• Such adaptation enables the reactivation of acinar-to-ductal metaplasia (ADM) upon subsequent inflammatory events, thereby limiting tissue damage through a rapid decrease of zymogen production. (nih.gov)
  • PD2/Paf1 was specifically expressed in amylase and CK19 double positive metaplastic ducts, representing intermediate structures during pancreatic acinar-to-ductal metaplasia (ADM). (oncotarget.com)
  • 10. Krüppel-like Factor 5, Increased in Pancreatic Ductal Adenocarcinoma, Promotes Proliferation, Acinar-to-Ductal Metaplasia, Pancreatic Intraepithelial Neoplasia, and Tumor Growth in Mice. (nih.gov)
  • Some studies have shown that acinar-to-ductal metaplasia (ADM), induced by pancreatic injury, pancreatitis, or genetic toxicity, is one of the most typical events observed during PaCa development. (biomedcentral.com)
  • As mineral particles, especially asbestos, are suspected to induce squamous metaplasia, we chose to study two specific transformations of the epithelium: the expression of cytokeratin-13 and the formation of cross-linked envelopes. (nih.gov)
  • Through a process of squamous metaplasia, the vagina and a variable portion of the ectocervix become covered with squamous epithelium. (medscape.com)
  • Immature squamous metaplasia shares biochemical and immunohistochemical features of both mature squamous epithelium and columnar mucinous epithelium. (medscape.com)
  • The transformation zone is the name given to the area of the cervix comprised of epithelium which has undergone metaplastic change. (eurocytology.eu)
  • Metaplasia is the name given to the process by which one fully differentiated type of epithelium changes into another. (eurocytology.eu)
  • Mature squamous metaplasia the undifferentiated cells have differentiated into mature squamous epithelium which is nearly indistinguishable from the original squamous epithelium. (eurocytology.eu)
  • In the cervix, the area of the epithelium that has undergone metaplastic change is called the transformation zone (TZ). (eurocytology.eu)
  • Major light microscopic alterations observed were proliferation and hypertrophy of the terminal bronchiolar cells, consisting of ciliated and Clara cells, hypersecretion of the epithelial mucin in the goblet cells of both the bronchial and the proximal bronchiolar epithelium, hyperplasia of alveolar epithelium, mobilization of alveolar macrophages and occasional presence of peribronchial or bronchiolar chronic inflammation. (cdc.gov)
  • However, antral biopsy may be needed for the adequate histological evaluation of precancerous lesions, such as atrophy and intestinal metaplasia. (medscape.com)
  • Chronic H. pylori infection results in mucosal atrophy and intestinal metaplasia. (medscape.com)
  • [ 25-27 ] The diagnosis of active H. pylori infection becomes difficult in patients with glandular atrophy and intestinal metaplasia, an environment in which H. pylori might disappear. (medscape.com)
  • [ 11-13 ] As the degree of atrophy progresses, the presence of active H. pylori infection appears to decrease, which is probably related to the transformation of the mucosal lining from the H. pylori -friendly normal superficial epithelial cells to intestinal metaplasia, which is not hospitable to H. pylori . (medscape.com)
  • Moderate-marked atrophy or intestinal metaplasia was more frequent in the false negative biopsy specimens, in which H. pylori was not detected despite the infection. (medscape.com)
  • Thus, our results support previous findings that the high prevalence of glandular atrophy and intestinal metaplasia at the antral mucosa prevent adequate evaluation of H. pylori status in patients with gastric cancer. (medscape.com)
  • Atrophy and intestinal metaplasia initiate from the antrum, due to chronic H. pylori infection, and extend to the corpus along the lesser curvature side. (medscape.com)
  • reported that extensive intestinal metaplasia, along the lesser curvature (so called Magenstraβe) or diffuse type (involving the entire stomach), was associated with increased risk of gastric cancer. (medscape.com)
  • Microscopic examination revealed moderate chronic active inflammation with focal intestinal metaplasia. (biomedcentral.com)
  • Intestinal metaplasia induced by ectopic expression of caudal-type homeobox (CDX)2 and/or CDX1 (CDX) is frequently observed around gastric cancer (GC). (cancer-genetics.org)
  • Gastric intestinal metaplasia (GIM), a common precancerous lesion of gastric cancer, can be caused by bile acid reflux. (gutnliver.org)
  • PURPOSE The intent of this solicitation is to promote research on the molecular and cellular mechanisms involved in hypersecretion of mucus and mucous cell metaplasia in human airway diseases. (nih.gov)
  • This Request for Applications (RFA), Molecular Mechanisms of Mucous Cell Metaplasia and Excess Mucous Secretion In Airway Diseases, is related to one or more of the priority areas. (nih.gov)
  • RESEARCH OBJECTIVES Background Mucous cell metaplasia with mucous hypersecretion is a prominent manifestation of many common inflammatory diseases of the upper and lower airways. (nih.gov)
  • Inflammation from airborne microbes can overwhelm compensatory mucociliary clearance mechanisms, leading to mucous cell metaplasia. (cdc.gov)
  • In conclusion, MyD88 deficiency enhances airway mucous cell metaplasia under environments with high TLR activation. (cdc.gov)
  • We report that long after its complete resolution, a transient inflammatory event primes pancreatic epithelial cells to subsequent transformation by oncogenic KRAS. (nih.gov)
  • Upon recovery from acute inflammation, pancreatic epithelial cells display an enduring adaptive response associated with sustained transcriptional and epigenetic reprogramming. (nih.gov)
  • Pleomorphic adenoma (or benign mixed tumor) is a common benign salivary gland neoplasm characterised by neoplastic proliferation of epithelial (ductal) cells along with myoepithelial components, having a malignant potentiality. (wikipedia.org)
  • Epithelial elements may be arranged in duct-like structures, sheets, clumps and/or interlacing strands and consist of polygonal, spindle or stellate-shaped cells (hence pleiomorphism). (wikipedia.org)
  • Knowledge of the molecular pathways that regulate secretion and metaplasia in the pulmonary mucous cells of individuals with airway diseases might aid the rational development of new drugs for the control of mucous function. (nih.gov)
  • The relative importance of cellular stimulation and of cellular metaplastic transformation is poorly understood, and differential regulation of epithelial goblet cells and submucosal glands has not been adequately examined. (nih.gov)
  • Effect of mineral particles containing iron on primary cultures of rabbit tracheal epithelial cells: possible implication of oxidative stress. (nih.gov)
  • Isolated neuroendocrine epithelial cells of argentaffin type or argyrophil type are admixed with the normal endocervical cells. (medscape.com)
  • Immature squamous metaplasia - the reserve cells proliferate to form a multilayer of undifferentiated cells. (eurocytology.eu)
  • Numerous studies have shown that the immature metaplastic epithelial cells are susceptible to carcinogens and most, if not all, cervical cancers arise here. (eurocytology.eu)
  • however, researchers suspect that they begin during the early stages of development in pregnancy (embryogenesis) and may result from metaplasia (abnormal transformation of cells). (tcdiazmd.com)
  • Finally, ODE-induced Muc5ac levels were enhanced in MyD88-deficient airway epithelial cells in vitro. (cdc.gov)
  • Using 3D organoids derived from patient samples (PDOs) or esophageal cancer cell lines, the Sachdeva Lab is studying the responses of esophageal epithelial and stromal cells to metabolic stress, and the way in which these stress response pathways contribute to malignant transformation. (massgeneral.org)
  • It involves exfoliating cells from the transformation zone of the cervix to enable examination of these cells microscopically for detection of cancerous or precancerous lesions. (medscape.com)
  • Thus, blocking gastric precancerous cells from malignant transformation is crucial for early detection and prevention of GC. (biomedcentral.com)
  • MUC1, also referred to as mammary-type mucin, has a role in the maintenance of the lumina of ductal epithelial cells, and is thought to have an inhibitory role in cell-cell and cell-stroma interactions and in cytotoxic immunity. (bmj.com)
  • Immortalized human meibomian gland and conjunctival epithelial cells were treated with placebo or dihydrotestosterone (DHT) and processed for molecular biologic procedures. (molvis.org)
  • Androgen treatment significantly influenced the expression of approximately 3,000 genes in immortalized human meibomian gland and conjunctival epithelial cells. (molvis.org)
  • Our findings support our hypothesis that androgens regulate gene expression in human meibomian gland and conjunctival epithelial cells. (molvis.org)
  • To continue to test our hypothesis, we examined the influence of androgens in gene expression in immortalized human meibomian gland and conjunctival epithelial cells. (molvis.org)
  • Immortalized human meibomian gland epithelial cells, which were recently generated in our laboratory [ 2 ], were cultured in Keratinocyte Serum-Free Medium [KSFM] supplemented with 50 μg/ml bovine pituitary extract (BPE), 5 ng/ml epidermal growth factor (EGF), and 100 U penicillin-streptomycin (Invitrogen, Carlsbad, CA). Cells were incubated in a humidified, 37 °C chamber under 5% CO 2 /95% air. (molvis.org)
  • Human Papillomavirus (HPV) Infection Human papillomavirus (HPV) infects epithelial cells. (msdmanuals.com)
  • Even though it has an origin which is exclusive to epithelial tissue, the variety of components accords it a mesenchymal appearance as a result of the production of secretions from the tumor cells themselves, which may be ductal or myoepithelial 7 . (bvsalud.org)
  • Here, we will review the evidence from animal models supporting the role of all major types of liver epithelial cells: hepatocytes, cholangiocytes, and their common progenitor as liver cancer cell-of-origin. (biomedcentral.com)
  • Variable degree of squamous, apocrine, mucinous or sebaceous metaplasia is common in luminal cells. (pathoclinics.com)
  • We sought to determine whether this hormone action involves the regulation of epithelial cell gene expression in these tissues. (molvis.org)
  • Though it is classified as a benign tumor, pleomorphic adenomas have the capacity to grow to large proportions and may undergo malignant transformation, to form carcinoma ex-pleomorphic adenoma, a risk that increases with time (9.5% chance to convert into malignancy in 15 years). (wikipedia.org)
  • The tumor extends through normal glandular parenchyma in the form of finger-like pseudopodia, but this is not a sign of malignant transformation. (wikipedia.org)
  • However, rarely, either the epithelial or the lymphoid component of Warthin's tumor can undergo malignant transformation. (rrml.ro)
  • Malignant transformation of the lymphoid component is relatively common but the epithelial malignancy is very rare. (rrml.ro)
  • H pylori causes chronic gastritis by manipulating the host's immune system to cause an inflammatory response that predisposes to malignant transformation. (medscape.com)
  • 1, 2 Such phenotypic alterations, considered the precursor of malignant transformation, have been defined as epithelial dysplasia. (bmj.com)
  • Therefore, the treatment of precancerous lesions with malignant transformation potential is of great significance to reduce the incidence of GC. (biomedcentral.com)
  • But almost all kinds of tumours ranging from benign epithelial tumours to carcinoids even rare like Maltomas, Lipomas, FAP, Peutz Jeghers polyps, metastatic tumours and malignant mesenchymal tumours were observed and highlighted in the study. (ispub.com)
  • Since epithelial and mesenchymal tumours are uncommon in midgut, lymphomas constitute a significant proportion i.e.30-50% of all malignant tumours occurring at this site. (ispub.com)
  • The incidence of ovarian epithelial endometrial cancer histological types varied across age groups, our study group including women aged between 34 and 64 years old. (coboramlaprima.ro)
  • 8. Maintenance of acinar cell organization is critical to preventing Kras-induced acinar-ductal metaplasia. (nih.gov)
  • It is also known as "Mixed tumor, salivary gland type", which refers to its dual origin from epithelial and myoepithelial elements as opposed to its pleomorphic appearance. (wikipedia.org)
  • Focal or rare presence of chondroid metaplasia resembles to salivary gland pleomorphic adenoma, considered as a variants of adenomyoepithelioma. (pathoclinics.com)
  • Classically it is biphasic and is characterized by an admixture of polygonal epithelial and spindle-shaped myoepithelial elements in a variable background stroma that may be mucoid, myxoid, cartilaginous or hyaline. (wikipedia.org)
  • [ 3 ] proposed WT with myxoid and squamous metaplasia. (researchsquare.com)
  • The change of name to "pleomorphic" adenoma was first suggested as recently as 1948, as this term describes the embryological basis for these tumors, which originate in the epithelial and connective tissue 3 . (bvsalud.org)
  • Utilitatea imunohistochimiei în diagnosticul carcinomului ovarian Incidence of endometriosis and atypical endometriosis in epithelial ovarian tumors Utilitatea imunohistochimiei în diagnosticul carcinomului ovarian V-ar putea interesa [Myometrial invasion as a prognostic factor in endometrial adenocarcinoma]. (coboramlaprima.ro)
  • It lacked the two layers of oncocytic epithelial tissue characteristic of WT. (researchsquare.com)
  • In KC mice, however, PD2/Paf1 mRNA level continued to decrease with progressive dysplasia and subsequent neoplastic transformation. (oncotarget.com)
  • BPH is characterized by an increase in epithelial cell numbers (hyperplasia) as well as an increase in epithelial cell size (hypertrophy), but the increase in cell number is more marked. (vin.com)
  • and/or 3) epithelial-mesenchymal interactions/transformation. (ersjournals.com)
  • Moreover, we will also propose mechanisms that promote liver cancer cell plasticity (dedifferentiation, transdifferentiation, and epithelial-to-mesenchymal transition) which may contribute to misinterpretation of the results and which make the issue of liver cancer cell-of-origin particularly complex. (biomedcentral.com)
  • This issue has been additionally complicated by dedifferentiation, transdifferentiation, and epithelial-to-mesenchymal transition (EMT), processes which have been shown to enable acquisition (at least transitory) of traits characteristic of different cell lineages. (biomedcentral.com)
  • Although the pathogenic pathways involved in IPF have not been fully elucidated, IPF is believed to be caused by repetitive alveolar epithelial cell injury and dysregulated repair, in which there is uncontrolled proliferation of lung fibroblasts and differentiation of fibroblasts into myofibroblasts, which excessively deposit extracellular matrix (ECM) proteins in the interstitial space. (ersjournals.com)
  • MyD88 controls airway epithelial Muc5ac expression during TLR activation conditions from agricultur al organic dust exposure. (cdc.gov)
  • Warthin's tumor is a benign salivary neoplasm occurring mainly in the parotid gland, and has an epithelial component and a lymphoid stroma. (rrml.ro)
  • Craniopharyngiomas are thought to arise from epithelial remnants of the craniopharyngeal duct or Rathke's pouch, which are developmental structures related to gut (stomach) formation. (tcdiazmd.com)
  • Recently, MUC2 has been shown to have tumour suppressor activity, as demonstrated by the neoplastic transformation seen in the gastrointestinal system of MUC2 knockout mice. (bmj.com)
  • The prevailing pathogenic hypotheses assume that either an inflammatory process or an independent epithelial/fibroblastic disorder may propagate the disease process. (ersjournals.com)
  • L'étude portait sur 20 patients atteints d'un carcinome gastrique, 20 patients souffrant d'une gastrite à H. pylori et 20 personnes en tant que groupe témoin. (who.int)
  • In most cases, examination of the biopsy specimen revealed only minor epithelial changes. (medscape.com)
  • Conclusion: The epithelial malignancy was labeled with CK and EMA. (rrml.ro)
  • Conclusion: In treating patients with post-operative CL, we recommend the MCT diet and EN as the first option, rather than fasting, parenteral nutrition (PN), or octreotide. (bvsalud.org)
  • We are a dynamic group of scientists and scientists-in-training from diverse backgrounds, with projects encompassing the fields of cancer cell biology, 3D epithelial organoid biology, cell metabolism and tumor-stromal interactions. (massgeneral.org)
  • Aim: We present a rare case with in situ carcinoma and squamous metaplasia arising in a Warthin's tumor of a parotid gland in a 79-year-old man and the differential diagnosis to be considered for this case. (rrml.ro)
  • Areas with squamous metaplasia and in situ carcinoma were also present. (rrml.ro)
  • KINETICS AND METABOLISM IN LABORATORY ANIMALS AND HUMANS 6.1 Absorption 6.1.1 Air 6.1.2 Oral 6.1.3 Dermal 6.2 Distribution 6.2.1 Inhalation exposure 6.2.2 Oral and dermal exposures 6.3 Metabolic transformation 6.4 Elimination and excretion 6.4.1 Inhalation exposure 6.4.2 Oral exposure 6.4.3 Dermal exposure 6.5 Retention and turnover 6.6 Reaction with body components 6.7 Modelling of pharmacokinetic data for benzene 7. (inchem.org)
  • SUMMARY AND CONCLUSIONS 1.1 Identity, physical and chemical properties, analytical methods 1.2 Sources of human exposure 1.3 Environmental transport, distribution and transformation 1.4 Environmental levels and human exposure 1.5 Kinetics and metabolism 1.6 Effects on laboratory mammals and in vitro test systems 1.6.1 Systemic toxicity 1.6.2 Genotoxicity and carcinogenicity 1.6.3 Reproductive toxicity, embryotoxicity and teratogenicity 1.6.4 Immunotoxicity 1.7 Effects on humans 1.8 Conclusions 2. (inchem.org)
  • The process of metaplasia is a patchy one: It starts initially in the crypts and at the tips of the endocervical villae which gradually fuse. (eurocytology.eu)