• Erythroleukemia is a subtype of acute myeloid leukemia ( AML ) that is distinguished by erythroblastic proliferation. (medscape.com)
  • [ 3 ] The 2016 revision of the World Health Organization (WHO) classification of myeloid neoplasms and acute leukemia continued to recognize pure erythroid leukemia but eliminated the erythroid/myeloid type of acute erythroleukemia. (medscape.com)
  • Cases previously classified as erythroid/myeloid subtype, based on the 2008 WHO classification, are currently categorized either as myelodysplastic syndrome with excess blasts or acute myeloid leukemia, not otherwise specified. (medscape.com)
  • Erythroleukemia is a neoplastic proliferation of erythroid and myeloid precursors of bone marrow hematopoietic stem cells . (medscape.com)
  • However, on the basis of a study of the genetic and transcriptional landscape of 33 patients with acute erythroleukemia, Fagnan et al propose a transcriptome-based space that helps distinguish acute erythroleukemia from other myeloid leukemias. (medscape.com)
  • Acute erythroid leukemia (AEL) is a highly aggressive subtype of acute myeloid leukemia. (bvsalud.org)
  • Acute erythroid leukemia (AEL) is a unique subtype of acute myeloid leukemia characterized by erythroid predominance and dysplasia. (bvsalud.org)
  • PURPOSE OF THE REVIEW: Acute erythroleukemia (AEL) is a rare form of acute myeloid leukemia recognized by erythroblastic proliferation. (bvsalud.org)
  • RATIONALE: Pure erythroid leukemia is a rare subcategory of acute myeloid leukemia characterized by predominant immature erythroid population. (bvsalud.org)
  • MEP)) and erythroid progenitors (CD71 + ) from Jak2 V617F-transduced p53-null leukemic mice had leukemia-initiating capacity, however, myeloid differentiated populations (Mac-1 + ) could not recapitulate the disease. (elsevierpure.com)
  • This clinical trial uses a laboratory test called a high throughput sensitivity assay in planning treatment for patients with relapsed or refractory acute myeloid leukemia. (clincosm.com)
  • Dimethyl sulfoxide (DMSO) induction of mouse erythroleukemia (MEL) cells represents a well-defined in vitro system of terminal erythroid differentiation. (tmu.edu.tw)
  • Reddy, PMS & Shen, CKJ 1993, ' Erythroid Differentiation of Mouse Erythroleukemia Cells Results in fr Reorganization of Protein-DNA Complexes in the Mouse β maj Globin Promoter but Not Its Distal Enhancer ', Molecular and Cellular Biology , 卷 13, 編號 2, 頁 1093-1103. (tmu.edu.tw)
  • Abcb10, a mitochondrial inner membrane ATP-binding cassette transporter highly induced during erythroid maturation in hematopoietic tissues, was found as one key protein that physically interacts with Mfrn1 during mouse erythroleukemia (MEL) cell differentiation. (anthropogeny.org)
  • The leukemic cells in erythroleukemia often carry complex karyotypes and mutations in oncogenes known to be associated with AML. (medscape.com)
  • The latter phase of disease is characterized by a clonal expansion of transformed leukemic cells causing an acute erythroleukemia in mice. (psu.edu)
  • Interestingly, recipients transplanted with CD71 + cells rapidly developed erythroid leukemia, which was in sharp contrast to leukemic KSL cells to cause lethal leukemia after the polycythemic state. (elsevierpure.com)
  • Acute lymphoblastic leukemia, also known as acute lymphocytic leukemia or acute lymphoid leukemia (ALL), is an acute form of leukemia, or cancer of the white blood cells, characterized by the overproduction and accumulation of cancerous, immature white blood cells, known as lymphoblasts. (kuality.ca)
  • Rearrangements of the KMT2A gene are characteristic of infantile acute lymphoblastic leukemia (ALL) and are associated with increased lineage plasticity and resistance to therapy. (authorea.com)
  • Erythroleukemia shares clinical and pathologic features with myelodysplastic syndromes , especially with erythroid-predominant myelodysplastic syndromes. (medscape.com)
  • Since the first recognition of an erythroid-predominant hematologic malignancy in the early 20th century, AEL has gone through a turnstile of changing definitions and nomenclature, including eritoleucemia, erythremic myelosis, AML-M6 and pure erythroid leukemia. (bvsalud.org)
  • Giovanni Di Guglielmo first described erythroleukemia in the early twentieth century, and the disorder is often still referred to as acute Di Guglielmo syndrome. (medscape.com)
  • Species of GAMMARETROVIRUS , containing many well-defined strains, producing leukemia in mice. (lookformedical.com)
  • However, we observe differences in the pathogenesis of Friend erythroleukemia in Lyn-/- mice. (psu.edu)
  • Here we show that retroviral overexpression of Jak2 V617F mutant into wild-type p53 murine bone marrow cells induced polycythemia vera (PV) in the recipient mice, whereas Jak2 V617F-transduced p53-null mice developed lethal leukemia after the preceding PV phase. (elsevierpure.com)
  • The symptoms of ALL are indicative of a reduced production of functional blood cells, because leukemia wastes the resources of the bone marrow that are normally used to produce new, functioning blood cells. (kuality.ca)
  • Our data show that Lyn signals are not required for susceptibility to Friend erythroleukemia, but Lyn plays a role in later events, the terminal differentiation of infected cells and the expansion of transformed cells. (psu.edu)
  • Here, we reveal that sodium salicylate selectively enhances the apoptotic effects of TNF in human erythroleukemia cells but does not affect primary human lymphocytes or monocytes. (elsevierpure.com)
  • Erythroleukemia cells were shown to possess markedly greater basal NF-κB responses and elevated Fas-associated protein with death domain-like IL-1converting enzyme (FLIP) levels. (elsevierpure.com)
  • Inhibition of NF-κB or FLIP levels in human erythroleukemia cells by pharmacological or molecular-biological means also resulted in switching the character of these cells from a TNF-responsive proliferative phenotype into an apoptotic one. (elsevierpure.com)
  • These findings expose that the enhanced proliferative nature of human leukemia cells is caused by elevated NF-κB and FLIP responses and basal levels, reversible by sodium salicylate to allow greater apoptotic responsiveness of cytotoxic stimuli such as TNF. (elsevierpure.com)
  • Such findings provide insight into the molecular mechanisms by which human leukemia cells can switch from a proliferative into an apoptotic phenotype. (elsevierpure.com)
  • The aim is to try to identify drugs that may be effective in killing leukemia cells for those patients who will not be cured with conventional chemotherapy. (clincosm.com)
  • Any cancer/malignancy (either a "solid tumor" or a leukemia/lymphoma/bone marrow malignancy/"liquid tumor", i.e. any ICD10 code from C00-C99) can be a comorbid diagnosis --- BUT it's vital to distinguish malignancies in this category based on whether they are believed to be cured or not. (kuality.ca)
  • Bone marrow aspiration and biopsy are critical in making the diagnosis of acute erythroleukemia (see the image below, and Workup ). (medscape.com)
  • Many controversies remain around diagnosis influencing prognostic and therapeutic implications relating to this unique leukemia subset. (bvsalud.org)
  • The treatment of acute erythroleukemia is similar to that used for other subtypes of AML (see Treatment and Medication ). (medscape.com)
  • Multiple Lineage Switches in KMT2A Rearranged Infant Leukemia, Responsive to Combinat. (authorea.com)
  • This retrospective review compares the clinical and laboratory features of DG and erythroleukemia (FAB M6) among 37 cases treated at a single institution over a 7-year period. (elsevierpure.com)
  • In this article, we discuss the evolving diagnostic concepts of erythroleukemia, genomics, clinical outcome, and promising therapeutic targets through an appraisal of the current literature. (bvsalud.org)
  • in which the predominant immature elements are proerythroblasts, are excluded from the French-American-British (FAB) classification for acute leukemia and do not fit neatly into any of the categories of myelodysplasia. (elsevierpure.com)
  • Primary acute erythroid leukemia is associated with complex and high-risk karyotypes including chromosomes 5q and 7q abnormalities. (bvsalud.org)
  • Here, we describe the case of a 9-month-old infant with infantile ALL who experienced multiple immunophenotypic switches in her leukemia throughout therapy and ultimately achieved remission with the combination of CPX-351 and Inotuzumab. (authorea.com)
  • Further work by Fagnan et al in an animal model found that aberrant expression of oncogenic driver transcription factors results in erythroleukemia by downregulating the GATA1-regulated erythroid epigenome. (medscape.com)
  • Ionizing radiation - Thorium dioxide suspension (Thorotrast), a radiographic contrast medium used in the 1940s, is associated with increased risk of erythroleukemia (latent period of 10-30 y after exposure). (medscape.com)
  • Furthermore, by primer extension of single-stranded oligonucleotide probes, we show that the theta 1-globin gene of humans is transcribed in an erythroleukemia cell line K562. (ox.ac.uk)
  • De novo cases of erythroleukemia are not associated with any identifiable risk factors. (medscape.com)
  • During the initial phase of Friend virus (FV) induced erythroleukemia, the interaction between the viral envelope glycoprotein gp55, the Erythropoietin receptor (EpoR) and the naturally occurring truncated version of the Mst1r receptor tyrosine kinase, called Sf-Stk, drives the polyclonal expansion of infected progenitors in an erythropoietin independent manner. (psu.edu)