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  • presence of ethanol
  • Results: Cultures maintained in the presence of ethanol demonstrated a G2/M cell cycle arrest that was associated with a reduction in DNA content and increased levels of p-Cdc2 and p21, compared with cells cultured in its absence. (mdpi.com)
  • Studies demonstrate that the removal of this accumulated ethanol does not immediately restore fermentative activity, and they provide evidence that the decline in metabolic rate is due to physiological changes (including possible ethanol damage) rather than to the presence of ethanol. (wikipedia.org)
  • reaction
  • This change in distribution of reaction products is related to stronger acidity character of surface OH groups and inhibition effect of formed water vapours on the oxidative dehydrogenation products (acetaldehyde). (springer.com)
  • Andrushkevich T, Kaichev V, Chesalov YA, Saraev A, Buktiyarov V (2017) Selective oxidation of ethanol over vanadia-based catalysts: the influence of support material and reaction mechanism. (springer.com)
  • The reaction showed a first order dependence with respect to acetaldehyde concentration, [Mn(VII)], fractional order to [H+] and independent on the ionic strength of the solution. (escipub.com)
  • In this reaction, ethanol is oxidized (losing two hydrogens) and O2 is reduced (by accepting hydrogen) to form H2O. (wikipedia.org)
  • redox
  • Beck B, Harth M, Hamilton NG, Carrero C, Uhlrich JJ, Trunschke A, Shaikhutdinov S, Schubert H, Freund H-J, Schlögl R (2012) Partial oxidation of ethanol on vanadia catalysts on supporting oxides with different redox properties compared to propane. (springer.com)
  • exerts
  • Ethanol exerts a wide array of effects. (frontiersin.org)
  • Two lines of research involving acetaldehyde are reviewed: (1) implications of the formation of acetaldehyde in brain areas such as the NArc, with high expression of ethanol metabolizing enzymes and presence of cell bodies of endorphinic neurons and (2) the formation of condensation products between DA and acetaldehyde such as salsolinol, which exerts its actions via OR. (frontiersin.org)
  • 2017
  • Boldog I, Čičmanec P, Ganjkhanlou Y, Bulánek R (2017) Surfactant templated synthesis of porous VO x -ZrO 2 catalysts for ethanol conversion to acetaldehyde. (springer.com)
  • consumption
  • We also show a meta-analytical correlational approach that proposes how differences in the activity of brain catalase across ontogeny, could be modulating patterns of ethanol consumption. (frontiersin.org)
  • The role of β-endorphin and µ-opioid receptors (OR) have been suggested to be of particular importance in mediating some of the behavioral effects of ethanol, including psychomotor stimulation and sensitization, consumption and conditioned place preference (CPP). (frontiersin.org)
  • Product analysis revealed the presence of carboxylic acid and stoichiometric study suggests the consumption of 2 moles of MnO4- by 3 moles of acetaldehyde in both solvents. (escipub.com)
  • A hangover is the experience of various unpleasant physiological and psychological effects following the consumption of ethanol, as found in wine, beer and distilled spirits. (wikipedia.org)
  • intake
  • Ethanol intake usually begins during adolescence, with a decrease in the average age of initiation in the United States from 17.8 years in 1987 to 15.9 years in 1996 ( Windle, 2003 ). (frontiersin.org)
  • Oral intake of slow-release L-cysteine 200 mg before challenge with ethanol. (clinicaltrials.gov)
  • pyruvate
  • Finally, pyruvate is converted to ethanol and CO2 in two steps, regenerating oxidized NAD+ needed for glycolysis: 1. (wikipedia.org)
  • ALDH2
  • Since ALDH2 assembles and functions as a tetramer and requires all four of its components to be active in order to metabolize acetaldehyde, heterozygotes have very little ALDH2 activity. (wikipedia.org)
  • exposure
  • Why Should we Study Early Ethanol Exposure Effects? (frontiersin.org)
  • Yet, ethanol exposure can occur involuntarily earlier in ontogeny ( Spear and Molina, 2005 ). (frontiersin.org)
  • Ethanol drinking during breastfeeding is still highly prevalent and implies an alternative mode of early exposure to the drug (e.g. (frontiersin.org)
  • These epidemiological studies highlight the need for developing experimental animal models for understanding the above mentioned effects of early ethanol exposure. (frontiersin.org)
  • Expected results show mitigated exposure of the gastric mucosa to acetaldehyde. (clinicaltrials.gov)
  • Based on these assumptions slow-release L-cysteine binds acetaldehyde to form inactive MTCA, which remains in gastric juice resulting in reduced local exposure of the gastric mucosa to carcinogenic acetaldehyde. (clinicaltrials.gov)
  • The initial symptoms of methanol exposure are usually less severe than the symptoms from the ingestion of a similar quantity of ethanol. (wikipedia.org)
  • The increased exposure to acetaldehyde in individuals with the catalytically inactive form may also confer greater susceptibility to many types of cancer. (wikipedia.org)
  • Exposure to oxygen can exacerbate the fault due to the oxidation of ethanol to acetaldehyde, which leaves the wine with a sharp vinegar-like taste. (wikipedia.org)
  • reactive
  • Although reactive oxygen species are thought to have a significant role in ethanol-induced hepatocellular damage, they may have a less important role in the inability of hepatocytes to replace dead or damaged cells. (mdpi.com)
  • metabolize
  • Background: Hepatocytes metabolize the vast majority of ingested ethanol. (mdpi.com)
  • The increase in rest energy expenditure has, according to some studies, been explained by indicating that the MEOS "expends" nine calories per gram of ethanol to metabolize versus 7 calories per gram of ethanol ingested. (wikipedia.org)
  • formate
  • In 1822, Georges-Simon Serullas added potassium metal to a solution of iodine in ethanol and water to form potassium formate and iodoform, called in the language of that time hydroiodide of carbon. (wikipedia.org)
  • ingestion
  • Buccal cells were collected before ethanol ingestion. (separationsnow.com)
  • First, methanol (whether it enters the body by ingestion, inhalation, or absorption through the skin) can be fatal due to its CNS depressant properties in the same manner as ethanol poisoning. (wikipedia.org)
  • receptors
  • Significant evidence implicates the endogenous opioid system (EOS) (opioid peptides and receptors) in the mechanisms underlying the psychopharmacological effects of ethanol. (frontiersin.org)
  • Ethanol modulates opioidergic signaling and function at different levels, including biosynthesis, release, and degradation of opioid peptides, as well as binding of endogenous ligands to opioid receptors. (frontiersin.org)
  • Evidence indicates that ethanol modulates the activity of different components of the endogenous opioid system (EOS), with a large body of data supporting the implication of opioid ligands and receptors in the mediation of some of the psychopharmacological effects of ethanol. (frontiersin.org)
  • increases
  • Ethanol increases the release of β-endorphin from the hypothalamic arcuate nucleus (NArc), which can modulate activity of other neurotransmitter systems such as mesolimbic dopamine (DA). (frontiersin.org)
  • intermediate
  • By using static headspace-gas chromatography for liquid phase analysis, we identify acetaldehyde as a minor product and key intermediate in the electroreduction of CO to ethanol on OD-Cu electrodes. (osti.gov)
  • consume
  • This is supported by research that determined the kinetic behavior of the ancestral ADH protein, which was found to be optimized to make ethanol, rather than consume it. (wikipedia.org)