• The newest addition could be useful in identifying and diagnosing the few known conditions related to genes in the Y chromosome. (nist.gov)
  • There are certainly aspects of fertility and some genetic disorders that are connected to genes in the Y chromosome," Zook said. (nist.gov)
  • In some affected individuals, genes near the ends of chromosome 20 are deleted when the ring chromosome forms. (medlineplus.gov)
  • In these people, the ring chromosome may change the activity of certain genes on chromosome 20, or the chromosome may be unable to copy (replicate) itself normally during cell division. (medlineplus.gov)
  • In order to ensure the proper expression level of genes on the X chromosome, one of the chromosomes is randomly inactivated in every cell in a female mammal. (drugdiscoverynews.com)
  • XIST attaches itself at different points all along the X chromosome, silencing the genes that are located on the X chromosome," said senior author Dr. Samie Jaffrey, a professor of pharmacology at Weill Cornell Medicine. (drugdiscoverynews.com)
  • Understanding how X chromosome inactivation occurs may enable researchers to develop therapies for a variety of diseases caused by mutations of genes on the X chromosome. (drugdiscoverynews.com)
  • The other two involve the ATM and ATR genes, which initiate a chain of events that stops cells from growing and dividing. (the-scientist.com)
  • This arrest is caused by an abnormal expression of genes, often as a result of chromosomal translocations or abnormalities of chromosome number. (medscape.com)
  • As a tool to understand one part of RNA's regulation of genes, Yildirim's lab is focused on the process that silences one of the two X chromosomes found in a female mammal. (duke.edu)
  • Female offspring get one X from each parent, but if the genes on both chromosomes were active, all sorts of things could go wrong. (duke.edu)
  • These Y chromosome sequences now provide new evidence that Neandertals and early modern humans met and exchanged genes before the major out of Africa migration - potentially as early as 370,000 years ago and certainly more than 100,000 years ago. (mpg.de)
  • This is essential in determining the genes carried by a gamete, as each will solely obtain one of many two homologous chromosomes. (styleslicker.com)
  • Baykara O, Bakir B, Buyru N, Kaynak K, Dalay N. Amplification of Chromosome 8 Genes in Lung Cancer. (jcancer.org)
  • The most frequently amplified genes were ZNF703, PRDM14 and MYC on chromosome 8 and the BIRC5 gene on chromosome 17. (jcancer.org)
  • Amplification of the ZNF703, PRDM14 and MYC genes were highly correlated suggesting that the genes displaying high copy number changes on chromosome 8 collaborate during lung carcinogenesis. (jcancer.org)
  • Characterisation of breakpoints in patients with apparently balanced constitutional chromosome rearrangements and phenotypic abnormalities has proved an invaluable strategy for identifying disease causing genes, especially those on the X chromosome. (bmj.com)
  • The continuously updated material also makes it possible to address scientific questions related to the mechanisms through which chromosomal/genomic changes participate in the carcinogenic process by elucidating why, how and when chromosome abnormalities are formed, the chromosomal anatomy of cytogenetic changes and genes involved in fusions, the role chromosome aberrations play in the formation of fusion genes, and the mechanisms by which gene fusions exert their effects. (lu.se)
  • Genes Chromosomes Cancer 58:149-154, 2019. (lu.se)
  • Genes Chromosomes Cancer 55:291-310, 2016. (lu.se)
  • However, molecular genetic studies have shown that some genes on the inactivated X chromosome (or chromosomes) remain functional, and these few are essential to normal female development. (msdmanuals.com)
  • XIST is the gene responsible for inactivating the genes of the X chromosome, producing RNA that triggers inactivation. (msdmanuals.com)
  • Do coronavirus genes slip into human chromosomes? (cdc.gov)
  • Competitive hybridization to these arrays using tumor and normal DNA samples reveals numerical chromosome abnormalities (deletions and amplifications) that can be accurately defined depending on the density of the arrays. (elsevierpure.com)
  • We have used comparative genomic hybridisation to analyse 19 constitutional chromosome abnormalities detected by G band analysis, including seven deletions, five supernumerary marker chromosomes, two interstitial duplications, and five chromosomes presenting with abnormal terminal banding patterns. (bmj.com)
  • Others have applied CGH to the study of constitutional chromosome abnormalities detected postnatally. (bmj.com)
  • Although the structural chromosome abnormalities in these cases were too small to identify the origin of the extra genomic material based on banding pattern, none of the abnormalities described by these authors can be considered to be subtle or cryptic. (bmj.com)
  • 3- 6 Phenotypic abnormalities seen in cases with apparently balanced chromosome rearrangements have usually been explained by the disruption of a gene at the breakpoint causing the loss of gene function. (bmj.com)
  • Sex chromosome abnormalities may involve aneuploidy, partial deletions or duplications of sex chromosomes, or mosaicism. (msdmanuals.com)
  • Abnormalities that affect autosomes (the 22 paired chromosomes that are alike in males and females) are more common than those that affect. (msdmanuals.com)
  • Sex chromosome abnormalities are common and cause syndromes that are associated with a range of congenital and developmental anomalies. (msdmanuals.com)
  • The effects of X chromosome abnormalities are not as severe as those resulting from analogous autosomal abnormalities. (msdmanuals.com)
  • Sex chromosome abnormalities. (msdmanuals.com)
  • Prior to the first meiotic division, homologous chromosomes pair, synapse, and recombine to ensure their proper disjunction at anaphase I. Additionally, telomeres tethered at the nuclear envelope cluster in the bouquet configuration where they are subjected to dramatic pulling forces acting from outside of the nucleus. (biorxiv.org)
  • In Which Part Of Meiosis Does Random Alignment Of Homologous Chromosomes Occur? (styleslicker.com)
  • Consider that the homologous chromosomes of a sexually reproducing organism are originally inherited as two separate sets, one from every mother or father. (styleslicker.com)
  • During prophase I, crossing over introduces genetic variation by swapping pieces of homologous chromosomes. (styleslicker.com)
  • Here, CDK2 is involved in the regulation of meiotic transcription, the pairing of homologous chromosomes, and the maturation of meiotic crossover sites. (lu.se)
  • If you already know about chromosomal evolution or do not care, jump directly to information on Drosera chromosome numbers. (carnivorousplants.org)
  • Ring chromosome 20 syndrome is caused by a chromosomal abnormality known as a ring chromosome 20 or r(20). (medlineplus.gov)
  • In particular, G band analysis usually does not show the chromosomal origin of small marker chromosomes or of a small amount of extra material detected on otherwise normal chromosomes. (bmj.com)
  • Chromosomal identification of marker chromosomes and extra bands on chromosomes through molecular techniques is always of clinical interest. (bmj.com)
  • Chromosomal alterations are frequent events in lung carcinogenesis and usually display regions of focal amplification containing several overexpressed oncogenes. (jcancer.org)
  • Human intersex is an organic phenomenon resulting from an imbalance between the factors and events responsible for sexual determination and differentiation, which takes place when an individual's body presents ambiguities, anomalies or inconsistencies in the biological components of his or her sexual identity, i.e., in his or her sex chromosomal, hormonal and/or morphological sex 2 . (bvsalud.org)
  • Analysis of tumor DNA samples using these arrays reveals small deletions and amplifications that were not detectable by chromosome analysis and provides a global view of these genetic changes in a single hybridization experiment in 24 hours. (elsevierpure.com)
  • The maintenance of a single centromere per chromosome is critical for establishing bipolar microtubule attachments to the mitotic spindle and achieving high-fidelity genome segregation 17 . (nature.com)
  • SMC5/6 is required for replication fork stability and faithful chromosome segregation during neurogenesis. (nih.gov)
  • Chromosome segregation errors during meiosis are the leading cause of birth defects and developmental delays in humans ( H assold and H unt 2001 ). (biorxiv.org)
  • Mechanistically, the CIP2A-TOPBP1 complex prematurely associates with DNA lesions within ruptured micronuclei during interphase, which poises pulverized chromosomes for clustering upon mitotic entry. (nature.com)
  • Mitotic clustering facilitates the reassembly of acentric fragments into rearranged chromosomes lacking the extensive DNA copy-number losses that are characteristic of canonical chromothripsis. (nature.com)
  • Dynein is involved in the movement of chromosomes and positioning the mitotic spindles for cell division. (wikipedia.org)
  • Cyclin dependent-kinase 2 (CDK2) plays important functions during the mitotic cell cycle and also facilitates several key events during germ cell development. (lu.se)
  • Replication is initiated at multiple origins of replication on multiple chromosomes simultaneously so that the duration of S phase is not limited by the total amount of DNA. (wikipedia.org)
  • When a few of these sequences are deleted, DNA is still copied from other intact origins, but when many are deleted, chromosome replication slows down dramatically. (wikipedia.org)
  • The ORC is a six subunit complex that binds DNA and provides a site on the chromosome where additional replication factors can assemble. (wikipedia.org)
  • The events of meiotic prophase follow a specialized round of DNA replication when the meiotic chromosome axis is formed. (biorxiv.org)
  • Telomeric sequences at the ends of chromosomes protect the coding DNA from erosion during DNA replication . (the-scientist.com)
  • Replication studies in the mother and daughter showed a skewed X inactivation pattern in lymphocytes, with the normal X chromosome preferentially inactivated. (bmj.com)
  • If we can understand how the normal X chromosome is turned off, we can start to figure out how to turn it back on and get the body to produce those necessary proteins," Jaffrey said. (drugdiscoverynews.com)
  • Screening for chromosome imbalances was carried out using comparative genomic hybridisation (CGH) in 14 frozen samples of tumour from a series of 13 breast cancer patients with multiploid (n = 11) and hypertetraploid (n = 2) tumours. (bmj.com)
  • For the Y chromosome, mutations appear to be sufficient to explain worldwide Y chromosome diversity. (creationresearch.org)
  • However, the researchers used computer simulations to show that the known small size of Neandertal populations may have led to an accumulation of deleterious mutations in their Y chromosomes which would reduce their evolutionary fitness. (mpg.de)
  • Constitutional chromosome studies involving conventional GTG band cytogenetic analysis, however, often show unbalanced karyotypes which cannot be fully defined because the extra material is too small to have a recognisable banding pattern. (bmj.com)
  • We thus show remarkable convergence in mating-type chromosome evolution, recurrent supergene formation, and repeated evolution of similar phenotypes through different genomic changes. (pacb.com)
  • Intriguingly, we found that the X chromosome breakpoint in the daughter could not be defined by a single breakpoint spanning genomic clone and further analysis showed a 650 kb submicroscopic duplication between DXS7067 and DXS7060 on either side of the X chromosome translocation breakpoint. (bmj.com)
  • Mitelman F, Johansson B, Mertens F, Schyman T, Mandahl N. Cancer chromosome breakpoints cluster in gene-rich genomic regions. (lu.se)
  • In order to trace the origins and migratory patterns that may have led to the genetic isolation and autosomal clustering in some of these communities we analyzed Y-chromosome STR and SNP sample data from 6327 individuals, in addition to whole genome autosomal sample data from 609 individuals, from Mount Lebanon and other surrounding communities. (nature.com)
  • Genetic loci for autosomal dominant pure hereditary spastic paraplegia (ADPHSP) have been mapped to chromosomes 2p, 8q, 12q, 14q, and 15q. (nih.gov)
  • Unlike the rest of the autosomal genome, which represents a rich tapestry of thousands of genealogies of any individual's ancestors, Y chromosomes have a peculiar mode of inheritance - they are passed exclusively from father to son. (mpg.de)
  • This whole package of DNA (genome) and protein (epigenome) in a chromosome is what controls the development and maintenance of eukaryotic organisms (protists, fungi, animals, and plants). (carnivorousplants.org)
  • The more similar the chromosomes (the genome and epigenome as well as chromosome number) the more likely hybrids will form and reproduce but also the more likely the net result will only be the introgression of genetic material from one species to the other. (carnivorousplants.org)
  • What was once the final frontier of the human genome - the Y chromosome - has just been mapped out in its entirety. (nist.gov)
  • Led by the National Human Genome Research Institute (NHGRI), a team of researchers at the National Institute of Standards and Technology (NIST) and many other organizations used advanced sequencing technologies to read out the full DNA sequence of the Y chromosome - a region of the genome that typically drives male reproductive development. (nist.gov)
  • Chromosomes all contain sections of very repetitive DNA, but well over half of the Y chromosome is like that," said study co-author Justin Zook, who leads NIST's Genome in a Bottle (GIAB) consortium. (nist.gov)
  • While GIAB has not yet produced a benchmark for the Y chromosome specifically, the consortium has studied one genome extensively, accumulating the largest collection of Y chromosome data prior to the new study. (nist.gov)
  • T2T-Y, in combination with the group's previous reference genome, T2T-CHM13, represents the world's first complete genome for the half of the population with a Y chromosome. (nist.gov)
  • The development of the human genome-wide bacterial artificial chromosome (BAC) libraries that were used as templates for the human genome project made it possible to design microarrays containing these BACs that can theoretically span the genome uninterrupted. (elsevierpure.com)
  • Cowell, JK & Nowak, NJ 2003, ' High-Resolution Analysis of Genetic Events in Cancer Cells Using Bacterial Artificial Chromosome Arrays and Comparative Genome Hybridization ', Advances in Cancer Research , vol. 90, pp. 91-125. (elsevierpure.com)
  • His lab engineers synthetic chromosomes and develops software to analyse 3D chromatin structure or to use Hi-C for genome assembly. (mpg.de)
  • People with ring chromosome 20 syndrome have one copy of this abnormal chromosome in some or all of their cells. (medlineplus.gov)
  • The chromosome deletion indicated more aggressive tumors, with patients living only about half as long as their counterparts who did not have the chromosome loss, says Dr. Gerold Bepler, assistant professor of medicine at Duke and chief of hematology/oncology services at the Veterans Administration Medical Center in Durham, North Carolina. (cancernetwork.com)
  • The Database of Chromosome Aberrations and Gene Fusions in Cancer, established in 1980, is an attempt to register systematically all published cytogenetic aberrations reported in cancer, including patient and tumor characteristics, gene fusions identified by cytogenetics or massively parallel sequencing, and studies pertaining to the clinical relevance of cytogenetic aberrations and/or gene rearrangements. (lu.se)
  • typically occurs as a random event during the formation of reproductive cells (eggs or sperm) or in early embryonic development. (medlineplus.gov)
  • Haplotype construction and analysis of recombination events narrowed the SPG12 locus to a 16.1-cM region between markers D19S868 and D19S902. (nih.gov)
  • Loci of interests in the X-chromosome (DXS9895, GATA172D05 and DXS9898) were amplified in a single PCR with primers of published sequences (1-3). (astm.org)
  • An international research team led by Martin Petr and Janet Kelso of the Max Planck Institute for Evolutionary Anthropology in Leipzig, Germany, has determined Y chromosome sequences of three Neandertals and two Denisovans. (mpg.de)
  • This allowed them to reconstruct the Y chromosome sequences of these individuals, which would not have been possible using conventional approaches. (mpg.de)
  • CGH has been widely applied to detect gains and losses of DNA sequences on specific chromosomes in the study of solid tumours, 1 but has not been extensively used to study unbalanced constitutional karyotypes. (bmj.com)
  • The stochastic inheritance of chromosome fragments by both newly formed daughter cells could in part contribute to the alternating DNA copy-number states that are characteristic of chromothripsis 2 . (nature.com)
  • The researchers pitted their complete Y chromosome sequence, named T2T-Y, against the most widely used reference genome's Y chromosome parts, which are riddled with stretches of absent code. (nist.gov)
  • Researchers are still working to determine the precise relationship between the ring chromosome 20 and the characteristic features of the syndrome. (medlineplus.gov)
  • The researchers also found a protein, called DC1, that binds to every methyl group on XIST and enables it suppress the X chromosome. (drugdiscoverynews.com)
  • Now, researchers in New York have shown what shelterin protects chromosomes from-six different DNA repair systems, including two not previously known to attack telomeres. (the-scientist.com)
  • In this study, the researchers identified three male Neandertals and two Denisovans that were potentially suitable for DNA analysis, and developed an approach to fish out human Y chromosome molecules from the large amounts of microbial DNA that typically contaminate ancient bones and teeth. (mpg.de)
  • The researchers also calculated that the most recent common ancestor of Neandertal and modern human Y chromosomes lived around 370,000 years ago, much more recently than previously thought. (mpg.de)
  • Researchers found that a portion of chromosome 11 was missing in 43% of patients who were heavy smokers. (cancernetwork.com)
  • In this way, you are invited to join us in Botucatu, Brazil in July 21-23 of 2019 for an excellent opportunity to bring exciting B-chromosome related topics and new technologies together for discussion under the view of the most outstanding chromosome biologists. (fems-microbiology.org)
  • By virtue of having 2 X chromosomes, females have 2 loci for every X-linked gene, as compared with a single locus in males. (msdmanuals.com)
  • A . Schematic of the bouquet configuration of chromosomes during meiotic prophase I. The spatial arrangement of chromosomes with telomeres clustered and attached at the inner nuclear membrane is shown. (biorxiv.org)
  • For decades, scientists have known that chromosomes are protected by repetitive DNA known as telomeres, which themselves are protected by a cap of six proteins called shelterin. (the-scientist.com)
  • There aren't four pathways, but six, that pose a threat to the integrity of the chromosome end, and that telomeres must protect against. (the-scientist.com)
  • Join us for the next edition of Cocktails & Chromosomes, "Are you really what you eat? (cshl.edu)
  • Join us for the next edition of Cocktails & Chromosomes, featuring CSHL Associate Professor, Ullas Pedmale. (cshl.edu)
  • The Weill Cornell Medicine investigators demonstrated that XIST is not alone empowered to turn off an X chromosome in every cell of a female mammal. (drugdiscoverynews.com)
  • To investigate the possibility that a novel candidate gene for XLMR was disrupted at the X chromosome translocation breakpoint, we mapped the breakpoint using fluorescence in situ hybridisation (FISH). (bmj.com)
  • The abnormality, called a translocation, occurs when part of a chromosome breaks off and becomes attached to another chromosome. (nih.gov)
  • As each chromosome contains a single centromere, it remains unclear how acentric fragments derived from shattered chromosomes are inherited between daughter cells during mitosis 6 . (nature.com)
  • Here we tracked micronucleated chromosomes with live-cell imaging and show that acentric fragments cluster in close spatial proximity throughout mitosis for asymmetric inheritance by a single daughter cell. (nature.com)
  • Here we show that pulverized chromosomes from micronuclei spatially cluster throughout mitosis and identify the CIP2A-TOPBP1 complex as an essential regulator of this process. (nature.com)
  • While a postdoctoral student at MIT, Tomomi Kiyomitsu discovered how dynein has a role as a motor protein in aligning the chromosomes in the middle of the cell during the metaphase of mitosis. (wikipedia.org)
  • It does this repeatedly so the chromosomes end up in the center of the cell, which is necessary in mitosis. (wikipedia.org)
  • In mitosis, the daughter cells have the identical variety of chromosomes as the mother or father cell, while in meiosis, the daughter cells have half the variety of chromosomes as the parent. (styleslicker.com)
  • Comprehensive analysis of pan-cancer genomes revealed clusters of DNA copy-number-neutral rearrangements-termed balanced chromothripsis-across diverse tumour types resulting in the acquisition of known cancer driver events. (nature.com)
  • These studies implicate a potential mechanism suppressing the loss of genetic material after chromosome pulverization, although how distinct patterns of rearrangements arise in cancer and germline disorders remains unclear. (nature.com)
  • Yildirim thinks there's an important link between Xist and cancer because some cancer cells are seen to lack the inactivated clump of X chromosome that Xist creates, which is known as the Barr body in human cells. (duke.edu)
  • The question was, is Xist loss or change in the amount of active X-chromosome a cause or a consequence of cancer? (duke.edu)
  • Chromosome analysis of cancer cells has been one of the primary means of identifying key genetic events in the development of cancer. (elsevierpure.com)
  • For the first time, scientists have directly observed events that lead to the formation of a chromosome abnormality that is often found in cancer cells. (nih.gov)
  • A study of lung cancer patients led by Duke University investigators and funded by the V Foundation showed chromosome loss in nearly half of those classified as "heavy smokers. (cancernetwork.com)
  • No chromosome loss was found in lung cancer patients who were nonsmokers. (cancernetwork.com)
  • While further studies need to be done, the finding could lead to more aggressive treatments for lung cancer patients who demonstrate the chromosome loss, he says. (cancernetwork.com)
  • In Notes, a publication from the Duke Comprehensive Cancer Center, Bepler says the missing length of chromosome may serve as a prognostic molecular marker to physicians, indicating an out-of-control, fast-growing tumor that needs intensive treatment measures. (cancernetwork.com)
  • The short arm of chromosome 11 (11p) is also altered in breast and bladder cancer and in the childhood tumor rhabdomyosarcoma and Wilms tumor, he adds. (cancernetwork.com)
  • In his search for a gene that causes lung cancer, he is concentrating on another portion of chromosome 11, the LOH11A region. (cancernetwork.com)
  • He says the research team came across the chromosome break in their search for a lung cancer gene. (cancernetwork.com)
  • It is unlikely that complete cause these events and how the events relate to the knowledge of how an agent causes cancer will exist, cancer process, this information can help reduce the certainly for the near term. (cdc.gov)
  • In human dividing cells 46 chromosomes can be observed. (carnivorousplants.org)
  • Orthologous to human SMC5 (structural maintenance of chromosomes 5). (nih.gov)
  • Human Chromosome Two: An Open Letter to BioLogos on the Genetic Evidence, Cont. (evolutionnews.org)
  • First, the specific DNA sequence found in the human chromosome in question, defies any such fusion event. (evolutionnews.org)
  • For such a fusion event would have occurred in, and spread through, an early human population. (evolutionnews.org)
  • The fused chromosome did not arise from another species, it was not inherited from a human-chimp common ancestor, or any other purported common ancestor. (evolutionnews.org)
  • And here is a typical lesson informing students that these chromosomes are "striking evidence of [human and ape] common ancestry. (evolutionnews.org)
  • The data show that Neandertals may have benefited from these interactions as the gene flow resulted in the complete replacement of the original Neandertal Y chromosomes by their early modern human counterparts. (mpg.de)
  • Y chromosomes, and also the maternally-inherited mitochondrial DNA, have been extremely valuable for studying human history. (mpg.de)
  • By comparing the archaic human Y chromosomes to each other and to the Y chromosomes of people living today, the team found that Neandertal and modern human Y chromosomes are more similar to one another than they are to Denisovan Y chromosomes. (mpg.de)
  • 18- 21 Xq28 is a highly gene rich region of the human X chromosome and we focused on the X chromosome breakpoint as the identification of a disrupted gene here would be a rapid way to identify a further candidate gene for X linked mental retardation within Xq28. (bmj.com)
  • In spite of our lack of attention to chromosomes and chromosome numbers in formally defining species, it is the chromosomes and the genetic material they contain that define true species and control the evolution of new species. (carnivorousplants.org)
  • 2018 is CDO's 26th year of providing support for all those coping with a rare chromosome disorder diagnosis. (chromodisorder.org)
  • It was not until the early 20 th century that it was demonstrated that chromosomes contain the material of hereditary and it took until the middle 20 th century to determine that DNA in chromosomes was the principle coding molecule of heredity. (carnivorousplants.org)
  • Thus, distinct patterns of chromothripsis can be explained by the spatial clustering of pulverized chromosomes from micronuclei. (nature.com)
  • is a circular structure that occurs when a chromosome breaks in two places and its broken ends fuse together. (medlineplus.gov)
  • Second, even if, somehow, such a fusion event occurred (in spite of the DNA sequence data), it would not demonstrate evolution as evolutionists claim. (evolutionnews.org)
  • Meiosis is a sequence of events that organize and separate chromosomes into daughter cells. (styleslicker.com)
  • The results of a study published in Nature demonstrate that this advance improves DNA sequencing accuracy for the chromosome, which could help identify certain genetic disorders and potentially uncover the genetic roots of others. (nist.gov)
  • Donate now to increase awareness and research into chromosome disorders. (chromodisorder.org)
  • Physicians, genetic counselors, therapists and other healthcare professionals, register now to help us learn more about rare chromosome disorders: the associated symptoms, new research and evolving treatments. (chromodisorder.org)
  • Help us in our efforts to raise awareness of rare chromosome disorders by visiting our online store. (chromodisorder.org)
  • In collaboration with the rest of the team, he also went some way to understanding the clever molecular trick that enabled cells to go on dividing indefinitely without suffering from shortened chromosome ends. (sciencedaily.com)
  • Chromosome 8 was found to harbor the most frequent copy number alterations. (jcancer.org)
  • and protein localization to chromosome, centromeric region. (nih.gov)
  • These Y chromosomes provide new insights into the relationships and population histories of archaic and modern humans, including new evidence for ancient gene flow from early modern humans into Neandertals. (mpg.de)
  • A randomized clinical trial is needed to determine whether the second-generation Abl-tyrosine kinase inhibitor dasatinib is more effective than the first-generation inhibitor imatinib mesylate for childhood Philadelphia chromosome-positive acute lymphoblastic leukemia (ALL). (nih.gov)
  • To determine whether dasatinib given at a daily dosage of 80 mg/m2 is more effective than imatinib mesylate at a daily dosage of 300 mg/m2 to improve event-free survival of children with Philadelphia chromosome-positive ALL in the context of intensive chemotherapy without prophylactic cranial irradiation. (nih.gov)
  • B chromosomes are enigmatic accessory elements to the regular chromosome set (A) and, since their discovery at the beginning of 20th century, Bs have ranked among the main topics of chromosome biology. (fems-microbiology.org)