Golden or Syrian hamsters (Mesocricetus auratus) are used to model the human medical conditions including various cancers, metabolic diseases, non-cancer respiratory diseases, cardiovascular diseases, infectious diseases, and general health concerns. (wikipedia.org)
Cardiovascular diseases cause a high mortality rate worldwide and represent a major burden for health care systems. (springer.com)
Experimental rodent models play a central role in cardiovascular disease research by effectively simulating human cardiovascular diseases. (springer.com)
Cardiovascular disease (CVD) is a world-leading health problem and encompasses a broad spectrum of disorders, including diseases of the blood vessels, the heart muscle, the electrical conduction system, and congenital heart disease. (springer.com)
Experimental gastrointestinal models of human diseases. (norecopa.no)
The cardiovascular system and models for human diseases. (norecopa.no)
Worldwide, 5.4 million new cases of cardiovascular diseases are diagnosed, most of them related to coronary artery atherosclerosis, and cause more than half a million deaths annually and an economic expenditure of billions of dollars 1 . (scielo.org.mx)
Abstract Major chronic diseases such as Cardiovascular Disease (CVD), diabetes, and cancer impose a significant burden on people and healthcare systems around the globe. (techscience.com)
Especially in Cardiovascular Diseases (CVD), the use of ML is indispensable to reducing human errors. (techscience.com)
Respiratory5
In this respect, epidemiological and experimental studies have suggested an association between respiratory exposure to ambient ultrafine particles and the progression of cardiovascular disease. (cdc.gov)
Our research efforts are currently directed to evaluate the cardiovascular effects, including vascular inflammation, blood cell coagulation status, atherosclerosis, as well as the related molecular mechanisms associated with respiratory exposure to different types of nanosized materials using animal models. (cdc.gov)
Since these types of oxidative modifications are considered to play a role in atherogenesis, we further evaluated the effects of SWCNT respiratory exposure on atherosclerosis progression in ApoE-/- transgenic mice, a widely used model of human atherosclerosis. (cdc.gov)
Cardiovascular and respiratory effects of exposure to experimental models of obstructive sleep apnoea-related intermittent hypoxia. (bham.ac.uk)
The model represents a fully differentiated and functional respiratory epithelium consisting of basal, goblet and ciliated cells [26] . (cas.cz)
Rodent models2
We evaluated whether siRNA targeting maternal hepatic angiotensinogen (Agt) could ameliorate symptoms of preeclampsia without adverse placental or fetal effects in 2 rodent models. (jci.org)
Thus, an RNAi therapeutic targeting Agt ameliorated the clinical sequelae and improved fetal outcomes in 2 rodent models of preeclampsia. (jci.org)
Centre2
4 DZHK (German Centre for Cardiovascular Research), Berlin, Germany. (jci.org)
The theme's Principal Investigators are internationally recognised researchers and hold substantial government, charitable and commercial funding as well as having senior leadership roles in national and international professional socitiesWe are co-located between the BHF Glasgow Cardiovascular Research Centre, The Davidson Building, the Queen Elizabeth University Hospital in Glasgow and the Glasgow Royal Infirmary. (gla.ac.uk)
Pharmacology2
2009). Journal of Cardiovascular Pharmacology. (uba.ar)
Tomaro, M.L. 'Lowering arterial pressure delays the oxidative stress generation in a renal experimental model of hypertension' (2009) Journal of Cardiovascular Pharmacology. (uba.ar)
Systemic1
Nanoparticle exposure and systemic/cardiovascular effects - experimental data. (cdc.gov)
Mice6
Effect of ghrelin on mortality and cardiovascular outcomes in experimental rat and mice models of heart failure: a systematic review and meta-analysis. (ox.ac.uk)
The aim of the study is to determine the effect of Ghrelin on mortality and cardiac function in experimental rats/mice models of HF.MethodsData sources: PUBMED, Scopus. (ox.ac.uk)
Search methods: We systematically searched for all controlled trials (upto November 2014) which assessed the effects of Ghrelin (irrespective of dose, form, frequency, duration and route of administration) on mortality and cardiac function in rats/ mice models of HF. (ox.ac.uk)
An impaired HRV was observed at 12 months of age in PLP-α-syn female but not in male mice, indicative of cardiovascular AF. (frontiersin.org)
In this study, the antinociceptive activity of (-)-linalool was examined in two different pain models in mice: the acetic acid-induced writhing response, a model of inflammatory pain, and the hot plate test, a model of supraspinal analgesia. (researchgate.net)
Using mice, the International Mouse Phenotyping Consortium (IMPC) aims to target each protein-coding gene and phenotype multiple organ systems in single-gene knockout models by a global network of mouse clinics. (springer.com)
Research8
3 Experimental and Clinical Research Center, Berlin, Germany. (jci.org)
Animal models have many facets that mimic various disease conditions in humans representing the importance for its tremendous use in biomedical research (Mukherjee et al. (springer.com)
Insights from chickens, frogs, and reptiles-model organisms that support research in this area-are also covered. (cshlpress.com)
Advanced insight into the use and limitation of animal models in biomedical research. (norecopa.no)
The overall objectives of my research are to develop clinically translatable tissue regeneration and drug delivery strategies, and three-dimensional, in vitro human disease models using biologically-derived biomaterials. (wpi.edu)
These new experimental possibilities would open new doors for the entire cardiovascular research community. (bu.edu)
Our preclinical research uses animal experimental models exhibiting ischemic or haemorrhagic stroke associated co-morbidities or genetically modified strains (and controls) and a transient model of occlusion with recanalisation. (gla.ac.uk)
As the use of zebrafish (Danio rerio) as a research model continues to rise, so too will the shipping and sharing of zebrafish strains across collaborating institutions. (awionline.org)
Hypertension2
Polizio, A.H. Lowering arterial pressure delays the oxidative stress generation in a renal experimental model of hypertension. (uba.ar)
In regression models, after adjusting for age, sex, and race, AKI-D incidence was associated with prevalence of and rates of hospitalization with five chronic health conditions--diabetes, hypertension, CKD, ASHD and COPD--and rates of hospitalization with cancer. (cdc.gov)
Transgenic2
Treatment also improved the angiogenic balance and proteinuria in the transgenic model, and it reduced angiotensin receptor activating antibodies in both. (jci.org)
There were insignificant changes in cardiac output (SMD 0.28, 95% CI -0.24 to 0.80, P=0.29) and left ventricular end systolic pressure (MD 1.48, 95% CI -3.86 to 6.82, P=0.59).ConclusionsThe existing data provides evidence to suggest that Ghrelin may lower the risk of mortality and improve cardiovascular outcomes. (ox.ac.uk)
Genetic1
In addition, the authors examine congenital heart disease, genetic variants and environmental risk factors (e.g., teratogens and nutritional deficiencies) that disrupt normal heart development and cause various malformations, and the use of cell and animal model systems to study disease pathogenesis and test therapeutic interventions. (cshlpress.com)
Rodents3
Rodents such as rats are the most common model in researching effects of cardiovascular disease, as the effects on rodents mimic those in humans. (wikipedia.org)
Give the participants insight in experimental surgical techniques in laboratory animals focusing on rodents. (norecopa.no)
Rodents as a model for urological disorders. (norecopa.no)
Rats1
We used as hypertensive model the aortic coarctated rats, which were treated with losartan or minoxidil for 7 days. (uba.ar)
System4
The cardiovascular AF in MSA is thought to be mainly due to a progressive neurodegeneration of several areas involved in autonomic control of the cardiovascular system such as inter alia , cholinergic neurons in the ventrolateral ambiguous nucleus and dorsal motor nucleus of the vagus nerve ( 5 ). (frontiersin.org)
Furthermore, we are presenting not yet associated loss-of-function genes affecting both, metabolism and the cardiovascular system, such as the RING finger protein 10 ( Rfn10 ), F-box protein 38 ( Fbxo38 ), and Dipeptidyl peptidase 8 ( Dpp8 ). (springer.com)
A strong advantage of the zebrafish model is the availability of in vivo imaging techniques, because the embryo is completely transparent and can live for several days without a functional cardiovascular system. (uni-potsdam.de)
Specifically, to investigate the impacts on the pulmonary system, we propose to use a 3D model of human upper airway epithelium (MucilAir TM , Epithelix Sàrl, Geneva, Switzerland) reconstituted from tissues of 8 healthy and 8 asthmatic individual donors. (cas.cz)
Development5
Rödel CJ , Abdelilah-Seyfried S. A zebrafish toolbox for biomechanical signaling in cardiovascular development and disease. (uni-potsdam.de)
Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology describes recent progress in our understanding of early heart development and the various cell lineages involved, as well as mechanisms and models of congenital heart disease. (cshlpress.com)
PET-scanning and development of models for studies of neurological disorders. (norecopa.no)
In this paper, we describe our coronary stent (INC-1) design and development, the way that we found the specific characteristics needed for our device including biophysics aspects, design, finite element testing, manufacturing, and mechanic trials, we submitted and animal models experiences. (scielo.org.mx)
During her Master's thesis, she contributed to the development of a physical model for integrating optoelectronic scaffolds with optogenetics to investigate their effects on human stem cell-derived cardiomyocyte functionality. (uniklinik-freiburg.de)
Theoretical2
The experiments are similar to those carried out by practising engineers and therefore provide experience of the challenges in acquiring meaningful results and the issues involved in producing a useful theoretical model. (sheffield.ac.uk)
For theoretical foundations or applications, the majority (n = 21, 36%) of doctoral theses had no specific theoretical/conceptual models as study frameworks. (scirp.org)
Organism1
Yet, the mouse shares a similar developmental trajectory to the human heart and a comparable four-chamber morphology that greatly enhances its translational value as a model organism, despite the substantial differences in size (Krishnan et al. (springer.com)
Zebrafish3
The zebrafish embryo is an excellent vertebrate model to address questions on CCM lesion formation. (uni-potsdam.de)
Blood Flow Matters in a Zebrafish Model of Cerebral Cavernous Malformations. (uni-potsdam.de)
Blood Flow Suppresses Vascular Anomalies in a Zebrafish Model of Cerebral Cavernous Malformations. (uni-potsdam.de)
Evaluate1
We placed the coronary stent INC-1 on a rabbit and dog models so we can evaluate efficacy and security of the device in relationship to its biomechanical properties including navigation capacity, traceability, symmetric expansion, and safety, as well as endothelial attachment, thrombogenicity, and lack of involvement of secondary branches in these models. (scielo.org.mx)
Effects2
siRNA treatment ameliorated the preeclamptic phenotype in both models, reduced blood pressure, and improved intrauterine growth restriction, with no observed deleterious effects on the fetus. (jci.org)
In our lab we use precisely engineered, two-dimensional and three-dimensional constructs as model systems to study the effects of external internal (cell-generated) forces on cell behavior, matrix biochemistry, and the biomechanics of soft tissues and biomaterials. (wpi.edu)
Tissue1
We also have programmes investigating the molecular basis of cerebral small vessel disease and intracerebral haemorrhaging using both human genetics as well as animal and tissue culture models. (gla.ac.uk)
Analgesia1
Knowledge about advanced experimental procedures such as microsurgery, imaging, telemetry as well as practical experience with handling, anaesthesia, analgesia, euthanasia and surgical procedures in rodent laboratory animals. (norecopa.no)
Chronic1
PTx2-3127 inhibits NaV1.7 currents in mouse and human sensory neurons and shows efficacy in rat models of chronic and thermal pain when administered intrathecally. (bvsalud.org)
Incidence1
Background: The incidence of delirium is high in older patients undergoing cardiovascular surgery with cardiopulmonary bypass (CPB). (mdpi.com)
Studies2
Many studies in MSA patients have already depicted cardiovascular autonomic impairments with a reduction in sympathetic and parasympathetic activities ( 6 - 9 ). (frontiersin.org)
Insight into strategies for planning and analyses of experimental animal studies, including the importance of standardisation of environmental, microbiological factors and use of humane endpoints. (norecopa.no)
University1
10 Department of Experimental Feto-Maternal Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. (jci.org)
Control1
The role of skeletal muscle afferent feedback in ventilator and cardiovascular control during human exercise. (bham.ac.uk)
Study1
The main benefit over current methods is that these tools can be easily used in cell models that are relevant to study heart or lung disease, which has been an important limitation in the field. (bu.edu)
Medicine2
Home › Herzzentrum › deutsch › Institut für Experimentelle Kardiovaskuläre Medizin › english › Experimental Cardiovascular Medicine › Team › Dr. rer. (uniklinik-freiburg.de)
Intensive Care Medicine Experimental, 11 (1). (oru.se)
Patients1
Methods: Patients older than 70 years of age scheduled for elective cardiovascular surgery using CPB were enrolled. (mdpi.com)
Widely1
They are widely considered to be the prime model of inherited human disease and share 99% of their genes with humans. (wikipedia.org)
Tools1
The goal of this project is to create new experimental tools that can transform how GPCRs are studied. (bu.edu)
Authors1
Data collection and analysis: Two authors independently assessed each abstract for eligibility and extracted data on characteristics of the experimental model used, intervention and outcome measures. (ox.ac.uk)
Data1
Here we used available structural and experimental data to guide Rosetta design of potent and selective ProTx-II-based peptide inhibitors of human NaV1.7 channels. (bvsalud.org)
Focus1
Sessions are delivered using a blended delivery model, with materials and tasks given in workbook format for students to prepare in advance for seminar and problem solving classes style with a focus on pair/ work and group work activities. (sheffield.ac.uk)