Epitope cross reactions. Medical search. Frequent questions

Cross-reaction was found between S. equina antigens and antibodies in the sera of Wuchereria bancrofti-infected patients, with the highest levels observed between sera of chronic infected patients and Setaria spp. (who.int)
Type I hyper - sensitive reaction is induced by certain types of antigens referred to as allergens that elicit specific IgE antibodies or from cross reactivity between common homologous allergens from different sources (Santos et al 1999). (ispub.com)
In atopic individuals, sensitizing T-cell epitopes can trigger a cascade of events that leads to synthesis of allergen-specific immunoglobulin E (IgE) antibodies as well as other immunological reactions. (ispub.com)
The IgE antibodies bind the intruding allergen, or a structurally similar cross-reacting protein, leading to release of mediators, which causes allergic reactions. (ispub.com)
Antibodies cross-reacting to both group A streptococcal cells and human heart tissue were identified in a patient with rheumatic fever suggesting a pathogenetic role in such an autoimmune disease [ 15 ]. (biomedcentral.com)
The RPA-T4 antibody recognizes a different epitope than the OKT4 monoclonal antibody, and these antibodies do not cross-block binding to each other's respective epitopes. (thermofisher.com)
As known to all, Polyclonal Antibodies represent a heterogeneous mix of antibodies from different B cells that recognize multiple epitopes on the same antigen. (cusabio.com)
Each of these individual antibodies recognizes a unique epitope that is located on that antigen. (cusabio.com)
Polyclonal antibodies offers greater sensitivity for detecting proteins that are present in low expression levels, as the target protein will bind more than one antibody molecule on its multiple epitopes (this is less advantageous for quantification experiments). (cusabio.com)
Antibodies against some DAMP molecules have been identified in many autoimmune diseases and oxidation-specific epitopes exposed on oxidized low-density lipoprotein. (terasaki.org)
Recently reported cross-recognition by polyreactive antibodies of apoptotic cells may be one of many unidentified recognition patterns that indicate existence of an immune system strategy for defending against a number of stress-induced targets as a set of \"danger. (terasaki.org)
Given all these findings the recent approach of identifying disease-specific panels of up-regulated proteins may help link them with pathogenic antibodies from the pool of heterogeneous antibodies whose pathological roles have remained unidentified helping us understand the effect of those antibodies-and vice versa helping us understand the impact of disease-specific antigens not just up-regulated antigens as a cause of humoral reactions. (terasaki.org)
Neutralization potency of monoclonal antibodies recognizing dominant and subdominant epitopes on SARS-CoV-2 Spike is impacted by the B.1.1.7 variant. (ox.ac.uk)
RBD is the dominant target for neutralizing antibodies, and several neutralizing epitopes on RBD have been molecularly characterized. (ox.ac.uk)
100 monoclonal antibodies targeting epitopes on RBD, NTD, and S2 from SARS-CoV-2-infected individuals. (ox.ac.uk)
This work demonstrates that neutralizing antibodies targeting subdominant epitopes should be considered when investigating antigenic drift in emerging variants. (ox.ac.uk)
We also evaluated 44 SARS-CoV-2 antibodies targeting seven epitope communities in the SARS-CoV-2 RBD, together with serum obtained from COVID-19 convalescents and vaccinees, to determine their cross-reaction against RsYN04. (zoores.ac.cn)
IgEs are antibodies your body produces when you come in contact with an allergen, and they are what causes an allergic reaction. (eatthis.com)
CCDs (cross-reactive carbohydrate determinants) are carbohydrate side chains inducing the production of specific IgE antibodies. (r-biopharm.com)
Occurrence of positive reactions to a high number of allergens for a specific sample in the in vitro test system but also discrepancies between skin prick test and serological test results are indicative of false positive reactions caused by anti-CCD IgE antibodies. (r-biopharm.com)
DENV antibodies can cross-react with other flaviviruses, (NS1) antigen tests in blood specimens. (cdc.gov)
Local surface sites on antibodies which react with antigen determinant sites on antigens (EPITOPES. (bvsalud.org)

In the presence of active S. equina infection, antigens from the adult and microfilaraemic stages showed the highest degree of cross-reaction with human sera. (who.int)
The vast majority of such strategies are based on tumor associated antigens (TAAs) which are shared wild type cellular self-epitopes highly expressed on tumor cells. (biomedcentral.com)
In the present study various peptides, synthesized according to the binding motifs for both the immunodominant epitope of myelin basic protein (MBP) 85-99, a candidate autoantigen in MS, and Cop 1, differentially inhibited binding of these antigens to disease-associated HLA-DR2 (DRB1*1501) molecules. (ox.ac.uk)
HIV-1-specific T cell responses in HUSNs and some HESNs likely represent cross-reactivity to self or foreign non-HIV-1 antigens. (ox.ac.uk)
The protection against SARS-CoV-2 induced by BCG vaccination may be mediated by cross-reactive T cell lymphocytes, which recognize peptides displayed by class I Human Leukocyte Antigens (HLA-I) on the surface of infected cells. (bvsalud.org)
A study in The Journal of Allergy and Clinical Immunology found that antigens in birch pollen and apples share allergenic epitopes that produce Immunoglobulin E (IgE) cross-reactivities. (eatthis.com)
This MoAb Showed no cross-reactivity with 12 other heterologous parasite antigens, including promastigotes of Leishmani. (bvsalud.org)
Triggers may induce an autoimmune reaction by mimicking molecular sequences in the epidermal basement membrane (molecular mimicry, as with drugs and possibly infections), by exposing or altering normally tolerated host antigens (as with physical triggers and certain disorders), or by other mechanisms. (msdmanuals.com)
Epitope spreading refers to the recruitment of autoreactive lymphocytes against normally tolerated host antigens, which contributes to disease chronicity and course. (msdmanuals.com)

In this study, we comprehensively screened HLA-A2 restricted MAGE-A3 tumor epitopes and characterized the corresponding TCRs using in vitro artificial antigen presentation cells (APC) system, single-cell transcriptome and TCR V(D)J sequencing, and machine-learning. (thno.org)
Recently, the first set of naturally presented human leukocyte antigen Class I (HLA-I) epitopes of MuV was identified by us. (mdpi.com)
Higher overall antibody affinity against the antigen due to recognition of multiple epitopes. (cusabio.com)
Serologic cross-reactivity of T11 target structure and lymphocyte function-associated antigen 3. (ox.ac.uk)

In order to overcome such limitations, analogue peptides with improved antigenicity and immunogenicity able to elicit a cross-reactive T cell response are needed. (biomedcentral.com)
Synthetic peptides that inhibit binding of the myelin basic protein 85-99 epitope to multiple sclerosis-associated HLA-DR2 molecules and MBP-specific T-cell responses. (ox.ac.uk)
The responses were mapped to single peptides, which often corresponded to epitopes restricted by multiple HLA-DR types that have previously been detected in HIV-1-infected patients. (ox.ac.uk)
Using previously identified clade B HIV-1 epitope peptides, we have now detected HIV-specific CTL in 6/15 highly exposed and apparently HIV-resistant Kenyan prostitutes, predominantly towards epitopes highly conserved between B and the Kenyan A & D clades of HIV-1. (ox.ac.uk)

In women with particularly intense exposure to what are likely to be multiple clades of HIV-1 in Nairobi Kenya, we have detected CTL directed towards epitopes conserved between HIV-1 clades. (ox.ac.uk)

Although cross-reactivity of murine CD8+ T cells does not directly translate to humans, the molecular interactions involved in triggering T cell responses are the same in mouse and man. (ox.ac.uk)

However, in seropositive donors from Oxford infected with African strains of HIV-1, we have defined CTL responses which are specific for particular clades and have mapped some unique A clade CTL epitopes, together with others to highly-conserved regions of the virus. (ox.ac.uk)
Parvalbumin has a highly conserved amino acid sequence and shows high percentage of identity among different fish species, making this protein the most common cause of cross reactivity in fish allergy. (usda.gov)

Cross-reactivity risk analysis of the candidates TCRs showed high binding stability to MAGE-A3-Mp4 epitope and low risk of cross-reaction. (thno.org)
No. A01860 ) exhibits stronger affinity because it has low cross-reactivity. (genscript.com)
We have detected HIV-specific CTL in two groups of highly-exposed but persistently seronegative female sex workers in Africa which show extensive cross-reactivity between different viral sequences. (ox.ac.uk)
In a small group of women exposed to both HIV-1 and HIV-2 in Gambia, studied over 4 years, we have repeatedly detected HLA-B35-restricted CTL which exhibit cross-reactivity between the HIV-1 and HIV-2 sequences of the CTL epitopes. (ox.ac.uk)
The frequency and the degree of cross-reactivity to other legumes are not known. (tno.nl)
We found that fish-allergic patients are mostly sensitized to beta-1 isoform of parvalbumin and its epitope C region (65-109) in salmonids is probably the causative agent of monosensitivity, while in beta-2 isoforms it may justify cross-reactivity of parvalbumins. (usda.gov)
We found that single-clade A, B and C vaccines applied alone induced only limited cross-clade reactivity and that the epitope hierarchy varied according to the immunizing clade. (ox.ac.uk)
Here we show that this functional cross-reactivity is most likely due to a structural homology of these molecules. (ox.ac.uk)
The cross-reactivity observed with the M. bovis and M. kansasii glycolipids was not inhibited by the synthetic disaccharide. (unboundmedicine.com)
These findings suggest that the cross-reactivity is associated with the phenol ring and implies the disaccharide may be a unique antigenic determinant of M. leprae. (unboundmedicine.com)
however, the cross-reactivity is most probably dependent on the epitope similarity as sequence similarity was not found between fibrinogen and FRePs on one hand and HLGP on the other. (jcu.cz)
Researchers say this is a result of cross-reactivity. (eatthis.com)
In a study that also appeared in The Journal of Allergy and Clinical Immunology , researchers found that there is one major allergen common to fruits of the Prunoideae subfamily, which includes peaches, cherries, apricots, and plums, that causes wide cross-reactivity. (eatthis.com)
Cross-reactivity between shellfish and house mite allergy is quite common. (familyallergy.org)
Meanwhile, the cross-reactivity of CD8+ and CD4+ T cells response to Dengue and Zika viruses provide important clues for further development of potential treatments. (frontiersin.org)
Consideration of the genetic identity of both the Dengue and Zika flaviviruses as well as the cross-reactivity of relevant T cells along with the actions of CD4+ cytotoxic cells in these infections are also presented. (frontiersin.org)
The properties of these MAbs (isotype and reactivity to various protein- isocyanate conjugate epitopes) were characterized using ELISA, dot blot, and Western blot analyses. (cdc.gov)
This report describes generation of a recombinant Sudan virus and demonstrates its utility by quantifying antibody cross-reactivity between Ebola and Sudan virus glycoproteins after human infection or vaccination with a licensed Ebola virus vaccine. (cdc.gov)
In studies with few COVID-19 cases, posi- because of antibody cross-reactivity. (cdc.gov)
Laboratory diagnosis of dengue disease focuses on the detec- with various serologic tests, indicating possible cross-reactivity tion of viral RNA by real-time reverse transcription-poly- in these tests for DENV and SARS-CoV-2 infections ( 1 , 2 ). (cdc.gov)
To assess the potential cross-reactivity of large percentage of cases during the first few days of illness ( 4 ). (cdc.gov)
Serologic cross-reactivity sorbent assay (ELISA) (InBios International). (cdc.gov)
Patients test specificity and minimal levels of cross-reactivity between might also have DENV-1-4 and SARS-CoV-2 coinfections. (cdc.gov)
Recent reports indicated possible cross-reactivity in Persons infected with SARS-CoV-2 can be asymptomatic serologic (IgM) tests for DENV in specimens from con- or experience a range of illnesses from mild fever to life- firmed COVID-19 cases ( 1 , 2 ). (cdc.gov)
As the two lineages have no cross-reactivity, the decision for vaccine lineage selection can be difficult in years when both influenza B lineages are circulating. (who.int)

However, combining single-clade HIV-1 vaccines into multi-clade formulations resulted in multiple forms of in vivo immune interference such as original antigenic sin and antagonism, which dampened or even abrogated induction of responses to epitope variants and reduced the breadth of induced T cell responses. (ox.ac.uk)
Simultaneous administration of individual clade-specific vaccines into anatomically separated sites on the body alleviated antagonism and increased the number of detectable epitope responses. (ox.ac.uk)

Crude antigenic preparations from Setaria equina were used in ELISA and Western blotting to examine cross-reaction with human sera from areas endemic for bancroftian filariasis. (who.int)
Des préparations d'antigènes bruts de Setaria equina ont été utilisées dans le cadre des méthodes ELISA et transfert Western afin d'étudier la réaction croisée avec des sérums humains en provenance de zones endémiques pour la filariose de Bancroft. (who.int)
These predicted LE candidates were further validated by ELISA assays for evaluating the strength of antigenicity and cross antigenicity. (biomedcentral.com)
The disaccharide, corresponding to the two terminal sugars of the M. leprae glycolipid has been chemically synthesized and shown to inhibit the reaction between glycolipid and antibody in the ELISA. (unboundmedicine.com)

The immunogenicity, antigenicity scores, and toxicity of these epitopes were evaluated and chosen based on their capacity to elicit an immune response. (springeropen.com)

The configuration of E Rosettes with sheep red blood cells and the expression of the epitope detected for the monoclonal antibody anti-CD2 was detected in mononuclear cells from 9 Cebus apella monkeys. (bvsalud.org)

Different types of transgenic proteins food allergen proteins sequences were scanned for IgE epitopes. (ispub.com)
In the present study, sequences of 40 CD8 + T cell epitope candidates, including previously and newly identified, obtained from Jeryl-Lynn mumps vaccine strains were compared with genomes from 462 circulating MuV strains. (mdpi.com)
Amino acid sequences of parvalbumins were retrieved from NCBI, and following alignment, the phylogenic tree was drawn and potential epitopes were determined and theirphysicochemical properties analyzed. (usda.gov)

We have scanned total 52 proteins for detection of allergenic IgE epitopes. (ispub.com)

Since many food allergens are proteins, introduction of a new protein in food by genetic engineering can in assumption cause allergic reactions. (ispub.com)
Allergic reactions to meals consumed outside the home are common and can be severe and sometimes fatal. (tno.nl)
Background: The use of lupine in food has been increasing during the last decade and allergic reactions to lupine have been reported, especially in peanut-allergic patients. (tno.nl)
Fish is one of the most common causes of IgE-mediated food allergic reactions and is responsible for approximately 0.4% of food allergic reactions in US population. (usda.gov)
Surely, any progresses in biochemical, immunological, and molecular mechanism of allergic reactions to fish allergens can improve accurate diagnosis of fish allergy and its' prevention and treatment in the future. (usda.gov)
Between 30-80% of individuals with latex allergy have associated allergic reactions to food. (familyallergy.org)
Allergic reactions involving the alimentary tract can result in a wide range of symptoms, stretching from harmless tingling of the mouth to life-threatening shock reactions and from lasting a few hours to many days. (familyallergy.org)

This ensures absence of protein-based IgE epitopes and hence maximum specificity. (r-biopharm.com)
The UniCAR is only activated upon cross-linking through a soluble tumor-targeting module carrying the UniCAR binding epitope, thereby achieving highest tumor specificity. (unimedizin-mainz.de)

However, limited data are available about sequence variability in CD8 + T cell epitope regions of mumps virus (MuV) proteins. (mdpi.com)
These proteins send mixed signals to your immune system and cause an allergic reaction or worsen existing symptoms. (eatthis.com)
The reason for the cross-reactions lies in the structural similarities among proteins of diverse sources, such as pollens and foods. (familyallergy.org)

The experimental results showed that four conserved epitopes among the Iridovirideae family, one exclusive epitope for invertebrate subfamily and two exclusive epitopes for vertebrate family were predicted. (biomedcentral.com)
Cherries are part of the Prunoideae subfamily, so they can cause a reaction to those allergic to birch tree pollen. (eatthis.com)

A cohort of HLA-A2+ NSCLC donors demonstrated that the number of epitope specific CD8+ T cells increased in NSCLC than healthy controls when measured with tetramer derived from the candidate MAGE-A3 epitopes, especially epitope Mp4 (MAGE-A3: 160-169, LVFGIELMEV). (thno.org)
Broadly cross-reactive HIV-specific cytotoxic T-lymphocytes in highly-exposed persistently seronegative donors. (ox.ac.uk)

Although innate immune cells do not respond to specific antigenic epitopes on pathogens, they do produce restricted responses to par- ticular classes of pathogens through pattern-recognition receptors (PRR), such as Toll-like receptors (TLR) (18). (cdc.gov)

We identified the HLA-A2 restricted T cell epitopes from MAGE-A3 that could effectively induce the activation and cytotoxicity of CD8+ T cells using artificial APC in vitro . (thno.org)
It was suggested that the detection of anti-CCD IgE in RAST-tests is due to monovalent binding of IgE to parts of the glycan epitopes which in vivo would not be sufficient to activate mast cells or basophiles and lead to clinical symptoms. (r-biopharm.com)
NK cells can enhance T-cell activation without production of cytokines linked to adverse reactions. (unimedizin-mainz.de)
This joint (Frankfurt/Mainz, Dresden, Essen, Heidelberg) translational immunotherapy project aims to combine NK cells as effector cells with universal epitope-specific CAR (UniCAR) with tunable activity. (unimedizin-mainz.de)

Clustered Iridoviridae subfamilies possess host-specific characteristics, which can be considered as exclusive features for in-silico prediction of effective epitopes for vaccine development. (biomedcentral.com)
Host-specific characteristics are important features and constraints for effective epitope prediction. (biomedcentral.com)

In this study, we computationally identified and mapped mono-sensitivity-causing epitopes of salmonid fish and their cross-reactive epitopes using in silico methods. (usda.gov)
This research is entirely reliant on the development of epitope-based vaccines, and these in silico findings would represent a major step forward in the development of a vaccine that might eradicate SARS-CoV-2 in Bangladeshi patients. (springeropen.com)

Therefore, computationally predicted IgE epitopes from GMF allergen might be an ideal peptide-based novel candidate for immunotherapy. (ispub.com)

To evaluate the effectiveness of nested polymerase chain reaction (PCR) for diagnosis of extrapulmonary tuberculosis (ETB), as well as the impact of PCR results on clinical management. (scielo.org.mx)
The development of DNA amplification techniques such as polymerase chain reaction (PCR) has focused the attention of investigators toward this direction. (scielo.org.mx)
Since PCR is too expensive to use in routine laboratories in Sri Lanka, one center could function as a reference laboratory where clinical samples can be tested using Polymerase Chain Reaction. (who.int)

This CTL activity towards conserved virus epitopes may represent protective immunity to HIV generated in response to repeated exposure, and prophylactic HIV vaccines should aim to generate similar CTL responses. (ox.ac.uk)

Since S-layers rapidly growing scientific and engineering discipline that are composed of a single protein or glycoprotein species crosses the boundaries of numerous existing fields. (2medicalcare.com)
Bioinformatics techniques are used to predict B cell and T cell epitopes from the new SARS-CoV-2 spike glycoprotein in order to build a unique multiple epitope vaccine. (springeropen.com)

Distinct recognition of closely-related HIV-1 and HIV-2 cytotoxic T-cell epitopes presented by HLA-B*2703 and B*2705. (ox.ac.uk)

Statistical and machine-learning based analyses demonstrated that the MAGE-A3-Mp4 epitope-specific CD8+ T cell clones were mostly in effector and proliferating state. (thno.org)

An important goal of a potential prophylactic vaccine against HIV is therefore to elicit a strong CTL response which is broadly cross-reactive against a diverse range of HIV strains. (ox.ac.uk)

Their CTL, repeatedly detected over two years, recognise epitopes presented by HLA-B35 which are cross-reactive between HIV-1 & HIV-2, suggesting they could have been primed first by HIV-2 exposure and subsequently boosted by exposure to HIV-1. (ox.ac.uk)

Hence, T-and B- (IgE) epitopes are both relevant targets for models and the detection of protein allergens. (ispub.com)
According to the American Academy of Allergy, Asthma, and Immunology , OAS is a pollen-food syndrome caused by cross-reacting allergens in pollen and raw fruits, vegetables, and some tree nuts. (eatthis.com)
SPTs showed sensitization exclusively to lettuce and not to any other known cross-reacting allergens, which contrasts with previous literature and highlights the uniqueness of this case. (explorationpub.com)

Typical allergy (Type I hyper sensitivity reaction) symptoms are rhinitis, asthma and atopic eczema, but more severe reactions such as acute and possibly fat an anaphylactic shock can occur also. (ispub.com)
The proportion of individuals experiencing these gut reactions to non-food allergies varies widely depending on the allergy and also the population. (familyallergy.org)

RPA-T4 blocks HIV binding and mixed lymphocyte reaction. (thermofisher.com)

The cross fertilization of biology, molecular biology, Crystalline bacterial cell surface layers, referred to as S- organic chemistry, material sciences, and physics has opened layers [1-3] have now been identified in hundreds of different up significant opportunities for innovation in previously species of bacteria and represent an almost universal feature unrelated fields. (2medicalcare.com)

This MAb is specific and shows minimal cross-reaction with other members of the EGFR-family. (neobiotechnologies.com)

It involves a series of reactions both intrinsic and extrinsic factors contributes in the development of disease and triggering the symptoms. (ispub.com)

Multiple studies have established the cross-reaction between birch tree pollen and peanuts. (eatthis.com)

Further information about the extent of cross-reactive CTL immunity will be important for future vaccine design and evaluation. (ox.ac.uk)

Because pears contain a protein that's similar to a protein in birch pollen, people may experience an allergic reaction after eating it. (eatthis.com)

Fish is one of the most common causes of IgE-mediated adverse reactions to food. (usda.gov)

As these cross-reactions produce positive results in in vitro laboratory test systems, they must be considered false positive. (r-biopharm.com)

at Stephen B. Thacker CDC Library on March 27, 2015 reactions in the lung are life threatening. (cdc.gov)

Endopep-MS currently uses an antibody-affinity concentration/purification step before the enzymatic reaction with the substrate, and the choice of antibody is critical for the success of this assay [ 5 ]. (cdc.gov)

the more widely used are GRA6 and GRA7, but most works report cross reactions among the classical strains (I, II, and III). (frontiersin.org)

Up to 80% of individuals with certain pollen allergies, for example, have reactions involving the mouth or intestinal tract. (familyallergy.org)

Unlike seasonal allergies, these food-related reactions can occur at any time of the year, and the type of reactions vary in people. (eatthis.com)

Anatomy1

Organisms1

Diseases6

Chemicals and Drugs5

Analytical, Diagnostic and Therapeutic Techniques and Equipment3

Phenomena and Processes2

Information Science2

Antibodies22

Antigens9

Antigen4

Peptides4

Towards epitopes1

Humans1

Highly-conserved2

Reactivity25

Clade2

ELISA4

Antigenicity1

Monoclonal antibody1

Sequences3

Allergenic1

Allergic reactions7

Specificity2

Proteins3

Subfamily2

Donors2

Antigenic1

Cells4

Prediction2

Silico2

Computationally1

Polymerase chain re3

Vaccines1

Glycoprotein2

Cytotoxic1

Effector1

Elicit1

Repeatedly detected1

Allergens3

Allergy2

Lymphocyte1

Species1

Specific1

Symptoms1

Multiple1

Vaccine design1

Birch1

Adverse reactions1

Vitro1

Lung1

Assay1

Strains1

Pollen1

Occur1