• VlsE
  • In addition to the previously characterized IR6 region in the variable domain, specific sequences in the N- and C-terminal invariable domains of VlsE were found to be major B cell epitopes in affected patients. (jpt.com)
  • plasmas
  • The central hypothesis of this pilot project is to describe the spectrum of B-cell epitopes that are represented in hemophilia A inhibitor patient plasmas to provide data for statistical analysis to design a prospective clinical trial comparing epitope spectrum and response to treatment with fVIII and to results of immune tolerance therapy. (grantome.com)
  • monoclonal antibody
  • The specific epitope (classical vs. nonclassical) within the C2 domain was more important than inhibitor titer in response to fVIII in acquired hemophilia plasma and a murine monoclonal antibody (MAb) system with very high titer nonclassical inhibitors responding to fVIII. (grantome.com)
  • cross-protective
  • Hence, screening for the identification of the topographical repertoire of B-cell epitopes that elicit cross-protective immune response seems essential in the engineering of a superior PspA-based vaccine. (frontiersin.org)
  • Identification
  • An important factor to consider in the identification of autoantigens and their epitope targets is the methodology that is used in the experimental setting. (biomedcentral.com)
  • Herein, we revisit epitope identification in PspA and the utility of hybridoma technology in directing the identification of protective epitope regions of PspA that can be used in vaccine research. (frontiersin.org)
  • Relevance
  • We also address the methods used to analyze these epitopes, the relevance of their determination, and how this knowledge can inform studies on autoantibody pathogenicity. (biomedcentral.com)
  • Herein, we review reported target epitope(s) for known antibody-mediated disorders of the nervous system, address the relevance of these studies, explore the notion of epitope spreading, and discuss the issue of double autoantibody-positive patients. (biomedcentral.com)
  • sera
  • The patterns of epitope reputation did not Geldanamycin modification as time passes in females whose sera had been analyzed 9 years after their first-seropositive go to. (biodigestor.net)
  • region
  • Deleting the region bearing the LYP20 epitope, from a wild-type CD62P construct, showed a decrease in polymorphonuclear leucocyte (PMNL) binding to transfected COS cells. (biochemj.org)
  • patients
  • In a subset of patients we will have two samples from different points in time and we will compare the change of epitope spectrum and response to fVIII at the different time points. (grantome.com)
  • Inhibitor development is the most significant complication in the management of patients with hemophilia A. The goal of this project is to increase our knowledge of different B-cell epitope spectrum seen in hemophilia A patients who develop inhbitors. (grantome.com)
  • Furthermore, we discuss triggers of autoimmunity, such as molecular mimicry, ectopic antigen expression, epitope spreading, and potential mechanisms for the rising number of double autoantibody-positive patients. (biomedcentral.com)
  • response
  • We will compare the epitope spectrum to genotype as well response to treatment with fVIII in multiple in vitro coagulation assays. (grantome.com)
  • domain
  • A minimal epitope of eight amino acids was identified in the metalloprotease domain and an epitope of 22 amino acids was identified in the disintegrin domain. (kzoo.edu)
  • Two cryptic epitopes were mapped to a domain of TTR, where most mutations associated with amyloidosis occur and which we propose is displaced at the initial phase of amyloid formation, opening up new surfaces necessary for autoaggregation of TTR monomers. (pnas.org)
  • further
  • By subjecting inserts from two clones into a second round of library construction and screening by immunoblot analysis, we further defined the epitope to EYLDMVLNETLRL. (aspetjournals.org)
  • good download epitope: country to Further freedoms in Analysis: carousel. (warren-nh.com)
  • However
  • however, other epitopes within the MPER were recognized by around one-third of HIV-1-infected individuals, although their neutralizing potential was not explored. (pubmedcentralcanada.ca)
  • found
  • One of the farms that probably decreased out to them from the terse download epitope mapping found the level that these beings spent in that calculus, and the zip that the weeks turned. (warren-nh.com)