• Moreover, siRNA-mediated knockdown of KLF5 blocked the expression of CDX2, MUC2 and villin, but transfection of a KLF5 expression vector into esophageal epithelial cells promoted their transdifferentiation into columnar-like cells, as demonstrated by increased expression of the intestinal markers CDX2, MUC2 and villin. (jcancer.org)
  • Numerous intestinal epithelial cells lining villi contain coccidial organisms representing various life stages, including meronts (Me) containing 8 to 12 merozoites, microgametocytes (Mi), macrogametocytes (Ma), and oocysts (O). Labels appear immediately to the right of the corresponding life stage. (avma.org)
  • The large number of macrophages in the intestinal tract, play a significant role in maintaining the homeostasis of microorganisms on the surface of the intestinal mucosa and in the continuous renewal of intestinal epithelial cells. (frontiersin.org)
  • Here, alterations in the gut microbiota and intestinal epithelial barrier were investigated as the causes of hippocampal neuroinflammation induced by high-fructose diet. (biomedcentral.com)
  • Gut microbiota compositional alteration, short-chain fatty acids (SCFAs) reduction, intestinal epithelial barrier impairment, NOD-like receptor family pyrin domain-containing 6 (NLRP6) inflammasome dysfunction, high levels of serum endotoxin, and FITC-dextran were observed in fructose-fed mice. (biomedcentral.com)
  • Of note, SCFAs, as well as pioglitazone (a selective peroxisome proliferator-activated receptor gamma (PPAR-γ) agonist), shaped the gut microbiota and ameliorated intestinal epithelial barrier impairment and NLRP6 inflammasome dysfunction in fructose-fed mice. (biomedcentral.com)
  • Our findings reveal that gut dysbiosis is a critical factor for a high-fructose diet-induced hippocampal neuroinflammation in C57BL/6N mice possibly mediated by impairing intestinal epithelial barrier. (biomedcentral.com)
  • Mechanistically, the defective colonic NLRP6 inflammasome is responsible for intestinal epithelial barrier impairment. (biomedcentral.com)
  • SCFAs can stimulate NLRP6 inflammasome and ameliorate the impairment of intestinal epithelial barrier, resulting in the protection against a high-fructose diet-induced hippocampal neuroinflammation and neuronal loss. (biomedcentral.com)
  • Unlike the normal mucosa, the UC mucosa contains large numbers of IgG plasma cells, reminiscent of a typical peripheral immune response towards an invading pathogen, leading to local deposition of IgG on epithelial cells. (bmj.com)
  • As PMN invade the site of active inflammation, the integrity of the intestinal epithelial barrier is lost, and adsorption of fluids and nutrients is impaired, resulting in clinical manifestations of shigellosis (e.g. diarrhea ). (wikidoc.org)
  • [6] Shigella is transcytosed across the epithelial layer of the intestinal M cells. (wikidoc.org)
  • Invasion of the intestinal epithelium continues from the basolateral side, and the bacteria further spreads to adjacent epithelial cells and avoids extracellular exposure by using intercellular actin polymerization processes (rocket propulsion). (wikidoc.org)
  • PMN destroy the integrity of the intestinal epithelial barrier and allow more Shigella organisms to directly and more easily invade the intestinal epithelium. (wikidoc.org)
  • The loss of the intestinal epithelial cells results in impaired adsorption of other nutrients and fluids and leads to clinical manifestations of shigellosis (diarrhea). (wikidoc.org)
  • Soybean-induced enteritis causes decreased height of mucosal folds/villi, disappearance of supranuclear vacuoles (SNV) in the intestinal epithelium, widening of lamina propria (LP) in the center of mucosal folds, infiltration of inflammatory cells in the lamina propria (Baeverfjord and Krogdahl, 1996), increased number of goblet cells (GC), and thicker sub-epithelial mucosa (SM) (Uran et al. (feednavigator.com)
  • The exudative lesion, or type II lesion, is a volcano-type epithelial ulceration with intact surrounding mucosa. (healthmanagement.org)
  • Macrophages and intestinal epithelial cells then attract T cells and neutrophils with interleukin 8 (IL-8), causing inflammation and suppressing the infection. (medscape.com)
  • The infection is restricted to the enteric tract, where the virus replicates in epithelial cells lining the gut mucosa. (cdc.gov)
  • In HHV-1 and HHV-2 oral infections, viral replication within the oral epithelium may cause lysis of epithelial cells, with vesicle formation. (medscape.com)
  • In this study, next generation sequencing (NGS) was used to survey the 16S rRNA ribotypes of the distal intestinal lumen and mucosal epithelium of farmed rainbow trout. (stir.ac.uk)
  • Barrett's esophagus (BE), also defined as columnar-lined esophagus, is a metaplastic condition in which the normal non-keratinizing squamous epithelium of the esophagus is replaced by a columnar mucosal epithelium [ 1 , 2 ]. (jcancer.org)
  • The inner mucosal layer consists of squamous epithelium and underlying connective tissue, within which lies a longitudinally oriented muscle layer called the muscularis mucosa. (nature.com)
  • The fibrovascular supporting core underlying mucosal epithelium, often containing lymphatics, blood vessels, and resident immune cells. (pressbooks.pub)
  • These mechanisms may lead to mucosal ischemia, followed by ulceration and fibromuscular obliteration of the mucosa. (radiologytoday.net)
  • [ 5 , 6 ] In a localized primary infection, the virus penetrates the mucosal epithelium and invades the cells of the basal layer, where the viral DNA inserts into the host DNA. (medscape.com)
  • Moreover, basal lamina of follicle-associated epithelium is more porous compared to intestinal villus. (wikipedia.org)
  • The lamina propria of the mucosa is infiltrated by moderate numbers of lymphocytes and plasma cells. (avma.org)
  • The lamina propria of the small intestine is the main site of the intestinal immune system, which contains a large number of macrophages, CD4 T cells, and dendritic cells. (frontiersin.org)
  • No degeneration or necrosis was observed in the lamina epithelium of the pyloric cecum. (peertechzpublications.com)
  • All pathogenic Salmonella species, when present in the gut are engulfed by phagocytic cells, which then pass them through the mucosa and present them to the macrophages in the lamina propria. (medscape.com)
  • Thirty-six Wistar rats were submitted to diversion of the fecal stream by proximal colostomy and distal mucous fistula. (scielo.br)
  • Trinta e seis ratos Wistar foram submetidos à derivação intestinal por colostomia proximal e fístula mucosa distal. (scielo.br)
  • Common types of esophageal atresia include (A) pure atresia of the esophagus, (B) esophageal atresia with proximal tracheoesophageal (TE) fistula, (C) esophageal atresia with distal TE fistula, and (D) esophageal atresia with double fistula. (medscape.com)
  • The proximal and distal colons are functionally different organs with respect to the intestinal flora, representing a bioreactor and a segregation device. (nih.gov)
  • A well-delineated region of non-glandular (squamous) gastric mucosa within the proximal portion of the stomach in the pig, immediately distal (aborad) to the esophagus. (pressbooks.pub)
  • A small proportion of cells with Rxfp4-dependent labelling was 5-HT-negative, 11-15% in the distal colon and rectum, and 35% in the proximal colon. (edu.au)
  • These disorders can be divided into 2 general categories, proximal (type II)and distal (types I and IV). (medscape.com)
  • The demarcation between the jejunum (proximal) and the ileum (distal) is not very clear. (medscape.com)
  • Dysbiosis within this homeostasis in the gut microbiota is associated with a multitude of health conditions affecting not only gut, but also distal organs like mouth, lung, brain, liver, vagina, etc. (frontiersin.org)
  • Apart from intestinal disorders (diabetes, obesity, colon cancer, inflammatory bowel disease, etc.), changes in dietary patterns and their effects on gut microbiota are implicated in disorders of other organs like lung (asthma, COPD, etc. (frontiersin.org)
  • Thus, it can modulate the composition and metabolic activity of the intestinal microbiota, which might potentially enhance the health of the host organism[ 5 , 6 ]. (ijpsonline.com)
  • It generally occurs because of an alteration of the intestinal microbiota due to antibiotic exposure that must be timely identified and diagnosed to start proper and early management. (healthmanagement.org)
  • The effect of antibiotics on the intestinal microbiota is well documented. (healthmanagement.org)
  • Probiotic supplementation, which restores gut microbiota composition and fortifies intestinal barrier function, has therapeutic potential to treat metabolic disease. (harvard.edu)
  • The comparison between the microbiota of the caecal and colonic mucosa in IBS has rarely been studied. (biomedcentral.com)
  • To determine the composition of both fecal and duodenal mucosa-associated microbiota in irritable bowel syndrome (IBS) patients and healthy subjects using molecular-based techniques. (wjgnet.com)
  • FAE differs from typical small intestinal villus epithelium: it has fewer goblet cells therefore mucus layer is thinner, and it is also characterized by the presence of specialized M cells or microfold cells, which provide uptake and transport of antigens from lumen. (wikipedia.org)
  • Peyer's patches thus establish their importance in the immune surveillance of the intestinal lumen and in facilitating production of the immune response within the mucosa. (wikipedia.org)
  • Peyer's patches are covered by a special follicle-associated epithelium that contains specialized cells called microfold cells (M cells) which sample antigen directly from the lumen and deliver it to antigen-presenting cells (located in a unique pocket-like structure on their basolateral side). (wikipedia.org)
  • A total of 90 bacterial genera were identified in the lumen of all fish sampled, compared with 159 in the mucosa. (stir.ac.uk)
  • The mucus layer that covers the colic epithelium represents the first line of defense against the aggression caused by antigens, virus, and bacteria in the intestinal lumen. (scielo.br)
  • Early or type I lesion: the patchy necrosis of the epithelium forms fibrin and fibrinous exudate in the lumen of the colon. (healthmanagement.org)
  • An intestinal polyp is any mass of tissue that arises from the bowel wall and protrudes into the lumen. (msdmanuals.com)
  • Influence of the application of enemas with oily extract of curcumin ( Curcuma longa ) on the tissue content of neutral and acidic mucins in the colonic mucosa without fecal stream ☆ ☆ Study conducted at Universidade São Francisco (USF), Programa de Pós-Graduação em Ciências da Saúde, Laboratório de Investigação Médica (LIM), Bragança Paulista, SP, Brazil. (scielo.br)
  • To verify if the application of enemas containing oily extracts of curcumin preserves the tissue content of mucins in the glands of the colonic mucosa without fecal stream. (scielo.br)
  • Ulcerative Colitis Ulcerative colitis is a chronic inflammatory and ulcerative disease arising in the colonic mucosa, characterized most often by bloody diarrhea. (msdmanuals.com)
  • They are not only responsible for innate immunity, but also participate in the development of intestinal inflammation. (frontiersin.org)
  • In addition, the effects of macrophages in the occurrence and development of inflammatory bowel disease (IBD), and their role in inducing fibrosis, activating T cells, reducing colitis, and treating intestinal inflammation were also reviewed in this paper. (frontiersin.org)
  • Macrophage apoptosis results in the release of proinflammatory cytokines (IL-1-beta and IL-18), which signal intestinal inflammation and consequent activation of the innate immune system . (wikidoc.org)
  • Animals with defects in mucus synthesis also display an increased incidence of intestinal tumours, the development of which may accelerated by the severity of the concomitant chronic inflammation. (edu.au)
  • Previous studies have suggested a sequence of events leading to EAC that starts from normal esophageal squamous epithelium to reflux esophagitis, followed by BE, dysplasia, and finally EAC [ 2 ]. (biomedcentral.com)
  • Barrett's esophagus (BE) is an acquired condition in which normal squamous epithelium is replaced with metaplastic columnar epithelium as a consequence of gastroesophageal reflux disease. (jcancer.org)
  • Validity of the specialized columnar epithelium as a diagnostic criterion of the short segment Barrett's esophagus. (korea.ac.kr)
  • The aim of this study was to test validity of the specialized columnar epithelium as a diagnostic criterion of the short segment Barrett's esophagus in Korea. (korea.ac.kr)
  • METHODS: During routine gastroscopy, the length of columnar-lined esophagus was measured and biopsy samples were taken from the mucosa immediately distal to the squamocolumnar junction. (korea.ac.kr)
  • RESULTS: Prevalence of the specialized columnar epithelium in cases without the columnar-lined esophagus and with the short segment columnar-lined esophagus were 57.1% and 31.2%, respectively (P = 0.0281). (korea.ac.kr)
  • The specialized columnar epithelium is frequently seen around the cardia in Koreans with or without the columnar-lined esophagus. (korea.ac.kr)
  • CONCLUSION: Simple presence of the specialized columnar epithelium is not a valid criterion for a diagnosis of Barrett's esophagus. (korea.ac.kr)
  • Dive into the research topics of 'Validity of the specialized columnar epithelium as a diagnostic criterion of the short segment Barrett's esophagus. (korea.ac.kr)
  • A thin layer of smooth muscle present in the mucosa of the stomach, intestine, and bronchi that separates the mucosa from the underlying submucosa. (pressbooks.pub)
  • In intestinal obstruction, the small intestine is dilated and gets filled with air and fluid. (medscape.com)
  • Penetration of crypts beyond the muscularis mucosae was observed infrequently (27% of Winnie mice after DSS) but was absent in wild-type (WT) animals irrespective of treatment. (edu.au)
  • Pathogenic microorganisms and other antigens entering the intestinal tract encounter macrophages, dendritic cells, B-lymphocytes, and T-lymphocytes found in Peyer's patches and other sites of gut-associated lymphoid tissue (GALT). (wikipedia.org)
  • A clear understanding of the function of macrophages, as well as their role in pathogens and inflammatory response, will delineate the next steps in the treatment of intestinal inflammatory diseases. (frontiersin.org)
  • In this review, we discuss the origin and development of macrophages and their role in the intestinal inflammatory response or infection. (frontiersin.org)
  • Feline coronaviruses occur as 2 pathotypes: nonvirulent feline enteric coronaviruses (FECVs), which replicate in intestinal epithelium cells, and lethal feline infectious peritonitis viruses (FIPVs), which replicate in macrophages. (cdc.gov)
  • Pathologically, multiple cystic structures consisting of cuboidal epithelium containing mucinous material are seen in the submucosa and may extend to penetrate the muscularis propria. (radiologytoday.net)
  • To study the role of intestinal flora in inflammatory bowel disease (IBD). (nih.gov)
  • Accumulating evidence supports the pivotal role of intestinal flora in irritable bowel syndrome (IBS). (biomedcentral.com)
  • Notice that the intestinal villi are severely atrophic and often fused. (avma.org)
  • Glands, located at the base of intestinal villi, in which reside the proliferative stem-like cells of the intestine. (pressbooks.pub)
  • The presence of microscopic projections called villi and microvilli in the intestinal wall increases the surface area of absorption for molecules to be transported to tissues and glands via the blood (OpenStax, 2021). (hafsaabbas.com)
  • The intestinal tract is the largest independent immune system in the body. (frontiersin.org)
  • Endometriosis is a common benign disease among women of reproductive age and affects the intestinal tract in 15%-37% of all patients with pelvic endometriosis [3]. (blogspot.com)
  • C. concisus primarily colonizes the human oral cavity and some strains can be translocated to the intestinal tract. (frontiersin.org)
  • Several Campylobacter species utilize humans as their natural host and accumulated evidence supports their role in chronic inflammatory diseases of the human intestinal tract. (frontiersin.org)
  • We conclude from our study that the CNS can be targeted by airborne solid ultrafine particles and that the most likely mechanism is from deposits on the olfactory mucosa of the nasopha- ryngeal region of the respiratory tract and subsequent translocation via the olfactory nerve. (cdc.gov)
  • Exercitatio Anatomico-Medica de Glandulis Intestinorum, Earumque Usu et Affectionibus [Anatomical-medical essay on the intestinal glands, and their function and diseases] (in Latin). (wikipedia.org)
  • These are the mucus secreting glands in the antrum of the stomach and here is the lining epithelium. (lindau-nobel.org)
  • Flexible sigmoidoscopy was performed the next day and showed a submucosal, nonobstructing, medium-sized, noncircumferential mass involving the distal rectum. (radiologytoday.net)
  • Lower rectal ultrasound was then performed and showed a 3.5 cm bilobed intramural (subepithelial) lesion in the distal rectum. (radiologytoday.net)
  • In the sequence, the formation of polyps into colorectal mucosa represents the pre-cancerous state, an event associated to mutation in crucial genes such as APC. (oncotarget.com)
  • Before the 1970s, well fixed specimens of gastric mucosa were rare. (lindau-nobel.org)
  • This study compared the long-term consequences of two common forms of bariatric surgery: one-anastomosis gastric bypass (OAGB) and Roux-en-Y Gastric Bypass (RYGB) in a preclinical rat model. (nature.com)
  • Beginning in the middle colon, a mucus gap of growing thickness physically separated all intestinal bacteria from contact with the epithelium. (nih.gov)
  • The stimulus for activation is thought to be commensal bacteria colonising the gut mucosa. (bmj.com)
  • The aim of this investigation was to compare the principal culturable bacterial populations on the rectal mucosa of UC patients, and to determine whether specific antibodies towards these bacteria can activate infiltrating PMN through opsonisation. (bmj.com)
  • Secretory intestinal pithelial cells located within intestinal crypts with eosinophilic, round cytoplasmic granules containing antimicrobial compounds. (pressbooks.pub)
  • Clearance of small intestinal crypts involves goblet cell mucus secretion by intracellular granule rupture and enterocyte ion transport. (gu.se)
  • The gastrointestinal hormone, insulin-like peptide 5 (INSL5), is found in large intestinal enteroendocrine cells (EEC). (edu.au)
  • There are many microorganisms colonized in the human intestine, and more than 1000 bacterial species in the intestinal ecosystem of a single individual. (frontiersin.org)
  • and, finally, the reticuloendothelial system traps and destroys the microorganisms that cross the mucosa (Martínez-Rodríguez et al. (healthmanagement.org)
  • A 20 mm × 13 mm cystic lesion is noted on the right side of the CBD, communicating with the CBD, representing fusiform dilatation of the cystic duct (Type VI)/saccular diverticulum from the CBD (Type II) [Figure 1] with the unremarkable distal CBD. (jiaps.com)
  • The spatial organization of intestinal flora was investigated in normal mice and in two models of murine colitis using fluorescence in situ hybridization. (nih.gov)
  • Here, we identify Bacteroides thetaiotaomicron (Bt) as a probiotic that associates with insulin sensitivity and report its beneficial effects on fortifying the gut epithelium and improving host metabolism when it is supplemented in HFD-fed female mice. (harvard.edu)
  • The distal colon of Winnie mice after completion of the DSS protocol revealed hyperplastic mucosa with glandular morphological abnormalities resembling pre-cancerous change. (edu.au)
  • The former maintains intestinal health, while the latter plays an important role in the occurrence of inflammatory reactions. (frontiersin.org)
  • The highly organized structure of the colonic flora, its specific arrangement in different colonic segments, and its specialized response to inflammatory stimuli indicate that the intestinal flora is an innate part of host immunity that is under complex control. (nih.gov)
  • Inflammatory processes in ulcerative colitis (UC) usually begin in the distal bowel, and progress proximally along the mucosa, with crypt abscesses causing severe tissue damage. (bmj.com)
  • These improvements in distal gut barrier architecture were associated with a reduction in circulating levels of pro-inflammatory lipopolysaccharide (LPS) and interleukin-6 (IL-6). (harvard.edu)
  • At the same time the paracellular pathway of follicle-associated epithelium is closed tightly to prevent penetration of antigens and continuous contact with immune cells. (wikipedia.org)
  • These cells play a key role in early resistance to intestinal pathogens. (frontiersin.org)
  • The mucosa in ulcerative colitis (UC) is replete with antibody producing plasma B cells and polymorphonuclear leucocytes (PMN). (bmj.com)
  • The aetiology of UC is unknown but the mucosa contains large numbers of polymorphonuclear leucocytes (PMN) and immunoglobulin secreting plasma cells. (bmj.com)
  • First of all there are a lot of cells in the lining of stomach near the neck of the gland, which, at a high power view here, you can see there are numerous polymorphs in the epithelium and this is an unusual feature. (lindau-nobel.org)
  • Initially, Shigella uses M cells from the basolateral side of the intestinal epithelium as entry port. (wikidoc.org)
  • The epithelium undergoes various turnovers via stem cells. (hafsaabbas.com)
  • As C. jejuni and C. coli are the main Campylobacter pathogens which cause human acute intestinal disease and they originate from animal sources, Campylobacteriosis has historically been considered to be zoonotic. (frontiersin.org)
  • NGS platform has been used to explore the rainbow trout intestinal microflora. (stir.ac.uk)
  • Peyer's patches are characterized by the follicle-associated epithelium (FAE), which covers all lymphoid follicles. (wikipedia.org)
  • The metabolites produced by them not only modulate gastro-intestinal immunity, but also impact distal organs like lung and brain. (frontiersin.org)
  • Enemas with curcumin preserve the content of neutral and acidic mucins in the colonic epithelium without fecal stream. (scielo.br)
  • Tissue quantification of neutral and acid mucins in the mucosa of the colon with and without fecal stream in rats. (scielo.br)
  • Fecal and duodenal mucosa brush samples were obtained from 41 IBS patients and 26 healthy subjects. (wjgnet.com)
  • On endoscopy, the CCP-related masses appear as sessile polyps with associated normal, inflamed, or ulcerated mucosa. (radiologytoday.net)
  • Schematic representation to depict assimilation of dietary nutrients by gut microbiome and their impact on distal organs. (frontiersin.org)
  • We evaluated the influence of biliopancreatic limb (BPL) length, malabsorption, and bile acid (BA) reflux on esogastric mucosa. (nature.com)
  • These little fragments of mucosa instantly fixed and were well-fixed specimens that we got. (lindau-nobel.org)
  • Cytology revealed pools of extracellular mucin with fragments of columnar mucosa. (radiologytoday.net)
  • The bi-directional cross-talk between gut and lung (termed as Gut-Lung axis) is best exemplified by intestinal disturbances observed in lung diseases. (frontiersin.org)
  • Animal models of UTI have revealed that the mannose-binding FimH adhesin of type 1 pili is critical for the colonization of and invasion into the bladder epithelium by UPEC, as well as other uropathogenic members of the Enterobacteriaceae family, such as Klebsiella, Enterobacter , and Citrobacter species. (justia.com)
  • There was no invasion of muscularis propria, and the overlying mucosa was intact. (radiologytoday.net)
  • "The present study was conducted to evaluate the nutritional value of camelina by-products fed to Atlantic salmon parr in terms of growth performance, carcass composition, as well as morphology and histology of the distal intestine," ​ said members of the research team. (feednavigator.com)
  • A hyalinized protein forming a thick, protective layer overlying the mucosa of the gizzard of birds. (pressbooks.pub)
  • and increased protein levels of mucin2 in the distal gut versus vehicle-treated controls. (harvard.edu)
  • The distal FimH adhesin protein is connected to the the pilus rod by the flexible tip fibrillum, which is composed of one copy each of FimF and FimG. (justia.com)