Estrogen promoter regions genetic. Medical search. Frequent questions

This gene encodes a member of the family of estrogen receptors and superfamily of nuclear receptor transcription factors. (cancerindex.org)
Interestingly, we show that functional cross talk of GPR30 with both activated EGFR and ERÎ± relies on a physical interaction among these receptors, further extending the potential of estrogen to trigger a complex stimulatory signaling network in hormone-sensitive tumors. (unical.it)
Evaluation of the state of estrogen receptors in breast cancer patients has become clinically important. (lookformedical.com)
There are two kinds of progesterone receptors, A and B. Both are induced by estrogen and have short half-lives. (lookformedical.com)
Approximately two thirds of breast cancer cases overexpress estrogen receptors (ER) and/or progesterone receptors (PgR) ( 7 , 8 ). (spandidos-publications.com)
This review highlights the genes and genetic polymorphisms currently studied, identified as influential in the genesis of IS, such as MMP-3, IL-6, type I collagen, and vitamin D and estrogen receptors. (scielo.br)
SUMO1 enhances 17-beta estradiol's effect on CRH promoter activation through estrogen receptors. (nel.edu)
Zhu H, Zhou J. SUMO1 enhances 17-beta estradiol's effect on CRH promoter activation through estrogen receptors. (nel.edu)
1997). Due to the numerous functions that estrogens play in the animals, estrogen receptors and their genes are considered candidates for the markers of production and functional traits in farm animals, including cattle. (ijlr.org)
Estrogen exerts its effects through the estrogen receptors, a member of the nuclear steroid thyroid hormone receptors superfamily, which is expressed in a cell and tissue-specific manner. (ijlr.org)
This specific pattern of estrogen receptors expression enables estrogens to direct their effects to target tissues (Green and Chambon, 1988). (ijlr.org)
Estrogen and estrogen receptors ( ER ) play an important role in development and maintenance of the female reproductive system, maintaining fertility and the regulation of bone development and maintenance (Anderson et al . (ijlr.org)

A single nucleotide polymorphism (SNP) in the 3′ untranslated region (UTR) of HDAC6 was found to segregate with the chondrodysplasia. (wikipedia.org)
In the third study, gene methylation was evaluated for promoters of vtg1 (8 CpGs) and vtg2 (10 CpGs) in both populations, and vtg1 promoter sequences were examined for single nucleotide polymorphism (SNPs). (oregonstate.edu)

Inhibitory AhR-ER crosstalk was investigated in Ishikawa cells using E2-induced cell proliferation and transcriptional activation assays in cells transfected with E2-responsive constructs containing promoter inserts from the progesterone receptor and vitellogenin A2 genes. (tamu.edu)
In this setting, a crescent focus has been placed on the identification of genes, associated genetic polymorphisms, and multiple susceptibility loci. (scielo.br)
En ese sentido, existe un creciente enfoque en la identificación de genes, polimorfismos genéticos asociados y loci de susceptibilidad múltiples. (scielo.br)
La presente revisión destaca los genes y polimorfismos genéticos actualmente estudiados, identificados como influyentes en la génesis de la EI, como los genes MMP-3, IL-6, colágeno tipo 1 y receptores de vitamina D y de estrógeno. (scielo.br)
Genetic susceptibility to cancer: the role of polymorphisms in candidate genes. (snpedia.com)
Polymorphisms in estrogen- and androgen-metabolizing genes and the risk of gastric cancer. (snpedia.com)
Genetic variants and prostate cancer risk: candidate replication and exploration of viral restriction genes. (snpedia.com)
The present study was carried out with the objective to determine the polymorphism of CYP19 (promoter) and ER1 genes and their possible association with cystic ovarian disease in HF crossbred cows. (ijlr.org)
We mapped all estrogen receptor and RNA polymerase II binding sites on a genome-wide scale, identifying the authentic cis binding sites and target genes, in breast cancer cells. (nature.com)
Combining this unique resource with gene expression data demonstrates distinct temporal mechanisms of estrogen-mediated gene regulation, particularly in the case of estrogen-suppressed genes. (nature.com)
Chronic exposure of killifish to a highly polluted environment desensitizes estrogen-responsive reproductive and biomarker genes. (oregonstate.edu)
Here, we characterized the effects on estrogen signaling and the transcriptional regulation of estrogen-responsive genes in this model population. (oregonstate.edu)
The second study assessed expression for various metabolism (cyp1a, cyp3a30, mdr) and estrogen receptor (ER α, ER βa, ER βb) genes under basal and estrogen treatment conditions in both populations. (oregonstate.edu)
The decreased transcriptional sensitivity of estrogen-responsive genes is suggestive of a broad effect on estrogen receptor pathway signaling, and provides insight into the mechanisms of the endocrine disrupting effects in the Newark Bay population. (oregonstate.edu)
Differential tissue distribution, developmental programming, estrogen regulation and promoter characteristics of cyp19 genes in teleost fish. (egejfas.org)
Expression of zebra fish Aromatase cyp19a and cyp19b genes in response to the ligands of estrogen receptor and aryl hydrocarbon receptor. (egejfas.org)
Methylation in promoter regions of the MTNR1A, MTNR1B, PGR, ESR1 and ESR2 genes was analyzed by pyrosequencing in a nested case-control study of female nurses, including 354 breast cancer cases and 356 healthy controls. (fortunejournals.com)
No association between promoter methylation levels and breast cancer risk was observed for the other receptor genes investigated. (fortunejournals.com)

To investigate the correlation between the polymorphism of estrogen receptor β gene (ESR2) rs3020450 and cancer susceptibility, and explore the epidemiological significance and the effect of ESR2 expression levels on the prognosis of ovarian cancer. (cancerindex.org)
PMID 22419734 ] Genetic Polymorphism CYP17 rs2486758 and Metabolic Risk Factors Predict Daily Salivary 17? (snpedia.com)
2014) explored genetic polymorphism of exon 2 of CYP19 gene and its association with ovarian activity in Egyptian buffaloes using PCR-SSCP and sequencing analysis. (ijlr.org)
The aim of this study was to identify and characterize the genetic polymorphism in promoter region of CYP19 gene by RFLP analysis and to elucidate the relationship between polymorphism in CYP19 gene and COD in HF crossbred cattle. (ijlr.org)

Estrogen receptor-alpha (ERalpha) promotes proliferation of breast cancer cells, whereas tumor suppressor protein p53 impedes proliferation of cells with genomic damage. (nih.gov)

Estrogen and aryl hydrocarbon receptor expression and crosstalk in human Ishikawa endometrial cancer cells. (tamu.edu)
Ishikawa endometrial cancer cells express the estrogen receptor (ER), and this study investigates aryl hydrocarbon receptor (AhR) expression and inhibitory AhR-ER crosstalk in this cell line. (tamu.edu)

In humans, one of the paired regions in the anterior portion of the THORAX. (lookformedical.com)

Excessive exposure to estrogen is a well-established risk factor for endometrial cancer (EC), particularly for cancers of endometrioid histology. (edu.au)

The transcriptional activity of the estrogen receptor (ER) may be modified by small-ubiquitin related modifier (SUMO1). (nel.edu)
The estrogen receptor is the master transcriptional regulator of breast cancer phenotype and the archetype of a molecular therapeutic target. (nature.com)
Analyses of the human AHR proximal promoter in MCF-7 human breast cancer cells using luciferase assays and electrophoretic mobility shift assays revealed multiple specificity protein (Sp) 1 binding sequences that are transcriptional activators in vitro. (umn.edu)

Furthermore, this resource has allowed the identification of cis -regulatory sites in previously unexplored regions of the genome and the cooperating transcription factors underlying estrogen signaling in breast cancer. (nature.com)
Figure 5: Involvement of cooperating transcription factors at estrogen receptor binding sites. (nature.com)

The basis for this recalcitrant phenotype could not be explained by a change in 17β-estradiol metabolism, nuclear estrogen receptor expression, promoter methylation (gene silencing) or SNPs, all of which were unaltered and normal in the Newark Bay population. (oregonstate.edu)
We demonstrate that increased methylation of the MTNR1A promoter is associated with increased risk of breast cancer (OR=1.13, 95% CI: 1.02 -1.24, P=0.019). (fortunejournals.com)

Overall, these studies show that multi-chemical exposures at Newark Bay have desensitized all reproductive biomarkers tested to estrogen. (oregonstate.edu)
TERT Promoter Mutations as Simple and Non-Invasive Urinary Biomarkers for the Detection of Urothelial Bladder Cancer in a High-Risk Region. (cdc.gov)

We found that estradiol could elevate CRH promoter activity to a much higher level in cells co-transfected with ER and SUMO1 than that with ER alone, and that the enhancement was blocked by the ER inhibitor, ICI182,780. (nel.edu)

Tamoxifen acts as an anti-estrogen (inhibiting agent) in the mammary tissue, but as an estrogen (stimulating agent) in cholesterol metabolism, bone density, and cell proliferation in the ENDOMETRIUM. (lookformedical.com)
Paralleling the emergence of targeted therapeutics in cancer treatment, a variety of experimental approaches has led to the conclusion that tumors bearing some specific genetic alterations may lead them to be uniquely sensitive to agents deregulating their cellular metabolism. (aacrjournals.org)
Women with polycystic ovarian syndrome (PCOS) have abnormalities in the metabolism of androgens and estrogen and in the control of androgen production. (medscape.com)

Clinical and genetic characteristics of amyotrophic lateral sclerosis patients with ANXA11 variants. (cdc.gov)

Location analysis of estrogen receptor {alpha} target promoters reveals that FOXA1 defines a domain of the estrogen response. (hum-molgen.org)

Cytoplasmic proteins that bind estrogens and migrate to the nucleus where they regulate DNA transcription. (lookformedical.com)
The effects of POP inhibition and knockdown on the proliferation of cultured human estrogen receptor-positive (ER+) MCF7 and T47D, and ER-negative (ER-) MDA-MB-231 breast cancer cell lines and the MCF12A non-tumorigenic epithelial cell line were tested by analyzing their influence on cell proliferation (WST-1 assay), cell viability (trypan blue exclusion assay), and cell cycle arrest (cell cycle analysis, cell cycle regulator proteins expression). (cancerindex.org)

Its phenotype is changing from single lesions to multiple lesions owing to the reduction in estrogen exposure and increasing incidence of obesity and metabolic syndrome as driving factors in the formation of hepatic adenoma. (medscape.com)
[ 1 ] HCAs are most often found in women of childbearing age and are strongly associated with estrogen exposure, most commonly in the form of oral contraceptive pills (OCPs). (medscape.com)

The physiological function of estrogen is primarily mediated by estrogen receptor alpha, encoded by ESR1. (edu.au)
There was evidence of an EC risk signal located at a potential alternative promoter of the ESR1 gene (lead SNP rs79575945, P=1.86x10⁻⁵), which was stronger for cancers of endometrioid subtype (P=3.76×10⁻⁶). (edu.au)
Bioinformatic analysis suggests that this risk signal is in a functionally important region targeting ESR1, and eQTL analysis found that rs79575945 was associated with expression of SYNE1, a neighbouring gene. (edu.au)
In the version of this article initially published online, the estrogen receptor and RNA PolII binding data were aligned incorrectly in the top panel of Figure 3, which represents estrogen receptor binding at the ESR1 gene region. (nature.com)

Association of Body Mass Index With 21-Gene Recurrence Score Among Women With Estrogen Receptor-Positive, ERBB2-Negative Breast Cancer. (cdc.gov)

Promoter region of CYP19 and 5' Region of ER1 gene was amplified by PCR using published primers. (ijlr.org)
2011) . Oestrogen biosynthesis is catalysed by the enzyme cytochrome P450 aromatase, which is encoded by CYP19 gene. (ijlr.org)

No such association was found between mir-433 variation and Parkinson's disease despite the fact that variation in the region of the FGF20 gene which binds to mir-433, is associated with Parkinson's disease. (wikipedia.org)
PMID 18006912 ] CYP17 genetic variation and risk of breast and prostate cancer from the National Cancer Institute Breast and Prostate Cancer Cohort Consortium (BPC3). (snpedia.com)
Common Genetic Variation in CYP17A1 and Response to Abiraterone Acetate in Patients with Metastatic Castration-Resistant Prostate Cancer. (snpedia.com)

Characterization of accessible chromatin regions in cattle rumen epithelial tissue during weaning. (usda.gov)
Analysis of the AHR proximal promoter region using chromatin immunoprecipitation confirmed that enhanced expression of AhR in LTEE cells involves changes in histone modifications, notably decreased trimethylation of histone 3, lysine 27. (umn.edu)

In the present study, we evaluated the regulation of G protein-coupled receptor (GPR)30 expression in estrogen receptor (ER)-positive endometrial, ovarian, and estrogen-sensitive, as well as tamoxifen-resistant breast cancer cells. (unical.it)
We demonstrate that epidermal growth factor (EGF) and TGFÎ± transactivate the GPR30 promoter and accordingly up-regulate GPR30 mRNA and protein levels only in endometrial and tamoxifen-resistant breast cancer cells. (unical.it)
Using gene-silencing experiments and specific pharmacological inhibitors, we have ascertained that EGF and TGFÎ± induce GPR30 expression through the EGFR/ERK transduction pathway, and the recruitment of c-fos to the activator protein-1 site located within GPR30 promoter sequence. (unical.it)

CHO-K1 cells were transfected with human ER and SUMO1 expressing plasmids together with the CRH promoter reporter gene. (nel.edu)

Dubin-Johnson syndrome is a benign disorder that requires no specific therapy, although patients should be warned that pregnancy, oral contraceptive use, administration of estrogens as a component of gender reassignment, and intercurrent illnesses can exacerbate the associated jaundice. (medscape.com)

Aromatase, encoded by CYP19A1 gene, catalyzes the final step of the conversion from androgens into estrogens ( 3 , 11 , 12 ). (spandidos-publications.com)

The etiology of breast cancer is complex and may involve multiple biological, lifestyle and genetic risk factors [1-5]. (fortunejournals.com)

In the present study, we aim to reveal the role of SUMO1 in the regulation of ER-mediated CRH promoter activation. (nel.edu)
The regulation of AhR expression was evaluated in long-term estrogen exposed (LTEE) MCF-7 cells, which showed increased AhR expression, enhanced CYP1 inducibility, and increased capacity to form DNA adducts when exposed to the dietary carcinogen, 2-amino-1-methyl-6-phenylimidazo[4,5-b] pyridine. (umn.edu)

Here, we investigated genetic and epigenetic mechanisms that affect AhR expression. (umn.edu)

We analyzed the harmonized database of the Lung Cancer Cohort Consortium (LC3) to assess the relationship between socioeconomic status and lung cancer incidence across different world regions. (who.int)

Figure 1: Summary of estrogen receptor and RNA PolII binding sites and correlation with nucleotide and gene number. (nature.com)

Treatment of Ishikawa cells with 10 nM TCDD induced a 9.7-fold increase in CYP1A1-dependent ethoxyresorufin O-deethylase (EROD) activity and a 10.5-fold increase in chloramphenicol acetyltransferase (CAT) activity in cells transfected with pRNH11c containing an Ah-responsive human CYP1A1 gene promoter insert (-1142 to +2434). (tamu.edu)
In contrast, neither estrogen nor progesterone inhibited EROD activity induced by TCDD in Ishikawa cells, whereas inhibitory ER-AhR crosstalk was observed in ECC-1 endometrial cells suggesting that these interactions were cell context-dependent. (tamu.edu)
F) The vast majority of -gal+ (PR+) cells in various regions in PRPL mice are neurons, as evidenced by co-labeling with NeuroTrace (fluorescent Nissl) in the arcuate and NeuN for the remaining regions. (cdc.gov)
200 cells analyzed for each region). (cdc.gov)

In premenopausal females, estrogen is predominantly produced by the ovary, with a small amount generated by the aromatization of adrenal and ovarian androgens in extragonadal tissue. (spandidos-publications.com)
Conversely, in postmenopausal females, the aromatization of androgens from extragonadal tissue becomes the prime origin of estrogen as the ovary ceases to function ( 7 , 12 , 13 ). (spandidos-publications.com)

Given that EGFR/HER2 overexpression is associated with tamoxifen resistance, our data may suggest that ligand-activated EGFR could contribute to the failure of tamoxifen therapy also by up-regulating GPR30, which in turn could facilitates the action of estrogen. (unical.it)

Figure 2: Estrogen-mediated transcript changes and correlation with estrogen receptor binding. (nature.com)

Neurodevelopmental effects of genetic frontotemporal dementia in young adult mutation carriers. (cdc.gov)

The transgene consists of an EF1a promoter 5' to an inverted taCasp3-T2A-TEVp sequence that is flanked by heterotypic loxP (open triangles) and lox2722 (closed triangles) sites. (cdc.gov)

rs2486758 represents a variant in the CYP17A1 gene located in the intergenic region 5' to, or perhaps in, the promoter region. (snpedia.com)
deletion) located approximately 400Kb upstream to IGFBP5, which overlaps an intergenic ERα-bound enhancer that loops to the IGFBP5 promoter. (duke.edu)

Circular dichroism spectroscopy revealed the ability of sequences of this GC-rich region to form guanine-quadruplex structures in vitro. (umn.edu)

Estrogen receptor-alpha directs ordered, cyclical, and combinatorial recruitment of cofactors on a natural target promoter. (nature.com)

Our results emphasize the need for new endocrine agents able to block widespread actions of estrogen without exerting any stimulatory activity on transduction pathways shared by the steroid and growth factor-signaling networks. (unical.it)
Its expression is under the control of various steroid hormones, such as estrogens. (nel.edu)

Figure 7: Assessment of estrogen receptor binding properties in different cell systems. (nature.com)

The reproduction and production traits are closely connected in cattle and therefore the genetic improvement of the reproduction traits is important for the efficient way of lactogenesis and lactopoesis. (ijlr.org)
Generally, low numbers of genetic marker (AFLP, RFLP) significantly influencing the reproduction traits have been detected, because most of them are characterized by low heritability. (ijlr.org)

Given SNPs located at this locus have been associated with risk for breast cancer, also a hormonally driven cancer, this study adds weight to the rationale for performing informed candidate fine-scale genetic studies across cancer types. (edu.au)
However, much of the genetic contribution to breast cancer risk remains unknown. (cancerindex.org)

The AHR promoter-luciferase reporter plasmid pGL3-hAhRP was a kind gift from Drs. Sandra Wolff and Josef Abel of the Medical Institute of Environmental Hygiene at the Heinrich-Heine-University, Düsseldorf, Germany. (umn.edu)

Type I tumors are more common, are usually estrogen -responsive, and are usually diagnosed in obese women and at younger ages (perimenopause or early in menopause). (msdmanuals.com)

Anatomy14

Organisms8

Diseases4

Chemicals and Drugs109

Analytical, Diagnostic and Therapeutic Techniques and Equipment27

Phenomena and Processes99

Disciplines and Occupations1

Information Science3

Health Care1

Receptors12

Single nucleotide p2

Genes18

Polymorphism4

Tumor1

Aryl hydrocar2

Humans1

Endometrial Cancer1

Transcriptional3

Transcription factors2

Methylation2

Biomarkers2

Estradiol1

Metabolism3

Variants1

Analysis of estrogen1

Proteins2

Exposure2

ESR14

Receptor-Positive1

CYP192

Variation3

Chromatin2

Protein3

Plasmids1

Oral contraceptive1

Aromatase1

Biological1

Regulation2

Mechanisms1

Lung Cancer1

Nucleotide1

Cells4

Androgens2

Tamoxifen1

Correlation1

Young Adult1

Sequence1

Intergenic2

Sequences1

Alpha1

Steroid2

Assessment1

Traits2

Breast2

Reporter1

Tumors1