• peptide based
  • MTEC will use unique Major Histocompatibility (MHC) class II tetramers containing T cell epitopes of the major cat allergen Fel d 1 in order to characterize allergen-specific T cells before and after intervention with (1) a peptide-based therapeutic vaccine comprised of immunodominant T cell epitopes of Fel d 1, and (2) bronchial (segmental) allergen challenge with cat allergen extract. (mcmaster.ca)
  • immunology
  • In immunology, cryptic self epitopes are a source of autoimmunity. (wikipedia.org)
  • The Immune Epitope Database and Analysis Resource (IEDB) is a project hosted by scientists at the La Jolla Institute for Allergy and Immunology (LIAI), with support from the National Institute of Allergy and Infectious Diseases (NIAID), a part of the National Institutes of Health (NIH), and Department of Health and Human Services (HHS). (wikipedia.org)
  • allergens
  • We demonstrate how IMMUNOCAT is utilized in a large-scale research contract that aims to identify epitopes in common allergens recognized by T cells from human donors, in order to facilitate the rational design of allergy vaccines. (hindawi.com)
  • In addition, epitopes from other infectious agents, allergens and autoantigens are being curated. (wikipedia.org)
  • cell
  • Identification of CD8+ T Cell Epitopes Against Mycobacterium tuberculosis, Understanding Tuberculosis Pere-Joan Cardona, IntechOpen, DOI: 10.5772/30644. (intechopen.com)
  • The McMaster T-cell Epitope Centre (MTEC) uses new epitope-specific tools to determine the frequency and function of T cells reactive with the cat allergen, Fel d 1. (mcmaster.ca)
  • However, self epitopes which appear in very low concentration on APC are termed cryptic in the sense that they do not delete autoreactive T-cells which will then join the peripheral adult T cell repertoire. (wikipedia.org)
  • The IEDB contains data related to antibody and T cell epitopes for humans, non-human primates, rodents, and other animal species. (wikipedia.org)
  • The mechanism of immunodominance in B cell activation focuses on the affinity of epitope binding to the B-cell receptor (BCR). (wikipedia.org)
  • These antibodies then out-compete the BCR for the epitope, and thus that B cell lineage will be unavailable for subsequent stimulation. (wikipedia.org)
  • The IEDB is groundbreaking because it contains antibody and T cell epitope data curated from scientific literature, presented collectively to facilitate basic research. (wikipedia.org)
  • plural
  • Still, because of the two possible epitopes and the different carrier structures, the plural CCDs is in frequent use even though core α1,3-fucose appears to be the single culprit. (wikipedia.org)
  • recognize
  • This leads to a greater expansion of the T cells that recognize a high affinity epitope and is favoured since these cells are likely to clear the infection much more quickly and effectively than their subdominant counterparts. (wikipedia.org)
  • vaccine
  • Herein, we revisit epitope identification in PspA and the utility of hybridoma technology in directing the identification of protective epitope regions of PspA that can be used in vaccine research. (frontiersin.org)
  • therapeutic
  • The finding of epitope spreading adds to the growing list of therapeutic mechanisms associated with live Lm therapy. (drugs.com)
  • predict
  • In addition to the database, the IEDB website hosts an Analysis Resource, which contains a collection of tools to predict and analyze epitopes. (wikipedia.org)
  • affinity
  • On the opposite end of the scale where BCRs have low affinity for the epitopes, these B cells are outcompeted for stimulation by B cells with BCRs that have higher affinities for their respective epitopes. (wikipedia.org)
  • That is, those within the 'goldilocks zone' for affinity will be available for subsequent T helper stimulation, allowing for class switching, affinity maturation and thus, resulting in immunodominance to that particular epitope. (wikipedia.org)
  • gene
  • Epitopes are often used in proteomics and the study of other gene products. (wikipedia.org)
  • Such as categorization of allergen cross-reactivity information, identification of cancer-associated gene variants and the classification of immune epitopes. (wikipedia.org)
  • identification
  • This provides a case study for the use of bioinformatics and information management techniques to track and analyze data produced in a translational research study aimed at epitope identification. (hindawi.com)
  • common
  • Common epitopes used for this purpose are Myc-tag, HA-tag, FLAG-tag, GST-tag, 6xHis and OLLAS. (wikipedia.org)
  • 1991, Japanese researchers determined the structure of the epitope common to horseradish peroxidase and Drosophila neurons as being an asparagine-linked oligosaccharide (N-glycan) containing a xylose and a core-linked α1,3-linked fucose residue. (wikipedia.org)
  • data
  • For this purpose, we have established "IMMUNOCAT", an interactive data management system for the epitope discovery research projects conducted by our group. (hindawi.com)
  • In addition to verifying antibody patentability, epitope mapping data has also been used to support broad antibody claims submitted to the United States Patent and Trademark Office. (wikipedia.org)
  • database
  • The Center for Infectious Disease is home to the world's largest database on how the immune system responds to infectious diseases, the Immune Epitope Database and Analysis Resource (IEDB). (wikipedia.org)