Evidence alternative splicing. Medical search. Frequent questions

Interestingly, a mouse ortholog of HAS2-AS1, Has2as, clearly exhibited a differential splicing pattern among three major splice variants in the Pnn-deficient mouse cornea. (molvis.org)
The sequence analyses and quantification of splice variants of candidate lncRNAs, including RP11-295B20.2, RP11-18I14.1, and RP11-322M19.1, demonstrated complex configuration of their splicing changes, with a significant impact of PNN on the process. (molvis.org)
Knockdown of PNN in HCET cells led to specific changes in the inclusion of multiple cassette exons as well as in the use of alternative splice sites in RP11-322M19.1 and RP11-18I14.1, resulting in considerable net changes in the ratio between the splice variants. (molvis.org)
I repeated my complaint that much of the predicted alternative splice variants are artifacts. (blogspot.com)
It makes no sense that conserved genes would be producing alternative protein variants that are species specific. (blogspot.com)
I am convinced that the EST databases are full of artifacts and that most predicted splice variants do not exist. (blogspot.com)
I suggested that he look at the predicted alternative splice variants of the two human genes and let me know if he is still convinced that these variants make biological sense. (blogspot.com)
Down the right-hand side of the page there are links to several other webpages, including a link to AceView , a database of alternative splice variants. (blogspot.com)
Before following this link to the POLR1A variants, let's note that on the annotated Entrez Gene website there are no alternative splice variants listed. (blogspot.com)
RefSeq annotates one representative transcript (NM included in AceView variant.a), but Homo sapiens cDNA sequences in GenBank, filtered against clone rearrangements, coaligned on the genome and clustered in a minimal non-redundant way by the manually supervised AceView program, support at least 11 spliced variants. (blogspot.com)
Alternative mRNA variants and regulation: The gene contains 29 different introns (28 gt-ag, 1 gc-ag). (blogspot.com)
Transcription produces 13 different mRNAs, 11 alternatively spliced variants and 2 unspliced forms. (blogspot.com)
The remaining 2 mRNA variants (1 spliced, 1 unspliced) appear not to encode good proteins. (blogspot.com)
Compared to RefSeq, this gene set has generally about 10% more protein-coding genes, approximately four times as many putative non-coding genes, and about twice as many splice variants. (ucsc.edu)
Moreover, 5′- and 3′-UTR sequences of 4378 genes have been retrieved and alternatively spliced variants of 69 genes have been identified. (biomedcentral.com)
Alternative splicing of this gene generates transcript variants that encode different isoforms. (thermofisher.com)
There is evidence of alternative splicing yet the full-length nature of these variants has not been described. (antibodies-online.com)
due to alternative slicing, "Alternatively spliced isoforms,,, appear to behave as if encoded by distinct genes rather than as minor variants of each other. (uncommondescent.com)
Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing - 2016 In Brief Alternatively spliced isoforms of proteins exhibit strikingly different interaction profiles and thus, in the context of global interactome networks, appear to behave as if encoded by distinct genes rather than as minor variants of each other. (uncommondescent.com)
Our single molecule deep sequencing approach identifies novel alternative splice variants and highly combinatorial alternative exon use, but also specific stereotyped restrictions in alternative exon combinations," they write. (pacb.com)
Furthermore, PQBP1 knockdown changes the alternative splicing of FGF receptor-2 ( FGFR2 ) transcripts, altering the incorporation of cassette exons that generate receptor variants ( FGFR2 IIIb or IIIc) with different ligand specificities. (xenbase.org)
Alternative splicing results in multiple transcript variants. (utsouthwestern.edu)

Now Urrutia and her team have evidence that, although their genes seem to be the same, the two lice read them differently. (newscientist.com)
Urrutia's team identified more than 3500 examples where genes were spliced differently in the two types of lice ( Molecular Biology and Evolution , doi.org/6bq ). (newscientist.com)
The salivary gland and feeding tract genes that body lice splice differently might have helped them adapt to living in clothes, which we most likely started wearing less than half a million years ago. (newscientist.com)
c , Heatmap of z -score normalized RPKM expression levels of the same genes which contain the splice events in a , preserving the ordering of rows as in a . d , Principal components analysis of the 24 samples, based on the overall splice events quantification, demonstrating clear separation of clusters by neuron subtype. (jneurosci.org)
Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses were performed to explore the function of splicing factors (SFs) that were associated with AS events. (frontiersin.org)
He is firmly convinced that most human genes express a number of different protein products that are produced as the result of alternatively spliced mRNA precursors. (blogspot.com)
Alternative splicing has been shown to affect more than one-third of all human genes. (berkeley.edu)
Recent reports have shown that more than one third of all human genes may be affected by alternative splicing[ 4 - 9 ]. (berkeley.edu)
To these ends, several groups have classified and catagorized known alternative isoforms in terms of changes in gene structure between alternative isoforms or by the functional classes of the genes that are involved[ 4 , 16 ]. (berkeley.edu)
The only general conclusion that can be drawn from these analyses, however, is that alternative splicing affects genes of nearly every functional class by modifying gene structure in every conceivable way, such as using mutually exclusive exons or alternative donor sites. (berkeley.edu)
Although there is strong evidence for the role of a genetic component in language disorder, we do not know which genes contribute to this disorder or how the inheritance of language problems work. (brookes.ac.uk)
Transcripts of protein-coding genes require the support of one RefSeq RNA, or one GenBank RNA sequence plus at least one additional line of evidence. (ucsc.edu)
Single-exon genes require either two RNAs or two additional lines of evidence beyond the single RNA. (ucsc.edu)
Sequence data of the revised genome annotation including several hundreds of novel transcripts, improved gene models and candidate genes for alternative splicing have been made accessible in a comprehensive database. (biomedcentral.com)
But in humans, these genes are spliced together in different ways to create various kinds of messenger RNA to produce the many different proteins humans require. (sciencedaily.com)
It makes genes splice from a long form into a short form. (sciencedaily.com)
Wang said that RBM4 is needed in the proper amount so that these genes are spliced properly and don't contribute to cancer development and metastasis. (sciencedaily.com)
In regards to alternative splicing patterns, as the following paper states, "A major question in vertebrate evolutionary biology is "how do physical and behavioral differences arise if we have a very similar set of genes to that of the mouse, chicken, or frog? (uncommondescent.com)
Post-transcriptional events play a major role in determining this signature, which is evidenced by the fact that alternative RNA splicing takes place in more than half of the human genes, and, among protein coding genes, more than 60% contain at least one conserved miRNA-binding site. (intechopen.com)
Alternative splicing is the primary mechanism by which a limited number of protein-coding genes can generate proteome diversity. (biologists.com)
Using genetic tools to implant genes that produce fluorescent proteins in the DNA of transparent C. elegans worms, John Calarco, a Bauer Fellow at the Faculty of Arts and Sciences Center for Systems Biology, and postdoctoral researcher Adam Norris were able to gather hard evidence that the alternative splicing process frequently works differently in different types of neurons.The study was described in a recent paper in Molecular Cell. (harvard.edu)
What they found was clear - different cells splice the same genes in different ways. (harvard.edu)
In additional experiments that targeted other genes, Calarco and Norris were able to identify unique patterns of splicing, suggesting that the process is different not only among different neuron types, but also among different genes. (harvard.edu)
In addition to studying the many splicing events found in these neurexin genes and working to ensure that their analysis covered even the relatively rare transcripts, the team followed up with a comparison of neurexin activity in other areas of the brain. (pacb.com)
A growing body of evidence shows that lncRNAs play important functional roles in diverse biological processes, such as epigenetic regulation, cell cycle regulation, cellular growth and differentiation, by regulating the level of target genes [ 3 , 4 ]. (biomedcentral.com)

There are 7 probable alternative promotors and 5 non overlapping alternative last exons (see the diagram). (blogspot.com)
The mRNAs appear to differ by truncation of the 5' end, truncation of the 3' end, overlapping exons with different boundaries, alternative splicing or retention of 4 introns. (blogspot.com)
The N-terminal A domain differs among the four subtypes of Ca 2+ channel β subunits (β 1 -β 4 ) primarily as the result of two duplications of an ancestral gene containing multiple alternatively spliced exons. (jneurosci.org)
Alternative splicing (AS) is the mechanism by which exons of a single gene can be spliced in various combinations to encode a diverse set of proteins. (biologists.com)

The exon junction complex (EJC) deposited on spliced mRNAs, plays a central role in the post-transcriptional gene regulation and specific gene expression. (nature.com)
When Calarco and Norris used the fluorescent protein to target two types of motor neurons in the worms, they immediately saw a distinctive fluorescent pattern emerge, meaning the two classes of neurons were splicing mRNAs differently. (harvard.edu)
Using a single cDNA sequencing approach, we detected 1,364 unique neurexin-α and 37 neurexin-β mRNAs produced by alternative splicing of neurexin pre-mRNAs," the scientists write. (pacb.com)
Alternative splicing of pre-mRNAs is an important means of regulating developmental processes, yet the molecular mechanisms governing alternative splicing in embryonic contexts are just beginning to emerge. (xenbase.org)
A real-time reverse transcription PCR, targeting 2 alternatively spliced mRNAs, was developed. (cdc.gov)

To further investigate PNN's role in regulating the alternative splicing of lncRNAs in a corneal epithelial context, we performed detailed analyses for detecting and identifying alternatively spliced lncRNAs. (molvis.org)

Here's the figure showing the various predicted alternatively spliced transcripts and the various different proteins. (blogspot.com)
For other multi-exon transcripts to be output, an edge supported by at least one additional line of evidence beyond the RNA is required. (ucsc.edu)
Evolution by Splicing - Comparing gene transcripts from different species reveals surprising splicing diversity. (uncommondescent.com)
Thus, SRSF3 and SRSF7 couple alternative splicing and polyadenylation to NXF1-mediated mRNA export, thereby controlling the cytoplasmic abundance of transcripts with alternative 3' ends. (uni-frankfurt.de)

the human form of the protein is 2316 amino acids long and can be expressed in multiple isoforms due to alternative splicing. (wikipedia.org)
We have found that many alternative isoforms are apparent targets of nonsense-mediated mRNA decay (NMD), an mRNA surveillance system. (berkeley.edu)
Alternative splicing is the process whereby a single genetic locus can be transcribed and processed to generate multiple, distinct isoforms[ 1 - 3 ]. (berkeley.edu)
Differences between isoforms of an alternatively spliced gene may be subtle or profound. (berkeley.edu)
indeed, a recent study of alternative isoforms in mice showed that 21% of splice variations do not affect coding potential[ 14 , 15 ]. (berkeley.edu)
Because of the prevalence of alternative splicing, researchers would like to know the regulatory mechanisms that control it and the functional consequences of the isoforms that are produced. (berkeley.edu)
The clinical significance of splice isoforms remains to be elucidated, mainly because their detection has until recently required time consuming cloning steps prior to sequencing. (biomedcentral.com)
This study aimed to go beyond accepted effects of alternative splicing in protein function to molecular diversity and how this splicing may "regulate temporal and spatial expression of certain neurexin isoforms," the authors note. (pacb.com)
The tau protein exists as multiple protein isoforms in the adult human CNS, generated by alternative splicing of the MAPT gene. (researchsquare.com)
The presence of tau splicing mutations results in disease-associated alterations in tau expression, specifically a dose-dependent increase in 4R tau isoforms in the presence of the MAPT 10+16 variant. (researchsquare.com)
Tau is present in the adult human CNS as multiple protein isoforms generated by alternative splicing, with either 0, 1 or 2 N-terminal inserts (0N, 1N, 2N) and either 3 or 4 C-terminal repeats (3R, 4R)(4). (researchsquare.com)
The precise stoichiometry of tau isoforms is tightly regulated: the levels of 3R and 4R in the adult human CNS are approximately equal, and this appears to have a direct influence on neuronal viability, as mutations in MAPT that disrupt tau splicing are causative of frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP17T) (5,6). (researchsquare.com)
Pathological tau aggregates can be composed of all tau isoforms - for example in Alzheimer's Disease - or a subset of tau isoforms, such as progressive supranuclear palsy (PSP), corticobasal degeneration (CBD) and FTD with splice-site mutations in MAPT , all of which show a predominant deposition of 4R isoforms(1). (researchsquare.com)
Although splice-site mutations in MAPT were discovered in 1998(5), we know little about the mechanism by which relative increases in certain isoforms can drive neurodegeneration. (researchsquare.com)

however, the prognostic value of AS products and splicing events remains to be elucidated. (spandidos-publications.com)

a , Heatmap of splice event variant inclusion frequencies (centered to the mean per variant across samples) across the samples, for events which were significantly differentially spliced in one neuron subtype compared with the other three. (jneurosci.org)
b , Heatmap, as in a , for splice events significantly differentially spliced in two neuron subtypes. (jneurosci.org)
We engineered fluorescent proteins in such a way that they can provide an indication of how the RNA is being differentially spliced. (harvard.edu)

Our results highlight the requirement of Sfrs1-mediated alternative splicing for the survival of retinal neurons, with sensitivity defined by the window of time in which the neuron was generated. (biologists.com)
Through their research on "alternative splicing," John Calarco (left), a Bauer Fellow at the Faculty of Arts and Sciences Center for Systems Biology, and postdoctoral researcher Adam Norris have a better understanding of how the process works in different neurons. (harvard.edu)
What we've been able to do is visualize the alternative splicing process in these animals in single neurons," he said. (harvard.edu)
Disruptions to tau splicing are associated with a number of tauopathies, however, in vitro and in vivo models to understand the consequences of disrupted tau splicing have been lacking, due in part to species differences in tau splicing and the developmental regulation of tau in human neurons. (researchsquare.com)

Here, using recombinant complex reconstitution and transcriptome-wide analysis, we showed that the EJC peripheral protein complexes ASAP and PSAP form distinct complexes with the EJC core and can confer to EJCs distinct alternative splicing regulatory activities. (nature.com)
A correlation network between DFS-SEs of splicing factors and non-splicing factors was constructed to determine the potential mechanisms in PRAD, which included the potential regulatory interaction between the splicing event of splicing factor RNA binding motif protein 5-alternate terminator (AT)-64957 and the splicing event of non-splicing factor heterochromatin protein 1 binding protein 3-AT-939. (spandidos-publications.com)
The program weighs as positive evidence the length of the protein, the presence of a Kozak consensus sequence at the start codon, and the length of the orthologous predicted protein in other species. (ucsc.edu)
WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. (thermofisher.com)
The protein RBM4, a molecule crucial to the process of gene splicing, is drastically decreased in multiple forms of human cancer, including lung and breast cancers, researchers have discovered. (sciencedaily.com)
Such "misregulated" protein expression would provide evidence that the proteins are involved in cancer development or metastasis. (sciencedaily.com)
However, a growing body of evidence suggests that recruitment, stability, and function of epigenetic factors can be mediated by non-protein-coding RNAs. (frontiersin.org)
We have investigated the role of the alternative-splicing factor Sfrs1, an arginine/serine-rich (SR)protein family member, during mouse retinal development. (biologists.com)
splicing has been shown to have an effect on molecular interactions and protein interfaces, with downstream impact on synaptic plasticity and more. (pacb.com)
Polyglutamine-binding protein 1 ( PQBP1 ) is an RNA-splicing factor that, when mutated, in humans causes Renpenning syndrome, an X-linked intellectual disability disease characterized by severe cognitive impairment, but also by physical defects that suggest PQBP1 has broader functions in embryonic development. (xenbase.org)

Historically, scientists haven't targeted the proteins in cancer cells that are involved in gene splicing," said Zefeng Wang, PhD, associate professor in the department of pharmacology and senior author of the Cancer Cell paper. (sciencedaily.com)
Through a series of biochemical experiments and high-throughput screening methods, his team identified about 20 proteins that are involved in regulating alternative splicing. (sciencedaily.com)
Just as a film editor can change the story with a few cuts, alternative splicing allows cells to stitch genetic information into different formations, enabling a single gene to produce up to thousands of different proteins. (harvard.edu)
Some proteins were influenced by alternative transcription and splicing events, as seen in HLA-C, HLA-E, NRP1 and NRP2. (cdc.gov)

That is, they mark the sites where the introns were spliced out. (berkeley.edu)

In the present study, the data of splicing events and the clinical information of PRAD patients were obtained from The Cancer Genome Atlas (TCGA)SpliceSeq and TCGA databases, respectively. (spandidos-publications.com)
clinical evidence of tolerance can be seen within just a few weeks. (ama-assn.org)
They provide a more accurate interpretation of previously mis-annotated mutations, highlighting the importance of integrating data types to understand the functional and the clinical implications of splicing mutations in human disease. (elsevierpure.com)
Our data have provided evidence for a comparable prediction of clinical outcome in CMF-treated breast cancer patients using conventional clinical variables and gene expression based markers. (lu.se)

An alternative splicing (AS) event is a highly complex process that plays an essential role in post-transcriptional gene expression. (frontiersin.org)
The alternative splicing (AS) event is a highly complex process that plays an essential role in post-transcriptional gene expression and is one of the foundations of biodiversity and complexity. (frontiersin.org)

For the past decade, cancer genomic studies have focused on mutations leading to splice-site disruption, overlooking those having splice-creating potential. (elsevierpure.com)
Here, we applied a bioinformatic tool, MiSplice, for the large-scale discovery of splice-site-creating mutations (SCMs) across 8,656 TCGA tumors. (elsevierpure.com)
We report 1,964 originally mis-annotated mutations having clear evidence of creating alternative splice junctions. (elsevierpure.com)
identify nearly 2,000 splice-site-creating mutations (SCMs) from over 8,000 tumor samples across 33 cancer types. (elsevierpure.com)
The Cancer Genome Atlas Research Network 2018, ' Systematic Analysis of Splice-Site-Creating Mutations in Cancer ', Cell Reports , vol. 23, no. 1, pp. 270-281.e3. (elsevierpure.com)
No evidence of patients and even within the same gene is expected somatic mutations was found in this study. (cdc.gov)

In eukaryotes, most lncRNAs are transcribed by RNA polymerase II and have a structure similar to that of mRNA, which includes 5′ capping, splicing and polyadenylation [ 2 ]. (biomedcentral.com)

This molecular diversity results from near-exhaustive combinatorial use of alternative splice insertions in Nrxn1α and Nrxn2α. (pacb.com)
Our analysis defines the molecular diversity of a critical synaptic receptor and provides evidence that neurexin diversity is linked to cellular diversity in the nervous system. (pacb.com)

thus, Pnn may affect crucial alternative splicing (AS) decisions and, in turn, impact cell-type specific gene expression. (molvis.org)
The coupling of alternative splicing with NMD is intriguing and could provide a general means of regulating gene expression. (berkeley.edu)
LncRNAs are involved in a wide range of regulatory mechanisms that impact gene expression, including chromatin remodeling, modulation of alternative splicing, fine-tuning of miRNA activity, and the control of mRNA translation or accumulation [ 5 ]. (biomedcentral.com)

DNA and mRNA sequence from the same tumour highlighted splicing alterations driven by somatic genomic changes, including exon 14 skipping in MET mRNA in 4% of cases. (nature.com)

They're specifically interested in those which modulate alternative mRNA splicing to address diseases of high unmet medical need. (nottingham.ac.uk)

These data place Pnn at the fulcrum point between chromatin and mRNA splicing. (molvis.org)

Neuron subtype-specific gene splicing. (jneurosci.org)
We were interested in looking at how splicing might be different in one type of neuron versus a different type of neuron," said Norris. (harvard.edu)
Targeted Combinatorial Alternative Splicing Generates Brain Region-Specific Repertoires of Neurexins ," from lead author Dietmar Schreiner, senior author Peter Scheiffele, and collaborators, was published this month in the journal Neuron . (pacb.com)

Moreover, to make this even more devatating to Darwinists, alternative splicing patterns are part of the developmental Gene Regulatoy Network (dGRN). (uncommondescent.com)
While the developmental regulation of tau splicing is conserved, maturation of tau splicing is accelerated in 3D cultures compared to 2D cultures. (researchsquare.com)

The traversal is guided by the initial RNAs to avoid a combinatorial explosion in alternative splicing. (ucsc.edu)

The presence, absence, abundance and activity of splicing factors can effect which regions of the pre-mRNA will be included in the mature mRNA. (berkeley.edu)
Depletion assays for numerous RBPs show that TE-derived binding sites affect transcript abundance and splicing similarly to nonrepetitive sites. (biomedcentral.com)

2003. Evidence for the widespread coupling of alternative splicing and nonsense-mediated mRNA decay in humans. (berkeley.edu)
In particular, the dialogue between T cells and beta cells is far more complex in humans and recent evidence supports potential type 1 diabetes 'endotypes' based on age at onset [ 8 , 9 ]. (springer.com)
A similar process, "alternative splicing," is at work inside the bodies of billions of creatures - including humans. (harvard.edu)

the papers show that most alternative splicing events differ widely between even closely related species. (uncommondescent.com)

The EJC core complex is associated with multiple peripheral factors involved in various post-splicing events. (nature.com)

Dismantled during translation, EJCs mark a very precise period in mRNA life between nuclear splicing and cytoplasmic translation. (nature.com)

Transcriptome-wide RNA-seq studies revealed that ASAP and PSAP complexes regulate distinct alternative splicing events both in EJC-independent and EJC-dependent manner. (nature.com)

TRA2A Promoted Paclitaxel Resistance and Tumor Progression in Triple-Negative Breast Cancers via Regulating Alternative Splicing. (nih.gov)
In addition, there is evidence that this gene behaves as a suppressor of tumor growth. (thermofisher.com)

Methods: Total RNA was isolated from PNN knockdown human corneal epithelial (HCET) cells or Pnn-deficient mouse corneas, and subjected to real-time-PCR (RT-PCR) assays, and the alternatively spliced lncRNAs were counted. (molvis.org)
Alternatively spliced lncRNAs were detected with in situ hybridization with variant-specific RNA probes on human cornea sections. (molvis.org)
If the mouse graph has an edge that is orthologous to an edge in the human graph, that is added to the evidence for the human edge. (ucsc.edu)
If an edge in the splicing graph is supported by two or more human ESTs, it is added as evidence for the edge. (ucsc.edu)
A muscle-type tropomyosin in human fibroblasts: evidence for expression by an alternative RNA splicing mechanism. (google.lv)

To develop a qualitative reverse transcription PCR to detect spliced mRNA from HBoV1 and to determine whether HBoV1 mRNA correlated better with RTIs than did HBoV1 DNA, we used samples from HBoV1 DNA-positive children, with and without RTIs, to evaluate the test. (cdc.gov)
The main objectives of this study were to develop a qualitative reverse transcription PCR (RT-PCR) detecting spliced mRNA from HBoV1 and to clarify whether HBoV1 mRNA detection may correlate better than DNA detection with RTIs in children. (cdc.gov)

Purpose: GG-H whole transcriptome array analysis suggested involvement of PININ (PNN) in the alternative splicing of multiple long non-coding RNAs (lncRNAs). (molvis.org)

The percent spliced in (PSI) values of AS events were acquired from the TCGA Splice-seq. (frontiersin.org)

A prognostic index (PI) was generated from disease-free survival-associated splicing events (DFS-SEs), which were identified by univariate/multivariate Cox regression analysis. (spandidos-publications.com)
In conclusion, the PIs derived from DFS-SEs are valuable prognostic factors for patients with PRAD, and the function of splicing events in PRAD deserves further exploration. (spandidos-publications.com)

our findings suggest that paclitaxel targets the TRA2A-RSRC2 splicing pathway, and deregulated TRA2A and RSRC2 expression may confer paclitaxel resistance. (nih.gov)

I challenged the Intelligent Design Creationists to explain not only that the sequences are similar but that the degree of similarity is evidence of evolution. (blogspot.com)

b , Examples of potassium channel differential splicing are illustrated for Kcnc2 (two distinct sites), Kcnc3 , Kcnt2 , and Kcnd3 . (jneurosci.org)
This study provides the first evidence that different EJCs can have distinct functions, illuminating EJC-dependent gene regulation. (nature.com)

Conclusions: The data suggest PNN's role in the alternative splicing of a specific subset of lncRNAs might have a significant impact on the corneal epithelium. (molvis.org)
Herein, we postulate that lncRNAs are central players in the unique epigenetic programming of AML and review recent evidence in support of this view. (frontiersin.org)

What's interesting is that RBM4 actually inhibits the expression of SRSF1 and therefore controls the splicing of many SRSF1 targets in an opposite fashion. (sciencedaily.com)
A growing body of evidence indicates that epigenetic regulators rely, amongst other factors, on their interaction with untranslated RNA molecules for guidance to particular targets on DNA. (frontiersin.org)

In genetics, this process is called alternative splicing. (sciencedaily.com)

Alternative sites for cell density regulation of the enzyme could rely on its sensitivity to sulfhydryl groups. (embl.de)
Splicing is an essential process in gene regulation that happens in most eukaryotic cells, all the time," Calarco said. (harvard.edu)

Mounting evidence supports the notion that the activation and evolution of islet autoimmunity in genetically susceptible people is contingent upon early life exposures affecting the islets, especially beta cells. (springer.com)

It's like a filmmaker splicing together bits of movie scenes to create alternative cuts of a movie. (sciencedaily.com)

The team tackled alternative splicing in neurexins, a gene family serving as receptors with an important role in synaptic morphology and function. (pacb.com)

337 bp of this gene are antisense to spliced gene pluvu, raising the possibility of regulated alternate expression. (blogspot.com)

What you see are examples of splicing errors where an intron has not been correctly removed. (blogspot.com)

We show that enCORs provide a robust and reproducible in vitro system for the analysis of tau expression and splicing in a 3D model. (researchsquare.com)

Anatomy15

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