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Germinal epitheliumTestesSertoliTestisSpermatogenicSpermTesticular lobulesInterstitiumLumenMyoid cellsInterstitial tissueDegenerativeLeydig cellsHyperplasiaGerm cellsEpididymisStagesMorphologicalBasalAdultCycleGroupGerminalTesticularDiameterConnective tissueSpermatogoniaSpermatogenesisTubularEpithelialLeydigAtrophicCompartmentSERTOLI CELLSThicknessEpididymalInterstitialSpermatidsMitoticBLOOD VESSELSImmatureMagnificationFluidDecreaseArrowsGlandsCellsBasementAnalysisHeightStructure and function

Germinal epithelium9

• Testicular seminoma originates in the germinal epithelium of the seminiferous tubules. (wikipedia.org)
• Seminoma is a type of testicular germ cell tumor that is believed to originate from the germinal epithelium of the seminiferous tubules. (medscape.com)
• Seminomas are generally believed to arise from the germinal epithelium of the seminiferous tubules because "seminoma cells" are morphologically similar to spermatogonia and also because seminomas are frequently found within the seminiferous tubules in early stages. (medscape.com)
• The main alterations include decreased germinal epithelium in tubule, and the loss of a continuous proliferation and differentiation gamete layer. (nel.edu)
• regular layering in the germinal epithelium was noted. (europa.eu)
• Each seminiferous tubule is lined by germinal epithelium. (saralstudy.com)
• Each is lined by germinal epithelium formed of germ cells and Sertoli (nurse) cells. (ncertmcq.com)
• Each ovary is lined by the germinal epithelium of germ cells which form primary follicles. (ncertmcq.com)
• In the 400 mg/kg/day group, seminiferous tubules exhibited disintegration of the germinal epithelium, germ cell depletion, and a reduction in round PROTAC MDM2 Degrader-2 PROTAC MDM2 Degrader-2 sperm. (irpa2006europe.com)

Testes10

• We induced high fat diet (HFD) obesity in low-density lipoprotein receptor knock-out Leiden (Ldlr −/− .Leiden) mice, and studied the morphological structure of the testes and histologically examined the proportion of Sertoli cells, spermatocytes and spermatids in the seminiferous tubules. (nature.com)
• Animal studies have shown that the development of the male reproductive system, especially the seminiferous epithelium of the testes, may be disrupted by in utero exposure to high doses of di-n-butyl phthalate during the critical period for reproductive development. (cdc.gov)
• Vertebrate testes are arranged into recurring cellular associations that vary with time and distance along the tubule. (jci.org)
• The tubules in the testes where spermatogenesis occurs. (mcw.edu)
• The histopathology of the testes treated with the middle and high 2BP dose showed a typical patch appearance with severely depleted atrophic tubules, exhibiting germ cell necrosis of spermatogonia and spermatocytes in the seminiferous tubules. (sjweh.fi)
• The production of sperms in the testes takes place in a highly coiled structure called the seminiferous tubules. (saralstudy.com)
• It takes place in seminiferous tubules present inside the testes. (saralstudy.com)
• Testes consist of numerous coiled seminiferous tubules (crypts). (ncertmcq.com)
• It begins in the seminiferous tubules within testes and then continues into the epididymis where maturation of the male gamete occurs, and they are further stored under ejaculation. (microbenotes.com)
• ZnO NPs Cause Testis Damage to Male Mice As shown in Physique 1A, the testes of vehicle-treated mice showed normal seminiferous tubules lined with both spermatogenic cells and Sertoli cells. (irpa2006europe.com)

Sertoli3

• The seminiferous tubules are coiled and coated internally by spermatogenic epithelium consisting of Sertoli cells, surrounded by a basement membrane in the presence of myoid cells. (bvsalud.org)
• It is the process when mature spermatozoa are released from the sertoli cells into the lumen of seminiferous tubules. (saralstudy.com)
• In the testis, Sertoli cells serve as supporting cells and reside as a basal epithelial lining within the seminiferous epithelium. (biomedcentral.com)

Testis6

• A ) The mammalian testis is composed of seminiferous tubules intertwined so that the "start" and "end" of these tubules are both connected to the rete testis. (jci.org)
• Immotile sperm flow from the lumen of the seminiferous tubules into the epididymis via the rete testis. (jci.org)
• B ) Histological cross section through an adult mouse testis depicting seminiferous tubules, the peritubular myoid cells, and the interstitium (space between tubules). (jci.org)
• The disruption of the seminiferous epithelium in the testis PROTAC MDM2 Degrader-2 is usually indicated by arrows. (irpa2006europe.com)
• This structure receives the name of mediastinum testis, or corpus Highmori, and is traversed by an exceedingly complicated network of fine canals, into which the minute tubules which compose the substance proper of the testis open. (co.ma)
• The testis has two primary functions: to supply sperm by meiotic division of sperm cells within the seminiferous tubules and to synthesize and secrete androgens that regulate the male reproductive processes. (healthtian.com)

Spermatogenic3

• Mice fed a HFD had a higher level of tubules in stages VII + VIII in the spermatogenic cycle. (nature.com)
• These changes over time and distance are designated the cycle of the seminiferous epithelium and the spermatogenic wave, respectively. (jci.org)
• In this Review, we briefly outline the roles that follicle-stimulating hormone (FSH) and testosterone play in regulating spermatogenesis and describe our current understanding of how vitamin A regulates germ cell differentiation and how it may lead to the generation of both the cycle of the seminiferous epithelium and the spermatogenic wave. (jci.org)

Sperm2

• RESULTS: WZ significantly increased sperm concentration and sperm viability, improved the degenerative histomorphology and elevated the seminiferous epithelium height. (bvsalud.org)
• Nestled within the testicular lobules are seminiferous tubules where spermatids from the epithelium of these tubules give birth to sperm. (vocal.media)

Testicular lobules1

• These tubules are located in the testicular lobules. (saralstudy.com)

Interstitium2

• The site of production of androgens in the Leydig cells that are located in the interstitium between seminiferous tubules. (healthtian.com)
• The processes are localized in two major morphological structures, the vascularized Leydig cells of the interstitium and the vascularized seminiferous tubules. (superbgrade.com)

Lumen1

• This epithelium has principal and basal cells, the main cell design stereocilia toward the lumen of the epididymal duct. (bvsalud.org)

Myoid cells1

• The epididymal ducts showed pseudostratified columnar epithelium with secretory cells of which stereocilia design, situated on a basement membrane filled by myoid cells. (bvsalud.org)

Interstitial tissue1

• The interstitial tissue between the seminiferous tubules, is composed of loose connective tissue, blood and lymph vessels, and Leydig cells in polyhedral shape. (bvsalud.org)

Degenerative1

• Similarly, in co-treated aluminum chloride and Ananas comosus extract, the degenerative seminiferous tubule histoarchitecture due to aluminum chloride in the negative control group was enhanced. (springeropen.com)

Leydig cells2

• (b) The leydig cells of the seminiferous tubules secrete the male sex hormone called testosterone. (saralstudy.com)
• There are large polygonal cells known as interstitial cells or leydig cells just adjacent to seminiferous tubules. (saralstudy.com)

Hyperplasia1

• Stomach, Glandular stomach, Epithelium - Hyperplasia in female F344/N rat from a chronic study. (nih.gov)

Germ cells2

• Seminiferous epithelium of both groups of rats displayed normal histology without any loss of germ cells. (biomedcentral.com)
• The lining of seminiferous epithelium is unique in the complexity of its arrangement which consists of supporting somatic cells, a proliferating population of germ cells that are displaced centripetally from the spermatogonia to the base of spermatozoa in the central compartment. (superbgrade.com)

Epididymis1

• The epididymis showed some degree of atrophy with vacuolization of the epididymal epithelium. (sjweh.fi)

Stages2

• Localization of protamine 1 mRNA in different stages of the cycle of the rat seminiferous epithelium. (rupress.org)
• Northern blot analyses of RNAs isolated from microdissected pools of seminiferous tubules show high P1 protamine mRNA concentrations during stages VIIc-XIV-III of the cycle and lower levels during stages IV-VIIb. (rupress.org)

Morphological2

• Short-term treatment with flutamide applied to adult rats exerts its primary effect on the basal ES, coexisting junctional complexes and their constituent proteins Cx43 and ZO-1, without any apparent morphological alterations in the seminiferous epithelium. (biomedcentral.com)
• Morphological developments include the formation of the seminiferous cords which differentiate into seminiferous tubules during puberty. (superbgrade.com)

Basal1

• Particular emphasis was placed on the basal ectoplasmic specialization (ES) in the seminiferous epithelium and expression of gap junction protein, connexin 43 (Cx43). (biomedcentral.com)

Adult1

• Seminiferous tubules constitute of at least75 % testicular mass in adult because of continuous cell multiplication. (superbgrade.com)

Cycle1

• A mouse protamine 1 cDNA probe was used to study P1 protamine gene expression during the cycle of the seminiferous epithelium in the rat. (rupress.org)

Group2

• In the 100 mg/kg/day ZnO NPs exposure group, no significant morphologic changes were observed at the seminiferous epithelium. (irpa2006europe.com)
• However, the seminiferous tubule exhibited mildly disorganized histo-architecture in the 200 mg/kg/day group. (irpa2006europe.com)

Germinal20

• The ERKO mouse develops seminiferous tubular dilation followed by severe germinal epithelial atrophy as it reaches puberty. (nih.gov)
• Testicular seminoma originates in the germinal epithelium of the seminiferous tubules. (wikipedia.org)
• The understanding of spermatogenesis needs detailed informations about the organization of the germinal epithelium, the structure and function of different types of germ cells, endocrine and paracrine cells and mechanisms, intratesticular and extratesticular regulation of spermatogenesis. (biomedcentral.com)
• The seminiferous tubule consists of the germinal epithelium and the peritubular tissue (lamina propria)(Fig. 1C ) [ 4 ]. (biomedcentral.com)
• The mean diameter of a seminiferous tubule is about 180 μm, the height of the germinal epithelium measures 80 μm and the thickness of the peritubular tissue is about 8 μm. (biomedcentral.com)
• The germinal epithelium (Fig. 2A ) consists of cells that include different developmental stages of germ cells, namely spermatogonia, primary and secondary spermatocytes and spermatids. (biomedcentral.com)
• A) Sector of the germinal epithelium in the seminiferous tubule. (biomedcentral.com)
• 900 (B) Sertoli cells divide the germinal epithelium in a basal and adluminal compartment. (biomedcentral.com)
• Each of the seminiferous tubules has a lining of germinal. (hinkhojdictionary.com)
• Seminiferous tubule diameter and germinal epithelium thickness were measured. (bezmialem.edu.tr)
• Results: MTX treatment caused seminiferous tubule degeneration with a decrease in Johnsen's score, the seminiferous tubule's diameter, and the germinal epithelium's thickness. (bezmialem.edu.tr)
• With partial (incomplete) hypo supisma, the germinal epithelium of the seminiferous tubules differentiates early, but the interstitial tissue is poorly developed. (synthroidnews.net)
• each lobule contains 1 to 4 highly-coiled seminiferous tubules lined by a germinal epithelium that is the site of sperm production. (histologyguide.com)
• large, columnar cells that extend the full thickness of the germinal epithelium. (histologyguide.com)
• Many dividing cells are seen in the germinal epithelium. (histologyguide.com)
• arise from spermatogonia and cross from the basal epithelial to luminal compartment of the germinal epithelium. (histologyguide.com)
• Overall, these results demonstrate significant effects of radio frequency-modulated EMF exposure on the proteome, including both structural and functional impacts such as a decrease in the diameter and weight of the seminiferous tubules and the mean height of the germinal epithelium (Ozguner et al. (nochoicestore.com)
• Several studies have shown that the germinal epithelium of the maldescended testis may be histologically abnormal. (medscape.com)
• Stage-dependent changes in the Cx43 mRNA level and in the localization pattern in the ST germinal epithelium were observed. (huji.ac.il)
• These results suggested that during gander testis development, function, regression, and recrudescence, the interaction between processes of cell proliferation, apoptosis, and changes in the localization of Cx43 protein in the germinal epithelium occurred. (huji.ac.il)

Testicular3

• In testicular sections, along with the evaluation of qualitative changes, the seminiferous tubule diameter (STD) and the epithelial height (SE) were measured. (indexindex.com)
• The incidence of stage XIV tubules in testicular sections, meiotic figures and step 14 spermatids/stage XIV tubule, and step 19 spermatids/stage VII tubule were estimated. (indexindex.com)
• Testicular weight was found to decrease by 4-fold at the NB stage with massive depletion of germ cells concomitantly with a reduction of seminiferous tubule (ST) diameter and ST lumen compared to the PR and OR stages. (huji.ac.il)

Diameter1

• The diameter (D) of seminiferous tubules was measured across the minor and major axes of the tubules by taking the average of two diameters, D1 and D2. (unina.it)

Connective tissue2

• found in the connective tissue (or interstitium) between seminiferous tubules. (histologyguide.com)
• Again, numerous lymphocytes (Lym) are in the underlying connective tissue, and heaps of have migrated into the epithelium in the nonkeratinized area. (gov.ph)

Spermatogonia1

• Histologically, in the seminiferous tubules, an undifferentiated germ epithelium with early spermatogonia is noted. (synthroidnews.net)

Spermatogenesis5

• Subject: [Histonet] PAS-H staining-rat seminiferous epithelium-doubts reg Dear Histonetters, This is with regard to PAS-Hotchkiss staining of rat seminiferous tubules for staging of spermatogenesis. (utsouthwestern.edu)
• The inter-Sertoli tight junctions (TJ) constitute the BTB that protects the seminiferous epithelium from invasion by molecules or cells that may disturb the process of spermatogenesis. (biomedcentral.com)
• There is no proof spermatogenesis in EI-300 seminiferous tubule (Fig. 2C, asterisk). (ap26113.com)
• These results suggest that cAMP signaling may cause the periodicity of Jagged1 expression in the seminiferous epithelial cycle, and controlling Jagged1 expression by adding TNF-α or cAMP may contribute to normal spermatogenesis in vitro. (cyberleninka.org)
• Notch signaling in Sertoli cells inactivated by deletion of the protein O-fucosyltransferasel showed normal spermatogen-esis [l2], whereas RBPj knockout in Sertoli cells led to abnormal spermatogenesis and an atrophic tubule [l5]. (cyberleninka.org)

Tubular3

• Seminiferous tubular dilatation with its sequel of atrophy has been reported for a number of chemicals, including the fungicide carbendazim, a PDE4 inhibitor, a leukotriene inhibitor, and endothelin antagonists. (nih.gov)
• Attention should also be paid to the incidence of unilateral or bilateral seminiferous tubule atrophy since this can be a progressive and end-stage lesion of tubular dilation. (nih.gov)
• The same tissue section used for measuring tubular diameters was used to measure the seminiferous epithelium height. (unina.it)

Epithelial3

• In addition, seminiferous tubules analysis revealed that the characteristics of interstitial space cells and epithelial germinative cells of the seminiferous tubules in the control group were better than the noise exposed groups. (scialert.net)
• The barrier between capillary blood and alveolar air comprising the alveolar EPITHELIUM and capillary ENDOTHELIUM with their adherent BASEMENT MEMBRANE and EPITHELIAL CELL cytoplasm. (lookformedical.com)
• The second is that the expression level of Jagged1 oscillates in the seminiferous epithelial cycle. (cyberleninka.org)

Leydig1

• The lobules consist of the seminiferous tubules and intertubular tissue, containing groups of endocrine Leydig cells and additional cellular elements. (biomedcentral.com)

Atrophic2

• Indeed, the rate of atrophic seminiferous tubules and jumbled appearance of the interstitial space were more observed in the noise stress exposed group than non-exposed ones. (scialert.net)
• GS induced structural changes such as sloughing of seminiferous epithelium, vacuoles and gaps in the epithelium, nuclear pyknosis and atrophic changes in a few tubules. (indexindex.com)

Compartment2

• A diploid spermatogonium throughout the basal compartment of the seminiferous tubules separates mitotically during spermatocytogenesis, forming two diploid intermediate cells termed primary spermatocytes. (vedantu.com)
• Every other primary spermatocyte, therefore, enters the adluminal compartment of the seminiferous tubules, copies its DNA, and passes through meiosis I to create two haploid secondary spermatocytes, which will then differentiate among haploid spermatids. (vedantu.com)

SERTOLI CELLS5

• The increased fluid can be due to decreased reabsorption of fluid in the efferent ducts, efferent duct blockage, decreased emptying of fluid from the seminiferous tubules, or increased production of seminiferous tubule fluid by the Sertoli cells. (nih.gov)
• or Tubuli Recti) - short, terminal section of each seminiferous tubule lined only by Sertoli cells. (histologyguide.com)
• Sertoli cells had been partly detached in the cellar membrane (BM) from the seminiferous epithelium (Fig. 3, asterisks), and cell membranes of adjacent Sertoli cells weren't joined up with (Fig. 3, arrows). (ap26113.com)
• Sertoli cells had been partly detached in the BM from the seminiferous epithelium (asterisks), as well as the cell membranes of adjacent Sertoli cells weren't joined up with (arrows). (ap26113.com)
• In this study, we revealed two new facts about Sertoli cells by western blotting experiments on different types of primary cells and microdissected tubules. (cyberleninka.org)

Thickness1

• Epididymal epithelium and fibromascular thickness were also improved in extract-treated rats compared to control or CP groups. (researchgate.net)

Epididymal1

• Among the four AE genes identified in mammals thus far, only Ae2 (Slc4a2) has been determined to be expressed in the male reproductive system, especially in developing spermatozoa and in epididymal epithelium. (cun.es)

Interstitial1

• Kruskal Wallis test showed no significant difference in laminin α5 expression in the ECM of the interstitial spaces of seminiferous tubules between the groups. (biomedres.info)

Spermatids1

• BPP-10c led to an increase in the number of round spermatids and total support capacity of Sertoli cell in stages I, V, VII/VIII of the seminiferous epithelium cycle, without affecting BTB permeability and the distribution of claudin-1 in the seminiferous epithelium. (biomedcentral.com)

Mitotic2

• The mitotic division of stem cells near the base membrane of the tubules initiates this process. (vedantu.com)
• There was no cytologic atypia or apparent mitotic activity, and no case had IGCNU in the seminiferous tubules. (qxmd.com)

BLOOD VESSELS2

• The barrier is formed by layers of cells from the VASCULAR ENDOTHELIUM of the capillary BLOOD VESSELS , to the SEMINIFEROUS EPITHELIUM of the seminiferous tubules. (bvsalud.org)
• A specialized transport barrier, in the EYE, formed by the retinal pigment EPITHELIUM, and the ENDOTHELIUM of the BLOOD VESSELS of the RETINA. (lookformedical.com)

Immature1

• has an immature seminiferous epithelium incapable of sperm production. (histologyguide.com)

Magnification2

• The right rectangular area contains the stratified squamous epithelium (StS) of the skin in the squamous zone of the anal canal and is examined at greater magnification in the bottom proper figure symptoms 1974 aricept 10 mg free shipping. (gov.ph)
• A larger magnification of the stratified columnar epithelium (StCol) and stratified cuboidal epithelium (StC) discovered in the transition zone is shown in the inset. (gov.ph)

Fluid1

• This occurs as a secondary consequence to the failure of the efferent ducts to resorb seminiferous tubule fluid, which is an estrogen-dependent function. (nih.gov)

Decrease1

• Between the two diamonds within the rectangular areas proven is epithelium of the decrease a part of the anal canal. (gov.ph)

Arrows1

• The BM from the seminiferous epithelium was regular and preserved its continuity (Fig. 4B, arrows), as well as the myoid cells had been also relatively regular (Fig. 4B, M). Fig. 3. (ap26113.com)

Glands1

• In some cases there were also glands lined by ciliated epithelium (4 tumors, including the pilomatrixoma-like variant), intestinal mucosa (1 tumor), and bone (2 tumors). (qxmd.com)

Cells2

• Three to five layers of myoid cells , which resemble smooth muscle cells, surround each seminiferous tubule. (pharmacy180.com)
• While the latter allows non synchronous development showing different type cells in the seminiferous tubule at different stages. (ksdb.org)

Basement1

• Seminiferous tubules and basement membrane were evaluated histopathologically. (bezmialem.edu.tr)

Analysis1

• Histological analysis of the samples showed hyalinization of the seminiferous tubules (Figure 1A) and focal ITGCN (Figure 1B), confirmed by immunohistochemical staining for placental-like alkaline phosphatase (Figure 1C). (medscape.com)

Height1

• the mean of these two values were considered as the height of the seminiferous tubule. (unina.it)

Structure and function1

• Considering the similarity between tACE and sACE (and since BPPs are able to distinguish between the two active sites of sACE), the effects of the BPP-10c and captopril on the structure and function of the seminiferous epithelium were characterized in the present study. (biomedcentral.com)