Experimental models biological. Medical search. Frequent questions

The journal serves as a forum for the exchange of new ideas and applications in computational, rigid and flexible multi-body system dynamics and all aspects (analytical, numerical, and experimental) of dynamics associated with nonlinear systems. (asme.org)
The broad scope of the journal encompasses all computational and nonlinear problems occurring in aeronautical, biological, electrical, mechanical, physical, and structural systems. (asme.org)
We describe a computational methodology allowing to systematically and quantitatively characterize a Boolean mathematical model of a biological network in terms of genetic interactions between all loss of function and gain of function mutations with respect to all model phenotypes or outputs. (researchgate.net)
In addition, we suggest several computational tools for studying the distribution of double mutants in the space of model phenotype probabilities. (researchgate.net)
To that end, we develop computational methods in statistics, probabilistic modeling, and bioinformatics, and work in a close collaboration with experimental labs to design and perform high-throughput experiments. (tau.ac.il)
A central challenge in computational modelling of dynamic biological systems is parameter inference from experimental time course measurements. (warwick.ac.uk)
Computational models can be used to better understand this process. (springer.com)
Computational models of ISR usually represent cells by on-lattice or freely moving agents, but continuum-based models have also been proposed. (springer.com)
Using experimental values from the performance of individual III-V NWs we create a realistic computational model of the complete artificial neural node circuit. (lu.se)
We are also active in analytical and computational modeling of biological and colloidal systems. (lu.se)
My core expertise combines light, X-ray and neutron scattering methods with coarse-grained modeling using analytical and computational approaches from statistical mechanics and stochastic processes. (lu.se)

We have sucessfully designed communication system models using in-silico and in-vitro models of different types of biological systems including, neurons, astrocytes, smooth muscle cells, epithelial cells as well as bacteria. (essex.ac.uk)
We work close with experimental in-vitro data in our in-silico models with the vision of developing validated digital twins solutions that one day can be translated to clinical practices. (essex.ac.uk)
There have been many in silico studies based on a Boolean network model to investigate network sensitivity against gene or interaction mutations. (researchgate.net)
We report on an approach for validation of an in silico 3D model of in-stent restenosis in porcine coronary arteries and illustrate this approach by comparing the modelling results to in vivo data for 14 and 28 days post-stenting. (springer.com)
The approach presented here provides a very detailed, location-specific, validation methodology for in silico restenosis models. (springer.com)
rsos from in silico dynamical modelling by tuning parameters for protein concentrations and other factors .r o y involved in the rate equations describing the systems. (lu.se)

He also served as guest editor for the IEEE Transactions on Molecular, Biological and Multi-Scale Communications and Digital Communications Networks journals. (essex.ac.uk)
Molecular communciations is a recent interdisciplinary research area that integrates concepts from telecommunications and computer networks for the dual goal of 1) designing communication using molecules for synthetically engineered cells or unconventional implantable medical devices and 2) further analyse biological communications for deeper understanding of tissues and organs functioning. (essex.ac.uk)
This investigation provides a detailed histological and molecular analysis of thrombus organization in the swine aneurysm model. (thejns.org)
4. Develop methods to understand and integrate experimental data from the molecular level to the whole organism. (cdc.gov)
Ideal candidates should have a Ph.D. in experimental biophysics, molecular/evolutionary biology or related topics, excellent experimental skills, independence, and capacity to work in a group that combines experiments and theory. (oist.jp)
This model has the potential to address the different sources of variability that are relevant to transcriptional and translational processes at the molecular level, namely, intrinsic noise due to the stochastic nature of the birth and deaths processes involved in chemical reactions, and extrinsic noise arising from the cell-to-cell variation of kinetic parameters associated with these processes. (warwick.ac.uk)
Quantitative studies of biomolecular interactions, dynamics and structure at the molecular level establish the necessary foundation for analyzing higher levels of biological complexity. (lu.se)
During sepsis, these host defence systems become pathologically augmented and deregulated and we develop experimental models to delineate cellular and molecular mechanisms involved. (lu.se)

Additional research is needed to develop better tools for toxicity analysis, exposure-response modeling, and physiologically based pharmacokinetic and pharmacodynamic (PB/PK and PB/PD) modeling. (cdc.gov)
These decisions include the selection of the appropriate internal dose measure(s) calculated using physiologically based pharmacokinetic (PBPK) modeling, and evaluating the relevance of the observations in animals to human health. (cdc.gov)

Experimentally characterized genetic interaction networks in model organisms provide important insights into relationships between different biological functions. (researchgate.net)

Our analytical study and experimental results show that SecureMR can ensure data processing service integrity while imposing low performance overhead. (ncsu.edu)

Relating in vitro to in vivo exposures with physiologically based tissue dosimetry and tissue response models. (cdc.gov)
These beneficial biological properties have been extensively studied in humans and animal models, both in vitro and in vivo . (hindawi.com)
The studies use both in vitro cellular models of bacterial communities (biofilms) to characterise the phenotype of disease-causing bacteria. (lu.se)

1998. Documentation of the threshold limit values and biological exposure indices. (cdc.gov)
Wallenstein, Kelso & Bressler (1995) for EEG correlates, and Jirsa, Fuchs & Kelso (1998) for cortical modelling thereof). (scholarpedia.org)

Chickens (Gallus gallus domesticus) and their eggs have been used extensively as research models throughout the history of biology. (wikipedia.org)
Today they continue to serve as an important model for normal human biology as well as pathological disease processes. (wikipedia.org)
1974. In: Biological handbooks: Biology data book. (cdc.gov)
besides, she has driven the foundation of the Division of Medicinal and Biological Chemistry within the Institute of Chemistry of Ireland (ICI) and its adherence to the European Federation of Medicinal Chemistry and Chemical Biology (EFMC) in 2022. (tcd.ie)
I aim for an integrative scientific approach, combining ideas from different research fields such as biology, chemistry and physics as well as bridging experimental data to theoretical concepts, to finally enable translation into applications. (lu.se)

In this paper, we present and analyze a mathematical model for polarization of a single macrophage which, despite its simplicity, exhibits complex dynamics in terms of multistability. (biorxiv.org)
The aim of this paper is to better understand the dynamics of crystallogenic and starting activity in biological fluids of patients throughout surgery and the late postoperative phase in alveococcosis. (scielo.br)
While this relationship is often true in physics models, a . quantitative relationship between the biochemical dynamics and the free energy landscape has not open been widely exploited in developmental processes. (lu.se)
My central research interest addresses the mechanistic understanding of dynamics, structure and assembly in soft biological matter. (lu.se)

5 Centre de Recherche en Cancérologie de l'Université Laval, Hôpital Hotel-Dieu de Quebec, Canada. (nih.gov)
Rossby Centre works in MERGE on research and climate model development. (lu.se)

I am currently accepting PhDs in Biological and Environmental Sciences, Nutrition and Health, Biomedical Sciences, Applied Health Sciences. (abdn.ac.uk)

Recently, there has been considerable research on active fault detection and model identification algorithms for linear systems. (ncsu.edu)
Copper in biological systems is usually found surrounded by imidazole moieties from histidine residues [ 13 , 14 ]. (hindawi.com)
The hsm-copper(II) system may be used to mimic the environment of this metal ion in some biological systems. (hindawi.com)
Thus, simplified biological systems have become an inherent component of animal experimental research. (mdpi.com)
The research unit studies biological systems using quantitative biophysical methods. (oist.jp)
It also merges over 40 naming systems, ending the frustration that comes from many names being applied to the same biological entity. (bio.net)
In particular we focus on highly deformable biological tissues and material systems used for biomedical applications. (empa.ch)
The ultimate aim is to understand biological systems and processes in terms of the underlying physical and chemical laws. (lu.se)

The use of this methodology for validating mathematical models from experimental data and designing new experiments is discussed. (researchgate.net)

MapReduce has become increasingly popular as a powerful parallel data processing model. (ncsu.edu)
One drawback to progress has been the absence of a model system that affords the precise analysis of behavioral patterns and pattern change both in terms of experimental data and theoretical tools. (scholarpedia.org)
Experimental results can rapidly be put into biological/functional context, extracting real knowledge from data. (bio.net)
The availability of multiple single cell data provides a unique opportunity to estimate such a model and explicitly quantify the sources of variation from experimental data. (warwick.ac.uk)
The neointimal area predicted by the model demonstrates a good agreement with the detailed experimental data. (springer.com)
It should be noted that including vessel curvature and ECM production in the model was paramount to obtain a good agreement with the experimental data. (springer.com)
Modellen är anpassad till experimentell data och förutsäger en tillståndsbytande kinematik som valideras med klondata. (lu.se)
The second focus is on methods to collect data about forest biomass and changes in the forest cover using radar remote sensing, for use in evaluation of ecosystem descriptions in climate models. (lu.se)

Mathematical and experimental modeling of physical and biological processes. (ncsu.edu)
Works on climate model evaluation and development by means of palaeoclimatic records, looking for new insights into the range of natural climate forcing processes and climate effects and how these might be missing in models. (lu.se)
Supports model development by laboratory-based experimental studies, aiming at improved model descriptions of key aerosol and cloud processes, such as SOA formation via BVOC oxidation, and SOA aging and associated changes in chemical and physical properties. (lu.se)

To investigate how genes and phenotypes are transmitted, we developed a general model that, for the first time, considers concurrently: multiple loci, quantitative and qualitative gene expression, assortative mating, dominance/recessivity inheritance and density-dependent demographic effects. (nature.com)
Indeed, HKB is probably the most extensively tested quantitative model in the field of human movement behavior (Fuchs & Jirsa, 2008). (scholarpedia.org)
Genetic interaction can be defined as a deviation of the phenotypic quantitative effect of a double gene mutation from the effect predicted from single mutations using a simple (e.g., multiplicative or linear additive) statistical model. (researchgate.net)

Workers are continuously exposed to a wide variety of chemical substances, biological agents, physical agents, and other stressors encountered both in and out of the workplace. (cdc.gov)
Surgical therapy results in a partial normalization of physical and chemical parameters, as well as the composition of the patient's biological fluids after the patient is discharged from the hospital. (scielo.br)
Assessement of Biological, Chemical and Combined Treatments for Color Removal and COD Reduction of Azo Dyes at Lab Scale. (lu.se)
He has served as president for the global lab-on-a-chip society Chemical and Biological Microsystems Society. (lu.se)

O estudo foi experimental utilizandose um modelo mecânico de pulmão ASL5000 (IngMar Medical, Pittsburg, PA, USA). (usp.br)
Os resultados mostram que, nas condições experimentais, C. auratus tem preferência significativa pelo escuro, uma característica relevante para o desenvolvimento de um modelo experimental de ansiedade com esta espécie. (bvsalud.org)

Dr. DeCoursey's research centered on chronobiology (biological rhythms), the study of internal timing mechanisms for organisms, related to environmental cycles such as tidal cycles, daily solar cycles, or annual cycles. (sc.edu)
3. Conduct research to better understand the toxicology (biological mechanisms) of mixed exposures. (cdc.gov)
Models and experimental observations allow characterizing the deformation mechanisms down to the length scale of single cells, allowing for investigations on the mechanobiology of novel implants, scaffolds for tissue engineering and coating materials for biomedical devices. (empa.ch)
We formulate physically based models of deformation, damage and fracture behavior of metals, with due consideration of underlying microstructural conditions and mechanisms. (empa.ch)

Experimental studies of rodent biological clocks hold out hope for understanding and correcting human dysfunctions such as jet lag, shift worker sleep problems, and insomnia of the elderly. (sc.edu)
In addition to - and often in close connection with - our experimental studies, we develop NMR theory and methodology. (lu.se)
Recent studies have indicated that exposures to methyl based pharmacokinetic (PBPK) modeling, and evaluat- iodide (MeI) produce a number of effects in laboratory ani- ing the relevance of the observations in animals to human mals, including fetal toxicity, neurotoxicity, and degenera- health. (cdc.gov)
Scientific research on the virus had been limited to experimental studies and early stage development work on vaccines within public entities interested in lines of defence against potential biological warfare. (who.int)

Rakotonarivo OS, Jones II, Bell AR, Duthie AB, Cusack JJ, Minderman J, Hogan J, Hodgson I & Bunnefeld N (2021) Experimental evidence for conservation conflict interventions: the importance of financial payments, community trust and equity attitudes. (stir.ac.uk)
We used a novel experimental game to understand farmer preferences regarding the design of goose conflict interventions in Scotland. (stir.ac.uk)
During the first meeting, ethicists and scientific experts concluded that it would be acceptable to offer to EVD patients as potential treatments unregistered interventions that have shown promising results in the laboratory and in animal models, but have not yet been evaluated for safety and efficacy in humans. (who.int)
On 11 November, the Organization convened a meeting of the newly created Scientific and Technical Advisory Group on Ebola Experimental Interventions (STAC-EE). (who.int)

As the final modification, we check the combined effect of using Michaelis-Menten kinetics and reversible reactions on the model behavior. (nature.com)
Because it was the first to establish that coordination in a complex biological system is an emergent, self-organized process and because it was able to derive emergent patterns of coordinated behavior from nonlinear interactions among the component subsystems, HKB stands as a basic foundation for understanding coordination in living things. (scholarpedia.org)
2001), and also because there constitute good models for the study behavior in a laboratory setup. (bvsalud.org)

These methods seem to work effectively for extremely sparse high dimensional linear models. (ncsu.edu)
2009). Interface problems and methods in biological and physical flows. (ncsu.edu)

Professor of Biological Physics. (foresight.org)

To validate an experimental setup designed to apply load onto bone tissue using osseointegrated implants in a rabbit model. (nih.gov)

Anne constantly subjected the theoretical model to rigorous experimental testing. (mpi.nl)
1984). HKB is the theoretical model that explicitly accounted for Kelso's observations and in turn predicted additional aspects. (scholarpedia.org)

Currently working on RNA modeling projects at Max Planck Medical Research. (foresight.org)
But there was a deeper, more biological objective in Anne's research. (mpi.nl)
A recently released report by the National Research Council, "Managing University Intellectual Property in the Public Interest" says, "because of the wide variety among institutions in their resources, the scale and focus of their research efforts, their experience in technology licensing, and not least their missions, there cannot be a single template for technology transfer that all institutions should attempt to model" (NRC Report). (lesi.org)
Biological Rhythms Research. (sc.edu)
Additionally, she has held positions as Director of the Medicinal Chemistry Moderatorship, member of the Fellowship Central committee, Head of Organic, Medicinal and Biological Chemistry at the School of Chemistry, Director of Postgraduate Teaching and Learning, Director of Research and Director of Global Relationships at the School of Chemistry, Director of Dublin Chemistry postgraduate program, Tutor and served in numerous College committees and selection panels. (tcd.ie)
OIST is rapidly gaining recognition in the worldwide academic community as a model for excellence in education and research. (oist.jp)
To carry out experimental research. (oist.jp)
Fishes have long been used in biological research because they represent the oldest and most diverse classes of vertebrates and live in many different habitats (Bolis et al. (bvsalud.org)
Oonagh Shannon is Associate Professor in Experimental Infection Medicine and she has a long-standing research interest in understanding the host response to bacteria that breach the bloodstream. (lu.se)

This multiscale model includes single-scale models for stent deployment, blood flow and tissue growth in the stented vessel, including smooth muscle cell (SMC) proliferation and extracellular matrix (ECM) production. (springer.com)

These results were obtained by developing regenerative and reparative techniques that helped to reestablish the periodontal structures and to preserve the biological width of the involved tissues 14 . (bvsalud.org)

Our principal experimental tool is nuclear magnetic resonance (NMR), in particular nuclear spin relaxation measurements. (lu.se)
Contributes with advanced climate-relevant aerosol measurements at various field sites as well as in laboratories, and process modelling in order to develop an validate parameterizations linking the carbon cycle to aerosol - cloud - climate interactions. (lu.se)

Our results reveal that the conclusions about how hybridization threatens a species can be biased if they are based on single-gene models, while considering two or more genes can correct this bias. (nature.com)
In the present work we reported the synthesis, characterization, and biological activity results of a copper mixed complex (see Figure 1 ), with hsm and nalidixic acid. (hindawi.com)
To put it simply, only experimental models with results that fitted the upper part of Figure 4 were selected. (researchgate.net)
Results indicate that, in such experimental conditions, C. auratus has a significant preference for a dark environment, a feature that might be relevant for the development of an experimental model of anxiety for the study of this species. (bvsalud.org)
Contributes with work on downscaling of climate model results to local scale, with focus on extreme precipitation and temperature events. (lu.se)

Focuses in MERGE on aerosol and in the context relevant atmospheric chemistry modelling (tropospheric ozone), using the EMEP model as a stepping stone to introducing new parameterizations in regional and over time global climate models. (lu.se)

Neurons with internal memory have been proposed for biological and bio-inspired neural networks, adding important functionality. (lu.se)

The relatively large size of the chick as a model organism allowed scientists during this time to make these significant observations without the help of a microscope. (wikipedia.org)
Our investigations are performed at the cellular level but also at the whole organism level in advanced animal models of sepsis. (lu.se)

Anders Håkansson is Professor in Experimental Infection Medicine at the Department of Translational Medicine and his group is focused on better understanding how bacteria interact with the host during severe infections such as pneumonia and sepsis. (lu.se)

Recently, a minimal mathematical model has been employed to describe the oscillations in Bacillus subtilis biofilms. (nature.com)
In this paper, we investigate four different modifications to that minimal model in order to better understand the oscillations in biofilms. (nature.com)

Experimental study and nuclear model calculations of 3He-induced nuclear reactions on zinc. (atomki.hu)

We demonstrate this methodology on three published models for each of which we derive the genetic interaction networks and analyze their properties. (researchgate.net)

But considering the full spectrum of traditional, experimental and hypothetical approaches allows us to understand the landscape, and peek beyond the horizon. (lesi.org)

The model was able to closely match both histology datasets with a single set of parameters. (springer.com)

We argue that our general model represents a powerful tool for the study of a wide range of biological and societal questions. (nature.com)
This study contributes to get better knowledge how a metal ion is required to carry the quinolones to their site of action and also to clarify how metal surroundings affect the biological action of quinolones drugs. (hindawi.com)
This system provides continuous positive pressure by injecting high gas flows (air/oxygen) through a cylinder connected to angulated lateral channels This study aims at assessing the laboratorial performance efficiency of the Boussignac CPAP System fed by an oxygen flow meter, using a mechanical lung model. (usp.br)
Experimental and theoretical study for the production of 51Cr using p, d, 3He and 4He projectiles on V, Ti and Cr targets. (atomki.hu)
On the other hand, no previous experimental study focused on the synergistic effects of edgetic mutations. (researchgate.net)
In the first case study, we observed that the real biological networks were most sensitive to overexpression/state-flip and edge-addition/-reverse mutations among node-based and edgetic mutations, respectively. (researchgate.net)

Applying Linear Regression and Neural Network Meta-Models for Evolutionary Algorithm Based Simulation Optimization. (ncsu.edu)

The authors describe the process of thrombus organization in the swine surgical aneurysm model. (thejns.org)

Although the Bayh-Dole Act is 30 years old, efforts to develop optimum models for operating academic TTOs are best understood as part of an ongoing evolution. (lesi.org)

Rodents serve as vital experimental models for circadian timing since they mirror in close detail the human circadian system. (sc.edu)

Biological evaluation was done by measur- of improvement in the nutritional quality of ing the protein quality of diets containing peas (Pisum sativum L.) by cooking and peas in raw and cooked form with and with- supplementation with different kinds of out supplementation with meat. (who.int)

Experienced in both theoretical and experimental lab work, inspired by biology's structural beauty. (foresight.org)

More radical and broader models have been proposed at a hypothetical level, such as allowing faculty to send their inventions to TTOs at any institutions they wish. (lesi.org)
Dark preference constitutes a behavioral model based on conflict and is part of a broader set of models characterized by the use of two opposed-valence stimuli, an appetitive (naturally preferred) and an aversive one (naturally avoided). (bvsalud.org)

She has been a beloved role model for her students and postdocs. (mpi.nl)
The Biological Complexity Unit at the Okinawa Institute of Science and Technology (OIST), Japan, headed by Prof. Simone Pigolotti, is seeking to hire two outstanding experimentalists (one postdocs and one lab technician). (oist.jp)

Since its publication in 1985, the HKB model has been elaborated and extended in numerous ways and at several different levels of analysis. (scholarpedia.org)

Anatomy24

Organisms26

Diseases24

Chemicals and Drugs52

Analytical, Diagnostic and Therapeutic Techniques and Equipment56

Psychiatry and Psychology1

Phenomena and Processes61

Disciplines and Occupations9

Anthropology, Education, Sociology and Social Phenomena2

Technology, Industry, Agriculture4

Information Science13

Health Care11

Computational11

Silico6

Molecular8

Physiologically based pharmacokinetic2

Experimentally1

Analytical1

Vitro3

19982

Biology5

Dynamics4

Centre2

Sciences1

Systems8

Mathematical Models1

Data8

Processes3

Quantitative3

Chemical4

Modelo2

Mechanisms4

Studies4

Interventions4

Behavior3

Methods2

Physics1

Implants1

Theoretical model2

Research9

Tissue1

Tissues1

Measurements2

Results5

Context1

Neurons1

Organism2

Professor1

Biofilms2

Calculations1

Methodology1

Approaches1

Parameters1

Study6

Simulation1

Process1

Develop1

System1

Protein1

Structural1

Broader2

Postdocs2

Analysis1