Experimentally databases protein. Medical search. Frequent questions

The database contains a gold standard core dataset of 213 manually curated, experimentally verified translocating human proteins + 1133 human proteins predicted to be translocated by high probability based on their GO and compartmentalized interactome properties. (linkgroup.hu)
Here, an overview of the publicly available knowledge about IDRs is reported, including manually curated resources, deposition databases and prediction repositories. (iucr.org)
The ELM relational database stores different types of data about experimentally validated SLiMs that are manually curated from the literature. (eu.org)
The experimentally validated phosphorylation sites as well as their catalytic kinases were extracted from public resources, and MS/MS phosphopeptides were manually curated from research articles. (nih.gov)

Protein-protein interactions (PPIs) play essential roles in many biological processes. (nature.com)
Identification of protein-protein interactions (PPIs) is important for understanding how proteins work together in a coordinated fashion in a cell to perform cellular functions. (nature.com)
Even for Arabidopsis , known PPI data cover interactions with only about 34.55% of proteins. (nature.com)
a map is constructed that shows interactions among molecular entities (such as genes, proteins and RNAs), using information from literature and databases. (hindawi.com)
The network combining putative targets of TF and miRNA regulation with experimentally proven molecular interactions was constructed and visualized. (hindawi.com)
However, besides physical or co-expression interactions there are many ways in which pairs of genes, or their protein products, can be associated. (biomedcentral.com)
These lists are commonly analyzed using software tools and databases that map genes to known pathways or construct subnetworks that connect input lists of genes using known protein-protein or other types of molecular interactions [ 1 - 10 ]. (biomedcentral.com)
posttranslational modifications, amino acid variations, computational mutation analysis, protein PTM predictor, network biology Introduction Protein PTMs are biochemical alterations of amino acids that change the physicochemical properties of target proteins, leading to structural changes and therefore regulating protein-protein interactions and cellular signal transduction in developmental and cancer pathways [1]. (deepdyve.com)
Predicting effects of mutations on the affinity of protein-protein interactions. (edu.au)
Optimised predictions of the effects of mutations on the affinity of protein-protein interactions. (edu.au)
I want to have a network of the interactions between the proteins of these 100 genes. (stackexchange.com)
I have used STRING pretty heavily, and have compared it to various other databases of protein interactions and signaling pathways. (stackexchange.com)
There are many different interaction detection methods ranging from those that only identify direct, binary interactions between two proteins (e.g. (stackexchange.com)
InnateDB , is an open-source, publicly-available database and systems biology analysis platform of all the genes, proteins, experimentally validated molecular interactions, and pathways in the human, mouse and bovine innate immune responses. (ubc.ca)
It enables unbiased examination of large transcriptome datasets as networks based on known protein-protein interactions. (ubc.ca)
RegPhos 2.0 aims to provide a more comprehensive view of intracellular signaling networks by integrating the information of metabolic pathways and protein-protein interactions. (nih.gov)
1. Algorithm development for the prediction of protein structure, function and interactions from amino acid sequence as well as construction of relevant databases. (uoa.gr)
gpDB: a database of GPCRs, G-proteins, effectors and their interactions. (uoa.gr)
Unique features of the structural model of hard cuticle proteins: implications for chitin-protein interactions and cross-linking in cuticle. (uoa.gr)
A database of human GPCRs, G-proteins, Effectors and their interactions. (uoa.gr)

Our method considers a variety of features including protein sequences, gene co-expression, functional association, and phylogenetic profiles. (nature.com)
Since biochemistry and genetics have not, by and large, enjoyed the same improvement of scale, public sequence repositories now predominantly contain putative protein sequences for which there is no direct experimental evidence of function. (plos.org)
The ELM prediction tool scans user-submitted protein sequences for matches to the regular expressions defined in ELM. (eu.org)
Jagat Singh Chhauhan, Adil H. Bhat, Alka Rao and Gajendra pal Singh Raghava : GlycoPP: A Webserver for Prediction of N- O-Glycosites in Prokaryotic Protein Sequences. (imtech.res.in)
Quantification of the extent of localised purifying selection in protein-coding sequences. (edu.au)
For protein structures of UniProt sequences please refer to SWISS-MODEL Repository (updated weekly for select core species), ModBase , RCSB PDB Protein Feature View or 3D Beacons Network . (proteinmodelportal.org)
Still, the number of known protein sequences is much larger than the number of experimentally solved protein structures. (proteinmodelportal.org)
The matching is com- plicated by the fact that there are protein modifications and the sequence databases store the unmodified sequences. (lu.se)

The Protein Databank (PDB) is an archive of experimentally determined three-dimensional structures of biological macromolecules, serving a global community of researchers, educators, and students. (okino.com)
To cause sensitization, a chemical must bind to macromolecules (proteins) in the skin. (cdc.gov)

In the paper we summarize the molecular mechanisms of cellular learning, including conformational memory of intrinsically disordered proteins and prions, signaling cascades, protein translocation, RNAs (microRNA and lncRNA), and chromatin memory. (linkgroup.hu)

The overall structures confirm the close relatedness to experimentally validated homoserine acetyl transferases, but simultaneously the structures exclude the ability of MekB and CgHle to bind homoserine and acetyl-CoA. (rcsb.org)
Be it an animal or plant species or more detailed information like genomes, microbes or DNA structures, we can help you with our specialized database creation services. (outsource2india.com)
The database is constantly updated as new structures are deposited by the international scientific community. (okino.com)
Knowledge-based methods, such as statstical potentials, for analyzing protein structures primarily consider the distances between pairs of bodies (atoms or groups of atoms). (purdue.edu)
This new technique is capable of producing convergent and consistent results when applied to a sufficiently large database of randomly chosen and experimentally solved protein structures. (purdue.edu)
These numbers may or may not suggest that there are 1200-2600 folds in the universe of protein structures. (rostlab.org)
Employing a set of experimentally solved native complexes, high probability values above 50% were obtained for 90% of these structures. (uni-regensburg.de)
ClueGO, a Cytoscape plug-in, is also used to compare groups of proteins and to visualize the functionally organized Gene Ontology (GO) terms and pathways in the form of dynamical network structures. (biomedcentral.com)
and (2) protein structures with bound ligands, from the BioLip database. (lbl.gov)
The goal of the Models Module was to develop a portal that gave access to the various models that can be leveraged from PSI targets and other experimental protein structures. (proteinmodelportal.org)
The Protein Structure Initiative has been successful in determining the structures of many unique proteins in a high throughput manner. (proteinmodelportal.org)
Homology (or comparative) modeling methods make use of experimental protein structures to build models for evolutionary related proteins. (proteinmodelportal.org)
Protein structures at protein data bank (PDB). (lu.se)

We could not find a correlation between the content of membrane proteins and the complexity of the organism. (rostlab.org)
In particular, we did not find significantly higher percentages of helical membrane proteins in eukaryotes than in prokaryotes or archae. (rostlab.org)
Quantitative targeted absolute proteomic analysis of 31 membrane proteins showed that P-glycoprotein (P-gp/mdr1a) protein expression levels were significantly increased in brain capillaries of PTZ (129%), EL (143%), and PHT mice (192%) compared with controls. (aspetjournals.org)
Predicting the effects of mutations on membrane proteins. (edu.au)
DUF533 family inner membrane protein. (string-db.org)
OMPdb: A database of ß-barrel outer membrane proteins from Gram negative bacteria. (uoa.gr)
Evaluation of methods for predicting the topology of β-barrel outer membrane proteins and a consensus prediction method. (uoa.gr)
Prediction of Membrane lipid-Binding Proteins. (uoa.gr)
A database of Molecular Recognition Features in Membrane Proteins. (uoa.gr)
A study by White et al (2009) found that psychosine's cytotoxic effects on oligodendroglia and Schwann cells was mediated through disruption of the architecture and composition of lipid rafts (cell membrane regions characterized by high cholesterol and sphingolipid concentration), followed by altered protein kinase C (PKC) function. (medscape.com)

A PPI network provides crucial information on how biological pathways are structured and coordinated from individual protein functions. (nature.com)
PPIs are essential for individual protein functions, forming various cellular pathways, and are also involved in the development of diseases. (nature.com)
A database system for the analysis of biochemical pathways. (dagstuhl.de)
Using functional annotation, we found that proteins belonging to pathways associated with regulation of the actin cytoskeleton, EGF/EGFR, TGF-β, MAPK signaling, integrin-mediated cell adhesion, and lipid metabolism were significantly enriched in the OA samples (p ≤10 −5 ). (biomedcentral.com)
We identified several pathways and proteins to be associated with OA chondrocytes. (biomedcentral.com)
The success of proteomics experiments, such as studies of protein function and cell signaling pathways, ultimately de- pends on how well the protein content in samples is identified and annotated. (lu.se)

This set of known sequence-function relationships will ultimately serve as the basis for making predictions for similar proteins whose functions have not been experimentally determined and can be used to train other types of prediction-generating algorithms. (plos.org)
Zhang Z, Henzel WJ: Signal peptide prediction based on analysis of experimentally verified cleavage sites. (hmdb.ca)
Proteomic analysis and prediction of amino acid variations that influence protein. (deepdyve.com)
To increase the utilization of current computational resources, we 﫿rst provide an overview of computational prediction of amino acid variations that influence protein PTMs and their functional analysis. (deepdyve.com)
Bharat Panwar and Gajendra Pal Singh Raghava : Prediction and Classification of Nucleic Acid Interacting Residues in a Protein using Composition Profile of Patterns. (imtech.res.in)
Quantitative prediction of the effects of missense mutations on protein dynamics and stability. (edu.au)
Derived by automated computational analysis using gene prediction method: Protein Homology. (string-db.org)
HMMpTM: Improving transmembrane protein topology prediction using phosphorylation and glycosylation site prediction. (uoa.gr)
Protein aggregation and amyloid fibril formation prediction software from primary sequence: towards controlling the formation of bacterial inclusion bodies. (uoa.gr)
Prediction of the coupling specificity of GPCRs to four families of G-proteins using hidden Markov models and artificial neural networks. (uoa.gr)
A method for the prediction of GPCRs coupling specificity to G-proteins using refined profile Hidden Markov Models. (uoa.gr)
Topology prediction of alpha-helical transmembrane proteins that incorporates phosphorylation and glycosylation sites prediction. (uoa.gr)

We predicted that approximately 15%-30% of all proteins contained transmembrane helices. (rostlab.org)
However, we found more proteins with seven transmembrane helices in eukaryotes and more with six and 12 transmembrane helices in prokaryotes. (rostlab.org)
ExTopoDB: A database of experimentally derived topological models of transmembrane proteins. (uoa.gr)
heuristic pairwise alignment for transmembrane proteins. (uoa.gr)

Formins are multidomain proteins defined by a conserved FH2 (formin homology 2) domain with actin nucleation activity preceded by a proline-rich FH1 (formin homology 1) domain. (biomedcentral.com)
Experimental structural biology and homology modeling thereby complement each other in the exploration of the protein structure space. (proteinmodelportal.org)

The recommendation system is a proof of concept based on active learning principles and includes, for a given protein, criteria including phylogenetic distribution of its protein family, biological and clinical phenotypes associated with it, the availability of protein structure data, and its sequence distance from experimentally determined proteins or from the other proteins in its family. (plos.org)
Distinction is made between matches that correspond to experimentally validated motif instances already curated in the ELM database and matches that correspond to putative motifs based on the sequence. (eu.org)
A functional site contains one to many ELM classes, which are described by a regular expression and list experimentally validated motif instances matching this sequence pattern. (eu.org)
NoV strains are currently classified according to alignment of the amino acid sequence for the major capsid protein. (cdc.gov)
These approaches depend on sequence databases that are used by the engines to match real spectra to theoretical in silico spectra. (lu.se)
PTMs from this list in conjunction with a protein sequence and a few precursor masses. (lu.se)

e.g. heavily modified proteins, very few lysine and arginine residues in a particular protein. (epfl.ch)
Consequently, amino acid variations through changing the type of residues of the target sites or key flanking residues could directly or indirectly influence PTM of protein and bring about a detrimental effect on protein function. (deepdyve.com)

The values of parameters in this model can be determind from literature, databases or they are directly estimated from quantitative experimental data using optimization methods. (hindawi.com)
Combining spatial and abundance information yielded an unprecedented quantitative view of HeLa cell anatomy and organellar composition, at the protein level. (elifesciences.org)
In this study we compared the quantitative changes in proteins synthesized in osteoarthritic compared to normal chondrocytes. (biomedcentral.com)

Structural database of experimentally measured effects of missense mutations on protein-ligand complexes. (edu.au)
Judgments are based on distributions of properties derived from a large database of native and false complexes. (uni-regensburg.de)

The peptides that exhibited the highest affinity for α 3 β 2 -nAChR were used as models for a small-molecule structure similarity search of the PubChem Compound database. (biomedcentral.com)
Abid Qureshi, Nishant Thakur and Manoj Kumar : HIPdb: A database of experimentally validated HIV inhibiting peptides. (imtech.res.in)
The orientation of the 15N chemical shielding tensor as well as its anisotropy and asymmetry are also in the range of values experimentally observed for peptides and proteins. (edu.au)

7] analyzed amino acid variations of 15 different PTMs and indicated that about 4.5% of amino acid variations may affect protein function through disruption of PTMs, and the mutation of 238 PTMs sites in human proteins was causative of disease. (deepdyve.com)
In this regard, comprehensive studies of the impact of amino acid variation on protein PTMs will be helpful for further understanding of how genetic polymorphisms are involved in regulating biological and pathological processes and providing instructive information for drug development of various related diseases. (deepdyve.com)
However, it often requires extensive laboratory work and considerable expense to make thousands of variant proteins and select amino acid variations that influence PTM sites. (deepdyve.com)
We confirmed that eukaryotes have relatively more long proteins than prokaryotes and archaes, and that the overall amino acid composition is similar among the three. (rostlab.org)

Collectively, our results suggest 11 FDA-approved protein kinase inhibitors as candidate drugs for the repurposing against COVID-19 in the elderly, among which three drugs have been tested or are currently being tested in clinical trials around the world," she concluded. (theregister.com)
The in silico study suggested that among all the molecular targets identified by our target fishing approach, Protein Kinase 3 (PK5) and Glycogen Synthase Kinase 3β (GSK-3β) are the most likely molecular targets for the synthesised compounds. (scielo.br)
Identification of protein kinase activating mutations. (edu.au)

The amyloid interactome: Exploring protein aggregation. (uoa.gr)
The interactome is significantly enriched with genes differentially expressed in MPM tumors compared with normal pleura and with other thoracic tumors, genes whose high expression has been correlated with un-favorable prognosis in lung cancer, genes differentially expressed on crocidolite exposure, and ex-osomederived proteins identified from malignant mesothelioma cell lines. (cdc.gov)

Studies that utilize genome-wide profiling methods which attempt to explain the differences between two or more experimental conditions such as cells treated with a drug vs. control, diseased tissue vs. normal, gene or protein expression at different time points during cellular differentiation or reprogramming, or candidate gene lists harboring mutations associated with a particular disease, produce lists of genes/proteins without apparent functional relationship. (biomedcentral.com)
As resistance against drugs targeting viral proteins emerges rapidly, we assessed the antiviral activity of already approved drugs that target cellular proteins involved in the viral life cycle and were orally bioavailable. (frontiersin.org)
A classification by cellular function verified that eukaryotes have a higher proportion of proteins for communication with the environment. (rostlab.org)
When administrated to some mammalian cells at the concentration of 1 µM, carnosic acid protects the cellular components ( i.e. lipids, proteins, DNA, RNA) against chemical stressors such as hydrogen peroxide (H 2 O 2 ), paraquat (an agrochemical), 6-hydroxydopamine (which is used to induce Parkinson's like disease experimentally), among other toxicants. (databasefootball.com)

Sequencing at that time directly resulted from the need to understand an experimentally determined phenotype or biochemical activity. (plos.org)
This study provides evidence for further testing on the molecular mechanism of the disease and also propose proteins as candidate markers of OA chondrocyte phenotype. (biomedcentral.com)

Next, they mapped the network of genes and proteins involved in both aging and SARS-CoV-2 infection. (theregister.com)
In principle, drugs targeting those upstream genes and proteins should be promising candidates for clinical trials. (theregister.com)
This study aimed to evaluate the expression levels of miR-34a and 11 of its bioinformatically selected target genes and proteins to test their potential dysregulation in RCC. (hindawi.com)

For instance, the SwissVariant database (http://swissvar.expasy.org/) contained 76 613 variants in 20 244 human proteins on 10 January 2018. (deepdyve.com)

ORF2 encodes the major capsid protein ( 12 ), and ORF3 codes for a minor structural protein ( 13 ). (cdc.gov)
SIV proteins, especially the viral core proteins (i.e., p24, capsid protein), are antigenically related to HIV-I proteins (9). (cdc.gov)

Intrinsically disordered regions (IDRs) lacking a fixed three-dimensional protein structure are widespread and play a central role in cell regulation. (iucr.org)

Maximizing our understanding of function over the universe of proteins in toto requires not only robust computational methods of inference but also a judicious allocation of experimental resources, focusing on proteins whose experimental characterization will maximize the number and accuracy of follow-on predictions. (plos.org)
COMBREX ( COM putational BR idges to EX periments, http://combrex.bu.edu ) is an NIH-funded enterprise that has brought computational and experimental biologists together, with the goal of greatly improving our overall understanding of microbial protein function [1] , [2] . (plos.org)
The database search features enable biologists to identify predictions whose experimental verification is particularly important. (plos.org)
Repositories, archives or deposition databases collect primary ( i.e. experimental) data. (iucr.org)
The antigen composition of the vaccines was selected based on previous immunogenicity studies in cattle and experimental knowledge from in vitro and in vivo expression studies with M. tuberculosis proteins in mice (101). (dtu.dk)
FET11 vaccine, a combination of a fusion protein of four early expressed MAP proteins and a latencyassociated MAP protein formulated in CAF01 adjuvant was tested by an experimental MAP challenge in calves. (dtu.dk)

Genes2FANs is a useful tool for interpreting the relationships between gene/protein lists in the context of their various functions and networks. (biomedcentral.com)
For instance, a system that we developed a few years ago, Genes2Networks, utilizes twelve protein-protein interaction databases to connect lists of mammalian gene products using a shortest path algorithm [ 1 ]. (biomedcentral.com)
GeneNet database: description and modeling of gene networks. (dagstuhl.de)
This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database. (innatedb.com)
Overview of Genetics A gene, the basic unit of heredity, is a segment of DNA containing all the information necessary to synthesize a polypeptide (protein) or a functional RNA molecule. (msdmanuals.com)
The neuraminidase (NA) gene encodes the other surface protein of the virus. (cdc.gov)

Our new database, Translocatome was published in the 2019 Database issue of Nucleic Acid Research (https://doi.org/10.1093/nar/gky1044) and is accessible here . (linkgroup.hu)
doi: 10.1093/database/bau034. (nih.gov)

The purpose of this study was to demonstrate experimentally that alterations of in vivo transporter function at the blood-brain barrier (BBB) in disease and during pharmacotherapy can be reconstructed from in vitro data based on our established pharmacoproteomic concept of reconstructing in vivo function by integrating intrinsic transport activity per transporter molecule and absolute protein expression level at the BBB. (aspetjournals.org)
In vitro, the FH2 domain competes with barbed-end capping proteins and is necessary and sufficient to nucleate actin polymerization, but the FH1 domain, which interacts with profilin-actin, funnels actin to the nucleation vicinity and confers full activity to the molecule [ 1 ]. (biomedcentral.com)

Subcellular localization critically influences protein function, and cells control protein localization to regulate biological processes. (elifesciences.org)
Protein function is critically determined by subcellular localization, as organelles offer different chemical environments and interaction partners. (elifesciences.org)
In order to regulate protein activity, many biological processes involve changes in protein subcellular localization. (elifesciences.org)
Anamika Thakur, Akanksha and Manoj Kumar : MSLVP: software for predicting multiple subcellular localization of viral proteins using support vector machine. (imtech.res.in)

As a rule of the thumb, we prefer to work on gel bands visible on Coomassie-stained gel but we can still identify proteins coming from silver staining. (epfl.ch)
The aim of the study was to identify proteins from different stages of infection and formulate them into a multi-stage subunit vaccine with activation of protective immune response in experimentally challenged calves, with a focus on cell-mediated immune responses chiefly interferon gamma (IFN-γ) and polyfunctional T cells. (dtu.dk)

Table 1 shows the statistics of experimentally identified PPIs in representative plant species taken from the BioGRID database 29 . (nature.com)
Other representative plant species cover even less protein involved in known PPIs. (nature.com)
Known PPIs of the 62 MPM associated genes were derived from Biological General Repository for Interaction Datasets (BioGRID) and Human Protein Reference Database (HPRD). (cdc.gov)

The efficiency of the methods was proved on various real world protein-protein interaction and signaling networks, as well as on synthetic benchmark graphs. (linkgroup.hu)
The development of better methods for mutation analysis-related protein PTMs will help to facilitate the development of personalized precision medicine. (deepdyve.com)
2. Application of a variety of Biophysical methods and techniques for protein structure determination and for structural studies of complex, physiologically important, Biological tissues such as insect chorion and cuticle. (uoa.gr)
Consequently, a lot of effort is put into identifying the constituent proteins using mass spectrometric methods. (lu.se)

Biological databases are highly crucial for bioinformatics and biological discovery purposes offering scientists with the opportunity to access an extensive variety of biologically applicable data. (outsource2india.com)
Our Biological Species Database Creation services are designed to make information available in a more organized and reliable manner. (outsource2india.com)
As a choiced biological species database creation service provider, we provide access to professional data entry experts who have ample experience in this specific domain. (outsource2india.com)
At Outsource2india, we have a clearly defined process to provide biological species database creation services to our clients. (outsource2india.com)
There are two types of biological databases. (iucr.org)
To this end database search engines were rapidly developed after the introduction of ionization techniques for biological mass spectrometry [1-5]. (lu.se)

In this work, we present a different paradigm for predicting miRNA-regulated genes based on the encoded proteins. (frontiersin.org)
We conclude that protein function is informative across species in predicting post-transcriptional miRNA regulation in living cells. (frontiersin.org)

Surprisingly, except for Arabidopsis thaliana , virtually no other plant species have experimentally determined PPI data available. (nature.com)
Keap1 may be viewed as the regulator of Nrf2, and reactive species/free radicals and electrophiles react with the Nrf2-Keap1 complex causing the release of Nrf2, which migrates to the cell nucleus and triggers the expression of selected genes whose products, i.e. proteins with or without enzymatic activity, participate in the antioxidant defense and in the metabolism of xenobiotics in mammals. (databasefootball.com)
Importantly, these proteins will defend the cells against reactive species/free radicals that are produced by several sources, including those originated as part of the mechanism of action of toxicants (pollutants, agrochemicals, other). (databasefootball.com)
Competing causes of mortali- or all of the animal species tested genetic variation, health status, life ty may prevent the development of experimentally. (who.int)

We describe a statistical measure, Mass Distance Fingerprint, for automatic de novo detection of predominant peptide mass distances, i.e., putative protein mod- ifications. (lu.se)

28 of the interactors of MPM proteins are targets of 147 U.S. Food and Drug Administration (FDA)approved drugs. (cdc.gov)

We also used WebGestalt, a web-based enrichment tool for the functional annotation and pathway analysis of the differentially synthesized proteins, using the Wikipathways database. (biomedcentral.com)

2007) of ProteinPilot v 5.0 was used to search the UniprotMammals database (version 03-2018) with the following parameters: Trypsin specificity, (iodoacetamide) cys-alkylation, taxonomy not restricted, and the search effort set to through. (datadryad.org)

Protein phosphorylation catalyzed by kinases plays crucial roles in regulating a variety of intracellular processes. (nih.gov)
Owing to an increasing number of in vivo phosphorylation sites that have been identified by mass spectrometry (MS)-based proteomics, the RegPhos, available online at http://csb.cse.yzu.edu.tw/RegPhos2/, was developed to explore protein phosphorylation networks in human. (nih.gov)
Furthermore, this update features an improved web interface to facilitate convenient access to the exploration of phosphorylation networks for a group of genes/proteins. (nih.gov)

Computational approaches attempt to leverage evidence associated with the ever-smaller fraction of experimentally analyzed proteins to predict function for these putative proteins. (plos.org)
Choosing compounds that affect the enzymes involved in the function of the protein could prevent symptoms like inflammation. (theregister.com)
The results of this research provide insight into recent work regarding the physical chemistry of amino acids and their role in the structure, function and evolution of proteins. (purdue.edu)
In vivo P-gp/mdr1a function at the BBB was reconstructed from the measured P-gp/mdr1a protein expression levels and intrinsic transport activity for verapamil per P-gp/mdr1a previously reported by our group. (aspetjournals.org)
Evolutionary insights derived from the analysis of protein structure and function. (edu.au)
The Biophysics and Bioinformatics Laboratory of the Department of Cell Biology and Biophysics of the University of Athens focuses over the last three decades on research related to the elucidation of the principles governing protein structure and function, under the supervision of Associate Professor Vassiliki A. Iconomidou . (uoa.gr)

When used on a high-diversity database of protein structure files, the new measure produced results in strong agreement with the information-theoretic study. (purdue.edu)
The techniques and insights presented in this work should be useful in the future development of knowledge-based tools for the evaluation of protein structure. (purdue.edu)
Educational resources about protein structure modeling can be found on ELIXIR's Training Portal (TESS). (proteinmodelportal.org)
The Protein Model Portal was developed as a module of the Protein Structure Initiative Knowledgebase (PSI KB). (proteinmodelportal.org)
The Protein Model Portal - a comprehensive resource for protein structure and model information. (proteinmodelportal.org)
This perspective focuses on two areas that have yielded new useful information during the last 20 years: (i) structure-activity relationship (SAR) studies of contact allergy based on the concept of hapten-protein binding and (ii) mechanistic investigations regarding activation of nonsensitizing compounds to contact allergens by air oxidation or skin metabolism. (cdc.gov)
Expert systems containing information about the relationship between the chemical structure and the ability of chemicals to haptenate proteins are available. (cdc.gov)

Protein degradation systems got more coverage in ELM. (eu.org)
Nitisinone, a tyrosine degradation inhibitor, has been used experimentally. (medscape.com)

We have developed and applied Dynamic Organellar Maps, a proteomic method that allows global mapping of protein translocation events. (elifesciences.org)

Comparing H281DRAFT_05856 FitnessBrowser__Burk376:H281DRAFT_05856 to proteins with known functional sites using BLASTp with E ≤ 0.001. (lbl.gov)
Comparing SMc02257 FitnessBrowser__Smeli:SMc02257 to proteins with known functional sites using BLASTp with E ≤ 0.001. (lbl.gov)

How much starting material do I need to submit for protein identification? (epfl.ch)
The proteomic analysis led to the identification of a total of ~2400 proteins. (biomedcentral.com)
The method can be used for automated detection of chemical/post- translational modifications, quality control of experiments and labelling approaches, and to control the modification settings of protein identification tools. (lu.se)

Aiding bioinformatic databases with authentic and well-researched data, in the form or texts or images, our data management experts work towards making data more readable and comprehensible. (outsource2india.com)
Outsource2india helps you design databases according to your business or professional needs while helping you reduce the operational cost of hiring in-house data management experts, or making extra expenditures on infrastructure. (outsource2india.com)
Sometimes resources are of both types, and the majority of deposition databases also process data to facilitate visualization. (iucr.org)
Searching through large databases of available drugs and inspecting their pharmacological effects to identify those that could treat a COVID-19 infection is no easy feat. Massive amounts of data have to be carefully analysed to home in on the right drug candidates that will effectively treat COVID-19. (theregister.com)
All other data is licensed under the terms of the originating database. (innatedb.com)
Limited data exist concerning the presence or concentration of virus in semen, cervical secretions, saliva, urine, breast milk, and amniotic fluids of experimentally or naturally infected nonhuman primates. (cdc.gov)

The silkmoth eggshell as a natural amyloid shield for the safe development of insect oocyte and embryo: Insights from studies of silkmoth chorion protein peptide-analogues of the B family. (uoa.gr)

Protein synthesis, folding. (msdmanuals.com)

Protein-protein, cell signaling, metabolic, and transcriptional interaction networks are useful for identifying connections between lists of experimentally identified genes/proteins. (biomedcentral.com)

Most PTMs are catalyzed by highly specific protein modifying enzymes, which have some specific recognition motif. (deepdyve.com)

Organisms4

Diseases6

Chemicals and Drugs9

Analytical, Diagnostic and Therapeutic Techniques and Equipment59

Psychiatry and Psychology2

Phenomena and Processes44

Disciplines and Occupations23

Anthropology, Education, Sociology and Social Phenomena10

Technology, Industry, Agriculture5

Information Science101

Named Groups1

Health Care60

Geographicals7

Manually curated4

Interactions20

Sequences8

Macromolecules2

Intrinsically disordered proteins1

Structures13

Membrane10

Pathways6

Prediction12

Transmembrane4

Homology2

Sequence6

Residues2

Quantitative3

Complexes2

Peptides3

Amino acid4

Kinase3

Interactome2

Cellular4

Phenotype2

Genes and proteins3

Human proteins1

Capsid protein2

Fixed three-dimensional1

Experimental6

Gene6

10.10932

Vitro2

Subcellular4

Identify proteins2

PPIs3

Methods4

Biological6

MiRNA2

Species4

Putative protein1

Targets1

Annotation1

20181

Phosphorylation3

Function6

Structure7

Degradation2

Translocation1

Functional Sites2

Identification3

Data6

Insights1

Synthesis1

Metabolic1

Motif1