• testosterone
  • Physicians do not have sufficient information from clinical trials to understand the risks associated with the prescription of testosterone in older men, according to a Comment in The Lancet Diabetes & Endocrinology , written by Professor Stephanie Page, of the University of Washington and Harborview Medical Center, Seattle, USA. (eurekalert.org)
  • Existing studies have produced conflicting findings over whether the prescription of testosterone is associated with increased cardiovascular risk in older men, and ongoing studies are unlikely to adequately address this question, meaning that even if an appropriately powered trial were to start today, reliable safety data are at least a decade away. (eurekalert.org)
  • Physicians need to discuss with their patients that we simply do not fully understand the risks associated with testosterone use in older men, and use conservative treatment guidelines - such as those provided by the Endocrine Society - to guide therapeutic decisions. (eurekalert.org)
  • The FDA has required that labels on testosterone include warnings about increased risk of heart attacks and stroke. (wikipedia.org)
  • In addition, a number of other effects of testosterone have led to research into possible therapeutic roles in: Erectile dysfunction[citation needed] Osteoporosis Diabetes mellitus Chronic heart failure Dementia, but the evidence base is small and the balance of benefit needs to be clarified Transgender hormone therapy for transgender men The risks of diabetes and of testosterone deficiency in men over 45 (i.e., hypogonadism, specifically hypoandrogenism) are strongly correlated. (wikipedia.org)
  • progression
  • In the phase 3 portion of the study, the selected nab-paclitaxel combination treatment will be compared to gemcitabine combined with carboplatin to evaluate progression free survival, safety and tolerability, overall survival, disease control rate and duration of response in women with metastatic triple negative breast cancer. (clinicaltrials.gov)
  • calculate
  • Under the guidance of Pinar Keskinocak, ISyE's William W. George Chair, and CDC subject matter experts (SMEs), the fall 2014 Senior Design team - Nishi Anand, Dylan Buczek, Nicholas Buczek, Timothy Lin, Tanay Rajore, and Muriel Wacker - developed two prototype tools to help physicians and their patients calculate the risk of infectious encephalitis and evaluate the benefits and risks of accepting IRD livers for transplant. (gatech.edu)
  • Actuarial statistics: The statistics used by actuaries to calculate liabilities, evaluate risks and plan the financial course of insurance, pensions, etc. (wikipedia.org)
  • auditors
  • The Statement on Auditing Standards (SAS) No. 99, Consideration of Fraud in a Financial Statement Audit , requires auditors to consider potential fraud risks before and during the information-gathering process. (kpmcpa.com)
  • Auditors generally are not required to investigate fraud, but they are required to communicate fraud risk findings to the appropriate level of management who can then take actions to prevent fraud in their organizations. (kpmcpa.com)
  • Once the trigger has been pulled, the PCAOB will require auditors to perform detailed testing around cyber risks and controls. (msbusiness.com)
  • benefits
  • Health officials this fall will reassess hormone replacement therapy for post-menopausal women in response to a recent study questioning the therapy's risks and benefits. (michigansthumb.com)
  • clarification needed] The introduction and spread of invasive species can also be managed with IPM by reducing risks while maximizing benefits and reducing costs. (wikipedia.org)
  • The theory behind due diligence holds that performing this type of investigation contributes significantly to informed decision making by enhancing the amount and quality of information available to decision makers and by ensuring that this information is systematically used to deliberate in a reflexive manner on the decision at hand and all its costs, benefits, and risks. (wikipedia.org)
  • bone
  • Clusters were identified as high, average or low fracture risk based on bone mineral density (BMD) characteristics. (springer.com)
  • It is also not usually recommended for improving cognition, the risk of heart disease, bone strength, or for generalized well being. (wikipedia.org)
  • stroke
  • In addition, because of the expected rates of infection such as upper respiratory infections, and psychological stress, the Haj pilgrimage brings a unique opportunity to evaluate any impact of such factors on the occurrence of stroke," he said. (com.sa)
  • Recent
  • are oral contraceptive drugs that have been the subject of recent lawsuits because of their link to an increased risk of blood clots. (unsafedrugs.com)
  • potential
  • Steinberg states in his article "Risk Taking in Adolescence: New Perspectives from Brain and Behavioral Science" that "systematic research does not support the stereotype of adolescents as irrational individuals who believe they are invulnerable and who are unaware, inattentive to, or unconcerned about the potential harms of risky behavior. (wikipedia.org)
  • A common example of due diligence in various industries is the process through which a potential acquirer evaluates a target company or its assets for an acquisition. (wikipedia.org)
  • take
  • Samuel Plimsoll pointed out the obvious downside of insurance: "The ability of shipowners to insure themselves against the risks they take not only with their property, but with other peoples' lives, is itself the greatest threat to the safe operation of ships. (wikipedia.org)
  • levels
  • DXA scan results could identify high-risk subjects with different antiresorptive treatment compliance levels based on similarities and differences in lumbar spine and hip region BMD. (springer.com)
  • The UN's Food and Agriculture Organization defines IPM as "the careful consideration of all available pest control techniques and subsequent integration of appropriate measures that discourage the development of pest populations and keep pesticides and other interventions to levels that are economically justified and reduce or minimize risks to human health and the environment. (wikipedia.org)
  • decision
  • We will only achieve acceptance for the new technology if we talk to the decision makers and the public about the risks as well. (empa.ch)
  • high-risk
  • A mean age of 60 years was the earliest that allowed for separation of high-risk clusters. (springer.com)
  • DUI Intensive Supervision Program (DISP): DISP is an intensive supervision program that targets high risk drunk driver and offenders whose offenses involve the use of alcohol/drugs and result in great bodily injury. (wikipedia.org)
  • greatest risk
  • The courses offered go beyond basic riding skills necessary to become licensed and focus on the specific arenas identified as posing the greatest risk to the military riders. (wikipedia.org)
  • model
  • The Active Region Model was evaluated as an alternative to the traditional, uniform flow model (Richard's equation) to describe bacterial transport in a wastewater treatment facility. (diva-portal.org)
  • This example shows how to model the market risk of a hypothetical global equity index portfolio with a Monte Carlo simulation technique using a Student's t copula and Extreme Value Theory (EVT). (mathworks.com)
  • look
  • To answer that question, let's first look at two universal risks in the supply chain today. (parcelindustry.com)
  • This fundamentally changes how cyber threats are evaluated and managed, enabling an independent, objective look at an organization's processes, policies and controls around cyber risks. (msbusiness.com)
  • With the number and size of penalties increasing, the Foreign Corrupt Practices Act (FCPA) is causing many U.S. institutions to look into how they evaluate all of their relationships overseas. (wikipedia.org)
  • consider
  • This study showed that statistical risk-factor assessments of groundwater contamination need to consider spatial interactions when the water sources are located close to each other. (diva-portal.org)
  • make
  • If conditions exist that make it impractical to plan an audit in a way that will adequately address fraud risks, an auditor may even decide to withdraw from the engagement. (kpmcpa.com)
  • Classification surveyors inspect ships to make sure that the ship, its components and machinery are built and maintained according to the standards required for their class In the second half of the 18th century, London merchants, shipowners, and captains often gathered at Edward Lloyds' coffee house to gossip and make deals including sharing the risks and rewards of individual voyages. (wikipedia.org)
  • manage
  • The big question is, how do you evaluate risk in your supply chain, and what action will best manage or avoid risk all together? (parcelindustry.com)
  • By anticipating the growing concerns and growing cyber threats, board members should start taking steps to manage cyber risks and help your business jump ahead of the competition by being first to the market with cyber resilience that makes your company more distinctive as a trusted partner. (msbusiness.com)
  • public
  • The supervision may be intensive for offenders whose behavior poses a continuous threat to public safety or mid-level for those whose offenses pose less of a risk to the public. (wikipedia.org)
  • often
  • Once these rules are in place, companies believe the risk has been mitigated and often lose sight of the total cost of these rules or whether there is a better way. (parcelindustry.com)
  • In the past, organs with a small risk of infection were often not chosen for transplant. (gatech.edu)
  • mean
  • Two clusters of younger subjects ( n = 1058, mean ages 30 and 51 years) were identified as low fracture risk with high to very high BMD. (springer.com)
  • Listing a study does not mean it has been evaluated by the U.S. Federal Government. (clinicaltrials.gov)
  • possible
  • In the near future, it's entirely possible that cyber risks will be included as part of the 10-K. In fact, there is legislation in the House now that would require cyber to be included in SOX certifications and testing. (msbusiness.com)
  • understand
  • It's important to not only understand what policies you have, but Independently evaluate those policies and controls to ensure your approach appropriately mitigates your cyber risks. (msbusiness.com)
  • technology
  • When it comes to managing risk, the rapid rate at which technology is changing and the growing cyber risks leave board members in a difficult position. (msbusiness.com)
  • study
  • The purposes of this study were to establish and quantify patient clusters of high, average and low fracture risk using an unsupervised machine learning algorithm. (springer.com)
  • In the phase 2 portion of the study, the combinations of nab-paclitaxel plus gemcitabine and nab-paclitaxel plus carboplatin will be evaluated, and a comparator arm of gemcitabine combined with carboplatin will be used. (clinicaltrials.gov)
  • Risk factors for faecal contamination of groundwater-fed drinking-water sources were evaluated in a case study in Juba, South Sudan. (diva-portal.org)
  • issue
  • A collaborative project between ISyE and the Centers for Disease Control and Prevention (CDC) addresses this issue of risk estimation and perception, with the goal of assessing the risk of infection in an organ donor, and evaluating the options of receiving an increased-risk donor (IRD) organ versus staying on the waitlist for a patient. (gatech.edu)
  • level
  • And lack of innovation eventually introduces a new risk level to not only the supply chain, but the whole business. (parcelindustry.com)
  • ahead
  • After several transmissions of infectious diseases that occurred through transplants where these infections (or the risk) were not detected ahead of time, use of many more organs were discouraged because of problems with understanding the risk. (gatech.edu)
  • competition
  • Steinberg also posits that this is because teenage risk-taking is generated by competition between the socioemotional and cognitive-control networks. (wikipedia.org)
  • growth
  • Risk factors are not limited to impaired and disproportionate growth, low birth weight, delayed skeletal maturity, short stature, systemic hormonal changes, and low economic index. (wikipedia.org)