Exacerbation of asthma asthma. Medical search. Frequent questions

FRIDAY, Jan. 6, 2023 (HealthDay News) -- Air pollution is an independent risk factor for asthma exacerbations among children living in urban areas, according to a study published in the January issue of The Lancet Planetary Health . (breathinglabs.com)
Cite this: Survey: 42% of PCPs Not Familiar With Biologics for Asthma - Medscape - Nov 10, 2023. (medscape.com)
Treatment with either omalizumab (anti-immunoglobulin E [anti-IgE]) or nonomalizumab (non-anti-IgE) biologics reduced exacerbations in patients with severe asthma and allergic rhinitis, with the benefits being more evident among those taking nonomalizumab agents, according to the CHRONICLE trial presented at AAAAI 2023. (mims.com)

We conclude that neutrophils predominate more frequently than eosinophils as the major inflammatory cell in sputum from patients with asthma in acute exacerbation. (nih.gov)
This study aimed to (i) identify health service costs of hospitalizations and (ii) factors associated with these costs in children admitted to an Australian paediatric hospital following an acute exacerbation of their bronchiectasis. (asthmafoundation.org.nz)
Acute exacerbation of asthma (Master's thesis). (nsk.hr)
Gershkovich D. Acute exacerbation of asthma [Master's thesis]. (nsk.hr)
Patients having an asthma exacerbation are instructed to self-administer 2 to 4 puffs of inhaled albuterol or a similar short-acting beta agonist up to 3 times spaced 20 minutes apart for an acute exacerbation and to measure peak expiratory flow (PEF) if possible. (msdmanuals.com)
80% of baseline), the acute exacerbation may be managed in the outpatient setting. (msdmanuals.com)

Appropriate drugs for asthma exacerbations include inhaled corticosteroids (ICS) and a combination of ICS treatment and long-acting beta-agonists. (medicalnewstoday.com)
Anti-inflammatory therapy is crucial for long-term asthma management, and inhaled corticosteroids (ICS) are recommended as a first-line treatment. (aaaai.org)
It was noted that most subjects failed to foresee the possibility of worsening of their asthma during travel and there was significant underuse of inhaled corticosteroids in all groups. (bmj.com)
Ever since inhaled corticosteroids (ICS) were first introduced as an effective prophylactic agent, there has been a debate over whether asthma exacerbations can be treated by increasing the dose. (bmj.com)
Short courses of systemic corticosteroids (scs), both oral and injectable, are very effective for the resolution of acute asthma symptoms, including. (clinicaaffetus.com)
Beta agonists Major drug classes commonly used in the treatment of asthma and asthma exacerbations include Bronchodilators (beta-2 agonists, anticholinergics) Corticosteroids Leukotriene modifiers Mast cell. (msdmanuals.com)
Outcomes were poor asthma control (based on asthma symptoms) and exacerbations rates (asthma-related visits to the emergency department, asthma-related hospitalisations or use of oral corticosteroids). (uu.nl)
Do you or your child have severe asthma that is not easily controlled by inhaled corticosteroids? (nih.gov)
10 × 109 /L, fever , use of systemic corticosteroids before admission, and early-onset asthma . (bvsalud.org)
Mild exacerbation was defined as being neither severe nor moderate exacerbation, and increasing usage of inhaled corticosteroids. (cdc.gov)
Results: BT significantly improved asthma control and quality of life at both 3 and 12 months and decreased the numbers of severe exacerbations and the dose of oral corticosteroids. (lu.se)

Asthma is a chronic respiratory condition that causes inflammation and narrowing of the airways. (medicalnewstoday.com)
Viral respiratory infections, such as the human rhinovirus subtypes A and C, are the most common causes of asthma exacerbations in adults and children. (medicalnewstoday.com)
However, having a respiratory infection does not necessarily mean that a person will experience an asthma exacerbation. (medicalnewstoday.com)
Fifty percent of the subjects with asthma reported that their asthma exacerbation was precipitated by a respiratory tract infection, and these subjects had a significantly higher percentage of neutrophils in their sputum (85% +/- 6% vs 57% +/- 12%, p = 0.05). (nih.gov)
We speculate that this may be because respiratory tract infections are a frequent precipitant of acute asthma. (nih.gov)
Kistler A , Avila PC , Rouskin S , Wang D , Ward T , Yagi S , Pan-viral screening of respiratory tract infections in adults with and without asthma reveals unexpected human coronavirus and human rhinovirus diversity. (cdc.gov)
The goal of asthma control should rely on a multi-disciplinary treatment protocol but not merely on efforts of respiratory physicians. (researchsquare.com)
The 966 participants were working adults with current asthma who participated in the follow-up phase of the European Community Respiratory Health Survey. (unipv.it)
Triggers for an asthma exacerbation can vary between individuals but commonly include exposure to allergens (such as dust mites, pollen, or pet dander), respiratory infections (like the common cold or flu), irritants (such as tobacco smoke or air pollution), exercise, stress, certain medications. (nsk.hr)
In assessing the severity of the exacerbation, it is crucial to evaluate pulse rate, respiratory rate, subjective assessment of respiratory distress, and accessory muscle use. (nsk.hr)
Further studies are needed to elucidate the complex immunological mechanisms that lead to asthma exacerbation after respiratory tract viral infection. (unipr.it)
Matthew C. Altman, M.D., from the University of Washington in Seattle, and colleagues examined the association between regional air pollutant concentrations and asthma exacerbations occurring in the absence of respiratory virus among children with asthma. (breathinglabs.com)
These data add to the growing body of evidence supporting the need to reduce outdoor air pollution as a means to decrease respiratory illnesses and asthma-related morbidity in children living in urban areas," the authors write. (breathinglabs.com)
Oxidative stress due to increased production of oxygen free radicals has been reported in various respiratory diseases including asthma and pneumonia. (pneumon.org)
One of the most common chronic respiratory conditions, asthma is a chronic disease of the airways (bronchi) to your lungs. (summahealth.org)
Asthma is a potentially life-threatening respiratory condition and one of the top ten leading chronic diseases afflicting the working population in the United States. (cdc.gov)

It is widely recognised that viral infections are the most frequent causes of asthma exacerbations both in children and in adults, being rhinovirus the most frequent identified virus. (unipr.it)

evaluated the association between statin use and an asthma diagnosis and asthma-related outcomes such as emergency department visits, hospitalization, and systemic steroid use using the Korean National Health Insurance Service-Health Screening Cohort data. (aaaai.org)
Some studies have shown an association between hospitalization for asthma during pregnancy and low birth weight of the neonate, whereas in others there was no correlation between birth weight and acute asthmatic attacks during pregnancy. (aafp.org)
The inclusion criteria for this study included patients with diagnosed severe asthma for at least 12 months, a FEV 1 of less than 80% of its predicted value, and a minimum of two asthma exacerbations required hospitalization. (2minutemedicine.com)

This clinical tool may assist clinicians to identify children at high risk for exacerbation that may benefit from more aggressive management. (aaaai.org)

In addition, the severity of exacerbations should likewise be assessed in the clinic to determine the appropriate management for these patients. (mims-cpd.com.my)

The number of patients needed to treat with quadruple self-management to prevent one severe asthma exacerbation was 15. (nejm.org)

Asthma is the most common chronic condition associated with complications during pregnancy and carries an increased risk of poor outcomes for the fetus. (aafp.org)
The relationship between severity of asthma during pregnancy and perinatal outcomes is unclear. (aafp.org)
Murphy and colleagues evaluated asthma exacerbations in 146 Australian women enrolled in a prospective cohort study of asthma to establish the rate of severe exacerbations during pregnancy and investigate the relationship between exacerbation rate and perinatal fetal outcomes. (aafp.org)
No statistically significant differences were found in overall pregnancy outcomes between women who experienced a severe exacerbation of asthma during pregnancy and those who did not, although there was a trend toward lower neonate birth weight in women who had a severe exacerbation. (aafp.org)
The study was too small to establish significant relationships between exacerbations of asthma and poor pregnancy outcomes, but it showed significantly reduced birth weight in male infants. (aafp.org)
NCT03347279 ) to calculate the annualized asthma exacerbation rate (AAER) over 1 year and secondary outcomes in the overall pooled population and in specific subgroups. (breathinglabs.com)
With respect to other outcomes, tezepelumab also improved lung function, asthma control, and HRQoL compared with placebo. (breathinglabs.com)
Rationale Progressive lung function (LF) decline in patients with asthma contribute to worse outcomes. (elsevierpure.com)
Hogan said that the results show the need for more studies to demonstrate that asthma specialists can improve outcomes and reduce healthcare costs. (medscape.com)
Although there are multiple biologics approved for uncontrolled severe asthma such as monoclonal antibody therapies, they have different mechanisms of action with outcomes that may vary by type (eg, IgE therapies vs other biologics)," said lead author Dr Warner Carr from the Allergy & Asthma Associates of Southern California in Mission Viejo, California, US. (mims.com)

The authors conclude that women with asthma experience an increased rate of exacerbations during pregnancy and require substantial medical interventions. (aafp.org)
At 6 months after biologic initiation, the overall rate of exacerbations was reduced by 47.8 percent (from 1.36 percent to 0.71 percent) in the omalizumab group and 55.3 percent (from 1.70 percent to 0.76) in the nonomalizumab group. (mims.com)

This Initial Check will help you assess your current knowledge about Environmental Triggers of Asthma. (cdc.gov)
What further questions might you ask about other environmental triggers of asthma in this household? (cdc.gov)

In addition to reductions in exacerbations in patients with high baseline BEC and FeNO levels, meaningful reductions were also observed in patients with low levels of T2 inflammatory biomarkers and across subgroups with varying perennial allergy status, maintenance OCS use, exacerbation history, ICS dose, history of nasal polyps, and BMI. (breathinglabs.com)
Reductions in exacerbations were also seen in patients with low levels of T2 inflammatory biomarkers and across subgroups with varying exacerbation history, nasal polyps history, body mass index, maintenance oral corticosteroid use, and inhaled corticosteroid dose. (breathinglabs.com)
As a result, reductions in exacerbations varied by patient age of onset and biologic, Ledford noted. (mims.com)

He suggests that "categorizing asthma exacerbations by putative cause, such as infection, nonadherence to medication, and other exposures, and thus to 'phenotype' asthma exacerbations" we may be able to better tailor "earlier interventions and appropriately matched treatments, some of which may not include glucocorticoids. (nejm.org)
Impact of occupational exposures on exacerbation of asthma: a population-based asthma cohort study. (cdc.gov)
The current study investigated the association between asthma exacerbations and occupational exposures. (cdc.gov)
All subjects completed a questionnaire about exposures, occupations and exacerbations of asthma. (cdc.gov)
Multiple logistic regression was applied to investigate the association between exacerbation of asthma and occupational exposures while adjusting for potential confounders. (cdc.gov)
Reduction of these occupational exposures may help to reduce exacerbation of asthma. (cdc.gov)
Because of the large number of adults whose asthma appears to result from exposures in the workplace, as well as the high percentage of people who report that their asthma is worse on the job, employers should seek to create "asthma-friendly" work environments. (cdc.gov)

However, predicting which children are at highest risk of asthma exacerbation is challenging given the wide variety of clinical presentations and triggers. (aaaai.org)
Niu et al in The Journal of Allergy and Clinical Immunology: In Practice analyzed longitudinal EMR data for over 3,000 participants with asthma seen at Cincinnati Children's Hospital Medical Center over a 7-year period. (aaaai.org)
A clinical tool to determine exacerbation risk was created based on this model. (aaaai.org)
This study provides a practical tool that may be used in the clinical setting to determine risk of exacerbations in children with asthma based on a variety of clinical characteristics and laboratory findings found in the electronic health record. (aaaai.org)
Despite positive preclinical data on statin use in patients with asthma, clinical trials and epidemiological studies have yielded conflicting results. (aaaai.org)
For this purpose, Global Initiative for Asthma (GINA) recommendations underline the need to identify and handle the comorbidities as a key part of clinical practices for asthma patients [ 1 ] . (researchsquare.com)
Medicine Central , im.unboundmedicine.com/medicine/view/5-Minute-Clinical-Consult/1688494/all/Asthma_Exacerbation__Pediatric_Acute. (unboundmedicine.com)
In patients with severe, uncontrolled asthma, tezepelumab treatment resulted in clinically meaningful reductions in asthma exacerbations across patient subgroups defined by inflammatory biomarker levels and clinical characteristics. (breathinglabs.com)
The analysis assessed tezepelumab efficacy and safety in subgroups of patients with severe, uncontrolled asthma defined by both clinical characteristics and inflammatory biomarker levels. (breathinglabs.com)
The aim of this study is to investigate the clinical characteristics of acute asthma exacerbations (AEs) with community -acquired pneumonia (CAP) in adults and establish a CAP prediction model for hospitalized patients with AEs. (bvsalud.org)
Objective: We sought to examine the effect of BT on bronchial structures and to explore the association with clinical outcome in patients with severe refractory asthma. (lu.se)

Three months ago, she was hospitalized for 3 days for an acute asthma exacerbation, leading to treatment with systemic glucocorticoids. (nejm.org)
studied 1922 patients aged 16 years or older who had at least one exacerbation requiring systemic glucocorticoids in the past 12 months. (nejm.org)
Systemic steroids are suggested in guidelines for pediatric asthma exacerbations. (medscape.com)
It is hoped that this will improve in the future, but even just having a low vitamin D level for a year or so will be more than enough to cause problems, as we will see below, systemic steroids asthma inhaler. (clinicaaffetus.com)

Adjusted linear growth models tested the association between mean annual exacerbation rate (AER) and lung function trajectory. (elsevierpure.com)

Race, allergic sensitization, and smoke exposure were significantly associated with an increased risk of asthma exacerbations across all age groups. (aaaai.org)
Conclusions: Comorbidities such as COPD, coronary heart disease and allergic rhinitis, may have an important role in the risk and/or frequency of annual hospitalisations due to asthma exacerbation. (researchsquare.com)
Data were analyzed from the MUPPITS1 cohort, which recruited 208 children aged 6 to 17 years living in urban areas with exacerbation-prone asthma, and validated in the ICATA cohort, which included 419 participants aged 6 to 20 years living in urban sites with persistent allergic asthma. (breathinglabs.com)
Biologics have become an important tool in the treatment of asthma and other allergic diseases such as atopic dermatitis (eczema), chronic rhinosinusitis with nasal polyps and eosinophilic esophagitis , and can prevent substantial ill results from occurring in patients who are eligible for them. (medscape.com)
Allergic bronchopulmonary aspergillosis is a hypersensitivity reaction to bronchial colonization by Aspergillus fumigatus mold, typically affecting patients with asthma or cystic fibrosis. (bmj.com)
The ongoing real-world observational study analysed 598 adults (aged ≥18 years) with severe asthma, of whom 339 had a diagnosis of allergic rhinitis, treated by subspecialists in the US. (mims.com)
While those with allergic rhinitis, the decrease in exacerbation rate was more pronounced among those treated with nonomalizumab than those treated with omalizumab (58.8 percent vs 39.3 percent). (mims.com)

However, not all patients achieve asthma control despite standard treatment, and some patients need additional therapies. (aaaai.org)
Pre-emptively identifying patients with asthma most at risk for exacerbation and intervening to improve their asthma control has the potential to save lives. (pcrs-uk.org)
Searching practice databases for patients with combinations of these characteristics and inviting them for urgent review could avoid the next potentially life-threatening exacerbation and get patients back on a pathway of stable control. (pcrs-uk.org)
Dr Ananth also highlighted the need for a holistic, patient-centred approach and suggested that, for example, patients with obesity-related non-eosinophilic asthma, strategies such as weight management, reflux control and macrolide therapy may be more beneficial that increasing ICS dose. (pcrs-uk.org)
Results: Among 3875 ambulatory asthma patients, 75.9% (2941/3875) had comorbidities, and 26.4% (1017/3858) experienced H-AX during past year. (researchsquare.com)
Asthma exacerbations, especially those necessitating hospital admissions, contribute to the majority of the healthcare expenses in asthma patients [ 2 ] . (researchsquare.com)
Nevertheless, the role of comorbidities on asthma exacerbations remains less recognised, particularly, in a huge population of Chinese patients. (researchsquare.com)
In that study steered with approval by the Ethics Committee of China Japan Friendship Hospital, data on demography, asthma control, medical and self- management, exacerbations, and disease perception were collected during face-to-face interviews with written informed consent from the patients. (researchsquare.com)
The patients were instructed to follow one of the following self-management plans when asthma control started to deteriorate: (a) continue the use of inhaled glucocorticoids at normal dose or (b) quadruple the dose of inhaled glucocorticoids (quadrupling group) for up to 14 days. (nejm.org)
The primary outcome was the percentage of patients who continued to experience asthma symptoms on day 7, along with quality-of-life scores. (medscape.com)
Exacerbations may occur with or without triggers hence it is important to recognize patients at risk for exacerbation. (mims-cpd.com.my)
Peripheral blood CD4 but not CD8 t-lymphocytes in patients with exacerbation of asthma transcribe and translate messenger RNA encoding cytokines which prolong eosinophil survival in the context of a Th2-type pattern: effect of glucocorticoid therapy. (atsjournals.org)
PEF home monitoring is especially useful to patients over 5 years of age with moderate persistent to severe persistent asthma. (cdc.gov)
The goal of asthma exacerbation treatment is to relieve symptoms and return patients to their best lung function. (msdmanuals.com)
1. Subcutaneous tezepelumab treatment reduced the rate of annual asthma exacerbations in patients with severe asthma compared to the placebo group. (2minutemedicine.com)
In patients with severe asthma, thymic stromal lymphopoietin (TSLP) is a cytokine that exacerbates airway obstruction and increases airway inflammation. (2minutemedicine.com)
In-Depth [randomized controlled trial]: This randomized control trial across 297 sites in 18 countries enrolled 1,061 patients between the ages of 12 and 80 with severe asthma. (2minutemedicine.com)
Together, this study demonstrated the benefit of tezepelumab in improving symptom control and quality of life for patients with severe asthma. (2minutemedicine.com)
Together, these findings further support the benefits of tezepelumab in a broad population of patients with severe, uncontrolled asthma ," noted the researchers. (breathinglabs.com)
Meloxicam is contraindicated in patients with aspirin-sensitive asthma. (nih.gov)
The EUA allows for the use of gammaCore Sapphire™ CV at home or in a healthcare setting to acutely treat adult patients with known or suspected COVID-19 who are experiencing exacerbation of asthma-related dyspnea and reduced airflow, and for whom approved drug therapies are not tolerated or provide insufficient symptom relief. (electrocore.com)
Methods This historical cohort study of a broad asthma patient population in the Optimum Patient Care Research Database, examined asthma patients with 3+ eligible post-18th birthday peak expiratory flow rate (PEF) records (primary analysis), or records of forced expiratory flow in 1 second (FEV1) (sensitivity analysis). (elsevierpure.com)
Earlier intervention with appropriate management in younger asthma patients could be of value to prevent excessive lung function decline. (elsevierpure.com)
We concluded that serum total antioxidant status in patients with severe exacerbation of bronchial asthma or community-acquired pneumonia is relatively low at the onset of the disease. (pneumon.org)
Total antioxidant status changes are associated with respective changes in parameters related to disease severity in both asthma and pneumonia patients. (pneumon.org)
ANAHEIM, California - Patients with uncontrolled asthma are seen more often by primary care providers (PCPs) than by allergists, but a survey has found that 42% of PCPs are unfamiliar with the biologics that have markedly improved asthma treatment options over the past two decades. (medscape.com)
Bijalben Patel, MD, with the Department of Internal Medicine, University of South Florida (USF) Morsani College of Medicine in Tampa, told Medscape Medical News that in addition to the considerable lack of knowledge of biologics in primary care, she was surprised that 77% of survey participants stated they only referred patients to specialists after two or more exacerbations. (medscape.com)
This is important because these patients are considered to have exacerbation-prone asthma which should be managed by specialists," she said. (medscape.com)
Familiarity did not vary in primary care with number of patients with asthma seen per month, the researchers noted. (medscape.com)
Patel explained that lab work such as obtaining immunoglobulin E levels and a complete blood count with a differential and examining the absolute eosinophil count help identify patients who are at high risk for future exacerbation and also treatable phenotypic traits, which can be targeted with biologic therapy. (medscape.com)
We know that asthma patients treated by an allergist have better asthma control, better quality of life, and reduced healthcare costs. (medscape.com)
http://www.ncbi.nlm.nih.gov/pubmed/22547692?tool=bestpractice.com Patients usually have a prior diagnosis of atopy, asthma, or cystic fibrosis. (bmj.com)
Among patients with total IgE levels of ≥150-400 IU/mL, treatment with nonomalizumab was associated with a greater reduction in exacerbation rates compared with omalizumab (62.6 percent vs 44.3 percent). (mims.com)
There was also a greater reduction in exacerbations among patients with a total IgE level of 400 IU/mL who received nonomalizumab than omalizumab (77.8 percent vs 50.0 percent). (mims.com)
Overall, among this large cohort of patients with severe asthma, exacerbations decreased following initiation of biologics, with greater magnitude among those with higher total IgE levels and in those treated with nonomalizumab agents," he noted. (mims.com)
Among those with late-onset asthma (aged ≥40 years), patients on nonomalizumab biologics achieved a greater reduction in exacerbation rates than those on omalizumab (60.8 percent vs 24.6 percent). (mims.com)
Patients may be referred for asthma specialty care when there is concern regarding the proper diagnosis, co-morbid conditions, difficulty in obtaining good asthma control or a need for additional testing. (summahealth.org)
Even with compliance to a plan of care, patients with asthma are at risk for "flare ups," or exacerbations, so an action plan also will be provided. (summahealth.org)
Background: The effectiveness of bronchial thermoplasty (BT) has been reported in patients with severe asthma, yet its effect on different bronchial structures remains unknown. (lu.se)
Methods: Bronchial biopsy specimens (n = 300) were collected from 15 patients with severe uncontrolled asthma before and 3 months after BT. (lu.se)
Conclusion: BT is a treatment option in patients with severe therapy-refractory asthma that downregulates selectively structural abnormalities involved in airway narrowing and bronchial reactivity, particularly ASM, neuroendocrine epithelial cells, and bronchial nerve endings. (lu.se)

Interventions that prevent hospitalized exacerbations and reduce severity of childhood bronchiectasis with even moderate effectiveness are likely to result in substantial hospital costs savings. (asthmafoundation.org.nz)
Over the last decade, numerous scientific studies and program evaluations have shown that a combination of interventions tailored to the individual can bring asthma under control cost-effectively. (cdc.gov)
An Asthma Regional Council/University of Massachusetts Lowell publication -- Insurance Coverage for Asthma: A Value and Quality Checklist -- recommends coverage elements, based on analysis of interventions shown to be cost-effective in the research literature. (cdc.gov)

Conditional and unconditional logistic regression analyses were used to evaluate the effect of the previous use of statins on an asthma diagnosis or asthma exacerbations (AE) after adjusting for multiple covariates. (aaaai.org)
This study showed there was no significant association between statin use and an asthma diagnosis (adjusted odds ratio [aOR]=1.01, 95% confidence interval [CI]=0.98-1.03, P=0.633 for one year of statin prescription). (aaaai.org)
1. Physician diagnosis of asthma 2. (cdc.gov)
Your primary working diagnosis for this patient is asthma. (cdc.gov)
The information for this answer comes from the "Differential Diagnosis of Asthma" section. (cdc.gov)

These include more than one exacerbation managed in primary care in the last 12 months, use of high-dose ICS, high use of SABA inhalers and high BMI. (pcrs-uk.org)
Severe exacerbation of asthma was defined as sought emergency care at a hospital, admitted to a hospital overnight, or made an urgent visit to a primary care physician or district medical office due to breathing problems during the last 12 months. (cdc.gov)

Factors associated with exacerbations included the winter season (43 percent of exacerbations), possible viral infection (34 percent), smoking (28 percent), and nonadherence to inhaled corticosteroid medication (29 percent). (aafp.org)
Role of viral infections in asthma exacerbations / Contoli, M. (unipr.it)

Bronchial asthma is a heterogeneous disease characterised by chronic airway inflammation and associated with hefty social and economic burdens [ 1 ] . (researchsquare.com)

Doctors use a measurement called the percent predicted passive expiratory volume or forced expiratory volume to classify the exacerbation as mild, moderate, severe, or life threatening. (medicalnewstoday.com)
Most of the time, if someone has a mild exacerbation, they can manage the treatment at home. (medicalnewstoday.com)
Prepregnancy asthma was classified as mild, moderate, or severe using national guidelines based on history, symptom severity and frequency, medication use, and pulmonary testing (e.g., forced expiratory volume and peak expiratory flow). (aafp.org)
A mild exacerbation, or loss of control, was defined as an episode managed by the patient and characterized by an increase in symptoms or medication use, or a period of decreased peak flow on home monitoring. (aafp.org)
Mild exacerbations were documented in 34 women (23 percent) at a median gestation of 28.5 weeks. (aafp.org)
Seven women reported mild and severe exacerbations. (aafp.org)
Eight percent of women with mild asthma before pregnancy experienced severe exacerbations during pregnancy compared with 47 percent of those with moderate background asthma and 65 percent of those with severe background asthma. (aafp.org)
The symptoms of an acute asthma exacerbation can range from mild to life-threatening. (nsk.hr)
In another case, 10-year-old Dynasty Reese, who had mild asthma, woke up in the middle of the night and ran to her grandfather's bedroom to tell him she couldn't breathe. (savvyessaywriters.org)
Asthmagens and low molecular weight agents classified by the N-JEM were associated with mild exacerbation, with OR 1.6[1.1-2.5] and OR 2.2[1.1-4.4], respectively. (cdc.gov)

In addition, the high IL-8 levels and free neutrophil elastase activity observed in asthmatic sputum suggests that IL-8 may mediate airway neutrophilia in acute asthma and that neutrophil elastase may mediate mucin glycoprotein hypersecretion in acute asthma, as has been proposed for the mucin hypersecretion in CF. (nih.gov)
After stratification for sex, the differences in odds ratios for girls and boys were similar, yet no longer statistically significant.In asthmatic children, obesity is associated with a minor increased risk of asthma exacerbations but not with poor asthma control. (uu.nl)
We aimed to evaluate the role of serum OPN and its association with 25-OH Vitamin D [25(OH)D] levels in asthmatic children and to investigate the possible role of associations during non-exacerbation and exacerbation periods and to compare the results with controls. (biomedcentral.com)
CD4+subsetofT-lymphocytesaswell fromamongattendeesatoutpatient taminehydrochloride)controls.Wheal aseosinophilsintheairwaysofpatients clinicswhocameforroutinevaccina- size was measured after 15 minutes with asthma than in non-asthmatic tionorregularcheck-ups. (who.int)

Besides these, having uncontrolled asthma is inherently related to frequent exacerbations [ 11 ] . (researchsquare.com)

A popular strategy is doubling the dose at the first sign of an exacerbation (sometimes termed the 'yellow zone'), but trials have not shown this to be effective. (bmj.com)
A 25-year-old woman who has had asthma since childhood is currently on a combination of inhaled glucocorticoid (at the lowest dose form for the brand) and a long-acting beta agonist (LABA). (nejm.org)
Two important trials in the March 8th issue of NEJM examined whether quadrupling the dose of inhaled glucocorticoids (option C) when asthma control starts to deteriorate reduces the incidence of subsequent severe asthma exacerbations. (nejm.org)
These compelling data show that a two-dose course of dexamethasone appears to be a very attractive option for treating children and young teens with asthma exacerbations. (medscape.com)

The primary goal of asthma treatment is to control an individual's symptoms and prevent exacerbations. (medicalnewstoday.com)

The symptoms of asthma exacerbations include coughing, wheezing, chest tightness, and shortness of breath. (medicalnewstoday.com)
An acute asthma exacerbation presents as an acute or subacute episode of progressive worsening of asthma symptoms, such as shortness of breath, wheezing, cough, and chest tightness. (nsk.hr)

These increases are significant enough that the individual needs to change their treatment methods or current asthma action plan. (medicalnewstoday.com)
Methods: Based on a national survey on asthma control and disease perception (CARN 2015 study), we analysed the impact of comorbidities on annual incidence and frequency of H-AX in China. (researchsquare.com)
Methods: The study comprised all currently working adults (n = 1356) who reported ever asthma in prior population-based cohorts. (cdc.gov)

Development of a nomogram to estimate the risk of community-acquired pneumonia in adults with acute asthma exacerbations. (bvsalud.org)

Due to this, doctors need to identify any people who may be at risk and have a management plan in place for them to use should they experience an asthma exacerbation. (medicalnewstoday.com)
Individuals with one or more risk factors for asthma-related death may need emergency care, as may children, who have an increased risk of complications during an asthma exacerbation. (medicalnewstoday.com)
Early identification of children at increased risk of asthma exacerbations would allow early intervention and possible reduction in the severity of these episodes. (aaaai.org)
Currently, no tool exists that accurately predicts exacerbation risk using electronic health record data. (aaaai.org)
Each age group was divided into an original group of children used to build the risk score model to predict exacerbation in the next 12 months and another to confirm the results of the original group of children. (aaaai.org)
For each age group, a higher score was associated with a higher risk of an asthma exacerbation in the subsequent year. (aaaai.org)
Asthma in adventure travelers: a prospective study evaluating the occurrence and risk factors for acute exacerbations. (bmj.com)
0.001), emergency department treatment in the previous year, pre-exercise wheezing, and significant wheezing after exercise were all identified as risk factors for worsening of asthma. (bmj.com)
demonstrated that 39% of doctor diagnosed pediatric asthma can be attributed to residential risk factors including environmental tobacco smoke (ETS) and indoor allergens [ 2 ]. (biomedcentral.com)
Abstract The goal of this study was to identify occupational risk factors for severe exacerbation of asthma and estimate the extent to which occupation contributes to these events. (unipv.it)
Based on this RR, the population attributable risk was 14.7% among workers with current asthma. (unipv.it)
Risk factors that sensitize the airways and cause the onset of asthma. (cdc.gov)
Risk factors that either augment the likelihood of asthma developing upon exposure to them, or may even increase susceptibility to asthma. (cdc.gov)
Risk factors involved in the development of the condition of asthma can be inherited, such as atopy. (cdc.gov)
Risk factors that cause asthma exacerbation in individuals who already have the condition. (cdc.gov)
What are some risk factors for asthma in this patient and her family? (cdc.gov)
However, there are still few studies on risk factors for work-exacerbated asthma. (cdc.gov)

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow restriction and airway hyperresponsiveness. (aaaai.org)
Asthma is a chronic inflammation of the airways that may have periods of adequate symptom control with episodes of exacerbations that are beyond the normal day-to-day fluctuation of baseline function. (mims-cpd.com.my)
Asthma can cause swelling, narrowing or spasms of the airways and extra mucus production. (summahealth.org)

The study determined tezepelumab treatment significantly reduced the annual rate of asthma exacerbations compared to the placebo treatment. (2minutemedicine.com)

The children were diagnosed with asthma if they had at least two previous episodes of wheezing that was responsive to beta agonists, and all were required to have asthma symptoms at enrollment, including wheezing, dyspnea, cough, or increased work of breathing. (medscape.com)
The most common symptoms of asthma include, shortness of breath, wheezing, chest pain and cough. (summahealth.org)

Asthma exacerbations are progressive increases in asthma symptoms , including coughing, shortness of breath, or wheezing. (medicalnewstoday.com)

Pediatric asthma is currently the most prevalent chronic disease in the United States, with children in lower income families disproportionately affected. (biomedcentral.com)
Pediatric asthma is currently the most prevalent chronic disease in the United States. (biomedcentral.com)
Asthma is a chronic disease meaning that there is no cure. (summahealth.org)
Background: Asthma is a prevalent chronic disease and occupation contributes to approximately 15 % of cases among adults. (cdc.gov)

Association of rhinovirus infections with asthma. (cdc.gov)
Despite optimised therapy, as suggested by International Guidelines, asthma exacerbations still occur Several data documents that rhinovirus is able to infect and replicate at lower airway epithelial level and is able to induce features of asthma including eosinophilic airway inflammation and to increase bronchial hyperresponsiveness. (unipr.it)

We combine indoor air quality modeling with a previously developed discrete event model for pediatric asthma exacerbation to simulate the effects of different types of energy retrofits implemented at an affordable housing site in Boston, MA. (biomedcentral.com)
with Anti-inflammatory effects) and PAGES (Pediatric Asthma Gene Environment Study)) and 11 previously published studies (cross-sectional and longitudinal studies). (uu.nl)

OPN might play a role in childhood asthma and can be a useful marker for prediction of exacerbation. (biomedcentral.com)

However, although it is possible to reduce the frequency of exacerbations, even the best treatment and management may not prevent them entirely. (medicalnewstoday.com)
Further studies are needed to assess the usefulness of optimising asthma control before travel, avoidance of intensive trekking, and the use of crisis management plans to minimise the frequency of asthma attacks in adventure travellers. (bmj.com)
Information on demographic characteristics, asthma comorbidities and annual incidence and frequency of H-AX were presented in this study. (researchsquare.com)

Moderate exacerbation was defined as both being not severe exacerbation and an additional visit to a primary care physician or district medical office, or had extra treatments with corticosteroid tablets. (cdc.gov)
Results: Approximately 26 % of the working asthmatics reported exacerbation, and more than two-thirds of them had moderate or severe exacerbation. (cdc.gov)

The results of the survey point to the need to improve the communication between primary care physicians and asthma care specialists, including regarding use of biologics," senior author Juan Carlos Cardet, MD, MPH, also an allergy specialist at USF, added in a press release . (medscape.com)

Symptoms of asthma in the past 12 mo 3. (cdc.gov)
Severe exacerbation of asthma was defined as self-reported unplanned care for asthma in the past 12 months. (unipv.it)

Asthma exacerbations commonly lead to costly unplanned emergency department visits and hospitalizations. (aaaai.org)
The participants included all consenting women who were pregnant and had asthma and who made two or more antenatal visits to a university clinic. (aafp.org)
Histopathologic parameters were associated based on Asthma Control Test scores, numbers of exacerbations, and visits to the emergency department (all P ≤ .02) 3 and 12 months after BT. (lu.se)

Exposure to high and low molecular weight agents, irritating agents and asthmagens were classified using the asthma-specific job exposure matrix for northern Europe (N-JEM). (cdc.gov)
Conclusions: Self-reported exposure to any gas, smoke or dust, organic dust, dampness and mold, cold conditions and physically strenuous work, and jobs handling low molecular weight agents were associated with exacerbation of asthma. (cdc.gov)
Furthermore, existing exposure limits might not be protective against asthma-like symptoms. (cdc.gov)

In citing study limitations, the investigators noted that there were some differences in eligibility criteria between the studies, including a small cohort of adolescents in NAVIGATOR but not in PATHWAY, as well as slightly different requirements relating to pre-study inhaled corticosteroid dosing and the number of exacerbations within the previous 12 months. (breathinglabs.com)
Conclusion To our knowledge this study is the largest nationwide cohort of its kind and demonstrates that asthma exacerbations are associated with faster lung function decline. (elsevierpure.com)

These situations continue to outline the importance of recognizing symptoms of asthma and providing immediate treatment, as well as distinguishing minor symptoms from serious, life-threatening symptoms. (savvyessaywriters.org)

Subgroup analysis showed a significantly decreased birth weight in male neonates whose mothers had a severe exacerbation. (aafp.org)
Total asthma cases had higher eosinophil counts and s-ECP levels than healthy children and partially controlled asthmatics had significantly higher levels of both markers than controlled asthmatics. (who.int)

If an individual has asthma, their doctor may use a measurement of airflow called diurnal variability to assess the condition. (medicalnewstoday.com)
a stimulus that causes an increase in asthma symptoms and/or airflow limitation. (cdc.gov)

Exacerbations are different than difficult-to-control asthma. (medicalnewstoday.com)
Diurnal variability measures the difference between a person's highest and lowest scores on a peak expiratory flow rate test , and it is a key marker of poor asthma control. (medicalnewstoday.com)
Although diurnal variability changes in people who find it difficult to control their asthma, it might not change during an exacerbation. (medicalnewstoday.com)
Purpose: While asthma comorbidities are associated with higher health care utilisation, lower quality of life and poorer asthma control, the impact of asthma comorbidities on hospitalisation for asthma exacerbation (H-AX) remains less recognised. (researchsquare.com)
Several studies have shown that comorbidities are associated with higher health care utilisation, lower quality of life and poorer asthma control [ 12 - 15 ] . (researchsquare.com)
Using data from a national survey on asthma control and disease perception, we aimed to analysis the impact of comorbidities on hospitalisation for asthma exacerbation (H-AX) in China. (researchsquare.com)
The present study was based on a national survey on asthma control and disease perception conducted by China Asthma Research Network (CARN 2015 study) [ 16 ] . (researchsquare.com)
Indications of deteriorating asthma control included the need for a reliever inhaler more than usual, an increase in nighttime awakenings due to asthma symptoms, or a peak flow below 80% of normal level. (nejm.org)
Regular follow-up appointments with a healthcare provider are necessary to monitor asthma control, ensure that medications are taken regularly and correctly, and to identify potential triggers. (nsk.hr)
A comprehensive approach to achieving and maintaining control of asthma. (cdc.gov)
Follow @CDCasthma on Twitter to learn more about helping people with asthma live healthier lives by gaining control over their asthma. (cdc.gov)
Managing exacerbations is an important part of living with asthma and Summa Health is here to give you strategies to effectively control exacerbations. (summahealth.org)
ABSTRACT This study evaluated peripheral eosinophil and serum eosinophilic cationic protein (s-ECP) levels as markers of asthma control. (who.int)
A negative correlation was noted between degree of asthma control and both eosinophil counts and s-ECP levels ( r = -0.60 and -0.75 respectively). (who.int)
s-ECP as well as peripheral eosinophil count may be helpful in the assessment of asthma control. (who.int)
Theassociationbetweeneosino- ofasthmaonpresentation,patientswere wereconsideredatopiciftheyhadat philiaandasthmawasobservedshortly given asthma control er medication least1positiveskin-pricktestresponse. (who.int)

As such this trial investigated the efficacy of tezepelumab to reduce the annual rate of asthma exacerbations. (2minutemedicine.com)
The efficacy of biologics for severe asthma treatment may vary by patient age at asthma onset due to the distinctly different mechanisms of action," said Dr Dennis Ledford from the University of South Florida in Tampa, Florida, US, who presented the subgroup analysis of the CHRONICLE trial. (mims.com)

Around 3.2 million children had at least one asthma attack in 2016, resulting in more than 80 thousand hospitalizations [ 1 ]. (biomedcentral.com)
Given that the substantial escalation in inhaled glucocorticoid therapy prevented exacerbations in adults (the STICS trial did not show any benefit in children), the main question arising from this trial is whether such high doses warrant use as an exacerbation-prevention strategy. (nejm.org)
The aim of the study was to determine whether two doses of dexamethasone were as effective as a 5-day course of prednisolone/prednisone in the management of asthma exacerbations in children. (medscape.com)
Children with severe exacerbations were excluded, as were children who needed admission to the intensive care unit, high-flow oxygen, or who received magnesium sulfate . (medscape.com)
The investigators concluded that dexamethasone represents a viable option for treating acute asthma exacerbation in children, and it performed as well as prednisone/prednisolone in this trial. (medscape.com)
Little is known about the role of air quality in fatal asthma exacerbations among children. (cdc.gov)
We collected information about 80 deaths that occurred in North Carolina from 2001 through 2016, among children aged 5-17 years, with asthma identified as the primary cause of death. (cdc.gov)
Editorial Comment on: „Short-acting β 2 -agonist use and asthma exacerbations in Swedish children: A SABINA Junior study. (authorea.com)
A total of 38 children with asthma (16 controlled and 22 partially controlled) were compared with 16 age- and sex-matched healthy children. (who.int)
Controlled asthma cases showed non-significant changes in both parameters versus healthy children. (who.int)
Too many adults and children suffer needlessly from asthma, resulting in a heavy burden for employers and employees alike. (cdc.gov)
Every day in the U.S., about 43,000 people miss work and school due to uncontrolled symptoms, and even more adults stay home from work to care for children too sick with asthma to go to school. (cdc.gov)
The good news is that with proper medical care and medications, quality education to help people manage their disease, and supplies and services to reduce environmental triggers, adults and children with asthma can thrive. (cdc.gov)

As a specialty, we need to disseminate more information about asthma management, the "new" asthma guidelines, SMART/MART therapy, and the importance of biologicals in asthma. (medscape.com)

Statins may benefit in the treatment of asthma through their pleiotropic anti-inflammatory effects. (aaaai.org)

Anatomy12

Organisms7

Diseases51

Chemicals and Drugs64

Analytical, Diagnostic and Therapeutic Techniques and Equipment66

Psychiatry and Psychology5

Phenomena and Processes20

Disciplines and Occupations3

Anthropology, Education, Sociology and Social Phenomena8

Humanities1

Information Science3

Named Groups2

Health Care69

Geographicals9

20233

Acute exacerbation6

Corticosteroids11

Respiratory16

Causes of asthma exacerbations1

Hospitalization3

High risk for exacerbation1

Severity of exacerbations1

Severe asthma exacerbation1

Outcomes10

Rate of exacerbations2

Triggers of asthma2

Reductions in exacerbations3

Exposures7

Clinical11

Systemic4

Annual exacerbation1

Allergic7

Patients41

Interventions3

Diagnosis5

Last 12 months2

Viral2

Bronchial asthma1

Mild10

Asthmatic4

Frequent1

Dose4

Goal of asthma1

Chest tightness2

Methods3

Community-acquired1

Risk17

Airways3

Tezepelumab treatment1

Cough2

Shortness of bre1

Chronic disease4

Rhinovirus2

Pediatric asthma2

Childhood1

Frequency3

Moderate2

Allergy1

Past 122

Visits3

Exposure3

Cohort2

Symptoms of asthma1

Significantly2

Airflow2

Control16

Efficacy2

Children13

Guidelines1

Treatment of asthma1