Examples organ specificity. Medical search. Frequent questions

The sensitivity and specificity of T 2 -weighted imaging for PCa vary widely due to differences in imaging techniques, reference standards, criteria for defining disease involvement on MRI, and interobserver variability [ 6 ]. (hindawi.com)
T 2 -weighted imaging showed a maximum joint sensitivity and specificity rate of 74% for the staging of PCa [ 7 ]. (hindawi.com)
A complete colonoscopy is the recommended method for CRC screening in average-risk men and women based on higher sensitivity and specificity when compared with other tests. (medscape.com)
however, standard-of-care imaging also has sensitivity and specificity limitations in this regard. (snmjournals.org)
From the ROC curve analysis, a cut-off value of presepsin was 929 pg/ml with sensitivity and specificity of 76% and 81%, respectively, with odds ratios and 95% CIs of 0.996 (0.992 to 0.998) and 3.376 (1.497 to 6.094). (biomedcentral.com)
HA has also been labeled with radioactive isotopes including 99mTc 3 111 125 and 11C to track its biodistribution with relatively high detection level of sensitivity and specificity [17-21]. (sciencepop.org)
The high specificity and level of sensitivity of the ICP-MS analysis enables the accurate dedication of low-abundance Pt and La [below parts per trillium (ppt)] in the native biological samples. (sciencepop.org)
Cases of individuals whose tumors could have been detected earlier without additional invasive testing are discussed.Main Outcomes and Measures: The primary outcome measures were the sensitivity and specificity of aneuploidy detection by CSF mNGS. (stanford.edu)
A blood test for cancer screening has been the 'holy grail' ever since the carcinoembryonic antigen blood test in the 1960s was claimed to have nearly 100% sensitivity and specificity - but turned out not to - for colorectal cancer," wrote David F. Ransohoff, MD, a gastroenterologist at the University of North Carolina (UNC), in a 2021 article . (medscape.com)
Diagnostic accuracy parameters (sensitivity, specificity, positive predictive value, negative predictive value, accuracy) were calculated to evaluate HemoCue performance compared to the AHA reference, overall and by sociodemographic, nutritional, and metabolic characteristics. (cdc.gov)
The HemoCue had 74.8% sensitivity and 91.2% specificity, compared to AHA. (cdc.gov)

Decellularization (also spelled decellularisation in British English) is the process used in biomedical engineering to isolate the extracellular matrix (ECM) of a tissue from its inhabiting cells, leaving an ECM scaffold of the original tissue, which can be used in artificial organ and tissue regeneration. (wikipedia.org)
Organ and tissue transplantation treat a variety of medical problems, ranging from end organ failure to cosmetic surgery. (wikipedia.org)
Scientists can use the acquired ECM scaffold to reproduce a functional organ by introducing progenitor cells, or adult stem cells (ASCs), and allowing them to differentiate within the scaffold to develop into the desired tissue. (wikipedia.org)
The produced organ or tissue can be transplanted into a patient. (wikipedia.org)
This process of decellularizing tissues and organs is still being developed, but the exact process of taking a tissue from a donor and removing all the cellular components is considered to be the decellularization process. (wikipedia.org)
As far as introducing the different liquidized chemicals and enzymes to an organ or tissue, perfusion and immersion decellularization techniques have been used. (wikipedia.org)
Perfusion decellularization is applicable when an extensive vasculature system is present in the organ or tissue. (wikipedia.org)
1 The Control Item, essentially an isotype control, is usually a molecule identical in structure to the test item (including labels such as biotin or FITC) but raised against a molecule unlikely to be found in human tissue-for example, green fluorescent protein, a plant protein, or even snake venom. (genengnews.com)
5) as cell-surface components concerned in cell recognition, species specificity, and tissue immunity. (medmuv.com)
A series of sublethal doses of radiation is directed at the patient's lymphoid tissue (spleen, thymus, and lymph nodes in the neck, chest, and abdomen), with bone marrow and other vital organs shielded from the exposure [ 387 ]. (nanomedicine.com)
The amount of this intrinsic absorption can be used to determine the physiological health of an organ-for example, whether the tissue is getting sufficient oxygenated blood flow. (nationalacademies.org)
How is the tissue specificity of immune cells generated and how is it affected by environmental influences, plasticity and the tissue microenvironment? (mdc-berlin.de)
Select organ toxicity potentially results from compound accumulation in a particular tissue, cell types within organs, metabolism, and off-target effects. (nih.gov)
There was variation in tissue specificity among OTUs as well as variation among sites. (confex.com)
For example, A. alternata was found almost exclusively in leaf tissue and Phialocephala sp. (confex.com)

Toxicity in mammalian organ systems, techniques for evaluating toxicity, as well as mechanisms of species specificity, and environmental interactions (with toxicant examples) are presented. (wisc.edu)

One of the greatest limitations to organ transplantation derives from organ rejection caused by antibodies of the transplant recipient reacting to donor antigens on cell surfaces within the donor organ. (wikipedia.org)
Transplantation is the transfer of living cells, tissues, or organs from one person, the donor, to another, the recipient (e.g., a blood transfusion), or from one part of the body to another (e.g., skin grafts) with the goal of restoring a missing function [ 361 ]. (nanomedicine.com)
IVDs for clinical decisions on diagnosis and treatment, as does screening of blood/blood products for transfusion and human organs/tissues for transplantation. (who.int)

Peripheral tolerance occurs in the secondary lymphoid organs (e.g. spleen, lymph nodes, and mucosal/gut associated lymphoid tissues) and peripheral tissues. (frontiersin.org)

As with nearly all plants studied, Phragmites serves as a host to endophytic fungi that asymptomatically colonize its various tissues and organs. (confex.com)

Essentially, the presence of therapeutic antibody binding in frozen ex vivo tissues is used to give an indication of potential organ toxicity in vivo . (genengnews.com)
The gamma radiation emitted by the radionuclide allows organs to be imaged in vivo tomographically. (en-academic.com)
Only approximately 5% of compounds showed differential toxicity responses in the cell lines with no obvious correlation to the known in vivo organ toxicity. (nih.gov)

Whether such staining actually correlates with organ toxicity is still regularly debated, but TCR studies remain a requirement in the data package for an IND/CTA submission for most biotherapeutics. (genengnews.com)
Failure to appreciate the value of including a suitable Control Item for comparison may result in any binding of the Test Item being mistakenly interpreted as specific and therefore indicative of potential organ toxicity. (genengnews.com)
Our results suggest that from a general screening perspective, different cell lines have relatively equal value in assessing general cytotoxicity and that specific organ toxicity cannot be accurately predicted using such a simple approach. (nih.gov)

Likewise, good quality IVDs for the detection of infectious agents, for example, are crucial to controlling their transmission and to the appropriate allocation of valuable and often limited resources (i.e. medicines, laboratory testing, clinical expertise). (who.int)

First, a body may reject any transplanted organ (eg, kidney, pancreas, heart, lung, liver, and intestine) because the recipient's immune system recognizes the organ as foreign and initiates a rejection response (this can be in the form of antibody production) which could eventually destroy the organ. (hrsa.gov)
It represents an instant, convenient, and basic method for discovering GCA to diagnose liver organ diseases. (eprf.ca)
Introduction Liver organ disease has taken tremendous risk to humans, impacting the ongoing health of thousands of people worldwide before years. (eprf.ca)
Harm to liver organ cholestasis or cells could cause GCA metabolic disorders. (eprf.ca)
As a total result, the power of liver organ cells to soak up GCA is normally reduced, that leads to a rise in GCA bloodstream levels.13,14 Serum GCA focus is a particular and private biomarker of hepatic function.15?21 Therefore, Serum GCA is of great significance for the clinical medical diagnosis of liver illnesses. (eprf.ca)

For example, a patient could develop antibodies to A2 and A24. (hrsa.gov)
In the case of an organ transplant, the body will recognize the HLA antigens on the transplanted organ as not being the same as its own, and form specific antibodies against those particular HLA antigens. (hrsa.gov)

Loss of immune tolerance to autoantigens associated with a specific organ results in the activation of organ-specific T and B cells that in turn cause organ-specific inflammation and the development of autoimmune diseases such as multiple sclerosis (MS) ( 5 ), rheumatoid arthritis (RA) ( 6 ), psoriasis ( 7 ), and type 1 diabetes (T1D) ( 8 ). (frontiersin.org)
Section 8.5.2.1 ) are closely matched to those of the donor, transplanted organs are usually rejected (beginning within minutes or hours of surgery [ 1832 ]) unless the recipient's immune system is carefully controlled. (nanomedicine.com)
Antibody: A protein molecule produced by the immune system in response to a foreign body, such as virus or a transplanted organ. (hrsa.gov)
Immune molecular monitoring is under investigation to screen for rejection, though these techniques have suffered from low specificity and lack of spatial information. (jci.org)
Researchers are uncovering ever more details about the complex system of organs, tissues, and different cell types that make up the human immune system. (mdc-berlin.de)

Diagnosis of organ transplant rejection relies upon biopsy approaches to confirm alloreactive T cell infiltration in the graft. (jci.org)
In this work, we identify and characterize OX40 as a surrogate biomarker for alloreactive T cells in organ transplant rejection and monitor its expression by utilizing immunoPET. (jci.org)

For instance Melendez-Alafort labeled a HA-paclitaxel conjugate with 99mTc to evaluate its biodistribution through four different administration routes by measuring gamma-ray activity in organs and conducting gamma ray image analysis [22]. (sciencepop.org)

Here, we investigated the utility of hepatic-, cardiac-, and kidney-derived cell lines to (1) accurately predict cytotoxicity and (2) to accurately predict specific organ toxicities. (nih.gov)
In the kidney, for example, NKCC1 type proteins ensure that these ions are reabsorbed from the urine, and generally NKCC1 is important for osmotic cell volume regulation. (technologynetworks.com)
The researchers will now continue to try to identify novel compounds that interfere with NKCC1 function and that may help in for example kidney and brain disorders. (technologynetworks.com)

At both high (x ray) and low (radio frequency [RF]) energies the body is mostly transparent, thus allowing the non-invasive imaging of the internal structure of organs and bones. (nationalacademies.org)
[12] Breast cancer, for example, tends to metastasize to the bones and lungs. (explained.today)

Under this mechanism and proper physiological conditions, treatments can diffuse equally to all of the cells within the organ. (wikipedia.org)

The new scanner will allow us to push the boundaries in resolution for imaging function/ microstructure/connectivity in the brain and other organs, beyond the limits of what is currently feasible, exampled in the Figure, for understanding with higher specificity health and disease. (nottingham.ac.uk)

The tumor may hemorrhage acutely, perforate, or cause pain by invasion of adjacent organs. (medscape.com)
Examples are CRISPR/Cas9-mediated mutagenesis, genetic mouse models, cell-fate-mapping, organoids and tumor explants, as well as GMP production of pharmaceuticals and many years of experience in conducting clinical studies. (mdc-berlin.de)
The authors used artificial neural croarrays is to study changes in gene ex- .nature organ the tumor arose from, how big it networks (ANNs) to identify gene-ex- pression that accompany changes in is, and what it looks like after it has pression signatures associated with spe- cell physiology, such as during develop- been imbedded in wax and colored cific subtypes of tumors. (lu.se)

and right-bottom, example of the correlation of PET Graft + all-CLN ROI values with BLI signal, and PET muscle ROI values with BLI signal. (jci.org)

Entering unacceptable antigens for candidates increases the efficiency of organ allocation by screening off incompatible donors. (hrsa.gov)

Medical products of human origin are defined as substances that are derived wholly or in part from the human body and intended for clinical application.1 Source components in the human body range from organs, tissues, blood, cells and gametes to breast milk, hair, nails, urine and faeces. (who.int)
Nevertheless, the available guidance is somewhat fragmented and generally oriented towards a number of specific products (e.g. blood and organs/tissues/cells). (who.int)
Type 1 diabetes results from organ-specific autoimmunity, which eliminates most of the insulin-producing pancreatic beta cells. (springer.com)
The fungal metabolite cyclosporin A (cyclosporine) [ 384 , 385 ] has a greater specificity for lymphoid T cells than other cells. (nanomedicine.com)

Central tolerance occurs during lymphocyte development in the primary lymphoid organs (i.e. thymus and bone marrow), where T or B cell clones that recognize autoantigens with high-affinity are deleted. (frontiersin.org)

The location of the metastases is not always random, with different types of cancer tending to spread to particular organs and tissues at a rate that is higher than expected by statistical chance alone. (explained.today)
And the presepsin values were significantly higher in the patients with the more severe septic condition (for example, sepsis, severe sepsis, septic shock). (biomedcentral.com)

Entre le 1er janvier et le 31 décembre 2013, nous avons utilisé les données de la surveillance des patients hospitalisés pour une infection respiratoire aiguë sévère (IRAS) dans trois hôpitaux publics égyptiens dans le district de Damanhour afin d'estimer le taux d'incidence de la grippe saisonnière confirmée en laboratoire. (who.int)

In our view this is not appropriate because serology identifies overall exposure to HPV infections but does not identify HPV infections of specific organs such as the prostate. (biomedcentral.com)
There has been considerable interest in sophisticated mass spectrometry techniques, which can be applied for example to skin secretions, in order to detect airway infection in CF . The true test of the utility of these techniques will be whether they can differentiate children with non-specific respiratory symptoms from true asthmatics, and predict steroid responsiveness in the asthmatics. (knowyourasthma.com)
For example, if a candidate has developed a specific antibody to the HLA antigen A2, that person is said to be "sensitized" to the A2 antigen. (hrsa.gov)
The intense, focused light of lasers with these colors can be used for a wide variety of unique therapeutic interventions: making incisions, cauterizing and sealing wounds, and selectively heating or even vaporizing specific regions of organs and tissues. (nationalacademies.org)
Several publications have aimed to predict specific organ toxicities. (nih.gov)

The steps to go from a decellularized ECM scaffold to a functional organ is under the umbrella of recellularization. (wikipedia.org)

You may take care of yourself by eating well and exercising regularly and still have low back pain, migraines, headaches, stomach issues, breathing issues, or any organ or muscle issue. (gohlclinic.com)

For example, of the seven ovarian cancers found during the study, six were detected with CancerSEEK. (hopkinsmedicine.org)
Patatin is a single lipolytic acyl-hydrolase with broad substrate specificity, firstly found in potato tubers in 1970 [ 16 ]. (biomedcentral.com)
We found that the majority of compounds, regardless of their designated organ toxicities, had similar effects in all three cell lines. (nih.gov)
for example, S mutans and Streptococcus sanguis typically adhere to hard surfaces, while Streptococcus salivarius is found primarily on the tongue. (medscape.com)

When the probe and an example filled with GCA (most likely forming a smaller sized cluster because of non-covalent connections between GCA) is normally mixed on the glass slide, a more substantial crimson cluster is normally formed over the slide because of the recognition between your GCA cluster and anti-GCA, enabling us to detect the GCA by naked-eye visualization from the crimson spots. (eprf.ca)

Cryo-EM structure of the human NKCC1 transporter reveals mechanisms of ion coupling and specificity. (technologynetworks.com)

Many general maternal health interventions also reduce the risk of stillbirth, for example, antenatal care attendance. (bmj.com)
Substantial example, legislation can create a ministry of health to realize nosocomial transmission of multidrug-resistant and exten- a constitutional right to health. (cdc.gov)

A majority of radiopharmaceuticals labelled with 99m Tc are synthesized by the reduction of the pertechnetate ion in the presence of ligands chosen to confer organ specificity of the drug. (en-academic.com)
For example a HA-OPots800 conjugate synthesized via an adipic acid dihydrazide (ADH) linker was orally administrated for real-time bioimaging to investigate the optimal molecular weights and degree of chemical changes of HA for an efficient drug delivery [13]. (sciencepop.org)

One of the particularly exciting findings was that 14 of 45 cancers were in organs for which no standard screening exists. (hopkinsmedicine.org)

That specificity is especially important if we're to use this test in people who have no history of cancer," Lennon says. (hopkinsmedicine.org)

This "technology offers the potential to detect asymptomatic cancer at several organ sites with a simple blood test, often called a 'liquid biopsy,'" the National Cancer Institute (NCI) said this month . (medscape.com)
The classic organ systems are influenced by ters DNA repair or causes genomic mutation theory of cancer no longer mechanistic events associated with instability, (4) induces epigenetic fully encompasses the mechanistic cancer induction. (who.int)

[ 1 ] The energy emitted from 99m Tc is 140 keV, which allows for the study of deep body organs. (en-academic.com)

Germany's Epigenomics, for example, secured the first FDA approval for a CRC blood test, Epi ProColon, in 2016. (medscape.com)

Persons with SCD experience numerous complications, including recurrent episodes of severe pain, pneumonia and acute chest syndrome, stroke, and organ damage. (cdc.gov)

Radiopharmaceuticals containing 99m Tc are currently being applied in the determining morphology of organs, testing of organ function, and scintigraphic and emission tomographic imaging. (en-academic.com)

There are other ways that binding specificity can be assessed, for example, competing out binding by preincubation with a molar excess of soluble antigen. (genengnews.com)

Briefly, as proven in Figure ?Amount11a, when the mAb examples had been diluted 128,000 situations, the mAb had good affinity for the antigen still. (eprf.ca)

MRI utilizes magnetic properties of ions in the body along with computer-generated radio waves to create detailed images of the body's organs and tissues 4 . (tufts.edu)

Ingestion typically leads to profuse vomiting and diarrhea followed by multisystem organ failure and possibly death within 36 to 72 hours of exposure. (cdc.gov)
What was the effect of failure to state with specificity the provisions of the Constitution that were alleged to have been violated in a constitutional petition? (kenyalaw.org)

For example, such information can inform the dose-response relationship below the experimental observable range of tumours. (cdc.gov)

For example, the single-autoantibody-positive stage generally has a significantly lower of risk of progression [ 12 ] and as such is not considered as the earliest stage of type 1 diabetes. (springer.com)

Five cranial nerves contribute to the complex innervation of this multifunctional organ. (medscape.com)

The substitution examples of Pt and La were determined by ICP-MS analysis (Agilent Systems 7500 i. (sciencepop.org)

Anatomy2

Analytical, Diagnostic and Therapeutic Techniques and Equipment1

Phenomena and Processes4

Information Science1

Health Care1

Sensitivity11

Tissue15

Species specificity1

Transplantation3

Associated lymphoid1

Tissues and organs1

Vivo3

Toxicity3

Detection1

Liver5

Antibodies2

Immune5

Rejection2

Gamma1

Kidney3

Bones2

Physiological1

Limits1

Tumor3

Correlation1

Antigens1

Cells4

High1

Higher2

Patients1

Specific5

Functional1

Muscle1

Found4

Forming a small1

Human1

Health2

Drug2

Findings1

Important1

Cancer2

Study1

Blood1

Severe1

Function1

Ways1

Figure1

Body1

Failure2

Range1

Risk1

Complex1

Systems1