Exposure pc12 cells. Medical search. Frequent questions

Deltamethrin exposure promoted free radical formation in rat brain and reactive oxygen species generation in PC12 cells. (cdc.gov)
Key findings: In the present study, we found that D3T pretreatment significantly increased cell viability and decreased reactive oxygen species (ROS) levels, lactate dehydrogenase (LDH) levels and the intracellular calcium concentration of rat pheochromocytoma (PC12) cells after Aβ 1-42 exposure. (elsevierpure.com)

Neurotoxicant actions are evaluated by cell-based screening using neuronotypic PC12 cells, primary neurons from fetal rat cerebral cortex, and neuronal-glial co-cultures, to screen for developmental neurotoxicity across the entire spectrum of neurodevelopmental events, from cell replication to differentiation into specific neuronal phenotypes. (nih.gov)
The effect of exposure of different stem cells types to extremely low frequency magnetic fields on neuronal differentiation in relation to gene expression should be investigated. (emf-portal.org)
Additionally, tests were conducted with Egr1-knockdown and Egr1- overexpressing human bone marrow - mesenchymal stem cells as Egr1 was supposed to play a crucial role in magnetic field mediated neuronal differentiation . (emf-portal.org)
Mounting evidence also suggests a role for p53 in differentiation of cells including neuronal precursors. (biomedcentral.com)
Within the PC12 neuronal context, putative p53-occupied genomic loci spanned the entire Rattus norvegicus genome upon NGF treatment. (biomedcentral.com)
We conclude that receptor-mediated p53 transcriptional activity is involved in PC12 differentiation and may suggest a contributory role for p53 in neuronal development. (biomedcentral.com)
p53 transcriptional activity may be further involved in the differentiation of other non-neuronal cell types. (biomedcentral.com)
C5a is thought to play a role during complement-activated neuronal apoptotic cell death in the central nervous system. (edu.au)
Aims: Increasing evidence displays that deposition of aggregated β-amyloid (Aβ) leads to neuronal cell apoptosis, thus aggravates the pathological progression of Alzheimer's disease (AD). (elsevierpure.com)
Neuronal PC12 cells and ventral midbrain dopaminergic neurons were assessed in vitro for survival, transcription factor levels and Trib3 or Parkin expression after exposure to 6-hydroxydopamine or 1-methyl-4-phenylpyridinium with or without adaptaquin co-treatment. (puppyreading.com)
The present results indicate that over-activation of AhR perturbs neuronal migration and morphological development in mammalian cortex, supporting previous observations of impaired dendritic structure, cortical dysgenesis, and behavioral abnormalities following perinatal dioxin exposure. (waseda.jp)
Many investigators once believed that TSE agents infected mainly, if not exclusively, cells of neuronal and lymphoid lineages. (cdc.gov)

PC12, a cell line derived from a pheochromocytoma of the rat adrenal medulla, is used widely as a model for catecholaminergic transmission. (biomedcentral.com)
This thesis examines the effects of nerve growth factor (NGF) and lithium on the regulation of neurotensin/neuromedin N (NT/N) gene expression in PC12 pheochromocytoma cells. (umassmed.edu)

Relating in vitro to in vivo exposures with physiologically based tissue dosimetry and tissue response models. (cdc.gov)
Moreover, the molecular mechanisms underlying neuroinflammation in vivo were further elucidated by treating BV2 and PC12 cells with ZnO NPs in vitro. (biomedcentral.com)
These observations are the first documented intracellular effects noted for the complement molecule C5a in in-vitro cultured cells. (edu.au)
A resonant system for in vitro studies emulating wireless power transfer exposure at 13.56 MHz. (zhadobov.fr)

These cells are popular because they are able to synthesize and release catecholamines in a similar manner as dopaminergic neurons and adrenal medullary chromaffin cells [ 4 ]. (biomedcentral.com)
Oxidative stress-induced cytoskeletal dysfunction of neurons has been implicated as a crucial cause of cell apoptosis or death in the central nervous system (CNS) diseases, such as neurodegenerative and psychiatric diseases. (ijbs.com)
Meanwhile, both MH and Ac-DEVD-CHO had similar eﬀects in protecting cell morphology, reducing LDH release, and inhibiting OGD-induced apoptosis in neurons. (syksignal.com)

p53 is recognized as a critical regulator of the cell cycle and apoptosis. (biomedcentral.com)
We hypothesized that p53 contributed to PC12 differentiation through the regulation of gene targets distinct from its known transcriptional targets for apoptosis or DNA repair. (biomedcentral.com)
The tumor suppressor p53 is recognized as a critical regulator of cell cycle progression and apoptosis, incorporating signals from DNA damage and other cellular stressors to decide cell fate [ 1 ]. (biomedcentral.com)
Main methods: MTT, DCFH-DA assay, LDH release assay, Fluo-3 AM assay, Flow cytometry and Western blot were used to examine cell viability, ROS level, LDH release, intracellular Ca 2+ concentration, cell apoptosis and related proteins level respectively. (elsevierpure.com)
In addition, D3T pretreatment inhibited Aβ 1-42 induced cell apoptosis as well as protein levels of Bax and Caspase-3 in PC12 cells. (elsevierpure.com)
Significance: Taken together, these findings suggest that D3T protects PC12 cells against Aβ 1-42 induced apoptosis through activation of the ERK1/2 pathway. (elsevierpure.com)
1. Sodium fluoride causes apoptosis of pancreatic beta-cells and this response is enhanced by pre-treatment with pertussis toxin. (fluoridealert.org)
LKB1 is present in both the cytoplasm and nucleus of living cells and translocates to mitochondria during apoptosis. (thermofisher.cn)
Early-Life Exposure to Bisphenol A Induces Liver Injury in Rats Involvement of Mitochondria-Mediated Apoptosis. (human-exposome.com)
Prenatal PFOS exposure induces oxidative stress and apoptosis in the lung of rat off-spring. (human-exposome.com)

Similarly, indices of cell loss (reduced DNA), cell size and neuritic outgrowth (protein/DNA and membrane/total protein ratios) were distinct for each region and did not necessarily follow the rank order of nAChR upregulation, suggesting the involvement of additional mechanisms such as oxidative stress. (nature.com)
The data show p53 protein was transcriptionally activated and contributed to NGF-mediated neurite outgrowth during differentiation of PC12 cells. (biomedcentral.com)
In the present study, plasma from rats undergoing intracranial self-stimulation (ICSS) produced neurite outgrowth in PC12-variant cells (PC12m3). (elsevierpure.com)

The Rg1 treatment also abolished H 2 O 2 -induced morphological changes, including cell rounding, membrane blebbing, neurite retraction and nuclei condensation, which were generated by myosin IIA-actin interaction. (ijbs.com)

the chromaffin cells settle near the sympathetic ganglia, the vagus nerve, paraganglia, and carotid arteries. (medscape.com)

Fetal brain regions and peripheral tissues were examined for nAChR subtypes, other neurotransmitter receptors, and indices of cell signaling and cell damage. (nature.com)
Essentially, by providing excessive cholinergic stimulation throughout fetal life, nicotine discoordinates the numerous events in cell replication, differentiation and synaptic development that are necessary to the proper assembly of the mammalian brain. (nature.com)
In the fifth week of fetal development, neuroblastic cells migrate from the thoracic neural crest to form the sympathetic chains and preaortic ganglia. (medscape.com)
The critical effects of acute duration iodomethane exposure are: (1) fetal losses in rabbits, (2) lesions in rat nasal epithelium, and (3) transient neurotoxicity in rats. (cdc.gov)

We have learned that genes in mammalian cells are transcribed into messenger RNAs (mRNAs), which are to be translated into polypeptides (proteins). (intechopen.com)
NGF rapidly, but transiently, induces the expression of several AP-1 genes in PC12 cells, suggesting that the effect of NGF on NT/N gene expression results from increased AP-1 activity. (umassmed.edu)

Therefore, nanoparticles tongue instillation is likely to be uptaken by taste bud cells and transported into CNS via the taste nerve pathway. (biomedcentral.com)
At nanomolar concentrations, A10E could inhibit Abeta oligomers-induced neurotoxicity via the activation of tyrosine kinase receptor B (TrkB)/Akt pathway in SH-SY5Y cells. (inrae.fr)
The pathway identified by lithium does not activate or require protein kinase C. This pathway is also active in neuronally-differentiated PC12 cells suggesting that it could be involved in the regulation of NT/N gcne exprcssion in the intact nervous system. (umassmed.edu)
The results demonstrate that RINm5F beta-cells express a pertussis toxin sensitive pathway that is anti-apoptotic. (fluoridealert.org)
The activity of this pathway is most evident in cells exposed to pro-apoptotic stimuli where the effects of pertussis toxin can be blocked by inhibitors of tyrosine kinase enzymes. (fluoridealert.org)
Stimulated PC12m3 cells also exhibited heightened activity of the p38 MAPK pathway. (elsevierpure.com)
In the PC12 cells and MPTP-induced Parkinson's disease animal models, SDA was highly efficacious in α-synuclein clearance associated with the activation of PGC-1α/Nrf2 signal pathway. (biomedcentral.com)

Effects of the exposure to intermittent 1.8 GHz radio frequency electromagnetic fields on HSP70 expression and MAPK signaling pathways in PC12 cells med. (emf-portal.org)

Studies in developing rodents indicate that nicotine is a neuroteratogen that disrupts brain development by stimulating nicotinic acetylcholine receptors (nAChRs) that control neural cell replication and differentiation. (nature.com)
Gene expression must be appropriately maintained to regulate development, differentiation, and proliferation of cells. (intechopen.com)
We studied the transcriptional role of p53 during nerve growth factor-induced differentiation of the PC12 line into neuron-like cells. (biomedcentral.com)
Thus, exogenous AhR induced catecholaminergic differentiation in N2a-Rα cells. (biomedcentral.com)
The excessive activation of AhR resulted in neural differentiation of Neuro2a cells. (biomedcentral.com)
Activated AhR may disrupt the strictly regulated brain formation with irregular differentiation occurring rather than cell death. (biomedcentral.com)
Dioxin and AHR impairs mesoderm gene expression and cardiac differentiation in human embryonic stem cells. (cas.cn)

The Neural and Behavioral Toxicity Assessment Core provides information concerning the cellular and neurobehavioral consequences of toxicant exposures being studied in the Superfund Center. (nih.gov)
Both linoleic acid and arachidonic acid are able to inhibit MPP + -induced toxicity in PC12 cells. (biomedcentral.com)

This is the first study to examine the protective role of linoleic acid and arachidonic acid and their potential interaction in a Parkinson's disease model simulated by exposing PC12 cells to MPP + neurotoxin. (biomedcentral.com)

2008) has reported the results of multi-plex genotyping as a biomarker of susceptibility to carcinogenic exposures. (who.int)
The objective of this study was to determine the potential susceptibility to infection of 5 cell lines used or proposed for manufacture of biological products, as well as other lines. (cdc.gov)
It has become clear, however, that the susceptibility of cells to infection with TSE agents cannot be reliably predicted either from their tissue of origin or level of expression of PrP C ( 11 , 12 ). (cdc.gov)

Röösli M, Moser M, Baldinini Y, Meier M, Braun-Fahrländer C: Symptoms of ill health ascribed to electromagnetic field exposure - A questionnaire survey. (karger.com)
To investigate the stress responses mediated by Hsp70 and mitogen-activated protein kinases rat PC12 cells exposed to a 1.8 GHz - electromagnetic field . (emf-portal.org)

Given that OKSM (Yamanaka) factors convert somatic cells into induced pluripotent stem (iPS) cells, alterations in transcriptional state could affect destiny of the cells. (intechopen.com)

Mechanism of neurotrophic action of nobiletin in PC12D cells. (rochester.edu)

In this study, we evaluated whether the single-nucleotide polymorphism (SNP) rs198585630 of 5-HT 1A receptor is associated with cognitive alterations in rats after microwave exposure with a frequency of 2.856 GHz and an average power density of 30 mW/cm 2 . (frontiersin.org)
Rats carrying rs198585630 C allele exhibited increased mRNA and protein expression of 5-HT 1A receptor and were more susceptible to 30 mW/cm 2 microwave exposure, showing cognitive deficits and inhibition of brain electrical activity. (frontiersin.org)
An international project to confirm soviet-era results on immunological and teratological effects of RF field exposure in wistar rats and comments on Grigoriev et al. (powerwatch.org.uk)
Results of key Soviet-era studies dealing with effects on the immune system and teratological consequences in rats exposed to radiofrequency (RF) fields serve, in part, as a basis for setting exposure limits in the USSR and the current RF standards in Russia. (powerwatch.org.uk)
3. N Jin YB et al , (December 2010) One-year, simultaneous combined exposure of CDMA and WCDMA radiofrequency electromagnetic fields to rats , Int J Radiat Biol. (powerwatch.org.uk)
Perinatal exposure to 4-nonylphenol affects adipogenesis in first and second generation rats offspring. (human-exposome.com)
Hepatic DNA methylation modifications in early development of rats resulting from perinatal BPA exposure contribute to insulin resistance in adulthood. (human-exposome.com)
Chronic exposure of rats resulted in increased thyroid follicular cell tumors from sustained perturbation of thyroid hormone homeostasis. (cdc.gov)

Nevertheless, it remained controversial if cytoplasmic phosphorylation of Akt is dispensable for its nuclear access: Nguyen and colleagues showed that Akt1TA and Akt1SA failed to translocate for the nucleus in PC12 cells [36], whereas the double phosphorylationdeficient mutant AktTASA was located inside the nuclear compartment utilizing reside imaging in hepatocellular carcinoma cells (HCC) [37]. (amparinhibitor.com)

3. The increase in cell death induced by 100 microM genistein was markedly inhibited by ciprofloxacin, a drug which binds to topoisomerase II. (fluoridealert.org)
4. Pertussis toxin markedly enhanced the extent of RINm5F cell death induced by NaF and this effect was completely prevented by 25 microM genistein. (fluoridealert.org)

NIEHS research uses state-of-the-art science and technology to investigate the interplay between environmental exposures, human biology, genetics, and common diseases to help prevent disease and improve human health. (nih.gov)

2006) reported increased rates of brain tumors (gliomas and menigomas) in relation to genetic polymorphisms in the ALAD gene and lead exposure suggesting a need to take genetic inheritance of ALAD polymorphisms into account with respect to lead exposures and development of these types of cancer. (who.int)
The biosynthesis and storage of catecholamines in chromaffin cell tumors may differ from the biosynthesis and storage in the normal medulla. (medscape.com)
This theory holds that tumors arise from 1 of 2 undifferentiated stem cells: the excretory duct reserve cell or the intercalated duct reserve cell. (medscape.com)

the authors reported the effects on the gene expression of Hsp70 in human trophoblast cells . (emf-portal.org)
In PC12 cells, the expression of the rat NT/N gene is strictly dependent on simultaneous exposure to combinations of NGF, glucocorticoids, activators of adenylate cyclase, and lithium. (umassmed.edu)

Dioxins and related compounds are suspected of causing neurological disruption in human and experimental animal offspring following perinatal exposure during development and growth. (biomedcentral.com)
Perinatal exposure to bisphenol A exacerbates nonalcoholic steatohepatitis-like phenotype in male rat offspring fed on a high-fat diet. (human-exposome.com)
Mitochondrial dysfunction in early life resulted from perinatal bisphenol A exposure contributes to hepatic steatosis in rat offspring. (human-exposome.com)

The transcriptional activity of 5-HT 1A receptor promoter was stimulated by 30 mW/cm 2 microwave exposure, and rs198585630 C allele was more sensitive to microwave exposure, as it showed stronger transcriptional activation. (frontiersin.org)

Anna Sannino, Olga Zeni, Stefania Romeo , Rita Massa, Maria Rosaria Scarfì, Adverse and beneficial effects in chinese hamster lung fibroblast cells following radiofrequency exposure, Bioelectromagnetics 38(4): 245-254, 2017. (cnr.it)

Chronic microwave exposure can induce cognitive deficits, and 5-HT system is involved in this effect. (frontiersin.org)
Chronic exposure of adult male rodents to cocaine increases levels of Kalirin 7 in the striatum. (biomedcentral.com)
Usage of the 3'-terminal exon unique to Kalirin 7 increases following chronic cocaine exposure. (biomedcentral.com)
To test whether chronic hypoxia was a stimulus for increased CBS expression, U87-MG human glioblastoma and PC12 rat phaeochromocytoma cells were exposed to 1% or 20%O 2 for 24-72 h. (elsevierpure.com)

Comparison of NT/N mRNA, pro NT/N synthetic rates, proNT/N proteins and mature NT levels in induced PC12 cells, demonstrated that NGF and lithium had no effect on the translation of NT/N mRNA and had only a modest effect on post-translational processing. (umassmed.edu)
Here, we now demonstrate that the overexpressed eGFPAkt1 mutant proteins could localize to the nuclear compartment of TrC1 prostate cancer cells under basal circumstances independently of their ability to undergo phosphorylation. (amparinhibitor.com)

Cell viability was then assessed by using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. (biomedcentral.com)
Cells treated with 500 μM MPP + for a day reduced cell viability to ~70% as compared to control group. (biomedcentral.com)

Using PC12 cells, we demonstrated that exposure to C5a led to inhibition of mitochondrial respiration, dehydrogenase and cytochrome c oxidase activities. (edu.au)
2. Exposure of RINm5F cells to low concentrations of genistein or tyrphostin A25 resulted in significant inhibition of cell death induced by 5 mM NaF. (fluoridealert.org)

To study the effects of pharmaceutical compounds on the ratio of Tubulin to Microtubules in cells. (cytoskeleton.com)
To study the effects of mutated cell lines versus their parent cell line for the change in ratio of Tubulin to Microtubules. (cytoskeleton.com)
Low-participation rate may create selection bias, and not blinding as to case or control status may give observational bias, especially in a study with such vague definition of cut-off for exposure as Interphone.Especially worrying as to observational bias are bed-side interviews of such a mentally ill patient group with brain tumour. (powerwatch.org.uk)
In the current study, the potential of two omega-6 fatty acids (i.e. arachidonic acid and linoleic acid) in alleviating 1-methyl-4-phenylpyridinium (MPP + )-induced cytotoxicity in PC12 cells was examined. (biomedcentral.com)
In the present study, tyrosine kinase inhibitors were used to investigate the mechanisms of action of NaF and pertussis toxin in the beta-cell line, RINm5F. (fluoridealert.org)
A Case-Control Study of Prenatal Thallium Exposure and Low Birth Weight in China. (human-exposome.com)
Pronounced phosphorylation and hence, the activation of Akt, was necessary for improving DSB repair and longterm survival upon exposure to IR in our earlier study and this was associated using the enhanced nuclear localization in the activationassociated and resistancepromoting Akt1mutants [7]. (amparinhibitor.com)
This study is limited due to lack of direct data on exposure, but adds to the positive evidence for brain cancer. (who.int)
Again this study is limited due to lack of direct data on exposure, but the lack of association weakens the IARC 2006 conclusion. (who.int)
This study is limited as blood lead was present at background environmental levels and reflected exposure in recent past (3 months). (who.int)
No PrP TSE or infectivity has been detected in any exposed cell line under study so far. (cdc.gov)
Sannino A, Romeo S , Scarfì MR, Massa R, d'Angelo R, Petrillo A, Cerciello V, Fusco R and Zeni O (2017) Exposure Assessment an d Biomonitoring of Workers in Magnetic Resonance Environment: An Exploratory Study. (cnr.it)

Discovery of non-genotoxic mechanisms through which p53 protein may be activated within tumor cells harboring wild-type p53 remains an important therapeutic objective, both in effort to alleviate traditional off-target chemotherapeutic side-effects and to prevent the unpredictable mutagenicity characteristic of these therapies. (biomedcentral.com)
The effect of 20 g/100 g diet of lactalbumin (L), casein (C), soy (S) and wheat (W) protein on the immune responsiveness of C3H/HeN mice has been investigated by measuring the humoral immune response to the T cell-independent antigen, TNP-Ficoll. (immunehealthscience.com)
CBS mRNA and protein expression were increased in hypoxic cells. (elsevierpure.com)

Exposure assessment in millimeter-wave reverberation chamber using murine phantoms. (zhadobov.fr)
The undifferentiated murine neuroblastoma Neuro2a cell line (ATCC) was stably transfected with AhR cDNA and the established cell line was named N2a-Rα. (biomedcentral.com)
Studies showing that murine fibroblast cell lines are susceptible to infection with mouse-adapted scrapie agent ( 11 , 12 ) increased concern that nonneuronal cell substrates used to propagate viruses for vaccine production might become infected with a TSE agent contaminating some component of culture medium, especially bovine serum ( 13 ). (cdc.gov)

Experimental studies show that exposure to microwave may lead to headache, sleep disorder, changes in EEG and cognitive function ( 1 - 3 ). (frontiersin.org)
In the present work, the same experimental conditions were applied but PC12 cells were used. (emf-portal.org)
After exposure to experimental animals, TCDD was detected in the brain and impaired their learning behavior. (biomedcentral.com)

Despite great progress in nanotechnology, the effects of ZnO NPs exposure on the human body, in general and specifically on the brain, are not well understood. (biomedcentral.com)
Human exposure may occur via inhalation due to the high vapor pressure of iodomethane. (cdc.gov)
A quantitative human health risk assessment was conducted for inhalation exposure. (cdc.gov)
A physiologically based pharmacokinetic (PBPK) model for iodomethane was developed to characterize poten- tial human health effects from iodomethane exposure. (cdc.gov)
Iodomethane is a new agricultural of approximately 24 hours due to the emission patterns of active ingredient, and there are no human exposure incident the compound and air dispersion patterns ( EPA OPP Health reports related to agricultural uses. (cdc.gov)

In brief, CA-AhR-expressing plasmid and AhR-expressing plasmid were each transfected into neural stems cells in the developing cerebrum by in utero electroporation on embryonic day 14.5. (waseda.jp)

Threshold limit values for chemical substances and physical agents and biological exposure indices. (cdc.gov)

The neurobehavioral screen provides detailed assessment of cognitive, emotional and appetitive functions affected by developmental toxicant exposures in test batteries that the researchers have designed for the diverse models studied within the Center. (nih.gov)
These results support that M2 cells could give shortly (in a T-cell-independent man- ner) to cognitive function, and capability be developed in the approaching as an exceptionally applicable restorative approach an eye to cognitive conditions associated with T-cell malfunction. (wgc2010.sk)

The activation of exogenous AhR in N2a-Rα cells was confirmed using RNAi, with si-AhR suppressing the expression of exogenous AhR. (biomedcentral.com)
N2a-Rα cells exhibited constant activation of the exogenous AhR. (biomedcentral.com)

Experiments in this thesis were designed to examine the regulatory mechanisms responsible for increased NT production in PC12 cells when treated with different inducer combinations and whether AP-1 factors could act as mediators in responses to NGF and lithium. (umassmed.edu)

Lysosomal and Mitochondrial benefit in pain reduction and return of function have a suboptimal response to the vaccine and should therefore continue to avoid exposure unless they are advised otherwise by their. (hewedi.com)
In addition, the efficacy of EGb761 in the Abeta-induced 3-(4,5 dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) reduction in PC12 cells was examined. (molvis.org)

The most reproducible and accurate method of determining the amount of microtubule content versus free-tubulin content in a cell population is to use western blot quantitation of microtubule and free-tubulin cellular fractions. (cytoskeleton.com)

Stem cell transplantations were conducted 4 weeks after injection of 6-OHDA and mice were exposed afterwards. (emf-portal.org)
The effect of graded amounts of dietary lactalbumin (L) and casein (C) hydrolyzates on the immune responsiveness of C3H/HeN and DBA/2 strain mice has been investigated by measuring both the specific humoral immune response to sheep red blood cells (SRBC) and the nonspecific splenic cell responsiveness to phytohemagglutinin, concanavalin A and Escherichia coli lipopolysaccharide after stimulation with Mycobacteriurn bovis, strain BCG. (immunehealthscience.com)

Within this context, it might be crucial that Akt1SA expressing cells had been nevertheless able to undergo phosphorylation at T308 whereas TrC1 overexpressing Akt1TA failed to undergo phosphorylation at S473. (amparinhibitor.com)

Cell lines were exposed to the infectious agents of sporadic and variant Creutzfeldt-Jakob disease and bovine spongiform encephalopathy (BSE). (cdc.gov)

Again, the overexpression on the phosphorylationdeficient Akt1TASA mutant and pretreatment of Akt1WT overexpressing cells using the Aktinhibitor MK2206 had similar inhibitory effects on DSB repair, whereas the effects of the single Acetamide site phosphorylation mutant Akt1SA have been less pronounced. (amparinhibitor.com)

Electromagnetic hypersensitivity (EHS) is a poorly understood condition in which patients report symptoms following perceived exposure to weak electromagnetic fields (EMFs) such as those produced by mobile phones or visual display units. (karger.com)

Hartwig V., Romeo S. , Zeni O., Occupational exposure to electromagnetic fields in magnetic resonance environment: basic aspects and review of exposure assessment approaches. (cnr.it)
Occupational exposure to an intermediate in the manufacture of some pharmaceu- iodomethane may occur 8 hours per day, 5 days per week, ticals, in methylation processes, and in the field of micro- during the application season. (cdc.gov)

Excretory stem cells give rise to squamous cell and mucoepidermoid carcinomas, while intercalated stem cells give rise to pleomorphic adenomas, oncocytomas, adenoid cystic carcinomas, adenocarcinomas, and acinic cell carcinomas. (medscape.com)

On the other hand, the overexpression of Akt1SA or Akt1TASA also as the pretreatment of Akt1WT expressing TrC1 with the allosteric Aktinhibitor MK2206 all reduced the kinetics of DSB repair and improved the sensitivity of TrC1 to IR when in comparison with cells overexpressing Akt1WT. (amparinhibitor.com)

Effects of tyrosine kinase inhibitors on cell death induced by sodium fluoride and pertussis toxin in the pancreatic beta-cell line, RINm5F. (fluoridealert.org)
Morphologically, N2a-Rα cells bore spontaneous neurites exhibiting axon-like properties with the localization of NF-H. In addition, cdc42 expression was increased in comparison to the control cell line. (biomedcentral.com)

2007) conducted nested-case control studies for 11 types of cancers and estimated lead exposure, with exposure estimated based on work history and expert assessment (Montreal/Siemiatycki data base). (who.int)
Nasal olfactory degeneration is the primary endpoint for risk assessment of acute exposure to iodomethane. (cdc.gov)

Repeated exposure to certain external stimuli accompanied by aberrant motivation may produce psychiatric diseases such as bipolar disorder and addiction via dysregulation of the central nervous system. (elsevierpure.com)

Similarly, Vitamin C supplementation had mixed effects, increasing nAChR responses while providing protection from cell damage in the caudate, the brain region most susceptible to oxidative stress. (nature.com)
2006. The effects of diazinon on lipid peroxidation and antioxidant enzymes in rat heart and ameliorating role of vitamin E and vitamin C. Cell Biol Toxicol 22(6):455-461. (cdc.gov)
Data on the effects of exposure to organic lead was sparse and no conclusions could be drawn. (who.int)

A genistein-sensitive tyrosine kinase does not appear to be involved in RINm5F cell survival under basal conditions. (fluoridealert.org)

We reported that Nrf2 expression was activated by deltamethrin (DM), a prototype of the widely used pyrithroid pesticides, in PC12 cells. (cdc.gov)

N2a-Rα cells expressed tyrosine hydroxylase (TH) mRNA as a functional marker of catecholaminergic neurotransmitter production. (biomedcentral.com)

Molecular mechanisms of the initiation of transcription from TATA box have been well known as the most essential nuclear events in mammalian cells. (intechopen.com)
Nuclear run-on assays showed that NT/N transcription is transicntly activated in maximally induced cells. (umassmed.edu)
Lastly, the exposure to IR induced a comparable slight raise in nuclear Akt1eGFP in all tested Akt1mutants. (amparinhibitor.com)

Exposure levels induced in curved body parts at mmWaves. (zhadobov.fr)

Etoposide (which inhibits topoisomerase II but has no effect on tyrosine kinase activity) also caused an increase in RINm5F cell death. (fluoridealert.org)
Our results demonstrated that SDA had neuroprotective effect in dopaminergic PC12 cells with 6-OHDA lesion. (biomedcentral.com)

PC12 cells were purchased from the American Type Culture Collection (ATCC, CRL-1721.1). (biomedcentral.com)

Anatomy2

Diseases3

Chemicals and Drugs8

Reactive oxygen2

Neuronal12

Pheochromocytoma2

Vitro4

Neurons3

Apoptosis10

Outgrowth3

Neurite1

Chromaffin cells1

Fetal4

Genes2

Pathway7

MAPK1

Differentiation7

Toxicity2

Parkinson's1

Susceptibility3

Electromagnetic field2

Induced plur1

Mechanism1

Rats8

Nucleus1

Markedly2

Genetics1

Tumors3

Gene2

Perinatal3

Transcriptional1

Radiofrequency1

Chronic4

Proteins2

Viability2

Inhibition2

Study12

Protein3

Murine3

Experimental3

Human5

Neural1

Indices1

Cognitive2

Activation2

Examine1

Reduction2

Cellular1

Mice2

Context1

Sporadic1

Phosphorylation1

EMFs1

Occupational2

Stem cells1

Pretreatment1

Line2

Assessment2

Stimuli1

Effects3

Basal1

Widely1

Catecholaminergic1

Nuclear3

Levels1

Effect2

ATCC1