neuroscience due to their simplified nervous system and similar genetics to humans. (coherent.com)
Zebrafish Paralogs brd2a and brd2b Are Needed for Proper Circulatory, Excretory and Central Nervous System Formation and Act as Genetic Antagonists during Development J Dev Biol. (usc.edu)
Zebrafish Paralogs brd2a and brd2b Are Needed for Proper Circulatory, Excretory and Central Nervous System Formation and Act as Genetic Antagonists during Development. (sc-ctsi.org)

As an optically transparent model organism with an endothelial blood-brain barrier (BBB), zebrafish offer a powerful tool to study the vertebrate BBB. (elifesciences.org)

The lhfpl5 Ohnologs lhfpl5a and lhfpl5b Are Required for Mechanotransduction in Distinct Populations of Sensory Hair Cells in Zebrafish Front Mol Neurosci. (usc.edu)
The role of DNA methylation on sexual determination and development in zebrafish germ cells. (exeter.ac.uk)
Moreover, we show that a subset of gut mpeg1.1 + cells express telomerase ( tert ) in young WT zebrafish, but that the relative proportion of these cells decreases with ageing. (biomedcentral.com)

Background: Rab proteins are GTPases responsible for intracellular vesicular trafficking regulation. (researchsquare.com)
Rab/Ypt proteins are small GTP-binding proteins of the Ras superfamily and are key players in intracellular vesicular trafficking regulation [1, 2]. (researchsquare.com)
Some family members, such as latrophilins and gliomedin, are membrane-bound proteins containing the olfactomedin domain in the extracellular N-terminal region, while the intracellular C-terminal domain of these proteins is essential for the transduction of extracellular signals to the intracellular signaling pathway. (nih.gov)

A freshwater zebrafish costs less than two bucks at the pet store, but it can do something priceless: Its spinal cord can heal completely after being severed, a paralyzing and often fatal injury for humans. (neurosciencenews.com)

In Brainbow mice, neurons randomly choose combinations of red, yellow and cyan fluorescent proteins, so that they each glow a particular. (cellimagelibrary.org)

In this radical paradigm, thirteen telencephalic territories constitute the zebrafish amygdaloid complex and each territory is distinguished by conserved molecular properties and structure-functional relationships with other amygdaloid structures. (frontiersin.org)
A zebrafish line with a mutation in ahr2 (ahr2(hu3335)), encoding the AHR paralogue responsible for mediating TCDD toxicity in zebrafish, was developed via Targeting Induced Local Lesions IN Genomes (TILLING) and predicted to express a non-functional AHR2 protein. (oregonstate.edu)
Fry protein is composed of an N-terminal Furry domain (FD) with HEAT/Armadillo repeats followed by five regions without any recognizable functional domains. (nature.com)

However, the subcellular and molecular mechanisms governing the formation and maintenance of the zebrafish BBB are only beginning to be characterized. (elifesciences.org)

The protein has 238 amino acids, three of them (Numbers 65 to 67) form a structure that emits visible green fluorescent light. (asu.edu)

Rab11 proteins, members of the Rab GTPase family, are known to regulate vesicular recycling during embryonic development. (researchsquare.com)
Among various Rab proteins, Rab11 is known to localize to recycling endosome and regulate vesicular recycling and primary ciliogenesis, playing a key role in Kupffer vesicle development in zebrafish [5-7]. (researchsquare.com)
We use a zebrafish model to study functions of Olfm1 in development. (nih.gov)
Our data suggest that zebrafish Runx1 functions in both blood and vessel development at the hemangioblast level, and contributes to both primitive and definitive hematopoiesis. (biologists.com)

It is also known that defects in mitochondrial functions, which are responsible for energy production in the cell, occur before the accumulation of amyloid b (Ab) that causes AD and are closely related to the accumulation of tau protein. (journalmeddbu.com)
6 , 7 ] Studies have shown that MB can delay aging by inhibiting the accumulation of tau protein[ 8 ] and by increasing mitochondrial respiration,[ 9 ] hence it is considered a significant chemical in regards to AD. (journalmeddbu.com)

Molecular characteristics such as the distribution of substance P and the calcium-binding proteins parvalbumin (PV) and calretinin (CR) indicate, that the zebrafish extended centromedial (autonomic and reproductive) amygdala is predominantly located in the GABAergic and isl1 -negative territory. (frontiersin.org)

In the jellyfish, GFP interacts with another protein, called aequorin, which emits blue light when added with calcium. (asu.edu)

Regionalized Protein Localization Domains in the Zebrafish Hair Cell Kinocilium J Dev Biol. (usc.edu)
Exp Biol Med (Maywood). (oregonstate.edu)
J Exp Biol. (sc-ctsi.org)

Regionalized Protein Localization Domains in the Zebrafish Hair Cell Kinocilium. (sc-ctsi.org)
Site-directed mutagenesis was utilised to map the domains involved in protein-protein interaction. (imperial.ac.uk)

The human CTGF protein is nearly 90% similar in its amino acid building blocks to the zebrafish form. (neurosciencenews.com)
Zebrafish rab11a was clustered in the Rab11a group, and rab11ba and rab11bb in the Rab11b group (Fig.1B) in the phylogenic tree constructed according to amino acid sequences of all the Rab11 proteins above. (researchsquare.com)
From 1979 to 1992, many researchers studied various aspects of GFP, including the use of Nuclear Magnetic Resonance to study the amino acids of the protein, the use of X-rays to study its crystal, and the evolution of GFP. (asu.edu)

The study introduces a long-needed testable molecular reference paradigm of the mature zebrafish extended amygdaloid complex studying neural underpinnings and evolution of emotion in this important model organism. (frontiersin.org)

Neurodegenerative Proteins in Epilepsy" Encyclopedia , https://encyclopedia.pub/entry/12708 (accessed December 10, 2023). (encyclopedia.pub)

Dr. Chowdhury's research goal is to understand the mechanisms through which RNA-binding proteins control RNA localization, stability, and assembly, and the contribution of these processes to neurodegeneration. (neuralsci.org)
The mechanisms whereby Mtb disseminates from the initial Ghon focus are not well understood, but studies in the zebrafish model of M. marinum infection suggest that Mtb is transported within infected monocytes [ 4 ]. (ersjournals.com)

While watching these fish repair their own spinal cord injuries, Duke University scientists have found a particular protein important for the process. (neurosciencenews.com)
Apart from brain, rab11a was also expressed in caudal vein, pronephric duct, proctodeum, pharyngeal arches and digestive duct, rab11ba was detected to express in muscle, and rab11bb was expressed in kidney, fin and spinal cord. (researchsquare.com)
Spinal muscular atrophy (SMA) is a neurodegenerative disease produced by low levels of Survival Motor Neuron (SMN) protein that affects alpha motoneurons in the spinal cord. (mdpi.com)

Expanding our understanding of the zebrafish BBB can thus reveal the mechanistic similarities between the zebrafish and mammalian BBB to further evaluate the position of zebrafish as a model organism for studying the BBB. (elifesciences.org)

Anatomy25

Organisms7

Diseases2

Chemicals and Drugs27

Analytical, Diagnostic and Therapeutic Techniques and Equipment11

Psychiatry and Psychology1

Phenomena and Processes24

Anthropology, Education, Sociology and Social Phenomena1

Information Science4

Transgenic zebrafish4

Embryos7

Genes18

Danio9

Larval zebrafish3

Show that the zebrafish1

Developmental9

CRISPR-Cas91

Transmembrane receptor proteins2

Male zebrafish1

Mutants3

Gene15

Neuronal4

Olfactory2

Receptors2

Knockout2

Green fluores4

MRNA expression1

Embryo1

Function9

Fluorescence5

Telencephalon2

Adult2

Mammals2

Nervous system3

Vertebrate1

Cells3

Intracellular3

Humans1

Neurons1

Functional3

Subcellular1

Fluorescent1

Development4

Mitochondrial2

Reproductive1

Interacts1

Biol3

Domains2

Amino3

Neural1

20231

Mechanisms2

Spinal3

Reveal1