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  • immunology
  • In immunology, cryptic self epitopes are a source of autoimmunity. (wikipedia.org)
  • The Immune Epitope Database and Analysis Resource (IEDB) is a project hosted by scientists at the La Jolla Institute for Allergy and Immunology (LIAI), with support from the National Institute of Allergy and Infectious Diseases (NIAID), a part of the National Institutes of Health (NIH), and Department of Health and Human Services (HHS). (wikipedia.org)
  • allergens
  • We demonstrate how IMMUNOCAT is utilized in a large-scale research contract that aims to identify epitopes in common allergens recognized by T cells from human donors, in order to facilitate the rational design of allergy vaccines. (hindawi.com)
  • In addition, epitopes from other infectious agents, allergens and autoantigens are being curated. (wikipedia.org)
  • cell
  • Recognition of oligonucleotide-encoded T cell epitopes indtroduce dinto a gene unrelated to the original antigen. (springer.com)
  • T cell epitopes are presented on the surface of an antigen-presenting cell , where they are bound to MHC molecules. (thefullwiki.org)
  • Hence, screening for the identification of the topographical repertoire of B-cell epitopes that elicit cross-protective immune response seems essential in the engineering of a superior PspA-based vaccine. (frontiersin.org)
  • Identification of CD8+ T Cell Epitopes Against Mycobacterium tuberculosis, Understanding Tuberculosis Pere-Joan Cardona, IntechOpen, DOI: 10.5772/30644. (intechopen.com)
  • However, self epitopes which appear in very low concentration on APC are termed cryptic in the sense that they do not delete autoreactive T-cells which will then join the peripheral adult T cell repertoire. (wikipedia.org)
  • This can be in concordance with an additional theory which states that immunodominance may be dependent on the affinity of the T-cell receptor (TCR) to the immunodominant epitope. (wikipedia.org)
  • The mechanism of immunodominance in B cell activation focuses on the affinity of epitope binding to the B-cell receptor (BCR). (wikipedia.org)
  • These antibodies then out-compete the BCR for the epitope, and thus that B cell lineage will be unavailable for subsequent stimulation. (wikipedia.org)
  • plural
  • Still, because of the two possible epitopes and the different carrier structures, the plural CCDs is in frequent use even though core α1,3-fucose appears to be the single culprit. (wikipedia.org)
  • gene
  • Epitopes are often used in proteomics and the study of other gene products. (wikipedia.org)
  • Such as categorization of allergen cross-reactivity information, identification of cancer-associated gene variants and the classification of immune epitopes. (wikipedia.org)
  • recognize
  • This leads to a greater expansion of the T cells that recognize a high affinity epitope and is favoured since these cells are likely to clear the infection much more quickly and effectively than their subdominant counterparts. (wikipedia.org)
  • Recognition
  • The identification of epitopes, the exact molecular unit of recognition within an antigen, also provides a mechanistic understanding of cross-reactivity of immune responses for different pathogens. (hindawi.com)
  • immune response
  • Epitopes that are not targeted or targeted to a lower degree during an immune response are known as subdominant epitopes. (wikipedia.org)
  • Having the immune response focused on a specific immunodominant epitope is useful because it allows the strongest immune response against a certain pathogen to dominate, thus eliminating the pathogen fast and effectively. (wikipedia.org)
  • The immunodominant epitope can be mutated in the virus, thus allowing HIV to avoid the adaptive immune response when reintroduced from latency. (wikipedia.org)
  • identification
  • Herein, we revisit epitope identification in PspA and the utility of hybridoma technology in directing the identification of protective epitope regions of PspA that can be used in vaccine research. (frontiersin.org)
  • This provides a case study for the use of bioinformatics and information management techniques to track and analyze data produced in a translational research study aimed at epitope identification. (hindawi.com)
  • affinity
  • On the opposite end of the scale where BCRs have low affinity for the epitopes, these B cells are outcompeted for stimulation by B cells with BCRs that have higher affinities for their respective epitopes. (wikipedia.org)
  • The immunodominant epitope will be a BCR that has a particular 'goldilocks' amount of affinity for its epitope determined by equilibrium binding affinity. (wikipedia.org)
  • That is, those within the 'goldilocks zone' for affinity will be available for subsequent T helper stimulation, allowing for class switching, affinity maturation and thus, resulting in immunodominance to that particular epitope. (wikipedia.org)
  • specific
  • In addition, such techniques can be relatively time-consuming and costly, especially if the screening for a specific epitope is required. (pnas.org)
  • concentrations
  • As an example of an application, we show that one of these antibodies inhibits the aggregation of α-synuclein at substoichiometric concentrations and that binding occurs at the selected epitope. (pnas.org)
  • common
  • Common epitopes used for this purpose are Myc-tag, HA-tag, FLAG-tag, GST-tag, 6xHis and OLLAS. (wikipedia.org)
  • 1991, Japanese researchers determined the structure of the epitope common to horseradish peroxidase and Drosophila neurons as being an asparagine-linked oligosaccharide (N-glycan) containing a xylose and a core-linked α1,3-linked fucose residue. (wikipedia.org)