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  • prevent
  • Can estrogen plus progestin prevent recurrent nonfatal myocardial infarction (MI) and coronary heart disease (CHD) mortality in postmenopausal women with established CHD? (acpjc.org)
  • women
  • Randomized trial of estrogen plus progestin for secondary prevention of coronary heart disease in postmenopausal women. (acpjc.org)
  • effects of estrogen
  • Finally, ERα appears to mediate positive feedback effects of estrogen on the brain's secretion of GnRH and LH, by way increasing expression of kisspeptin in neurons of the arcuate nucleus and anteroventral periventricular nucleus. (wikipedia.org)
  • Although classical studies have suggested that negative feedback effects of estrogen also operate through ERα, female mice lacking ERα in kisspeptin-expressing neurons continue to demonstrate a degree of negative feedback response. (wikipedia.org)
  • ethinylestradiol
  • Treatment with up to extremely high doses of ethinylestradiol (fourteen 100-µg patches per week) had no effect on any of his symptoms of hypoestrogenism, did not produce any estrogenic effects such as gynecomastia, and had no effect on any of his physiological parameters (e.g., hormone levels or bone parameters), suggesting a profile of complete estrogen insensitivity syndrome. (wikipedia.org)
  • produced by the ovaries
  • In addition to being produced by the ovaries, estrogen is also produced by the body's fat tissue. (webmd.com)
  • Busy estrogen, produced by the ovaries and later by the placenta, helps the uterus grow, maintains the uterine lining (where your budding baby is safely nestled), steps up blood circulation, and activates and regulates the production of other key hormones. (whattoexpect.com)
  • selective
  • 17β-Dihydroequilenin has unexpectedly shown a selective estrogen receptor modulator-like profile of estrogenic activity in studies with monkeys, in which beneficial effects on bone and the cardiovascular system were noted but proliferative responses in breast or endometrium were not observed. (wikipedia.org)
  • It is a fixed-dose combination drug containing the selective estrogen receptor modulator bazedoxifene and conjugated estrogens being marketed by the pharmaceutical company Pfizer. (wikipedia.org)
  • On the other hand, virtually all selective estrogen receptor modulators (SERMs) are nonsteroidal, with triphenylethylenes like tamoxifen and clomifene having been derived from DES, and these drugs remain widely used in medicine for the treatment of breast cancer among other indications. (wikipedia.org)
  • Estrogen Action, Selective Estrogen Receptor Modulators, and Women's Health: Progress and Promise. (wikipedia.org)
  • In addition, the different estrogen receptor combinations may respond differently to various ligands, which may translate into tissue selective agonistic and antagonistic effects. (wikipedia.org)
  • The concept of selective estrogen receptor modulators is based on the ability to promote ER interactions with different proteins such as transcriptional coactivator or corepressors. (wikipedia.org)
  • ovarian
  • Esterified estrogens are indicated to replace estrogen in women with ovarian failure or other conditions that cause a lack of natural estrogen in the body. (drugbank.ca)
  • This adult ovarian phenotype suggests that in the absence of ERα, estrogen is no longer able to perform negative feedback on the hypothalamus, resulting in chronically elevated LH levels and constant ovarian stimulation. (wikipedia.org)
  • androgen
  • When used in high doses, estrogens are powerful antigonadotropins, strongly inhibiting secretion of the gonadotropins luteinizing hormone and follicle-stimulating hormone from the pituitary gland, and in men are able to completely suppress gonadal androgen production and reduce testosterone levels into the castrate range. (wikipedia.org)
  • uterus
  • Esterified estrogens increase the risk of developing a condition (endometrial hyperplasia) that may lead to cancer of the lining of the uterus. (cardiosmart.org)
  • Therefore, if your uterus has not been removed, your doctor may prescribe a progestin for you to take together with the estrogen. (cardiosmart.org)
  • The uterus of female ERKO mice is hypoplastic, suggesting that ERα mediates mitosis and differentiation in the uterus in response to estrogen stimulation. (wikipedia.org)
  • testosterone
  • The ovaries produce both testosterone and estrogen . (webmd.com)
  • All of the different forms of estrogen are synthesized from androgens , specifically testosterone and androstenedione , by the enzyme aromatase . (wikipedia.org)
  • Also, be aware that Testosterone CAN (not necessarily, but can) convert to Estrogens and DHT. (exrx.net)
  • Testosterone, which is available as a medication, is metabolized in part to estrogens such as estradiol, and can produce significant estrogenic effects at high dosages, most notably gynecomastia. (wikipedia.org)
  • Estrogen levels were dramatically and persistently elevated (estradiol levels were 2,340 pg/mL, regarded as being about 10 times the normal level, and ranged from 750-3,500 pg/mL), gonadotropin levels were mildly elevated (follicle-stimulating hormone and luteinizing hormone levels were 6.7-19.1 mIU/mL and 5.8-13.2 mIU/mL, respectively), and testosterone levels were slightly elevated (33-88 ng/dL). (wikipedia.org)
  • actions of estrogen
  • The actions of estrogen are mediated by the estrogen receptor (ER), a dimeric nuclear protein that binds to DNA and controls gene expression. (wikipedia.org)
  • Indeed, as many as four hundred different actions of estrogen have been identified, affecting such diverse systems as circulation, brain activity, sexual behavior, bone biology, sleep patterns, intestinal absorption of food, and immune activity. (encyclopedia.com)
  • woman's body
  • Estrogen is a hormone produced in a woman's body and tends to raise HDL cholesterol, helping women to have higher levels of "good" cholesterol levels than men. (heart.org)