Protein StabilityEnzyme StabilityDrug StabilityGenes, EssentialMolecular Sequence DataAmino Acid SequenceProtein DenaturationProtein FoldingMutationModels, MolecularThermodynamicsProtein BindingSaccharomyces cerevisiaeProtein Structure, TertiarySaccharomyces cerevisiae ProteinsProteinsProtein ConformationTemperatureRNA StabilityBase SequenceSequence Homology, Amino AcidProtein Structure, SecondaryBacterial ProteinsProtein Interaction MapsMutagenesis, Site-DirectedEscherichia coliUbiquitinationProtein Interaction MappingFungal ProteinsCircular DichroismNuclear ProteinsProteasome Endopeptidase ComplexProteolysisSequence AlignmentCell LineRecombinant Fusion ProteinsBinding SitesDNA-Binding ProteinsUbiquitinTwo-Hybrid System TechniquesGuanidineKineticsProtein EngineeringAmino Acid SubstitutionCell Cycle ProteinsEscherichia coli ProteinsGenes, FungalPlasmidsRNA, MessengerMutant ProteinsRecombinant ProteinsMembrane ProteinsGenetic Complementation TestModels, BiologicalProtein UnfoldingPhosphorylationHeLa CellsMutagenesisCloning, MolecularMinichromosome Maintenance ProteinsCrystallography, X-RayDNA PrimersProtein TransportRNA-Binding ProteinsTranscription, GeneticEscherichia coli K12Amino Acid MotifsStreptothricinsCarrier ProteinsGene DeletionMultiprotein ComplexesUbiquitin-Protein LigasesTranscription FactorsStructure-Activity RelationshipCalorimetry, Differential ScanningPhenotypeCell NucleusMolecular ChaperonesRNA InterferenceHot TemperatureHalf-LifeComputational BiologyConserved SequenceProtein Processing, Post-TranslationalUreaSignal TransductionProtein-Serine-Threonine KinasesGenes, SuppressorHEK293 CellsGene Expression RegulationHydrogen BondingMuramidaseRNA Processing, Post-TranscriptionalSolventsTime FactorsDimerizationTransfectionBlotting, WesternNuclear Matrix-Associated ProteinsSequence Deletion