• secretory vesicles
  • Rab11b mutants that fix Rab11b in the GTP- or GDP-bound state both effectively inhibited Ca 2+ -induced exocytosis but seemed to act by distinct mechanisms: whereas GDP-bound Rab11b greatly stimulated constitutive secretion of hGH and depleted hGH stores in secretory vesicles, GTP-bound Rab11b only had a moderate effect on constitutive secretion and no effect on vesicular hGH stores. (jneurosci.org)
  • Regulating
  • Especially, regulating exocytosis of the nanoparticles is a key factor in the fabrication of effective nanocarriers for chemotherapeutic treatments but orthogonal control of exocytosis in the cellular environment is a major challenge. (rsc.org)
  • Herein, we present the first example of regulating exocytosis of gold nanoparticles (AuNPs), a model drug carrier, by using a simple host-guest supramolecular system. (rsc.org)
  • cells
  • Exocytosis is "infiltration of the epidermis by inflammatory or circulating blood cells. (wikipedia.org)
  • In contrast, SNAP-23 is a ubiquitously expressed SNAP-25 homolog that is critical for regulated exocytosis in non-neuronal cells. (wordnik.com)
  • These results suggest that, consistent with a GTP-dependent regulation of Rab function, GDP-bound Rab11b indirectly inhibits Ca 2+ -triggered exocytosis by causing the loss of hGH from the PC12 cells, whereas GTP-bound Rab11b directly impairs Ca 2+ -triggered exocytosis. (jneurosci.org)
  • fusion
  • Activation of purinergic P2Y 1 receptors with a specific agonist 2MeSADP (20 μM) stimulates glutamate exocytosis as measured by number of fusion events (Suppl. (hindawi.com)