Special Populations: The effects of renal impairment, hepatic impairment, or ethnicity on the pharmacokinetics of cevimeline have not been investigated. (guidelinecentral.com)
Urine3
When ammi visnaga extract is taken daily, as a tea or as a pill, calcium oxalate kidney stone formation is inhibited, making it a good treatment for hyperoxaluria (a condition in which there is excessive oxalate excretion in the urine, causing kidney stones). (wikipedia.org)
Chronic kidney disease (CKD) is a chronic complication of diabetes, characterized by the presence of pathological quantities of urine albumin excretion and/or accompanied by a gradual deterioration in the glomerular filtration rate (GFR). (medsci.org)
Low levels are associated with hyperthyroidism, and with the rare condition of idiopathic hypophosphatasia associated with rickets and the excretion of excess phosphatidyl ethanolamine in the urine. (cdc.gov)
Albumin2
Significant increases in the urinary excretion of albumin, retinol binding protein, beta 2 microglobulin, N-acetylglucosaminidase (NAG), alkaline phosphatase, gamma-glutamyl transferase and significant decreases in the renal reabsorption of calcium, urate, and phosphate were found in the exposed group compared with the referent group. (mcmaster.ca)
And gamma gt gamma glutamyl transferase is present in the serum albumin, level, is reported to hour. (hybridnutrition.co.za)
Transferase1
Monitor liver tests, including AST, ALT, total bilirubin, direct bilirubin, alkaline phosphatase (ALP) and gamma-glutamyl transferase (GGT), before starting therapy, weekly for first 8 wk, every 2 wk for next mo and every 3 mo thereafter. (unboundmedicine.com)
Elevated levels are associated with acute and chronic renal insufficiency and urinary tract obstruction. (cdc.gov)
Liver3
Relations between liver cadmium, cumulative exposure, and renal function in cadmium alloy workers. (mcmaster.ca)
Using cumulative exposure index and liver cadmium as estimates of dose, a two phase linear regression model was applied to identify an inflection point signifying a threshold level above which changes in renal function occur. (mcmaster.ca)
Unwanted side effects include dizziness, reversible cholestatic jaundice, pseudoallergic reaction, and elevated levels of liver enzymes (transaminases and gamma-glutamyltransferase). (wikipedia.org)
Tubular3
Fatty acid-binding protein 3 (FABP3) located in renal mesangial and distal tubular cells, and had been shown to be a sensitive marker of renal injury, potentially be a mediator in pathogenesis of chronic kidney disease (CKD). (medsci.org)
An increase in serum phosphatase activity is associated with primary hyperparathyroidism, secondary hyperparathyroidism owing to chronic renal disease, rickets, and osteitis deformans juvenilia due to vitamin D deficiency and malabsorption or renal tubular dystrophies. (cdc.gov)
However, excess myoglobin can occlude the renal filtration system leading to acute tubular necrosis and acute renal dysfunction. (passmed.uk)
Rifampin2
The half-life of rifampin at a dose of 720 mg daily has not been established in patients with renal failure. (nih.gov)
Following a single 900 mg oral dose of rifampin in patients with varying degrees of renal insufficiency, the mean half-life increased from 3.6 hours in healthy adults to 5, 7.3, and 11 hours in patients with glomerular filtration rates of 30 to 50 mL/min, less than 30 mL/min, and in anuric patients, respectively. (nih.gov)
Creatinine2
The test is frequently requested in conjunction with the serum creatinine test for the differential diagnosis of prerenal, renal, and postrenal uremia. (cdc.gov)
Creatinine is an endogenous molecule, synthesised in the body, that is freely filtered by the glomerulus (but also secreted by the renal tubules in very small amounts). (passmed.uk)
Filtration2
Glomerular filtration rate (GFR) is the volume of fluid filtered from the renal glomerular capillaries into the Bowman's capsule per unit time. (passmed.uk)
Inulin was originally used as it is not reabsorbed by the kidney after glomerular filtration, therefore its rate of excretion is directly proportional to the rate of filtration of water and solutes across the glomerular filter. (passmed.uk)
Patients3
The half-life does not differ in patients with renal failure at doses not exceeding 600 mg daily, and, consequently, no dosage adjustment is required. (nih.gov)
It affects approximately 20-40% of patients with diabetes mellitus and is recognized as the most common cause of end-stage renal disease (ESRD) [ 1 ]. (medsci.org)
Because of these hidden sources freely from the vascular compartment plasma, ph, is required the normal response, patients with major burns renal and renal application of Diclac diseases. (hybridnutrition.co.za)
Mean half-life1
Excretion: The mean half-life of cevimeline is 5+ /-1 hours. (guidelinecentral.com)
Function tests1
Question 3 - A 78-year-old diabetic man undergoes renal function tests. (passmed.uk)
Disease1
Khellin has been used as an herbal folk medicine, with use in the Mediterranean dating back to Ancient Egypt, to treat a variety of maladies including: renal colic, kidney stones, coronary disease, bronchial asthma, vitiligo, and psoriasis. (wikipedia.org)
Blood1
Sometimes it contains skin-like excretion mixed with blood. (bio.net)
Male1
Detailed biochemical investigations of renal function were made on 75 male workers exposed to cadmium and an equal number of referents matched for age, sex, and employment status. (mcmaster.ca)
Loss1
In upper motor neuron lesions, the stretch reflexes tend to be brisk due to loss of inhibitory signals on gamma neurons through the lateral reticulospinal tract. (passmed.uk)
Hepatic4
Specific emphasis was placed on the potential adverse effects on hepatic and renal function in this species. (up.ac.za)
Serum bile acids and serum gamma glutamyltransferase activity were measured to evaluate the effect of this treatment regime on hepatic function. (up.ac.za)
Studies of IFEX in patients with hepatic or renal impairment have not been conducted [see Use In Specific Populations ]. (rxlist.com)
Untreated HFI may result in renal and hepatic failure. (beds.ac.uk)
Result in renal1
Nephrotoxicity can be severe and result in renal failure. (rxlist.com)
Fanconi1
Consequently, dysfunction of VPS33B may lead to disruption of cell polarization in many organs, thereby resulting in a multisystem disorder with Fanconi syndrome (FS), myoskeletal anomalies, and cholestasis with normal gamma-glutamyl transpeptidase (GGT) being the core manifestations [ 5 , 6 ]. (hindawi.com)
Serum1
The test is frequently requested in conjunction with the serum creatinine test for the differential diagnosis of prerenal, renal, and postrenal uremia. (cdc.gov)
Diuretic2
The plant mixture had diuretic properties that were seen to relieve renal colic by relaxing the ureter and acting as a diuretic. (wikipedia.org)
Low dietary intake of magnesium or increased excretion of magnesium due to diuretic use, are the most common causes of magnesium deficiency. (knowledgeofhealth.com)
Function3
Little information in the literature exists about the possible synergistic or antagonistic effects of heavy metals on renal function. (cdc.gov)
The rapid return to previous baseline values supported reported observations that changes between 25 and 100 IU/g may be a function of drug excretion and are not necessarily indicative of significant nephrotoxicity. (up.ac.za)
maximum, 1,500 microg/L). Indicators of cytotoxicity and kidney function did not show evidence of renal damage. (bvsalud.org)
Evaluate1
The purpose of the first medical survey was to evaluate various indicators of renal and immunologic status in male workers exposed to cadmium and nickel dusts in the plate-making and pressed plate area of the plant. (cdc.gov)
Kidney1
Khellin has been used as an herbal folk medicine, with use in the Mediterranean dating back to Ancient Egypt, to treat a variety of maladies including: renal colic, kidney stones, coronary disease, bronchial asthma, vitiligo, and psoriasis. (wikipedia.org)