In the event the gametes are set while in the lattice from the arrangement, that will be exhibited from the structure, the grille you may start to see the sequence from the arrangement of genotypes: one particular grille are homozygotes, whereas heterozygotes for just two enzymes. (smokeoilsalt.com)
Inbreeding results in an excess of homozygotes and hence a deficiency of heterozygotes. (lacteoscienelac.com)
The chromosomal translocation generates a translocation-bearing altered insect population, the translocation-bearing altered insect population comprises translocation-bearing individuals that are translocation heterozygotes and translocation-bearing individuals that are translocation homozygotes for the chromosomal translocation, and the translocation-bearing individuals display a fitness that is greater than that of the wildtype (non-translocation-bearing) individuals when challenged in a condition in which a translocation-based drive occurs. (justia.com)
Frequencies2
This heterozygote advantage presumably explains the presence of the allele at frequencies above those to be expected from the simple replacement of a homozygously-lethal allele by mutation alone. (bmj.com)
However, Zei's analysis did not comprehensively confirm Haldane's theory, because in each homogeneous area of malaria incidence the villages for which genetic data were also available showed high heterogeneity with respect to heterozygote frequencies for thalassemia and G6PD deficiency. (indexarticles.com)
Fertility5
This near-optimal birthweight together with the possibly higher effective fertility observed in PKU heterozygous couples (at least in those who married before 1940), has apparently more than outweighed the disadvantages of the allele in PKU homozygous offspring as shown, for example, in an excessive number of pre- and perinatal deaths among the total offspring of PKU heterozygotes, to say nothing of the PKU survivors who, often, used to die young. (bmj.com)
The two effects--fertility and viability--apparently both contribute in the same direction, to give a biological fitness in excess of 1 for the heterozygote. (bmj.com)
On the other hand, pericentric inversions often lead to decreased fertility in females [ 6 , 7 ], which may also explain the preponderance of polymorphic paracentric over pericentric inversions in species like Drosophila spp. (biomedcentral.com)
Therefore we studied the relation between heterozygote frequency and fertility rates, disregarding the characterization for incidence of malaria. (indexarticles.com)
The aims of this study are to test the hypothesis that differential fertility is a selection-induced mechanism that maintains balanced polymorphisms and to investigate the reasons for and the effects on reproduction of the incomplete correspondence of heterozygote frequency and malarial morbidity levels on Sardinia. (indexarticles.com)
Receptor2
The different cells have been inhabited by hetero system (heterozygotes for a single receptor). (smokeoilsalt.com)
gem homozygous receptor mutant HCs display normal cell viability, afferent synaptogenesis, and peripheral innervation, yet exhibit strongly reduced extracellular potentials (∼50% of wild-type potentials). (jneurosci.org)
Advantage3
Heterozygote advantage for the phenylketonuria allele. (bmj.com)
We test for a heterozygote advantage on other fitness components but find no evidence for heterosis for any of the inversions. (biomedcentral.com)
Haldane's (1949) theory of a selective advantage of heterozygotes in the presence of malaria has been largely tested and confirmed, principally for the sickle cell gene and glucose-6-phosphate dehydrogenase (G6PD) deficiency, in areas where malaria is still endemic (Africa, tropical zones). (indexarticles.com)
Largely1
A high concern in conservation, which is influenced by such functional genetic variation, is the species capacity to immunologically respond to pathogens, because it may largely determine their survival and long term viability [ 8 , 9 ]. (biomedcentral.com)
Biological2
5 , 6 While these associations may in part be explained by sharing the same childhood environment, a number of studies have described a closer relation between the weights of adoptees and their biological parents rather than their adoptive parents. (bmj.com)
Biological invasions are impacting biota worldwide, and explaining why some taxa tend to become invasive is of major scientific interest. (cyberleninka.org)
Effect2
While complete loss of catalase activity confers a severe viability effect, residual levels are sufficient to restore viability to wild type levels. (lookformedical.com)
These results suggest a threshold effect for viability and offer an explanation for the general lack of phenotypic effects associated with the known mammalian acatalasemics. (lookformedical.com)
Fitness1
However, the first demonstration of the higher fitness (in terms of number of children) of heterozygotes comes from a study on thalassemia in Italy, when Haldane's hypothesis had only just been formulated. (indexarticles.com)
Population1
Reproductive compensation was originally a theory to explain why recessive genetic disorders may persist in a population. (wikipedia.org)
High1
1975), have concentrated on revealing a high frequency of heterozygotes for thalassemia and G6PD deficiency in areas of past malaria morbidity. (indexarticles.com)
Evolution1
The addition of molecular genetics has led to evolutionary developmental biology , which explains evolution at the molecular level. (handwiki.org)
Recessive2
Reproductive compensation was originally a theory to explain why recessive genetic disorders may persist in a population. (wikipedia.org)
The nonviable XX, YY and ZZ possibilities would mean 1 in 4 conceptions would end in miscarriage as is the case with humans when the 2 parents are heterozygotes for a recessive gene which is lethal as the homozygote. (stackexchange.com)
Differing lethal1
Whereas heterozygote advantage can explain the persistence of high carrier rates of lethal alleles in certain regions (e.g. sickle-cell disease in Central and West Africa), Johan Koeslag and Stephen Schach have suggested that reproductive compensation might explain why different communities have high carrier rates for differing lethal alleles, despite living in similar or sometimes the same environment. (wikipedia.org)
Alleles1
The rapidity of resistance to monotherapy (in 1C2 weeks) was explained by the deterministic selection of alleles that preexist therapy in minute quantities [1]. (irjs.info)
Normal2
This has ductive modes are not only important for understand- modified the normal meiotic cycle in hybrids so that ing the evolution of parthenogenesis and explaining chromosome segregation and recombination is absent the paradox of sex (Otto & Lenormand, 2002), they or limited during gametogenesis. (eddoctor24h.com)
To enrich for the recovery of insertions required for normal motor neuron function we performed initial viability screens in backgrounds in which the function of the dynactin complex is usually impaired in motor neurons. (morainetownshipdems.org)