• We investigated pairwise exposure to five occupational exposures: asbestos, respirable crystalline silica, metals (i.e. nickel, chromium VI), and polycyclic aromatic hydrocarbons (pah), on lung cancer risk, both overall and by major subtypes, whil. (researchgate.net)
  • Food is expected to be the primary source of exposure to furan for Canadians. (canada.ca)
  • 2 Crystalline silica has also been determined to be an occupational lung carcinogen 4,5 and there is evidence that inhaling respirable silica dust causes chronic obstructive pulmonary disease (COPD), chronic renal (kidney) disease and various autoimmune diseases. (cdc.gov)
  • Further characterize the extent of dioxin exposure in the community. (cdc.gov)
  • 2007). This study found that AM accounted for only 2-12% of the detected metabolites, that most of the subjects had detectable atrazine exposure, and that future biomonitoring studies would likely need to include analysis of at least AM, DACT, DIA, and DEA in order to characterize the extent of atrazine exposure in a population. (who.int)
  • The review included exposure to environmental agents carcinogenic to humans (International Agency for Research on Cancer classification), as well as lifestyle factors known to affect cancer risk. (who.int)
  • Those include the carcinogenic potency of the substance, the level and duration of exposure, and an individual's susceptibility to the carcinogenic action of the substance. (nih.gov)
  • Many chemicals on the market and in the environment have not undergone exhaustive carcinogenicity testing, and significant knowledge gaps remain on the potential carcinogenic effects of low levels of exposure to combinations of chemicals throughout our lifetime. (europa.eu)
  • Exposure to carcinogenic chemicals comes from multiple sources and pathways, including outdoor and indoor air pollution, smoking, either directly or second hand, consumer products, drinking water and food, and in relation to several occupations. (europa.eu)
  • Apart from carcinogenic chemicals, UV radiation and asbestos, occupational exposure to metals, dusts, ionising radiation, stress and other factors related to work organisation and working conditions have also been linked to cancer. (europa.eu)
  • Rationale: Benzene has been classified as carcinogenic to humans, but there is limited evidence linking benzene exposure to lung cancer. (researchgate.net)
  • It was later decided to include nitions of carcinogens were based on pollution, occupational exposure to a review of lifestyle factors that are the January 2013 list of agents classified carcinogenic compounds, and lifestyle known to influence cancer risk. (who.int)
  • Exposure to secondhand smoke can lead to lung cancer, acute and chronic coronary heart disease (CHD), and eye and nasal irritation in adults. (tobaccoatlas.org)
  • However, rapidly fatal cases of acute silicosis resulting from very intense exposures over only a few months or years are well documented among sandblasters, tunnelers, miners, and some other occupational groups. (cdc.gov)
  • The study also found that the proportion of these urinary metabolites varied considerably depending on whether the subjects had high or low acute exposures or whether the subjects had general environmental exposures (i.e., not agricultural workers). (who.int)
  • Thus, radon exposure represents a readily preventable cause of the most lethal and common cancer type, and is a priority area of public health intervention and cancer prevention. (nature.com)
  • Many chemicals in the environment and the workplaces are known or suspected carcinogens. (europa.eu)
  • Governments must enact measures to eliminate exposures to SHS in public and workplaces and homes. (tobaccoatlas.org)
  • Humans can prevent themselves from a number of workplace and environmental carcinogens. (moam.info)
  • Methods: A structured questionnaire was used to collect information on carcinogen exposure in the workplace and environment through trained field staff from volunteers after gaining informed consent. (moam.info)
  • State and federal agencies limit exposure to the substance in the workplace and the environment through regulation. (nih.gov)
  • The most common workplace carcinogens are generated when carrying out specific tasks or applying specific technologies (cutting stone, grinding or cutting wood, welding, processing metal products, combustion, etc.) rather than substances that are marketed or used as such. (europa.eu)
  • For these process-generated workplace carcinogens, exposure is mainly reduced through prevention measures such as local exhaust ventilation. (europa.eu)
  • Exposure to a wide variety of substances causing or contributing to cancer happens in the workplace or in relation to certain occupations. (europa.eu)
  • Objectives: To assess exposure to carcinogens, risky behaviours and associated preventive methods. (moam.info)
  • Evaluate strategies to assess past exposures to dioxin. (cdc.gov)
  • Systematic reviews play a similar role today as literature reviews in the past in that both attempt to provide an overview of the literature on a particular topic, either within a discipline (e.g., epidemiology) or across disciplines, and typically assess the evidence for causality for the association between exposure and disease. (nih.gov)
  • To investigate potential worker health hazards in this rapidly expanding industry and address the existing lack of information on occupational dust and chemical exposures associated with hydraulic fracturing, NIOSH initiated the NIOSH Field Effort to Assess Chemical Exposures in Oil and Gas Extraction Workers . (cdc.gov)
  • The United States Environmental Protection Agency, Region VI, will develop activities to evaluate human exposure pathways to hazardous substances in the environment. (cdc.gov)
  • Thus, hazardous radon exposure is largely an anthropogenic environmental health issue. (nature.com)
  • 2015). For example, from the priority list of 16 groups of commonly used hazardous substances in the European Human Biomonitoring Initiative (HBM4EU) (HBM4EU, 2022), in which the EEA participated), six groups of substances (anilines, arsenic, cadmium, chromium, mycotoxins and PAHs) include known or presumed carcinogens as set out in the EU Classification, Labelling and Packaging (CLP) Regulation and by the International Agency for Research on Cancer (IARC). (europa.eu)
  • More than 70 of these compounds are carcinogens, which has led the US Environmental Protection Agency and the International Agency for Research on Cancer to classify SHS as a group A and group 1 carcinogen, respectively, indicating the most hazardous cancer-causing compounds. (tobaccoatlas.org)
  • Eight substances have been added to the Report on Carcinogens, bringing the total list to 256 substances that are known, or reasonably anticipated, to cause cancer in humans. (nih.gov)
  • The Working Group concluded that the animal mammary tumors associated with exposure to atrazine involve a non-DNA-reactive, hormonally mediated mechanism that is not relevant to humans. (who.int)
  • A recent study evaluated the urinary levels of 9 atrazine metabolites in humans and concluded that DACT was the primary metabolite regardless of exposure scenario, and that exposure assessment based on measuring only AM or any single atrazine metabolite resulted in an underestimate of atrazine exposure (Barr et al. (who.int)
  • The defi- such as exposure to environmental air humans. (who.int)
  • Objectives: We examined the association between long-term exposure to air pollution and vaccine-induced antibody response. (researchgate.net)
  • In fact, a significant proportion of exposure to carcinogens, including chemicals, in Europe happens in occupational settings (see Box 1). (europa.eu)
  • Pursuant to section 68 or 74 of the Canadian Environmental Protection Act, 1999 (CEPA), the Minister of the Environment and the Minister of Health conducted a screening assessment of four of five substances referred to collectively under the Chemicals Management Plan as the Furan Compounds Group. (canada.ca)
  • and contribution to the burden of cancer posure to chemicals and pollutants medical diagnostics (e.g. exposure to worldwide ( 2 ). (who.int)
  • A Data Exploration Dashboard (https://ntp.niehs.nih.gov/whatwestudy/assessments/cancer/roc/data/index.html?utm_source=direct&utm_medium=prod&utm_campaign=ntpgolinks&utm_term=roc15d) for the 15th Report on Carcinogens provides an easy-to-understand visual breakdown of all substances listed in the document and their associated cancers. (nih.gov)
  • While we have estimates for some substances, we are not certain about the overall contribution of chemical carcinogens to the burden of cancer in Europeans. (europa.eu)
  • Many more groups of substances on the list include deemed presumed or suspected carcinogens by European authorities. (europa.eu)
  • A risk matrix is used to assign a low, moderate or high level of potential concern for substances on the basis of their hazard and exposure profiles. (canada.ca)
  • The dangers from SHS also extend to the e-cigarette aerosols that users exhale, which contain harmful and potentially harmful substances, including nicotine, heavy metals, and carcinogens. (tobaccoatlas.org)
  • This is the 15th Report on Carcinogens (https://ntp.niehs.nih.gov/go/roc15) , which is a cumulative report mandated by Congress and prepared by the National Toxicology Program (NTP) for the Secretary of the U.S. Department of Health and Human Services. (nih.gov)
  • pesticide exposure via the dermal, oral, or inhalatory routes. (moam.info)
  • Occupational exposure may occur through both inhalation and dermal adsorption during the manufacture of atrazine, its formulation, and its application. (who.int)
  • Results: Participants were exposed to recognized carcinogens and environmental hazards. (moam.info)
  • Thirty-five (83.3%) [95% CI: 72.0- 94.6] participants knew the carcinogen names they were exposed to. (moam.info)
  • Thirty (71.4%) [95% CI: 65.0 - 77.0] participants had been instructed in the use of protective equipment against carcinogens. (moam.info)
  • ATSDR also held a public availability session to allow the participants to discuss their test results with environmental and health officials. (cdc.gov)
  • ATSDR (Division of Health Education and Promotion) facilitated access to an Association of Occupational and Environmental Clinics (AOEC) environmental medical expert in dioxin to review medical information for the 28 EI participants and determine the next clinical steps for these individuals. (cdc.gov)
  • The limited data on occupational exposure suggests that the greatest risks for workers in the construction industry are likely to be from environmental dust and related air pollutants. (who.int)
  • Extended monitoring of the composition of and human exposure to air pollutants is recommended. (who.int)
  • Introduction To summarize the epidemiological evidence on occupational asbestos exposure and the risk of esophageal, stomach and colorectal cancer. (researchgate.net)
  • Evaluate potential pathways for human exposure to dioxin from environmental and dietary sources. (cdc.gov)
  • Reduce human exposures to dioxin from significant exposure pathways that are identified. (cdc.gov)
  • We review the strengths and limitations of risk of bias assessments, in particular, for reviews of observational studies of environmental exposures, and we also comment more generally on methods of evidence synthesis. (nih.gov)
  • The flame-retardant chemical antimony trioxide, and six haloacetic acids (HAAs) found as water disinfection byproducts are listed as reasonably anticipated to be a human carcinogen. (nih.gov)
  • As the identification of carcinogens is a key step in cancer prevention, publication of the report represents an important government activity towards improving public health. (nih.gov)
  • ABSTRACT To meet the country's health goals for 2011-2016, a qualitative review of exposure to risk factors for cancer in Qatar was conducted in 2013. (who.int)
  • These changes can be inherited or can accrue from damage caused by environmental factors. (healthandenvironment.org)
  • Environmental factors that are poten- risk factors for cancer in Qatar. (who.int)
  • Highest exposure occurs among workers who produce the substance or use it to make flame retardants. (nih.gov)
  • Initial hazard assessments identified exposure to crystalline silica during hydraulic fracturing as the most significant known health hazard to workers and this has been the focus of the NIOSH study to date. (cdc.gov)
  • The significance of these findings is that even if workers are properly using half-mask air-purifying respirators, they would not be sufficiently protected because half-mask air-purifying respirators have a maximum use concentration of 10 times the occupational health exposure limit. (cdc.gov)
  • NIOSH recently collected 116 air samples at 11 different hydraulic fracturing sites in five different states (AR, CO, ND, PA and TX) to evaluate worker exposure to crystalline silica. (cdc.gov)
  • Evidence synthesis (or evidence integration) is widely used to summarize findings of epidemiologic studies of environmental and occupational exposures. (nih.gov)
  • The evidence base for the relationship between exposure to second-hand smoke and health conditions is also extensive. (who.int)
  • The ERC is a risk-based approach that employs multiple metrics for both hazard and exposure, with weighted consideration of multiple lines of evidence for determining risk classification. (canada.ca)
  • It is widely recognized through scientific evidence that there is no safe level of exposure to SHS. (tobaccoatlas.org)
  • Evidence shows persistent disparities in secondhand smoke exposure by ethnicity, education, and income level. (tobaccoatlas.org)
  • These activities will include: (1) air toxics monitoring in the Mossville area (to be conducted in conjunction with the Louisiana Department of Environmental Quality) and (2) sediment and water sampling of estuaries. (cdc.gov)
  • Metrics considered in the exposure profiles include potential emission rate, overall persistence, and long-range transport potential. (canada.ca)
  • Typically, people with lower educational attainment are less knowledgeable about SHS exposure risks. (tobaccoatlas.org)
  • Cancer affects almost everyone's life, either directly or indirectly," said Rick Woychik, Ph.D. , director of the National Institute of Environmental Health Sciences and NTP. (nih.gov)
  • ATSDR (Division of Health Studies) will review both the dioxin data and further environmental characterization data to determine if a more extensive exposure investigation or a health study follow-up is appropriate. (cdc.gov)
  • RÉSUMÉ Afin d'atteindre les objectifs de santé fixés par le pays pour 2011-2016, une analyse qualitative de l'exposition aux facteurs de risque de cancer au Qatar a été conduite en 2013. (who.int)
  • Regression analyses indicates that the modern North American Prairie residential environment displays exceptionally high and worsening radon exposure, with more recent construction year, greater square footage, fewer storeys, greater ceiling height, and reduced window opening behaviour all associated with increased radon. (nature.com)
  • mine glycol as an indicator of exposure to agents causing oxidative damage to DNA. (moam.info)
  • Environmental Carcinogen Method of Analysis and Exposure Measurement 299-342 (1991). (cdc.gov)
  • A meta-analysis yields a quantitative effect estimate, such as the strength of the association between an exposure and an outcome. (nih.gov)
  • 3 The disease typically develops after long periods of exposure and progresses gradually. (cdc.gov)