MalignantClear cell renal cell carcMucinousPapillary renal carcinomaTumorBenignMedullary carcinomaLymph nodesLiverHistologicEpithelial cellsRespiratory epitheliumTubularAdenocarcinomaGastricImmunohistochemistryNeuroendocrineSpindle cellMetastasisCancersArisesTumoursChoriocarcinomaProliferationTumors basedMesenchymalCollecting ductClinicalClassificationLungCortexDysfunctionSituGeneticBonesParathyroidAbnormalAriseHemangiomaThyroidBasalKidneyPrimaryIncidenceRecurrentCancerEpithelioidMalignancyApoptosisVascularSerum
Malignant11
- Rare, aggressive malignant neoplasm found almost exclusively in patients with sickle cell trait , or, less frequently, sickle cell disease. (capsulehealth.one)
- Clear cell renal cell carcinoma (CCRCC) is a renal cortical tumor typically characterized by malignant epithelial cells with clear cytoplasm and a compact-alveolar (nested) or acinar growth pattern interspersed with intricate, arborizing vasculature. (medscape.com)
- Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms . (lookformedical.com)
- It is also employed for the detection of malignant tumors including those of the brain, liver, and thyroid gland. (lookformedical.com)
- Ab-3 shows no reaction with a variety of normal tissues .CEA is not found in benign glands, stroma, or malignant prostatic cells. (samatashkhis.com)
- Angiosarcomas and hemangioendotheliomas are rare malignant vascular neoplasms (MVTs). (turkjpath.org)
- Malignant vascular tumors (MVTs), mainly composed of angiosarcoma (AS) and hemangioendothelioma (HE), are considered one of the rarest soft tissue neoplasms in contrast to their benign counterparts. (turkjpath.org)
- Although Kaposi's sarcoma is also classified as a malignant vascular neoplasm, there are contradictory data about the vascular origin and differentiation of this tumor. (turkjpath.org)
- Salivary gland type malignant neoplasm arising from bronchial seromucinous glands. (cancerhealthcenter.com)
- Anal cancer is a disease in which malignant (cancer) cells form in the tissues of the anus. (cancerhealthcenter.com)
- Mast cell tumors, often malignant (and fatal) in the dog, are invariably benign and associated with a good prognosis in ferrets. (veteriankey.com)
Clear cell renal cell carc2
- Typical gross presentation of clear cell renal cell carcinoma (lower left) with golden color due to intracellular lipid accumulation. (medscape.com)
- The renal tumors are frequently multifocal and/or bilateral and are always of the clear cell renal cell carcinoma (CCRCC) histologic type. (medscape.com)
Mucinous3
- Patients with low-grade appendiceal mucinous carcinomas (LAMNs) treated with cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) have a favorable prognosis. (rare-cancer.org)
- Weak GATA3 staining of glandular cells (mostly mucinous). (ms-validatedantibodies.com)
- Collins K , Segura S, Hwang M. Endocrine cell micronests in an ovarian mucinous borderline tumor: a potential diagnostic pitfall for microinvasion. (iu.edu)
Papillary renal carcinoma1
- Other genetically linked conditions also increase the risk of RCC, including hereditary papillary renal carcinoma, hereditary leiomyomatosis, Birt-Hogg-Dube syndrome, hyperparathyroidism-jaw tumor syndrome, familial papillary thyroid carcinoma, von Hippel-Lindau disease and sickle cell disease. (wikipedia.org)
Tumor13
- More than 80% of renal tumors of childhood are Wilms tumor (nephroblastoma) ( 1 , 2 ). (abdominalkey.com)
- The tumor is usually circumscribed by a pseudocapsule formed of compressed renal and perirenal tissues. (abdominalkey.com)
- One patient who had 50-gene panel only also had his metastatic site (esophagus) of his tumor tested with FoundationOne. (cancerindex.org)
- Note tumor extension along the renal vein. (medscape.com)
- TGF-beta and immune cells: an important regulatory axis in the tumor microenvironment and progression. (academicinfluence.com)
- Acosta AM, Al-Obaidy KI, Sholl LM, Dickson BC, Lindeman NI, Hirsch MS, Collins K , Fletcher CD, Idrees MT. Sarcomatoid Yolk Sac Tumor Harbors Somatic Mutations That Are Otherwise Rare in Testicular Germ Cell Tumors. (iu.edu)
- A benign tumor that arises from glandular epithelial cells. (amboss.com)
- Tumor initiation is the process by which normal cells are changed so that they are able to form tumors. (doctorlib.info)
- thus, tumors with a high cell turnover are most susceptible (certain leukemias and lymphomas, small proliferating tumors, "recruited" tumor cells, and micrometastases). (doctorlib.info)
- The killing of tumor cells follows first-order kinetics. (doctorlib.info)
- To produce a cure, therapy must continue until the final tumor cell has been eradicated. (doctorlib.info)
- The protein products of tumor suppressor genes are normal genes that slow down cell division, repair DNA mistakes, and tells when to undergo apoptosis (programmed cell death). (doctorlib.info)
- P53 is a tumor suppressor gene that codes for a transcription factor that regulates the expression of other genes and arrests the cell cycle. (doctorlib.info)
Benign3
- Primary mesenteric solid neoplasms are rare and the majority of them are benign. (sajr.org.za)
- A benign mass composed of mature cells that are native to the tissue of origin but have abnormal tissue organization (e.g. (amboss.com)
- For example, insulinoma in the ferret is a neoplasm that rarely metastasizes and behaves in a benign fashion, as opposed to the same neoplasm in dogs and cats, which metastasizes widely and rapidly and results in short survival times. (veteriankey.com)
Medullary carcinoma4
- High-grade renal adenocarcinoma with histologic and immunophenotypic findings consistent with those of medullary carcinoma occurring in a patient with no evidence of a hemoglobinopathy is best categorized as unclassified renal cell carcinoma (RCC) with medullary phenotype. (capsulehealth.one)
- A Model Linking Sickle Cell Hemoglobinopathies and SMARCB1 Loss in Renal Medullary Carcinoma. (capsulehealth.one)
- Metastatic renal medullary carcinoma in a regional lymph node. (capsulehealth.one)
- A) Pathologic representation of renal medullary carcinoma. (capsulehealth.one)
Lymph nodes2
- Widespread metastases occur early in the course of the disease, with common spread to the mediastinal lymph nodes, liver, bones, adrenal glands, and brain. (medscape.com)
- Transfer of a neoplasm from its primary site to lymph nodes or to distant parts of the body by way of the lymphatic system. (lookformedical.com)
Liver2
- Wiedemann-Beckwith syndrome is related to abnormalities on chromosome 11p15 and characterized by multiple craniofacial anomalies, abdominal wall defects, and tumors of the genitourinary tract, liver, adrenal gland, and central nervous system among other abnormalities. (abdominalkey.com)
- It is highly expressed in adrenal gland, small intestine, and colon, and may play an important role in liver carcinogenesis. (cancerindex.org)
Histologic2
- Of all histologic types of lung cancer, SCLC and squamous cell carcinoma have the strongest correlation to tobacco. (medscape.com)
- Baranov E‡, Davis JL , Winsnes K, Church A, Breen M, Janeway KA, Dubois S, Al-Ibraheemi A. Histologic characterization of targeted therapy-treated pediatric mesenchymal neoplasms with kinase alterations. (iu.edu)
Epithelial cells5
- Strong GATA3 positivity in all epithelial cells. (ms-validatedantibodies.com)
- Moderate to strong GATA3 positivity of a epithelial cells. (ms-validatedantibodies.com)
- Variable (weak to strong) GATA3 positivity in squamous epithelial cells. (ms-validatedantibodies.com)
- Weak to moderate GATA3 positivity in epithelial cells including hair follicles. (ms-validatedantibodies.com)
- Epithelial cells have a specific microscopic structure with different lateral , apical, and basal membrane domains. (amboss.com)
Respiratory epithelium2
- High-power photomicrograph of small cell carcinoma on the left side of the image with normal ciliated respiratory epithelium on the right side of the image. (medscape.com)
- A weak cytoplasmic GATA3 staining can occur in goblet cells of respiratory epithelium (probably non-specific staining). (ms-validatedantibodies.com)
Tubular2
- The tumour arises from the cells of the proximal renal tubular epithelium. (wikipedia.org)
- Composed of epithelial and myoepithelial cells in cribriform, tubular and solid growth patterns. (cancerhealthcenter.com)
Adenocarcinoma1
- Salivary Gland Polymorphous Adenocarcinoma: Clinicopathological Features and Gene Alterations in 36 Japanese Patients. (nagoya-u.ac.jp)
Gastric2
- Antibody to CEA is useful in detecting early foci of gastric carcinoma and in distinguishing pulmonary adenocarcinomas (60-70% are CEA+) from pleural mesotheliomas (rarely or weakly CEA+). (samatashkhis.com)
- A weak cytoplasmic GATA3 staining can occur in gastric glands (probably non-specific staining). (ms-validatedantibodies.com)
Immunohistochemistry1
- The role of genotyping and ancillary tools, in particular immunohistochemistry, in correctly classifying these tumors is highlighted in the section on Renal Cell Carcinoma. (abdominalkey.com)
Neuroendocrine1
- SCLC is a neuroendocrine carcinoma that exhibits aggressive behavior, rapid growth, early spread to distant sites, exquisite sensitivity to chemotherapy and radiation, and frequent association with distinct paraneoplastic syndromes, including hypercalcemia, Eaton-lambert syndrome, syndrome of inappropriate diuretic hormone, and many others. (medscape.com)
Spindle cell1
Metastasis2
- Abrogation of TGF beta signaling in mammary carcinomas recruits Gr-1+CD11b+ myeloid cells that promote metastasis. (academicinfluence.com)
- ix Capacity of cancer tissue to produce abundant PA likely contributes to cancer cell's higher growth rates.ix ,x High concentrations of PA enhance cancer cells to invade, and is associated with less apoptosis and increased expression of the genes affecting metastasis.ix ,xi The association of increased polyamine synthesis and cancer was first reported in the late 1960s. (justia.com)
Cancers3
- Small cell lung cancer (SCLC), previously known as oat cell carcinoma, is considered distinct from other lung cancers, which are called non-small cell lung cancers (NSCLCs) because of their clinical and biologic characteristics. (medscape.com)
- The present invention relates to compositions and methods for treating cancerous tumors, including naïve, metastatic and recurrent cancers. (justia.com)
- 14. Which of the following lymphatic cancers is associated with multinucleated Reed-Sternberg cells and EBV? (mockdocs.org)
Arises2
- Small cell lung carcinoma (SCLC) arises in peribronchial locations and infiltrates the bronchial submucosa. (medscape.com)
- The second neoplasm may have the same or different histological type and can occur in the same or different organs as the previous neoplasm but in all cases arises from an independent oncogenic event. (lookformedical.com)
Tumours2
- Although primary neoplasms arising in the mesentery are rare, the mesentery is a major avenue for the dissemination of tumours, which can spread through hematogenous, lymphatic, direct or peritoneal seeding. (sajr.org.za)
- Secondary involvement of the mesentery from tumours elsewhere is much more common than primary mesenteric neoplasms such as desmoid tumour, inflammatory myofibroblastic tumour (IMFT), and others. (sajr.org.za)
Choriocarcinoma1
- and human chorionic gonadotropin (hCG), seen in choriocarcinoma testicular germ cell neoplasms. (doctorlib.info)
Proliferation3
- The following text points out several possibilities and chemical pathways in which "Intume" chlorine dioxide intervention can destroy tumors and prevent proliferation of cancer cells. (justia.com)
- Tumors develop when the normal regulation of the balance between cell proliferation (mitosis) and programmed cell death (apoptosis) is lost. (doctorlib.info)
- These genes are deleted or inactivated in cancer cells, allowing unregulated proliferation. (doctorlib.info)
Tumors based1
- Tumors in which eosinophilic cells predominate were previously classified as "granular cell" carcinoma but are currently included among CCRCCs in the 2004 World Health Organization classification of renal tumors based on the presence of vasculature and genetic alterations typical of CCRCC. (medscape.com)
Mesenchymal2
- This is followed by coverage of neoplasms in the more traditional categories of epithelial, mesenchymal, and other categories. (abdominalkey.com)
- Vimentin is a developmentally regulated intermediate filament protein (IFP) found in cells of mesenchymal origin. (thermofisher.com)
Collecting duct1
- Kidney: A moderate to strong nuclear staining reaction should be seen in a fraction of collecting duct cells and podocytes in glomeruli. (ms-validatedantibodies.com)
Clinical4
- Genetic profiling as a clinical tool in advanced parathyroid carcinoma. (cancerindex.org)
- See Small Cell Lung Cancer: Beating the Spread, a Critical Images slideshow, to help identify the key clinical and biologic characteristics of small cell lung cancer, the staging criteria, and the common sites of spread. (medscape.com)
- 68 With the current expansion of literature regarding neoplastic disease in this species as well as our desire to expand the discussion of available and emerging clinical treatments, frequency data of common neoplasms are presented based on the available literature for this species. (veteriankey.com)
- The clinical behavior, prognosis, and paraneoplastic syndromes in ferrets are often far different from what is seen with similar neoplasms in dogs or cats. (veteriankey.com)
Classification1
- The classification of epithelial tumors of the kidney has in particular undergone substantial progress in the last two decades with major contributions from genetic typing of renal cell carcinomas (RCCs). (abdominalkey.com)
Lung3
- The predominant cause of small cell lung cancer (SCLC) (and non-SCLC) is tobacco smoking. (medscape.com)
- The incidence of small cell lung cancer (SCLC) has declined over the last few years. (medscape.com)
- Approximately 60-70% of patients with small cell lung cancer (SCLC) have clinically disseminated or extensive disease at presentation. (medscape.com)
Cortex2
- The renal cortex is isosmotic to plasma, whereas the renal medulla becomes progressively more hypertonic up to ∼1,200 mOsm/L in the inner medulla. (capsulehealth.one)
- chiefly, tumors of the pancreatic islets and the adrenal cortex (the two overall most common neoplasms in the ferret, as previously discussed). (veteriankey.com)
Dysfunction2
- urgent intervention indicated Definition:A dysfunction characterised by insufficiently wholesome hematapoietic cell manufacturing by the bone marrow. (ehd.org)
- Secondary outcomes included major adverse kidney events within 30 days - a composite of death from any cause, new renal-replacement therapy, or persistent renal dysfunction (defined as an elevation of the creatinine level to ≥200% of baseline) - all censored at hospital discharge or 30 days, whichever occurred first. (regenerativemedicine.net)
Situ1
- H) was categorized as normal(no dysplasia/malignancy),delicate, reasonable and severe dysplasia (stage 1 to three),carcinoma In Situ(level 4) and carcinoma(level 5)(table 4). (ehd.org)
Genetic1
- The development of the second neoplasm may or may not be related to the treatment for the previous neoplasm since genetic risk or predisposing factors may actually be the cause. (lookformedical.com)
Bones1
- Bone cancer is a cancer of the cells that make up the bones of the body. (cancerhealthcenter.com)
Parathyroid2
- Parathyroid carcinoma (PC) is a rare endocrine malignancy with no approved systemic therapies for unresectable locally invasive or distant metastatic disease. (cancerindex.org)
- Like other proteins of the GATA family (GATA1-6), GATA3 is a transcription factor that regulates various cellular programs during embryogenesis and differentiation in several organ systems, including parathyroid gland, kidney, breast epithelium, urothelium, and the nervous system. (ms-validatedantibodies.com)
Abnormal1
- Abnormal growths of tissue that follow a previous neoplasm but are not metastases of the latter. (lookformedical.com)
Arise1
- Arise from the renal papillae or calyceal epithelium and may be triggered by chronic medullary hypoxia as a result of sickled red cells in individuals with HbS and is suggested by strong expression of vascular endothelial growth factor and hypoxia-inducible factor. (capsulehealth.one)
Hemangioma1
- Toklu A , Mesa H, Collins K . Incidental adrenal hemangioma clinically suspicious for malignancy: diagnostic considerations and review of the literature. (iu.edu)
Thyroid1
- Tumors or cancer of the THYROID GLAND. (lookformedical.com)
Basal2
- Weak GATA3 positivity in some basal cells (not in all samples). (ms-validatedantibodies.com)
- Weak to moderate staining of tall columnar cells and basal cells of the corpus. (ms-validatedantibodies.com)
Kidney1
- Renal cell carcinoma (RCC) is a kidney cancer that originates in the lining of the proximal convoluted tubule, a part of the very small tubes in the kidney that transport primary urine. (wikipedia.org)
Primary1
- Examination of cells whether from a primary or secondary site, including fluids aspirated using endoscopes or needles. (who.int)
Incidence1
- The incidence of renal cell carcinoma (RCC) has been rising steadily in Europe and the United States for the past 3 decades, with a particular rise in the proportion of small, asymptomatic tumors detected incidentally via abdominal imaging. (medscape.com)
Recurrent1
- The hypoxic microenvironment facilitates the sickling of RBCs resulting in recurrent regional ischemia and microinfarctions in the renal inner medulla, which reduce the osmolarity in the medullary interstitium. (capsulehealth.one)
Cancer4
- Depletion of carcinoma-associated fibroblasts and fibrosis induces immunosuppression and accelerates pancreas cancer with reduced survival. (academicinfluence.com)
- Cancer cells are rich in polyamines which is necessary for survival and growth of tumors. (justia.com)
- Bile duct cancer, also called cholangiocarcinoma, is when unusual cells grow out of control inside your bile ducts. (cancerhealthcenter.com)
- What is metastatic bone cancer? (cancerhealthcenter.com)
Epithelioid1
- MVTs showing variable morphologic characteristics may be misdiagnosed as carcinomas or epithelioid sarcoma, especially when epithelioid morphology dominates. (turkjpath.org)
Malignancy1
- Neutrophilic eccrine hidradenitis (NEH) is a neutrophilic dermatosis primarily affecting the eccrine glands and occurs most commonly in patients undergoing chemotherapy for a malignancy. (annals.edu.sg)
Apoptosis1
- The antibody is useful for studying the phenomenon of cell death by apoptosis as a pathogenic mechanism of numerous pathologies: nerve damage, neurodegenerative diseases, cardiovascular diseases, autoimmune diseases, AIDS and malignancies. (samatashkhis.com)
Vascular1
- Due to its proclivity for endothelium, this component can be detected in peritubular capillaries in both chronic renal allograft rejection as well as hyperacute rejection, acute vascular rejection, acute cellular rejection, and borderline rejection. (samatashkhis.com)
Serum1
- Neoplasms containing cyst-like formations or producing mucin or serum. (lookformedical.com)